메뉴 건너뛰기




Volumn 45, Issue 6, 2014, Pages 1294-1301

Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis

Author keywords

Ground glass hepatocytes; HBx; Hepatocellular carcinoma; mTOR signals; Pre S2 deletion mutant

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VIRUS X PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; RAF PROTEIN; VASCULOTROPIN A;

EID: 84901414896     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.10.039     Document Type: Article
Times cited : (28)

References (29)
  • 1
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus: A prospective study of 22 707 men in Taiwan
    • R.P. Beasley, L.Y. Hwang, C.C. Lin, and C.S. Chien Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22 707 men in Taiwan Lancet 2 1981 1129 1133
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Hwang, L.Y.2    Lin, C.C.3    Chien, C.S.4
  • 2
    • 84901445048 scopus 로고    scopus 로고
    • Chemoprevention and novel therapy for hepatocellular carcinoma associated with chronic hepatitis B virus infection
    • I.J. Su, W.C. Hsieh, H.W. Tsai, and H.C. Wu Chemoprevention and novel therapy for hepatocellular carcinoma associated with chronic hepatitis B virus infection Hepatobiliary Surg Nutr 2 2013 37 39
    • (2013) Hepatobiliary Surg Nutr , vol.2 , pp. 37-39
    • Su, I.J.1    Hsieh, W.C.2    Tsai, H.W.3    Wu, H.C.4
  • 3
    • 84864681003 scopus 로고    scopus 로고
    • Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B
    • G. Sitia, R. Aiolfi, and P. Di Lucia et al. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B Proc Natl Acad Sci U S A 109 2012 E2165 E2172
    • (2012) Proc Natl Acad Sci U S A , vol.109
    • Sitia, G.1    Aiolfi, R.2    Di Lucia, P.3
  • 4
    • 84984552538 scopus 로고    scopus 로고
    • Viral hepatocarcinogenesis: From infection to cancer
    • A. Tan, S.H. Yeh, C.J. Liu, C. Cheung, and P.J. Chen Viral hepatocarcinogenesis: from infection to cancer Liver Int 28 2008 175 188
    • (2008) Liver Int , vol.28 , pp. 175-188
    • Tan, A.1    Yeh, S.H.2    Liu, C.J.3    Cheung, C.4    Chen, P.J.5
  • 5
    • 0028135497 scopus 로고
    • Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade
    • J. Benn, and R.J. Schneider Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade Proc Natl Acad Sci U S A 91 1994 10350 10354
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10350-10354
    • Benn, J.1    Schneider, R.J.2
  • 6
    • 3042579870 scopus 로고    scopus 로고
    • Evaluation of nuclear factor-kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma
    • C.F. Chan, T.O. Yau, D.Y. Jin, C.M. Wong, S.T. Fan, and I.O. Ng Evaluation of nuclear factor-kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma Clin Cancer Res 10 2004 4140 4149
    • (2004) Clin Cancer Res , vol.10 , pp. 4140-4149
    • Chan, C.F.1    Yau, T.O.2    Jin, D.Y.3    Wong, C.M.4    Fan, S.T.5    Ng, I.O.6
  • 7
    • 0035907311 scopus 로고    scopus 로고
    • The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
    • Y.I. Lee, S. Kang-Park, and S.I. Do The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade J Biol Chem 276 2001 16969 16977
    • (2001) J Biol Chem , vol.276 , pp. 16969-16977
    • Lee, Y.I.1    Kang-Park, S.2    Do, S.I.3
  • 8
    • 0032566516 scopus 로고    scopus 로고
    • HBx protein of hepatitis B virus activates Jak1-STAT signaling
    • Y.H. Lee, and Y. Yun HBx protein of hepatitis B virus activates Jak1-STAT signaling J Biol Chem 273 1998 25510 25515
    • (1998) J Biol Chem , vol.273 , pp. 25510-25515
    • Lee, Y.H.1    Yun, Y.2
  • 9
    • 84864587705 scopus 로고    scopus 로고
    • Hepatitis B virus X protein upregulates mTOR signaling through IKKbeta to increase cell proliferation and VEGF production in hepatocellular carcinoma
    • C.J. Yen, Y.J. Lin, and C.S. Yen et al. Hepatitis B virus X protein upregulates mTOR signaling through IKKbeta to increase cell proliferation and VEGF production in hepatocellular carcinoma PLoS One 7 2012 e41931
    • (2012) PLoS One , vol.7 , pp. 41931
    • Yen, C.J.1    Lin, Y.J.2    Yen, C.S.3
  • 10
    • 33747496317 scopus 로고    scopus 로고
    • Chronic hepatitis B in hepatocarcinogenesis
    • N.H. Park, I.H. Song, and Y.H. Chung Chronic hepatitis B in hepatocarcinogenesis Postgrad Med J 82 2006 507 515
    • (2006) Postgrad Med J , vol.82 , pp. 507-515
    • Park, N.H.1    Song, I.H.2    Chung, Y.H.3
  • 11
    • 0345707640 scopus 로고    scopus 로고
    • Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress
    • H.C. Wang, H.C. Wu, C.F. Chen, N. Fausto, H.Y. Lei, and I.J. Su Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress Am J Pathol 163 2003 2441 2449
    • (2003) Am J Pathol , vol.163 , pp. 2441-2449
    • Wang, H.C.1    Wu, H.C.2    Chen, C.F.3    Fausto, N.4    Lei, H.Y.5    Su, I.J.6
  • 12
    • 6444242588 scopus 로고    scopus 로고
    • Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage
    • Y.H. Hsieh, I.J. Su, and H.C. Wang et al. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage Carcinogenesis 25 2004 2023 2032
    • (2004) Carcinogenesis , vol.25 , pp. 2023-2032
    • Hsieh, Y.H.1    Su, I.J.2    Wang, H.C.3
  • 13
    • 8744260946 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase
    • J.H. Hung, I.J. Su, and H.Y. Lei et al. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase J Biol Chem 279 2004 46384 46392
    • (2004) J Biol Chem , vol.279 , pp. 46384-46392
    • Hung, J.H.1    Su, I.J.2    Lei, H.Y.3
  • 14
    • 68949091981 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis
    • J.C. Yang, C.F. Teng, and H.C. Wu et al. Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis Hepatology 49 2009 1962 1971
    • (2009) Hepatology , vol.49 , pp. 1962-1971
    • Yang, J.C.1    Teng, C.F.2    Wu, H.C.3
  • 15
    • 35649014367 scopus 로고    scopus 로고
    • Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients
    • C.H. Chen, C.H. Hung, and C.M. Lee et al. Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients Gastroenterology 133 2007 1466 1474
    • (2007) Gastroenterology , vol.133 , pp. 1466-1474
    • Chen, C.H.1    Hung, C.H.2    Lee, C.M.3
  • 16
    • 79959593444 scopus 로고    scopus 로고
    • A clustered ground-glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery
    • H.W. Tsai, Y.J. Lin, and P.W. Lin et al. A clustered ground-glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery Cancer 117 2011 2951 2960
    • (2011) Cancer , vol.117 , pp. 2951-2960
    • Tsai, H.W.1    Lin, Y.J.2    Lin, P.W.3
  • 17
    • 84880330401 scopus 로고    scopus 로고
    • Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B
    • A.M. Mathai, J. Alexander, F.Y. Kuo, M. Torbenson, P.E. Swanson, and M.M. Yeh Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B Hum Pathol 44 2013 1665 1671
    • (2013) Hum Pathol , vol.44 , pp. 1665-1671
    • Mathai, A.M.1    Alexander, J.2    Kuo, F.Y.3    Torbenson, M.4    Swanson, P.E.5    Yeh, M.M.6
  • 18
    • 16244375544 scopus 로고    scopus 로고
    • Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes
    • H.C. Wang, W.T. Chang, and W.W. Chang et al. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes Hepatology 41 2005 761 770
    • (2005) Hepatology , vol.41 , pp. 761-770
    • Wang, H.C.1    Chang, W.T.2    Chang, W.W.3
  • 19
    • 30144444237 scopus 로고    scopus 로고
    • Blocking of G1/S transition and cell death in the regenerating liver of hepatitis B virus X protein transgenic mice
    • B.K. Wu, C.C. Li, and H.J. Chen et al. Blocking of G1/S transition and cell death in the regenerating liver of hepatitis B virus X protein transgenic mice Biochem Biophys Res Commun 340 2006 916 928
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 916-928
    • Wu, B.K.1    Li, C.C.2    Chen, H.J.3
  • 20
    • 80053331166 scopus 로고    scopus 로고
    • Novel feedback inhibition of surface antigen synthesis by mammalian target of rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and therapy
    • C.F. Teng, H.C. Wu, H.W. Tsai, H.S. Shiah, W. Huang, and I.J. Su Novel feedback inhibition of surface antigen synthesis by mammalian target of rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and therapy Hepatology 54 2011 1199 1207
    • (2011) Hepatology , vol.54 , pp. 1199-1207
    • Teng, C.F.1    Wu, H.C.2    Tsai, H.W.3    Shiah, H.S.4    Huang, W.5    Su, I.J.6
  • 21
    • 0023025683 scopus 로고
    • Diverse virological, histopathological and prognostic implications of seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection
    • I.J. Su, M.Y. Lai, and H.C. Hsu et al. Diverse virological, histopathological and prognostic implications of seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection J Hepatol 3 1986 182 189
    • (1986) J Hepatol , vol.3 , pp. 182-189
    • Su, I.J.1    Lai, M.Y.2    Hsu, H.C.3
  • 23
    • 34547605613 scopus 로고    scopus 로고
    • IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
    • D.F. Lee, H.P. Kuo, and C.T. Chen et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway Cell 130 2007 440 455
    • (2007) Cell , vol.130 , pp. 440-455
    • Lee, D.F.1    Kuo, H.P.2    Chen, C.T.3
  • 24
    • 79953192507 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4
    • H.K. Cho, K.J. Cheong, H.Y. Kim, and J. Cheong Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4 Biochem J 435 2011 431 439
    • (2011) Biochem J , vol.435 , pp. 431-439
    • Cho, H.K.1    Cheong, K.J.2    Kim, H.Y.3    Cheong, J.4
  • 25
    • 54449091313 scopus 로고    scopus 로고
    • Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis
    • W.H. Wang, R.L. Hullinger, and O.M. Andrisani Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis J Biol Chem 283 2008 25455 25467
    • (2008) J Biol Chem , vol.283 , pp. 25455-25467
    • Wang, W.H.1    Hullinger, R.L.2    Andrisani, O.M.3
  • 26
    • 33846783316 scopus 로고    scopus 로고
    • Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners
    • S. Kim, H.Y. Kim, and S. Lee et al. Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners J Virol 81 2007 1714 1726
    • (2007) J Virol , vol.81 , pp. 1714-1726
    • Kim, S.1    Kim, H.Y.2    Lee, S.3
  • 27
    • 79952036568 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in hepatocellular carcinoma development
    • L. Min, B. He, and L. Hui Mitogen-activated protein kinases in hepatocellular carcinoma development Semin Cancer Biol 21 2011 10 20
    • (2011) Semin Cancer Biol , vol.21 , pp. 10-20
    • Min, L.1    He, B.2    Hui, L.3
  • 28
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • L. Ma, Z. Chen, H. Erdjument-Bromage, P. Tempst, and P.P. Pandolfi Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis Cell 121 2005 179 193
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 29
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • A. Carracedo, L. Ma, and J. Teruya-Feldstein et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer J Clin Invest 118 2008 3065 3074
    • (2008) J Clin Invest , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.