Aberrant Salience Is Related to Dysfunctional Self-Referential Processing in Psychosis

Schizophrenia Bulletin

Volumn 42, Issue 1, 2016, Pages 67-76

  Pankow, Anne ^a   Katthagen, Teresa ^a   Diner, Sarah ^a   Deserno, Lorenz ^a,b,c   Boehme, Rebecca ^a   Kathmann, Nobert ^d   Gleich, Tobias ^a   Gaebler, Michael ^a,b,e   Walter, Henrik ^a   Heinz, Andreas ^a   Schlagenhauf, Florian ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX PLANCK INSTITUTE FOR HUMAN COGNITIVE AND BRAIN SCIENCES   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d HUMBOLDT UNIVERSITY   (Germany)

^e UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

fMRI; psychosis; psychosis continuum; salience; self referential processing; vmPFC

Indexed keywords

ADOLESCENT; ADULT; ATTENTION; BRAIN; CASE CONTROL STUDY; COGNITIVE DEFECT; DECISION MAKING; DELUSION; FEMALE; FUNCTIONAL NEUROIMAGING; HUMAN; IMAGE PROCESSING; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOLOGY; PSYCHOSIS; REACTION TIME; SCHIZOPHRENIA; SELF CONCEPT; YOUNG ADULT;

ADOLESCENT; ADULT; ATTENTION; BRAIN; CASE-CONTROL STUDIES; COGNITION DISORDERS; DELUSIONS; FEMALE; FUNCTIONAL NEUROIMAGING; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; JUDGMENT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PREFRONTAL CORTEX; PSYCHOTIC DISORDERS; REACTION TIME; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SELF CONCEPT; YOUNG ADULT;

EID: 84954338716     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbv098     Document Type: Article

References (73)

1. Gray JA. Integrating schizophrenia. Schizophr Bull. 1998;24:249-266.
2. Heinz A. Dopaminergic dysfunction in alcoholism and schizophrenia-psychopathological and behavioral correlates. Eur Psychiatry. 2002;17:9-16.
3. Kapur S. Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry. 2003;160:13-23.
4. Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III-The final common pathway. Schizophr Bull. 2009;35:549-562.
5. Heinz A, Schlagenhauf F. Dopaminergic dysfunction in schizophrenia: salience attribution revisited. Schizophr Bull. 2010;36:472-485.
6. Gray DM. Failing to self-ascribe thought and motion: towards a three-factor account of passivity symptoms in schizophrenia. Schizophr Res. 2014;152:28-32.
7. Mishara AL, Lysaker PH, Schwartz MA. Self-disturbances in schizophrenia: history, phenomenology, and relevant findings from research on metacognition. Schizophr Bull. 2014;40:5-12.
8. Heinz A, Bermpohl F, Frank M. Construction and interpretation of self-related function and dysfunction in Intercultural Psychiatry. Eur Psychiatry. 2012;27(suppl 2):S32-S43.
9. Kraepelin E. Klinische Psychiatrie, Teil 2. Vol 8. Leipzig, Germany: Verlag von Johann Ambrosius Barth; 1913.
10. Bleuler E. Dementia praecox oder Gruppe der Schizophrenien. Leipzig, Germany: Franz Deuticke; 1911.
11. Berze J. Die primäre Insuffizienz der psychischen Aktivität: Ihr Wesen, ihre Erscheinungen und ihre Bedeutung als Grundstörung der Dementia praecox und der Hypophrenien überhaupt. Leipzig, Germany: Franz Deuticke; 1914.
12. Nelson B, Whitford TJ, Lavoie S, Sass LA. What are the neurocognitive correlates of basic self-disturbance in schizophrenia? Integrating phenomenology and neurocognition. Part 2 (Aberrant salience). Schizophr Res. 2014;152:20-27.
13. Nelson B, Whitford TJ, Lavoie S, Sass LA. What are the neurocognitive correlates of basic self-disturbance in schizophrenia? Integrating phenomenology and neurocognition. Part 1 (Source monitoring deficits). Schizophr Res. 2014;152:12-19.
14. Kelley WM, Macrae CN, Wyland CL, Caglar S, Inati S, Heatherton TF. Finding the self? An event-related fMRI study. J Cogn Neurosci. 2002;14:785-794.
15. van der Meer L, Costafreda S, Aleman A, David AS. Selfreflection and the brain: A theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neurosci Biobehav Rev. 2010;34:935-946.
16. Murray RJ, Schaer M, Debbane M. Degrees of separation: A quantitative neuroimaging meta-analysis investigating self-specificity and shared neural activation between self-and other-reflection. Neurosci Biobehav Rev. 2012;36:1043-1059.
17. Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, Panksepp J. Self-referential processing in our brain-A meta-analysis of imaging studies on the self. Neuroimage. 2006;31:440-457.
18. van Buuren M, Gladwin TE, Zandbelt BB, Kahn RS, Vink M. Reduced functional coupling in the default-mode network during self-referential processing. Hum Brain Mapp. 2010;31:1117-1127.
19. Holt DJ, Cassidy BS, Andrews-Hanna JR, et al. An anteriorto-posterior shift in midline cortical activity in schizophrenia during self-reflection. Biol Psychiatry. 2011;69:415-423.
20. Shad MU, Keshavan MS, Steinberg JL, et al. Neurobiology of self-awareness in schizophrenia: an fMRI study. Schizophr Res. 2012;138:113-119.
21. Blackwood NJ, Bentall RP, Ffytche DH, Simmons A, Murray RM, Howard RJ. Persecutory delusions and the determination of self-relevance: an fMRI investigation. Psychol Med. 2004;34:591-596.
22. Bedford NJ, Surguladze S, Giampietro V, Brammer MJ, David AS. Self-evaluation in schizophrenia: an fMRI study with implications for the understanding of insight. BMC Psychiatry. 2012;12:106.
23. Menon M, Schmitz TW, Anderson AK, et al. Exploring the neural correlates of delusions of reference. Biol Psychiatry. 2011;70:1127-1133.
24. van der Meer L, de Vos AE, Stiekema AP, et al. Insight in schizophrenia: involvement of self-reflection networks? Schizophr Bull. 2013;39:1288-1295.
25. Pauly KD, Kircher TT, Schneider F, Habel U. Me, myself and I: temporal dysfunctions during self-evaluation in patients with schizophrenia. Soc Cogn Affect Neurosci. 2014;9:1779-1788.
26. Schmitz TW, Johnson SC. Relevance to self: A brief review and framework of neural systems underlying appraisal. Neurosci Biobehav Rev. 2007;31:585-596.
27. D'Argembeau A. On the role of the ventromedial prefrontal cortex in self-processing: The valuation hypothesis. Front Hum Neurosci. 2013;7:372.
28. Wang L, Metzak PD, Woodward TS. Aberrant connectivity during self-other source monitoring in schizophrenia. Schizophr Res. 2011;125 136-142.
29. Clithero JA, Rangel A. Informatic parcellation of the network involved in the computation of subjective value. Soc Cogn Affect Neurosci. 2014;9:1289-1302.
30. Kable JW, Glimcher PW. The neural correlates of subjective value during intertemporal choice. Nat Neurosci. 2007;10:1625-1633.
31. Barron HC, Dolan RJ, Behrens TE. Online evaluation of novel choices by simultaneous representation of multiple memories. Nat Neurosci. 2013;16:1492-1498.
32. Nicolle A, Klein-Flugge MC, Hunt LT, Vlaev I, Dolan RJ, Behrens TE. An agent independent axis for executed and modeled choice in medial prefrontal cortex. Neuron. 2012;75:1114-1121.
33. Gaebler AJ, Mathiak K, Koten JW Jr, et al. Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia. Brain. 2015;138:1410-1423.
34. Gray N, Hemsley D, Gray J. Abolition of latent inhibition in acute, but not chronic, schizophrenics. Neurol Psychol Brain Res. 1992;1:83-89.
35. Romaniuk L, Honey GD, King JR, et al. Midbrain activation during Pavlovian conditioning and delusional symptoms in schizophrenia. Arch Gen Psychiatry. 2010;67:1246-1254.
36. Diaconescu AO, Jensen J, Wang H, et al. Aberrant effective connectivity in schizophrenia patients during appetitive conditioning. Front Hum Neurosci. 2011;4:239.
37. Jensen J, Willeit M, Zipursky RB, et al. The formation of abnormal associations in schizophrenia: neural and behavioral evidence. Neuropsychopharmacology. 2008;33:473-479.
38. Schlagenhauf F, Huys QJ, Deserno L, et al. Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. Neuroimage. 2014;89:171-180.
39. Schlagenhauf F, Sterzer P, Schmack K, et al. Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. Biol Psychiatry. 2009;65:1032-1039.
40. Roiser JP, Stephan KE, den Ouden HE, Barnes TR, Friston KJ, Joyce EM. Do patients with schizophrenia exhibit aberrant salience? Psychol Med. 2009;39:199-209.
41. Greenwald AG, McGhee DE, Schwartz JL. Measuring individual differences in implicit cognition: The implicit association test. J Pers Soc Psychol. 1998;74:1464-1480.
42. Schmidt K, Roiser JP. Assessing the construct validity of aberrant salience. Front Behav Neurosci. 2009;3:58.
43. Winton-Brown TT, Fusar-Poli P, Ungless MA, Howes OD. Dopaminergic basis of salience dysregulation in psychosis. Trends Neurosci. 2014;37:85-94.
44. Jensen J, Walter H. Incentive motivational salience and the human brain. Restor Neurol Neurosci. 2014;32:141-147.
45. Johns LC, van Os J. The continuity of psychotic experiences in the general population. Clin Psychol Rev. 2001;21:1125-1141.
46. van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L. A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis pronenesspersistence-impairment model of psychotic disorder. Psychol Med. 2009;39:179-195.
47. Peters E, Joseph S, Day S, Garety P. Measuring delusional ideation: The 21-item Peters et al. Delusions Inventory (PDI). Schizophr Bull. 2004;30:1005-1022.
48. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV® Axis I Disorders (SCID-I), Clinician Version, Administration Booklet. Washington, DC: American Psychiatric Publishing; 2012.
49. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-276.
50. Raine A. The SPQ: A scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull. 1991;17:555-564.
51. Oldfield RC. The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia. 1971;9:97-113.
52. Schmidt K-H, Metzler P. Wortschatztest (WST). Weinheim, Germany: Beltz; 1992.
53. Bora E. Developmental lag and course of cognitive deficits from the premorbid to postonset period in schizophrenia. Am J Psychiatry. 2014;171:369.
54. Gruhn D, Smith J. Characteristics for 200 words rated by young and older adults: age-dependent evaluations of German adjectives (AGE). Behav Res Methods. 2008;40:1088-1097.
55. Vo ML, Conrad M, Kuchinke L, Urton K, Hofmann MJ, Jacobs AM. The Berlin Affective Word List Reloaded (BAWL-R). Behav Res Methods. 2009;41:534-538.
56. Ashburner J, Friston KJ. Unified segmentation. Neuroimage. 2005;26:839-851.
57. van Erp TG, Preda A, Nguyen D, et al. Converting positive and negative symptom scores between PANSS and SAPS/ SANS. Schizophr Res. 2014;152:289-294.
58. Balzan R, Delfabbro P, Galletly C, Woodward T. Confirmation biases across the psychosis continuum: The contribution of hypersalient evidence-hypothesis matches. Br J Clin Psychol. 2013;52:53-69.
59. Balzan RP, Delfabbro PH, Galletly CA, Woodward TS. Illusory correlations and control across the psychosis continuum: The contribution of hypersalient evidence-hypothesis matches. J Nerv Ment Dis. 2013;201:319-327.
60. Kuipers E, Garety P, Fowler D, Freeman D, Dunn G, Bebbington P. Cognitive, emotional, and social processes in psychosis: refining cognitive behavioral therapy for persistent positive symptoms. Schizophr Bull. 2006;32(suppl 1):S24-S31.
61. Peters ER, Joseph SA, Garety PA. Measurement of delusional ideation in the normal population: introducing the PDI (Peters et al. Delusions Inventory). Schizophr Bull. 1999;25:553-576.
62. Bak M, Delespaul P, Hanssen M, de Graaf R, Vollebergh W, van Os J. How false are "false" positive psychotic symptoms? Schizophr Res. 2003;62:187-189.
63. Schultze-Lutter F, Michel C, Ruhrmann S, Schimmelmann BG. Prevalence and clinical significance of DSM-5-attenuated psychosis syndrome in adolescents and young adults in the general population: The Bern Epidemiological At-Risk (BEAR) study. Schizophr Bull. 2014;40:1499-1508.
64. Roiser JP, Howes OD, Chaddock CA, Joyce EM, McGuire P. Neural and behavioral correlates of aberrant salience in individuals at risk for psychosis. Schizophr Bull. 2013;39:1328-1336.
65. Murray GK, Corlett PR, Clark L, et al. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol Psychiatry. 2008;13:267-276.
66. Murphy ER, Brent BK, Benton M, et al. Differential processing of metacognitive evaluation and the neural circuitry of the self and others in schizophrenia: A pilot study. Schizophr Res. 2010;116:252-258.
67. van Buuren M, Vink M, Kahn RS. Default-mode network dysfunction and self-referential processing in healthy siblings of schizophrenia patients. Schizophr Res. 2012;142:237-243.
68. Whitfield-Gabrieli S, Thermenos HW, Milanovic S, et al. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc Natl Acad Sci U S A. 2009;106:1279-1284.
69. Modinos G, Renken R, Ormel J, Aleman A. Self-reflection and the psychosis-prone brain: an fMRI study. Neuropsychology. 2011;25:295-305.
70. Debbané M, Vrtička P, Lazouret M, Badoud D, Sander D, Eliez S. Self-reflection and positive schizotypy in the adolescent brain. Schizophr Res. 2014;152:65-72.
71. D'Argembeau A, Jedidi H, Balteau E, Bahri M, Phillips C, Salmon E. Valuing one's self: medial prefrontal involvement in epistemic and emotive investments in self-views. Cereb Cortex. 2012;22:659-667.
72. Abraham A. The world according to me: personal relevance and the medial prefrontal cortex. Front Hum Neurosci. 2013;7:341.
73. Roy M, Shohamy D, Wager TD. Ventromedial prefrontalsubcortical systems and the generation of affective meaning. Trends Cogn Sci. 2012;16:147-156.