Homeostatic dysregulation proceeds in parallel in multiple physiological systems

Aging Cell

Volumn 14, Issue 6, 2015, Pages 1103-1112

  Li, Qing ^a   Wang, Shengrui ^a   Milot, Emmanuel ^a,d   Bergeron, Patrick ^a,e   Ferrucci, Luigi ^b   Fried, Linda P ^c   Cohen, Alan A ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b HARBOR HOSPITAL   (United States)

^c Mailman School of Public Health   (United States)

^d UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

^e BISHOP'S UNIVERSITY   (Canada)

Author keywords

Aging; Biomarker; Homeostasis; Multi system dysregulation; Physiology; Statistical distance

Indexed keywords

25 HYDROXYVITAMIN D; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA CAROTENE; ASPARTATE AMINOTRANSFERASE; BETA CRYPTOXANTHIN; BIOLOGICAL MARKER; CALCIUM; CHLORIDE; CHOLESTEROL; CYANOCOBALAMIN; FERRITIN; FOLIC ACID; GAMMA GLUTAMYLTRANSFERASE; GAMMA TOCOPHEROL; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IRON; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; MAGNESIUM; PHOSPHATE; POTASSIUM; RETINOL; SODIUM; TRIACYLGLYCEROL; URIC ACID;

AGE; ARTICLE; BASOPHIL; CANCER INCIDENCE; CHRONIC DISEASE; COMORBIDITY; DIABETES MELLITUS; ERYTHROCYTE COUNT; ERYTHROCYTE DISTRIBUTION WIDTH; ERYTHROCYTE PARAMETERS; HEART DISEASE; HEMATOCRIT; HOMEOSTASIS; HUMAN; LEUKOCYTE COUNT; LYMPHOCYTE; MEAN CORPUSCULAR HEMOGLOBIN; MONOCYTE; MORTALITY; NEUTROPHIL; PRIORITY JOURNAL; ADULT; AGING; PHYSIOLOGY;

ADULT; AGING; BIOMARKERS; CHRONIC DISEASE; HOMEOSTASIS; HUMANS;

EID: 84954374841     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12402     Document Type: Article

References (43)

1. Arbeev KG, Ukraintseva SV, Akushevich I, Kulminski AM, Arbeeva LS, Akushevich L, Culminskaya IV, Yashin AI (2011) Age trajectories of physiological indices in relation to healthy life course. Mech. Ageing Dev. 132, 93-102.
2. Bender R, Lange S (2001) Adjusting for multiple testing-when and how? J. Clin. Epidemiol. 54, 343-349.
3. Cohen AA, Martin LB, Wingfield JC, McWilliams SR, Dunne JA (2012) Physiological regulatory networks: ecological roles and evolutionary constraints. Trends Ecol. Evol. 27, 428-435.
4. Cohen AA, Milot E, Yong J, Seplaki CL, Fülöp T, Bandeen-Roche K, Fried LP (2013) A novel statistical approach shows evidence for multi-system physiological dysregulation during aging. Mech. Ageing Dev. 134, 110-117.
5. Cohen AA, Milot E, Li Q, Legault V, Fried LP, Ferrucci L (2014) Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Exp. Gerontol. 57, 203-210.
6. Cohen AA, Li Q, Milot E, Leroux M, Faucher S, Morissette-Thomas V, Legault V, Fried LP, Ferrucci L (2015a) Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition. PLoS One 10, e0122541.
7. Cohen AA, Milot E, Li Q, Bergeron P, Poirier R, Dusseault-Bélanger F, Fülöp T, Leroux M, Legault V, Metter EJ (2015b) Detection of a novel, integrative aging process suggests complex physiological integration. PLoS One 10, e0116489.
8. Crimmins EM, Johnston M, Hayward M, Seeman T (2003) Age differences in allostatic load: an index of physiological dysregulation. Exp. Gerontol. 38, 731-734.
9. Ferrucci L (2005) An exciting thought. J. Gerontol. A Biol. Sci. Med. Sci. 60, 56.
10. Ferrucci L (2009) The Baltimore Longitudinal Study on Aging: a 50 year long journey and plans for the future. Giornale di Gerontologia 57, 3-8.
11. Ferrucci L, Bandinelli S, Benvenuti E, Di Iorio A, Macchi C, Harris TB, Guralnik JM (2000) Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J. Am. Geriatr. Soc. 48, 1618-1625.
12. Fried LP, Kasper KD, Guralnik JM, Simonsick EM (1995) The women's health and aging study: an introduction. In The Women's Health and Aging Study: Health and Social Characteristics of Old Women With Disability (Guralnik JM, Fried LP, Simonsick EM, Kasper KD, Lafferty ME, eds). Bethesda, MD: National Institute on Aging, pp. 1-8.
13. Fried LP, Xue Q-L, Cappola AR, Ferrucci L, Chaves P, Varadhan R, Guralnik JM, Leng SX, Semba RD, Walston JD (2009) Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J. Gerontol. A Biol. Sci. Med. Sci. 64, 1049-1057.
14. Guralnik JM, Fried LP, Kasper JD, Simonsick EM, Lafferty ME (1995) The Women's Health and Aging Study: Health and Social Characteristics of Older Women With Disabilityed. Washington, DC: National Institute on Aging.
15. Hoffman JM, Soltow QA, Li S, Sidik A, Jones DP, Promislow DE (2014) Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster. Aging Cell 13, 596-604.
16. Holland JH (1992) Complex adaptive systems. Daedalus 121, 17-30.
17. Karlamangla AS, Singer BH, McEwen BS, Rowe JW, Seeman TE (2002) Allostatic load as a predictor of functional decline: MacArthur studies of successful aging. J. Clin. Epidemiol. 55, 696-710.
18. Kauffman SA (1993) The Origins of Order: Self-Organization and Selection in Evolution. New York: Oxford University Press.
19. Kirkwood TBL (2005) Understanding the odd science of aging. Cell 120, 437-447.
20. Kirkwood TBL (2011) Systems biology of ageing and longevity. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 64-70.
21. Kriete A (2013) Robustness and aging - a systems-level perspective. Biosystems 112, 37-48.
22. Levine ME (2013) Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age? J. Gerontol. A Biol. Sci. Med. Sci. 68, 667-674.
23. Lipsitz LA (2004) Physiological complexity, aging, and the path to frailty. Sci. Aging Knowledge Environ. 2004, pe16.
24. Maggio M, Lauretani F, De Vita F, Basaria S, Lippi G, Butto V, Luci M, Cattabiani C, Ceresini G, Verzicco I (2014) Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons. Curr. Pharm. Des. 20, 3119-3148.
25. Mahalanobis PC (1936) Mahalanobis distance. Proc. Natl. Inst. Sci. India 49, 234-256.
26. Managbanag J, Witten TM, Bonchev D, Fox LA, Tsuchiya M, Kennedy BK, Kaeberlein M (2008) Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity. PLoS One 3, e3802.
27. McEwen BS (1998) Stress, adaptation, and disease: allostasis and allostatic load. Ann. N. Y. Acad. Sci. 840, 33-44.
28. Medvedev ZA (1990) An attempt at a rational classification of theories of ageing. Biol. Rev. 65, 375-398.
29. Milot E, Cohen AA, Vézina F, Buehler DM, Matson KD, Piersma T (2014a) A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation. Methods Ecol. Evol. 5, 146-155.
30. Milot E, Morissette-Thomas V, Li Q, Fried LP, Ferrucci L, Cohen AA (2014b) Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations. Mech. Ageing Dev. 141-142, 56-63.
31. Moeller M, Hirose M, Mueller S, Roolf C, Baltrusch S, Ibrahim S, Junghanss C, Wolkenhauer O, Jaster R, Köhling R, Kunz M, Tiedge M, Schofield PN, Fuellen G (2014) Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching. Aging Cell 13, 729-738.
32. Rothman KJ (1990) No adjustments are needed for multiple comparisons. Epidemiology 1, 43-46.
33. Seplaki CL, Goldman N, Glei D, Weinstein M (2005) A comparative analysis of measurement approaches for physiological dysregulation in an older population. Exp. Gerontol. 40, 438-449.
34. Shock NW (1984) Normal Human Aging: The Baltimore Longitudinal Study of Aginged. Washington, DC: National Institute of Aging, pp. 661.
35. Szanton SL, Allen JK, Seplaki CL, Bandeen-Roche K, Fried LP (2009) Allostatic load and frailty in the women's health and aging studies. Biol. Res. Nurs. 10, 248-256.
36. Tan P-N, Steinbach M, Kumar V (2006) Introduction to Data Mining. Boston: Pearson Addison Wesley.
37. Varadhan R, Seplaki CL, Xue QL, Bandeen-Roche K, Fried LP (2008) Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. Mech. Ageing Dev. 129, 666-670.
38. Wagner A (1999) Causality in complex systems. Biol. Philos. 14, 83-101.
39. Weinert BT, Timiras PS (2003) Invited review: theories of aging. J. Appl. Physiol. 95, 1706-1716.
40. Yashin AI, Arbeev KG, Akushevich I, Arbeeva L, Kravchenko J, Il'Yasova D, Kulminski A, Akushevich L, Culminskaya I, Wu D (2010a) Dynamic determinants of longevity and exceptional health. Curr. Gerontol. Geriatr. Res. 2010.
41. Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (2010b) Joint influence of small-effect genetic variants on human longevity. Aging 2, 612-620.
42. Yashin AI, Arbeev KG, Akushevich I, Kulminski A, Ukraintseva SV, Stallard E, Land KC (2012) The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span. Phys. Life. Rev. 9, 177-188.
43. Zellner A (1962) An efficient method of estimating seemingly unrelated regressions and tests for aggregation bias. J. Am. Stat. Assoc. 57, 348-368.