A biphasic response pattern of lipid metabolomics in the stage progression of hepatitis B virus X tumorigenesis

Molecular Carcinogenesis

Volumn 55, Issue 1, 2016, Pages 105-114

  Teng, Chiao Fang ^a   Hsieh, Wen Chuan ^a   Yang, Ching Wen ^b   Su, Hui Min ^c   Tsai, Ting Fen ^a,d   Sung, Wang Chou ^a   Huang, Wenya ^b   Su, Ih Jen ^a,b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Cholesterol; Fatty acids; Hepatocellular carcinoma; Metabolic syndrome; Triglycerides

Indexed keywords

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; APOLIPOPROTEIN A4; ARACHIDONATE 5 LIPOXYGENASE; CHOLESTEROL; COMPLEMENTARY DNA; FATTY ACID; FATTY ACID BINDING PROTEIN 4; HEPATITIS B VIRUS X PROTEIN; LIPOPROTEIN LIPASE; MONOUNSATURATED FATTY ACID; SATURATED FATTY ACID; TRIACYLGLYCEROL; LIPID; TRANSACTIVATOR PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; GENE EXPRESSION; HEPATITIS B; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIPID LIVER LEVEL; LIPID METABOLISM; LIPOGENESIS; LIVER CARCINOGENESIS; MALE; METABOLOMICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BLOOD; CANCER STAGING; CARCINOMA, HEPATOCELLULAR; DISEASE MODEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; LIVER; LIVER NEOPLASMS; METABOLISM; METABOLOME; PATHOLOGY; PROCEDURES; TRANSGENIC MOUSE; VIRUS CELL TRANSFORMATION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELL TRANSFORMATION, VIRAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FATTY ACIDS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPID METABOLISM; LIPIDS; LIVER; LIVER NEOPLASMS; METABOLOME; METABOLOMICS; MICE; MICE, TRANSGENIC; NEOPLASM STAGING; TRANS-ACTIVATORS;

EID: 84954375870     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22266     Document Type: Article

References (36)

1. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 1981; 2:1129-1133.
2. Sitia G, Aiolfi R, Di Lucia P, et al. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Di Lucia P 2012; 109:E2165-E2172.
3. Su IJ, Hsieh WC, Tsai HW. Chemoprevention and novel therapy for hepatocellular carcinoma associated with chronic hepatitis B virus infection. Hepatobiliary Surg Nutr 2013; 2:37-39.
4. Kew MC. Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma. J Gastroenterol Hepatol 2011; 26 144-152.
5. Wu YF, Fu SL, Kao CH, et al. Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice. Cancer Res 2008; 68:2033-2042.
6. Lin HC, Chen YF, Hsu WH, Yang CW, Kao CH, Tsai TF. Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse model. Cancer Prev Res (Phila) 2012; 5:952-962.
7. Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection. Hepatology 2010; 51:1820-1832.
8. Siegel AB, Zhu AX. Metabolic syndrome and hepatocellular carcinoma: Two growing epidemics with a potential link. Cancer 2009; 115:5651-5661.
9. Patterson AD, Maurhofer O, Beyoglu D, et al. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. Cancer Res 2011; 71:6590-6600.
10. Welzel TM, Graubard BI, Zeuzem S, El-Serag HB, Davila JA, McGlynn KA. Metabolic syndrome increases the risk of primary liver cancer in the United States: A study in the SEER-Medicare database. Hepatology 2011; 54:463-471.
11. Wu BK, Li CC, Chen HJ, et al. Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice. Biochem Biophys Res Commun 2006; 340:916-928.
12. Culling CFAHandbook of Histopathological and Histochemical Techniques. London: Butterworth; 1974.
13. Yang JC, Teng CF, Wu HC, et al. Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis. Hepatology 2009; 49:1962-1971.
14. Wu HC, Tsai HW, Teng CF, et al. Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis. Hum Pathol 2014; 45:1294-1301.
15. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37:911-917.
16. Chung WL, Chen JJ. Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. J Nutr 2008; 138:1165-1171.
17. Wang HC, Chang WT, Chang WW, et al. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 2005; 41:761-770.
18. Teng CF, Wu HC, Tsai HW, Shiah HS, Huang W, Su IJ. Novel feedback inhibition of surface antigen synthesis by mammalian target of rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and therapy. Hepatology 2011; 54:1199-1207.
19. Chisari FV, Klopchin K, Moriyama T, et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 1989; 59:1145-1156.
20. Yang PL, Althage A, Chung J, et al. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 2010; 107:798-802.
21. Bissell DM, Gores GJ, Laskin DL, Hoofnagle JH. Drug-induced liver injury: Mechanisms and test systems. Hepatology 2001; 33:1009-1013.
22. Choi J, Ou JH. Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol 2006; 290:G847-G851.
23. Kutami R, Nakashima Y, Nakashima O, Shiota K, Kojiro M. Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans. J Hepatol 2000; 33:282-289.
24. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7:11-20.
25. Ricchi M, Odoardi MR, Carulli L, et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 2009; 24:830-840.
26. Nakamura MT, Nara TY. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 2004; 24:345-376.
27. Radmark O, Werz O, Steinhilber D, Samuelsson B. 5-Lipoxygenase: Regulation of expression and enzyme activity. Trends Biochem Sci 2007; 32:332-341.
28. Mead JR, Irvine SA, Ramji DP. Lipoprotein lipase: Structure, function, regulation, and role in disease. J Mol Med (Berl) 2002; 80:753-769.
29. Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov 2008; 7:489-503.
30. Agarwal AK, Sukumaran S, Bartz R, Barnes RI, Garg A. Functional characterization of human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 9: Cloning, tissue distribution, gene structure, and enzymatic activity. J Endocrinol 2007; 193:445-457.
31. Chen CH, Albers JJ. Activation of lecithin: cholesterol acyltransferase by apolipoproteins E-2, E-3, and A-IV isolated from human plasma. Biochim Biophys Acta 1985; 836:279-285.
32. Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Curr Biol 2009; 19:R1046-R1052.
33. Cornu M, Albert V, Hall MN. MTOR in aging, metabolism, and cancer. Curr Opin Genet Dev 2013; 23:53-62.
34. Miller DM, Thomas SD, Islam A, Muench D, Sedoris K. C-Myc and Cancer Metabolism. Clin Cancer Res 2012; 18:5546-5553.
35. Bishayee A, Politis T, Darvesh AS. Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat Rev 2010; 36:43-53.
36. Feher J, Lengyel G. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol 2012; 13:210-217.