메뉴 건너뛰기




Volumn 73, Issue , 2016, Pages 127-168

Biochemistry of Statins

Author keywords

Cardiovascular disease; Low density lipoprotein cholesterol; Statins

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 84954306698     PISSN: 00652423     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.acc.2015.10.005     Document Type: Chapter
Times cited : (41)

References (217)
  • 1
    • 44049091020 scopus 로고    scopus 로고
    • Clinical efficacy and safety of statins in managing cardiovascular risk
    • Kapur N.K., Musunuru K. Clinical efficacy and safety of statins in managing cardiovascular risk. Vasc. Health Risk Manag. 2008, 4:341-353.
    • (2008) Vasc. Health Risk Manag. , vol.4 , pp. 341-353
    • Kapur, N.K.1    Musunuru, K.2
  • 2
    • 0038004785 scopus 로고    scopus 로고
    • Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors
    • Tobert J.A. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. 2003, 2:517-526.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 517-526
    • Tobert, J.A.1
  • 3
    • 0000162951 scopus 로고
    • Ultracentrifugal studies of lipoproteins of human serum
    • Gofman J.W., Lindgren F.T., Elliott H. Ultracentrifugal studies of lipoproteins of human serum. J. Biol. Chem. 1949, 179:973-979.
    • (1949) J. Biol. Chem. , vol.179 , pp. 973-979
    • Gofman, J.W.1    Lindgren, F.T.2    Elliott, H.3
  • 4
    • 37049244034 scopus 로고
    • The role of lipids and lipoproteins in atherosclerosis
    • Gofman J.W., Lindgren F. The role of lipids and lipoproteins in atherosclerosis. Science 1950, 111:166-171.
    • (1950) Science , vol.111 , pp. 166-171
    • Gofman, J.W.1    Lindgren, F.2
  • 5
    • 4644298842 scopus 로고
    • Serum lipoproteins and the evaluation of atherosclerosis
    • Gofman J.W. Serum lipoproteins and the evaluation of atherosclerosis. Ann. N. Y. Acad. Sci. 1956, 64:590-595.
    • (1956) Ann. N. Y. Acad. Sci. , vol.64 , pp. 590-595
    • Gofman, J.W.1
  • 6
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2013 update: a report from the American Heart Association
    • Go A.S., Mozaffarian D., Roger V.L., Benjamin E.J., Berry J.D., Borden W.B., et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation 2013, 127:e6-e245.
    • (2013) Circulation , vol.127 , pp. e6-e245
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3    Benjamin, E.J.4    Berry, J.D.5    Borden, W.B.6
  • 7
    • 0035528772 scopus 로고    scopus 로고
    • Statins: mechanism of action and effects
    • Stancu C., Sima A. Statins: mechanism of action and effects. J. Cell. Mol. Med. 2001, 5:378-387.
    • (2001) J. Cell. Mol. Med. , vol.5 , pp. 378-387
    • Stancu, C.1    Sima, A.2
  • 9
    • 27744593677 scopus 로고    scopus 로고
    • 'Teachers' topics: antihyperlipidemic statins: a self-contained, clinically relevant medicinal chemistry lesson
    • Roche V.F. 'Teachers' topics: antihyperlipidemic statins: a self-contained, clinically relevant medicinal chemistry lesson. Am. J. Pharm. Educ. 2005, 69:546-560.
    • (2005) Am. J. Pharm. Educ. , vol.69 , pp. 546-560
    • Roche, V.F.1
  • 10
    • 0141560665 scopus 로고    scopus 로고
    • Comparative pharmacology of rosuvastatin
    • McTaggart F. Comparative pharmacology of rosuvastatin. Atheroscler. Suppl. 2003, 4:9-14.
    • (2003) Atheroscler. Suppl. , vol.4 , pp. 9-14
    • McTaggart, F.1
  • 12
    • 0036708020 scopus 로고    scopus 로고
    • A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin
    • White C.M. A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin. J. Clin. Pharmacol. 2002, 42:963-970.
    • (2002) J. Clin. Pharmacol. , vol.42 , pp. 963-970
    • White, C.M.1
  • 14
    • 0035843962 scopus 로고    scopus 로고
    • Structural mechanism for statin inhibition of HMG-CoA reductase
    • Istvan E.S., Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 2001, 292:1160-1164.
    • (2001) Science , vol.292 , pp. 1160-1164
    • Istvan, E.S.1    Deisenhofer, J.2
  • 15
    • 0028929401 scopus 로고
    • Pharmacology of competitive inhibitors of HMG-CoA reductase
    • Corsini A., Maggi F.M., Catapano A.L. Pharmacology of competitive inhibitors of HMG-CoA reductase. Pharmacol. Res. 1995, 31:9-27.
    • (1995) Pharmacol. Res. , vol.31 , pp. 9-27
    • Corsini, A.1    Maggi, F.M.2    Catapano, A.L.3
  • 17
    • 13444251203 scopus 로고    scopus 로고
    • Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update
    • Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam. Clin. Pharmacol. 2005, 19:117-125.
    • (2005) Fundam. Clin. Pharmacol. , vol.19 , pp. 117-125
    • Schachter, M.1
  • 19
    • 9344235448 scopus 로고    scopus 로고
    • Pharmacodynamic effects and pharmacokinetics of atorvastatin after administration to normocholesterolemic subjects in the morning and evening
    • Cilla D.D., Gibson D.M., Whitfield L.R., Sedman A.J. Pharmacodynamic effects and pharmacokinetics of atorvastatin after administration to normocholesterolemic subjects in the morning and evening. J. Clin. Pharmacol. 1996, 36:604-609.
    • (1996) J. Clin. Pharmacol. , vol.36 , pp. 604-609
    • Cilla, D.D.1    Gibson, D.M.2    Whitfield, L.R.3    Sedman, A.J.4
  • 20
    • 0029166810 scopus 로고
    • Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors
    • Garnett W.R. Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am. J. Health Syst. Pharm. 1995, 52:1639-1645.
    • (1995) Am. J. Health Syst. Pharm. , vol.52 , pp. 1639-1645
    • Garnett, W.R.1
  • 21
    • 0031881755 scopus 로고    scopus 로고
    • Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors
    • Hamelin B.A., Turgeon J. Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol. Sci. 1998, 19:26-37.
    • (1998) Trends Pharmacol. Sci. , vol.19 , pp. 26-37
    • Hamelin, B.A.1    Turgeon, J.2
  • 22
    • 0038171260 scopus 로고    scopus 로고
    • Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin
    • Nezasa K., Higaki K., Takeuchi M., Nakano M., Koike M. Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin. Xenobiotica 2003, 33:379-388.
    • (2003) Xenobiotica , vol.33 , pp. 379-388
    • Nezasa, K.1    Higaki, K.2    Takeuchi, M.3    Nakano, M.4    Koike, M.5
  • 25
    • 0024994209 scopus 로고
    • Physiological disposition of HMG-CoA-reductase inhibitors
    • Duggan D.E., Vickers S. Physiological disposition of HMG-CoA-reductase inhibitors. Drug Metab. Rev. 1990, 22:333-362.
    • (1990) Drug Metab. Rev. , vol.22 , pp. 333-362
    • Duggan, D.E.1    Vickers, S.2
  • 26
    • 0034726386 scopus 로고    scopus 로고
    • Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: the role of metabolism-monograph for physicians
    • Bottorff M., Hansten P. Long-term safety of hepatic hydroxymethyl glutaryl coenzyme A reductase inhibitors: the role of metabolism-monograph for physicians. Arch. Intern. Med. 2000, 160:2273-2280.
    • (2000) Arch. Intern. Med. , vol.160 , pp. 2273-2280
    • Bottorff, M.1    Hansten, P.2
  • 28
    • 0030953045 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences
    • Lennernas H., Fager G. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences. Clin. Pharmacokinet. 1997, 32:403-425.
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 403-425
    • Lennernas, H.1    Fager, G.2
  • 29
    • 52949104006 scopus 로고    scopus 로고
    • Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin
    • Kitamura S., Maeda K., Wang Y., Sugiyama Y. Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab. Dispos. 2008, 36:2014-2023.
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 2014-2023
    • Kitamura, S.1    Maeda, K.2    Wang, Y.3    Sugiyama, Y.4
  • 30
    • 0034495168 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events
    • Hatanaka T. Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events. Clin. Pharmacokinet. 2000, 39:397-412.
    • (2000) Clin. Pharmacokinet. , vol.39 , pp. 397-412
    • Hatanaka, T.1
  • 31
    • 84878309461 scopus 로고    scopus 로고
    • Statins and cancer in gastroenterology: new insight?
    • Gazzerro P., Bifulco M. Statins and cancer in gastroenterology: new insight?. Gastroenterology 2013, 144:1572-1573.
    • (2013) Gastroenterology , vol.144 , pp. 1572-1573
    • Gazzerro, P.1    Bifulco, M.2
  • 32
    • 0017043554 scopus 로고
    • Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity
    • Endo A., Kuroda M., Tanzawa K. Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett. 1976, 72:323-326.
    • (1976) FEBS Lett. , vol.72 , pp. 323-326
    • Endo, A.1    Kuroda, M.2    Tanzawa, K.3
  • 33
    • 0026496233 scopus 로고
    • Biosynthesis and characterization of (S)-and (R)-3-hydroxy-3-methylglutaryl coenzyme A
    • Bischoff K.M., Rodwell V.W. Biosynthesis and characterization of (S)-and (R)-3-hydroxy-3-methylglutaryl coenzyme A. Biochem. Med. Metab. Biol. 1992, 48:149-158.
    • (1992) Biochem. Med. Metab. Biol. , vol.48 , pp. 149-158
    • Bischoff, K.M.1    Rodwell, V.W.2
  • 34
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 1986, 232:34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 35
    • 0028306052 scopus 로고
    • Enhanced cellular metabolism of very low density lipoprotein by simvastatin. A novel mechanism of action of HMG-CoA reductase inhibitors
    • Sehayek E., Butbul E., Avner R., Levkovitz H., Eisenberg S. Enhanced cellular metabolism of very low density lipoprotein by simvastatin. A novel mechanism of action of HMG-CoA reductase inhibitors. Eur. J. Clin. Invest. 1994, 24:173-178.
    • (1994) Eur. J. Clin. Invest. , vol.24 , pp. 173-178
    • Sehayek, E.1    Butbul, E.2    Avner, R.3    Levkovitz, H.4    Eisenberg, S.5
  • 36
    • 70349258349 scopus 로고    scopus 로고
    • Immunomodulation by statins: mechanisms and potential impact on autoimmune diseases
    • Chow S.C. Immunomodulation by statins: mechanisms and potential impact on autoimmune diseases. Arch. Immunol. Ther. Exp. (Warsz.) 2009, 57:243-251.
    • (2009) Arch. Immunol. Ther. Exp. (Warsz.) , vol.57 , pp. 243-251
    • Chow, S.C.1
  • 37
    • 77951709095 scopus 로고    scopus 로고
    • Pleiotropic effects of statins-basic research and clinical perspectives
    • Zhou Q., Liao J.K. Pleiotropic effects of statins-basic research and clinical perspectives. Circ. J. 2010, 74:818-826.
    • (2010) Circ. J. , vol.74 , pp. 818-826
    • Zhou, Q.1    Liao, J.K.2
  • 38
    • 84894368054 scopus 로고    scopus 로고
    • Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy
    • Egom E.E., Rose R.A., Neyses L., Soran H., Cleland J.G., Mamas M.A. Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy. Crit. Rev. Clin. Lab. Sci. 2013, 50:79-89.
    • (2013) Crit. Rev. Clin. Lab. Sci. , vol.50 , pp. 79-89
    • Egom, E.E.1    Rose, R.A.2    Neyses, L.3    Soran, H.4    Cleland, J.G.5    Mamas, M.A.6
  • 39
    • 0019979503 scopus 로고
    • Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins
    • Miettinen T.A. Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins. J. Lipid Res. 1982, 23:466-473.
    • (1982) J. Lipid Res. , vol.23 , pp. 466-473
    • Miettinen, T.A.1
  • 40
    • 0002472086 scopus 로고    scopus 로고
    • A general assessment of the safety of HMG CoA reductase inhibitors (statins)
    • Black D.M. A general assessment of the safety of HMG CoA reductase inhibitors (statins). Curr. Atheroscler. Rep. 2002, 4:34-41.
    • (2002) Curr. Atheroscler. Rep. , vol.4 , pp. 34-41
    • Black, D.M.1
  • 41
    • 84875200123 scopus 로고    scopus 로고
    • Intermittent nondaily dosing strategies in patients with previous statin-induced myopathy
    • Keating A.J., Campbell K.B., Guyton J.R. Intermittent nondaily dosing strategies in patients with previous statin-induced myopathy. Ann. Pharmacother. 2013, 47:398-404.
    • (2013) Ann. Pharmacother. , vol.47 , pp. 398-404
    • Keating, A.J.1    Campbell, K.B.2    Guyton, J.R.3
  • 42
    • 0031873289 scopus 로고    scopus 로고
    • A comparison of fluvastatin 40 mg every other day versus 20 mg every day in patients with hypercholesterolemia
    • Rindone J.P., Hiller D., Arriola G. A comparison of fluvastatin 40 mg every other day versus 20 mg every day in patients with hypercholesterolemia. Pharmacotherapy 1998, 18:836-839.
    • (1998) Pharmacotherapy , vol.18 , pp. 836-839
    • Rindone, J.P.1    Hiller, D.2    Arriola, G.3
  • 43
    • 0036791192 scopus 로고    scopus 로고
    • Is alternate daily dose of atorvastatin effective in treating patients with hyperlipidemia? The Alternate Day Versus Daily Dosing of Atorvastatin Study (ADDAS)
    • Matalka M.S., Ravnan M.C., Deedwania P.C. Is alternate daily dose of atorvastatin effective in treating patients with hyperlipidemia? The Alternate Day Versus Daily Dosing of Atorvastatin Study (ADDAS). Am. Heart J. 2002, 144:674-677.
    • (2002) Am. Heart J. , vol.144 , pp. 674-677
    • Matalka, M.S.1    Ravnan, M.C.2    Deedwania, P.C.3
  • 45
  • 46
    • 33751001363 scopus 로고    scopus 로고
    • Efficacy and safety of rosuvastatin every other day compared with once daily in patients with hypercholesterolemia
    • Wongwiwatthananukit S., Sansanayudh N., Dhummauppakorn R., Kitiyadisai C. Efficacy and safety of rosuvastatin every other day compared with once daily in patients with hypercholesterolemia. Ann. Pharmacother. 2006, 40:1917-1923.
    • (2006) Ann. Pharmacother. , vol.40 , pp. 1917-1923
    • Wongwiwatthananukit, S.1    Sansanayudh, N.2    Dhummauppakorn, R.3    Kitiyadisai, C.4
  • 47
    • 58749110138 scopus 로고    scopus 로고
    • Once-a-week rosuvastatin (2.5 to 20 mg) in patients with a previous statin intolerance
    • Ruisinger J.F., Backes J.M., Gibson C.A., Moriarty P.M. Once-a-week rosuvastatin (2.5 to 20 mg) in patients with a previous statin intolerance. Am. J. Cardiol. 2009, 103:393-394.
    • (2009) Am. J. Cardiol. , vol.103 , pp. 393-394
    • Ruisinger, J.F.1    Backes, J.M.2    Gibson, C.A.3    Moriarty, P.M.4
  • 48
    • 0034666406 scopus 로고    scopus 로고
    • Conversion of patients from simvastatin to lovastatin in an outpatient pharmacy clinic
    • Fugit R.V., Resch N.D. Conversion of patients from simvastatin to lovastatin in an outpatient pharmacy clinic. Am. J. Health Syst. Pharm. 2000, 57:1703-1708.
    • (2000) Am. J. Health Syst. Pharm. , vol.57 , pp. 1703-1708
    • Fugit, R.V.1    Resch, N.D.2
  • 49
    • 0032930858 scopus 로고    scopus 로고
    • Impact of therapeutic interchange from pravastatin to lovastatin in a Veterans Affairs Medical Center
    • Patel R.J., Gray D.R., Pierce R., Jafari M. Impact of therapeutic interchange from pravastatin to lovastatin in a Veterans Affairs Medical Center. Am. J. Manag. Care 1999, 5:465-474.
    • (1999) Am. J. Manag. Care , vol.5 , pp. 465-474
    • Patel, R.J.1    Gray, D.R.2    Pierce, R.3    Jafari, M.4
  • 50
    • 3042594722 scopus 로고    scopus 로고
    • Approximate equivalent rosuvastatin doses for temporary statin interchange programs
    • Kendrach M.G., Kelly-Freeman M. Approximate equivalent rosuvastatin doses for temporary statin interchange programs. Ann. Pharmacother. 2004, 38:1286-1292.
    • (2004) Ann. Pharmacother. , vol.38 , pp. 1286-1292
    • Kendrach, M.G.1    Kelly-Freeman, M.2
  • 51
    • 7044237064 scopus 로고    scopus 로고
    • Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors
    • Jacobson T.A. Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors. Am. J. Cardiol. 2004, 94:1140-1146.
    • (2004) Am. J. Cardiol. , vol.94 , pp. 1140-1146
    • Jacobson, T.A.1
  • 52
    • 0036291921 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors
    • Williams D., Feely J. Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Clin. Pharmacokinet. 2002, 41:343-370.
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 343-370
    • Williams, D.1    Feely, J.2
  • 53
    • 33750731687 scopus 로고    scopus 로고
    • Role of P-glycoprotein in statin drug interactions
    • Holtzman C.W., Wiggins B.S., Spinler S.A. Role of P-glycoprotein in statin drug interactions. Pharmacotherapy 2006, 26:1601-1607.
    • (2006) Pharmacotherapy , vol.26 , pp. 1601-1607
    • Holtzman, C.W.1    Wiggins, B.S.2    Spinler, S.A.3
  • 55
    • 84975824612 scopus 로고    scopus 로고
    • accessed on February 19
    • (accessed on February 19). http://www.fda.gov/Safety/MedWatch/SafetyInformation/ucm200635.htm.
  • 56
    • 33845420011 scopus 로고    scopus 로고
    • Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance
    • Neuvonen P.J., Niemi M., Backman J.T. Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin. Pharmacol. Ther. 2006, 80:565-581.
    • (2006) Clin. Pharmacol. Ther. , vol.80 , pp. 565-581
    • Neuvonen, P.J.1    Niemi, M.2    Backman, J.T.3
  • 57
    • 84975841309 scopus 로고    scopus 로고
    • Product information for Livalo. Kowa Pharmaceuticals America IM, AL 36117. February 2012.
    • Product information for Livalo. Kowa Pharmaceuticals America IM, AL 36117. February 2012.
  • 58
    • 84975824617 scopus 로고    scopus 로고
    • PL Detail-Document, OATP Fruit Juice Drug Interactions
    • Pharmacist's Letter/Prescriber's Letter. June 2011.
    • PL Detail-Document, OATP Fruit Juice Drug Interactions. Pharmacist's Letter/Prescriber's Letter. June 2011.
  • 60
  • 61
    • 0032032592 scopus 로고    scopus 로고
    • Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
    • Jones P., Kafonek S., Laurora I., Hunninghake D. Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study). Am. J. Cardiol. 1998, 81:582-587.
    • (1998) Am. J. Cardiol. , vol.81 , pp. 582-587
    • Jones, P.1    Kafonek, S.2    Laurora, I.3    Hunninghake, D.4
  • 62
    • 1542748421 scopus 로고    scopus 로고
    • Rosuvastatin: a new inhibitor of HMG-coA reductase for the treatment of dyslipidemia
    • Rosenson R.S. Rosuvastatin: a new inhibitor of HMG-coA reductase for the treatment of dyslipidemia. Expert Rev. Cardiovasc. Ther. 2003, 1:495-505.
    • (2003) Expert Rev. Cardiovasc. Ther. , vol.1 , pp. 495-505
    • Rosenson, R.S.1
  • 63
    • 0038645309 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial)
    • Jones P.H., Davidson M.H., Stein E.A., Bays H.E., McKenney J.M., Miller E., et al. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial). Am. J. Cardiol. 2003, 92:152-160.
    • (2003) Am. J. Cardiol. , vol.92 , pp. 152-160
    • Jones, P.H.1    Davidson, M.H.2    Stein, E.A.3    Bays, H.E.4    McKenney, J.M.5    Miller, E.6
  • 64
    • 0031692691 scopus 로고    scopus 로고
    • Treating patients with documented atherosclerosis to National Cholesterol Education Program-recommended low-density-lipoprotein cholesterol goals with atorvastatin, fluvastatin, lovastatin and simvastatin
    • Brown A.S., Bakker-Arkema R.G., Yellen L., Henley R.W., Guthrie R., Campbell C.F., et al. Treating patients with documented atherosclerosis to National Cholesterol Education Program-recommended low-density-lipoprotein cholesterol goals with atorvastatin, fluvastatin, lovastatin and simvastatin. J. Am. Coll. Cardiol. 1998, 32:665-672.
    • (1998) J. Am. Coll. Cardiol. , vol.32 , pp. 665-672
    • Brown, A.S.1    Bakker-Arkema, R.G.2    Yellen, L.3    Henley, R.W.4    Guthrie, R.5    Campbell, C.F.6
  • 66
    • 0025183769 scopus 로고
    • Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
    • Brown G., Albers J.J., Fisher L.D., Schaefer S.M., Lin J.T., Kaplan C., et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N. Engl. J. Med. 1990, 323:1289-1298.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 1289-1298
    • Brown, G.1    Albers, J.J.2    Fisher, L.D.3    Schaefer, S.M.4    Lin, J.T.5    Kaplan, C.6
  • 68
    • 0034126502 scopus 로고    scopus 로고
    • Comparison of effects of simvastatin versus atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I levels
    • Kastelein J.J., Isaacsohn J.L., Ose L., Hunninghake D.B., Frohlich J., Davidson M.H., et al. Comparison of effects of simvastatin versus atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I levels. Am. J. Cardiol. 2000, 86:221-223.
    • (2000) Am. J. Cardiol. , vol.86 , pp. 221-223
    • Kastelein, J.J.1    Isaacsohn, J.L.2    Ose, L.3    Hunninghake, D.B.4    Frohlich, J.5    Davidson, M.H.6
  • 69
    • 66549089455 scopus 로고    scopus 로고
    • Effects of rosuvastatin and atorvastatin on LDL and HDL particle concentrations in patients with metabolic syndrome: a randomized, double-blind, controlled study
    • Rosenson R.S., Otvos J.D., Hsia J. Effects of rosuvastatin and atorvastatin on LDL and HDL particle concentrations in patients with metabolic syndrome: a randomized, double-blind, controlled study. Diabetes Care 2009, 32:1087-1091.
    • (2009) Diabetes Care , vol.32 , pp. 1087-1091
    • Rosenson, R.S.1    Otvos, J.D.2    Hsia, J.3
  • 70
    • 0030967489 scopus 로고    scopus 로고
    • Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Atorvastatin Study Group I
    • Davidson M., McKenney J., Stein E., Schrott H., Bakker-Arkema R., Fayyad R., Black D. Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Atorvastatin Study Group I. Am. J. Cardiol. 1997, 79:1475-1481.
    • (1997) Am. J. Cardiol. , vol.79 , pp. 1475-1481
    • Davidson, M.1    McKenney, J.2    Stein, E.3    Schrott, H.4    Bakker-Arkema, R.5    Fayyad, R.6    Black, D.7
  • 71
    • 9044230921 scopus 로고    scopus 로고
    • Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia
    • Bakker-Arkema R.G., Davidson M.H., Goldstein R.J., Davignon J., Isaacsohn J.L., Weiss S.R., et al. Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia. JAMA 1996, 275:128-133.
    • (1996) JAMA , vol.275 , pp. 128-133
    • Bakker-Arkema, R.G.1    Davidson, M.H.2    Goldstein, R.J.3    Davignon, J.4    Isaacsohn, J.L.5    Weiss, S.R.6
  • 72
    • 0031195278 scopus 로고    scopus 로고
    • A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia
    • Dart A., Jerums G., Nicholson G., d'Emden M., Hamilton-Craig I., Tallis G., et al. A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia. Am. J. Cardiol. 1997, 80:39-44.
    • (1997) Am. J. Cardiol. , vol.80 , pp. 39-44
    • Dart, A.1    Jerums, G.2    Nicholson, G.3    d'Emden, M.4    Hamilton-Craig, I.5    Tallis, G.6
  • 76
    • 33846464226 scopus 로고    scopus 로고
    • Safety and efficacy of statins in Asians
    • Liao J.K. Safety and efficacy of statins in Asians. Am. J. Cardiol. 2007, 99:410-414.
    • (2007) Am. J. Cardiol. , vol.99 , pp. 410-414
    • Liao, J.K.1
  • 77
    • 0035916233 scopus 로고    scopus 로고
    • Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization
    • Crisby M., Nordin-Fredriksson G., Shah P.K., Yano J., Zhu J., Nilsson J. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation 2001, 103:926-933.
    • (2001) Circulation , vol.103 , pp. 926-933
    • Crisby, M.1    Nordin-Fredriksson, G.2    Shah, P.K.3    Yano, J.4    Zhu, J.5    Nilsson, J.6
  • 78
    • 18144435700 scopus 로고    scopus 로고
    • Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys
    • Williams J.K., Sukhova G.K., Herrington D.M., Libby P. Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys. J. Am. Coll. Cardiol. 1998, 31:684-691.
    • (1998) J. Am. Coll. Cardiol. , vol.31 , pp. 684-691
    • Williams, J.K.1    Sukhova, G.K.2    Herrington, D.M.3    Libby, P.4
  • 79
    • 0035902442 scopus 로고    scopus 로고
    • Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging
    • Corti R., Fayad Z.A., Fuster V., Worthley S.G., Helft G., Chesebro J., et al. Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation 2001, 104:249-252.
    • (2001) Circulation , vol.104 , pp. 249-252
    • Corti, R.1    Fayad, Z.A.2    Fuster, V.3    Worthley, S.G.4    Helft, G.5    Chesebro, J.6
  • 80
    • 0037016049 scopus 로고    scopus 로고
    • Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging
    • Corti R., Fuster V., Fayad Z.A., Worthley S.G., Helft G., Smith D., et al. Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging. Circulation 2002, 106:2884-2887.
    • (2002) Circulation , vol.106 , pp. 2884-2887
    • Corti, R.1    Fuster, V.2    Fayad, Z.A.3    Worthley, S.G.4    Helft, G.5    Smith, D.6
  • 81
    • 0023025526 scopus 로고
    • Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)
    • Stamler J., Wentworth D., Neaton J.D. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 1986, 256:2823-2828.
    • (1986) JAMA , vol.256 , pp. 2823-2828
    • Stamler, J.1    Wentworth, D.2    Neaton, J.D.3
  • 83
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
    • Shepherd J., Cobbe S.M., Ford I., Isles C.G., Lorimer A.R., MacFarlane P.W., et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N. Engl. J. Med. 1995, 333:1301-1307.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3    Isles, C.G.4    Lorimer, A.R.5    MacFarlane, P.W.6
  • 84
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study
    • Downs J.R., Clearfield M., Weis S., Whitney E., Shapiro D.R., Beere P.A., et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998, 279:1615-1622.
    • (1998) JAMA , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3    Whitney, E.4    Shapiro, D.R.5    Beere, P.A.6
  • 85
    • 0037420492 scopus 로고    scopus 로고
    • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
    • Sever P.S., Dahlof B., Poulter N.R., Wedel H., Beevers G., Caulfield M., et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003, 361:1149-1158.
    • (2003) Lancet , vol.361 , pp. 1149-1158
    • Sever, P.S.1    Dahlof, B.2    Poulter, N.R.3    Wedel, H.4    Beevers, G.5    Caulfield, M.6
  • 87
    • 77954179995 scopus 로고    scopus 로고
    • Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants
    • Ray K.K., Seshasai S.R., Erqou S., Sever P., Jukema J.W., Ford I., Sattar N. Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch. Intern. Med. 2010, 170:1024-1031.
    • (2010) Arch. Intern. Med. , vol.170 , pp. 1024-1031
    • Ray, K.K.1    Seshasai, S.R.2    Erqou, S.3    Sever, P.4    Jukema, J.W.5    Ford, I.6    Sattar, N.7
  • 88
    • 84864832599 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials
    • Mihaylova B., Emberson J., Blackwell L., Keech A., Simes J., Barnes E.H., et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 2012, 380:581-590.
    • (2012) Lancet , vol.380 , pp. 581-590
    • Mihaylova, B.1    Emberson, J.2    Blackwell, L.3    Keech, A.4    Simes, J.5    Barnes, E.H.6
  • 89
    • 84897970506 scopus 로고    scopus 로고
    • ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Stone N.J., Robinson J.G., Lichtenstein A.H., Bairey Merz C.N., Blum C.B., Eckel R.H., et al. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2013, 129:S1-S45.
    • (2013) Circulation , vol.129 , pp. S1-S45
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6
  • 90
    • 84903165096 scopus 로고    scopus 로고
    • ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Goff D.C., Lloyd-Jones D.M., Bennett G., Coady S., D'Agostino R.B., Gibbons R., et al. ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 2013, 63:2935-2959.
    • (2013) J. Am. Coll. Cardiol. , vol.63 , pp. 2935-2959
    • Goff, D.C.1    Lloyd-Jones, D.M.2    Bennett, G.3    Coady, S.4    D'Agostino, R.B.5    Gibbons, R.6
  • 92
    • 84895792670 scopus 로고    scopus 로고
    • Controversy over clinical guidelines: listen to the evidence, not the noise
    • Guallar E., Laine C. Controversy over clinical guidelines: listen to the evidence, not the noise. Ann. Intern. Med. 2014, 160:361-362.
    • (2014) Ann. Intern. Med. , vol.160 , pp. 361-362
    • Guallar, E.1    Laine, C.2
  • 93
    • 84888789096 scopus 로고    scopus 로고
    • Statins: new American guidelines for prevention of cardiovascular disease
    • Ridker P.M., Cook N.R. Statins: new American guidelines for prevention of cardiovascular disease. Lancet 2013, 382:1762-1765.
    • (2013) Lancet , vol.382 , pp. 1762-1765
    • Ridker, P.M.1    Cook, N.R.2
  • 94
    • 84897020170 scopus 로고    scopus 로고
    • ACC/AHA guideline on the treatment of blood cholesterol: a fresh interpretation of old evidence
    • Psaty B.M., Weiss N.S. ACC/AHA guideline on the treatment of blood cholesterol: a fresh interpretation of old evidence. JAMA 2013, 311:461-462.
    • (2013) JAMA , vol.311 , pp. 461-462
    • Psaty, B.M.1    Weiss, N.S.2
  • 95
    • 84898761815 scopus 로고    scopus 로고
    • The new cholesterol and blood pressure guidelines: perspective on the path forward
    • Krumholz H.M. The new cholesterol and blood pressure guidelines: perspective on the path forward. JAMA 2014, 311:1403-1405.
    • (2014) JAMA , vol.311 , pp. 1403-1405
    • Krumholz, H.M.1
  • 96
    • 84889833385 scopus 로고    scopus 로고
    • Accumulating evidence for statins in primary prevention
    • Robinson J.G. Accumulating evidence for statins in primary prevention. JAMA 2013, 310:2405-2406.
    • (2013) JAMA , vol.310 , pp. 2405-2406
    • Robinson, J.G.1
  • 97
    • 84937413953 scopus 로고    scopus 로고
    • Cholesterol lowering in 2015: still answering questions about how and in whom
    • Greenland P., Lauer M.S. Cholesterol lowering in 2015: still answering questions about how and in whom. JAMA 2015, 314:127-128.
    • (2015) JAMA , vol.314 , pp. 127-128
    • Greenland, P.1    Lauer, M.S.2
  • 98
    • 84937460144 scopus 로고    scopus 로고
    • Guideline-based statin eligibility, coronary artery calcification, and cardiovascular events
    • Pursnani A., Massaro J.M., D'Agostino R.B., O'Donnell C.J., Hoffmann U. Guideline-based statin eligibility, coronary artery calcification, and cardiovascular events. JAMA 2015, 314:134-141.
    • (2015) JAMA , vol.314 , pp. 134-141
    • Pursnani, A.1    Massaro, J.M.2    D'Agostino, R.B.3    O'Donnell, C.J.4    Hoffmann, U.5
  • 99
    • 84904535033 scopus 로고    scopus 로고
    • A look at statin cost-effectiveness in view of the 2013 ACC/AHA cholesterol management guidelines
    • Deano R.C., Pandya A., Jones E.C., Borden W.B. A look at statin cost-effectiveness in view of the 2013 ACC/AHA cholesterol management guidelines. Curr. Atheroscler. Rep. 2014, 16:438.
    • (2014) Curr. Atheroscler. Rep. , vol.16 , pp. 438
    • Deano, R.C.1    Pandya, A.2    Jones, E.C.3    Borden, W.B.4
  • 100
    • 84937423830 scopus 로고    scopus 로고
    • Cost-effectiveness of 10-year risk thresholds for initiation of statin therapy for primary prevention of cardiovascular disease
    • Pandya A., Sy S., Cho S., Weinstein M.C., Gaziano T.A. Cost-effectiveness of 10-year risk thresholds for initiation of statin therapy for primary prevention of cardiovascular disease. JAMA 2015, 314:142-150.
    • (2015) JAMA , vol.314 , pp. 142-150
    • Pandya, A.1    Sy, S.2    Cho, S.3    Weinstein, M.C.4    Gaziano, T.A.5
  • 101
    • 79952046691 scopus 로고    scopus 로고
    • Benefits of statin therapy and compliance in high risk cardiovascular patients
    • Lardizabal J.A., Deedwania P.C. Benefits of statin therapy and compliance in high risk cardiovascular patients. Vasc. Health Risk Manag. 2010, 6:843-853.
    • (2010) Vasc. Health Risk Manag. , vol.6 , pp. 843-853
    • Lardizabal, J.A.1    Deedwania, P.C.2
  • 102
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 103
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators
    • Sacks F.M., Pfeffer M.A., Moye L.A., Rouleau J.L., Rutherford J.D., Cole T.G., et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N. Engl. J. Med. 1996, 335:1001-1009.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3    Rouleau, J.L.4    Rutherford, J.D.5    Cole, T.G.6
  • 104
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N. Engl. J. Med. 1998, 339:1349-1357.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1349-1357
  • 105
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002, 360:7-22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 107
    • 84902576469 scopus 로고    scopus 로고
    • ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Stone N.J., Robinson J.G., Lichtenstein A.H., Bairey Merz C.N., Blum C.B., Eckel R.H., et al. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 2013, 63:2889-2934.
    • (2013) J. Am. Coll. Cardiol. , vol.63 , pp. 2889-2934
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6
  • 108
    • 35748962429 scopus 로고    scopus 로고
    • The safety of statins in clinical practice
    • Armitage J. The safety of statins in clinical practice. Lancet 2007, 370:1781-1790.
    • (2007) Lancet , vol.370 , pp. 1781-1790
    • Armitage, J.1
  • 109
    • 0036787998 scopus 로고    scopus 로고
    • Can statins cause chronic low-grade myopathy?
    • Grundy S.M. Can statins cause chronic low-grade myopathy?. Ann. Intern. Med. 2002, 137:617-618.
    • (2002) Ann. Intern. Med. , vol.137 , pp. 617-618
    • Grundy, S.M.1
  • 110
    • 44949247555 scopus 로고    scopus 로고
    • Toward "pain-free" statin prescribing: clinical algorithm for diagnosis and management of myalgia
    • Jacobson T.A. Toward "pain-free" statin prescribing: clinical algorithm for diagnosis and management of myalgia. Mayo Clin. Proc. 2008, 83:687-700.
    • (2008) Mayo Clin. Proc. , vol.83 , pp. 687-700
    • Jacobson, T.A.1
  • 111
    • 67249111853 scopus 로고    scopus 로고
    • Narrative review: statin-related myopathy
    • Joy T.R., Hegele R.A. Narrative review: statin-related myopathy. Ann. Intern. Med. 2009, 150:858-868.
    • (2009) Ann. Intern. Med. , vol.150 , pp. 858-868
    • Joy, T.R.1    Hegele, R.A.2
  • 113
    • 17744379378 scopus 로고    scopus 로고
    • Molecular clues into the pathogenesis of statin-mediated muscle toxicity
    • Baker S.K. Molecular clues into the pathogenesis of statin-mediated muscle toxicity. Muscle Nerve 2005, 31:572-580.
    • (2005) Muscle Nerve , vol.31 , pp. 572-580
    • Baker, S.K.1
  • 115
    • 0028831354 scopus 로고
    • Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans
    • Laaksonen R., Jokelainen K., Sahi T., Tikkanen M.J., Himberg J.J. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin. Pharmacol. Ther. 1995, 57:62-66.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 62-66
    • Laaksonen, R.1    Jokelainen, K.2    Sahi, T.3    Tikkanen, M.J.4    Himberg, J.J.5
  • 116
    • 0027158373 scopus 로고
    • Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study
    • Ghirlanda G., Oradei A., Manto A., Lippa S., Uccioli L., Caputo S., et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J. Clin. Pharmacol. 1993, 33:226-229.
    • (1993) J. Clin. Pharmacol. , vol.33 , pp. 226-229
    • Ghirlanda, G.1    Oradei, A.2    Manto, A.3    Lippa, S.4    Uccioli, L.5    Caputo, S.6
  • 117
    • 2942587374 scopus 로고    scopus 로고
    • Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke
    • Rundek T., Naini A., Sacco R., Coates K., DiMauro S. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch. Neurol. 2004, 61:889-892.
    • (2004) Arch. Neurol. , vol.61 , pp. 889-892
    • Rundek, T.1    Naini, A.2    Sacco, R.3    Coates, K.4    DiMauro, S.5
  • 120
    • 0030012771 scopus 로고    scopus 로고
    • The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle
    • Laaksonen R., Jokelainen K., Laakso J., Sahi T., Harkonen M., Tikkanen M.J., Himberg J.J. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am. J. Cardiol. 1996, 77:851-854.
    • (1996) Am. J. Cardiol. , vol.77 , pp. 851-854
    • Laaksonen, R.1    Jokelainen, K.2    Laakso, J.3    Sahi, T.4    Harkonen, M.5    Tikkanen, M.J.6    Himberg, J.J.7
  • 123
    • 84927742065 scopus 로고    scopus 로고
    • Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management
    • Stroes E.S., Thompson P.D., Corsini A., Vladutiu G.D., Raal F.J., Ray K.K., et al. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur. Heart J. 2015, 36:1012-1022.
    • (2015) Eur. Heart J. , vol.36 , pp. 1012-1022
    • Stroes, E.S.1    Thompson, P.D.2    Corsini, A.3    Vladutiu, G.D.4    Raal, F.J.5    Ray, K.K.6
  • 124
    • 0032441653 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitor accelerates aging effect on diaphragm mitochondrial respiratory function in rats
    • Sugiyama S. HMG CoA reductase inhibitor accelerates aging effect on diaphragm mitochondrial respiratory function in rats. Biochem. Mol. Biol. Int. 1998, 46:923-931.
    • (1998) Biochem. Mol. Biol. Int. , vol.46 , pp. 923-931
    • Sugiyama, S.1
  • 125
    • 24344509230 scopus 로고    scopus 로고
    • Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients
    • Mabuchi H., Higashikata T., Kawashiri M., Katsuda S., Mizuno M., Nohara A., et al. Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. J. Atheroscler. Thromb. 2005, 12:111-119.
    • (2005) J. Atheroscler. Thromb. , vol.12 , pp. 111-119
    • Mabuchi, H.1    Higashikata, T.2    Kawashiri, M.3    Katsuda, S.4    Mizuno, M.5    Nohara, A.6
  • 126
    • 34247849275 scopus 로고    scopus 로고
    • Statins provoking MELAS syndrome. A case report
    • Thomas J.E., Lee N., Thompson P.D. Statins provoking MELAS syndrome. A case report. Eur. Neurol. 2007, 57:232-235.
    • (2007) Eur. Neurol. , vol.57 , pp. 232-235
    • Thomas, J.E.1    Lee, N.2    Thompson, P.D.3
  • 128
    • 84655169258 scopus 로고    scopus 로고
    • Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes
    • Kwak H.B., Thalacker-Mercer A., Anderson E.J., Lin C.T., Kane D.A., Lee N.S., et al. Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic. Biol. Med. 2012, 52:198-207.
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 198-207
    • Kwak, H.B.1    Thalacker-Mercer, A.2    Anderson, E.J.3    Lin, C.T.4    Kane, D.A.5    Lee, N.S.6
  • 129
    • 77249121018 scopus 로고    scopus 로고
    • Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy
    • Mullen P.J., Luscher B., Scharnagl H., Krahenbuhl S., Brecht K. Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy. Biochem. Pharmacol. 2010, 79:1200-1209.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1200-1209
    • Mullen, P.J.1    Luscher, B.2    Scharnagl, H.3    Krahenbuhl, S.4    Brecht, K.5
  • 130
    • 0031795348 scopus 로고    scopus 로고
    • Myopathy induced by HMG-CoA reductase inhibitors in rabbits: a pathological, electrophysiological, and biochemical study
    • Nakahara K., Kuriyama M., Sonoda Y., Yoshidome H., Nakagawa H., Fujiyama J., et al. Myopathy induced by HMG-CoA reductase inhibitors in rabbits: a pathological, electrophysiological, and biochemical study. Toxicol. Appl. Pharmacol. 1998, 152:99-106.
    • (1998) Toxicol. Appl. Pharmacol. , vol.152 , pp. 99-106
    • Nakahara, K.1    Kuriyama, M.2    Sonoda, Y.3    Yoshidome, H.4    Nakagawa, H.5    Fujiyama, J.6
  • 131
    • 9144239260 scopus 로고    scopus 로고
    • Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats
    • Schaefer W.H., Lawrence J.W., Loughlin A.F., Stoffregen D.A., Mixson L.A., Dean D.C., et al. Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats. Toxicol. Appl. Pharmacol. 2004, 194:10-23.
    • (2004) Toxicol. Appl. Pharmacol. , vol.194 , pp. 10-23
    • Schaefer, W.H.1    Lawrence, J.W.2    Loughlin, A.F.3    Stoffregen, D.A.4    Mixson, L.A.5    Dean, D.C.6
  • 132
    • 79961157905 scopus 로고    scopus 로고
    • Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats
    • Obayashi H., Nezu Y., Yokota H., Kiyosawa N., Mori K., Maeda N., et al. Cerivastatin induces type-I fiber-, not type-II fiber-, predominant muscular toxicity in the young male F344 rats. J. Toxicol. Sci. 2011, 36:445-452.
    • (2011) J. Toxicol. Sci. , vol.36 , pp. 445-452
    • Obayashi, H.1    Nezu, Y.2    Yokota, H.3    Kiyosawa, N.4    Mori, K.5    Maeda, N.6
  • 133
    • 84856108187 scopus 로고    scopus 로고
    • Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1
    • Bouitbir J., Charles A.L., Echaniz-Laguna A., Kindo M., Daussin F., Auwerx J., et al. Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1. Eur. Heart J. 2012, 33:1397-1407.
    • (2012) Eur. Heart J. , vol.33 , pp. 1397-1407
    • Bouitbir, J.1    Charles, A.L.2    Echaniz-Laguna, A.3    Kindo, M.4    Daussin, F.5    Auwerx, J.6
  • 134
    • 0029837064 scopus 로고    scopus 로고
    • Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio
    • De Pinieux G., Chariot P., Ammi-Said M., Louarn F., Lejonc J.L., Astier A., et al. Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br. J. Clin. Pharmacol. 1996, 42:333-337.
    • (1996) Br. J. Clin. Pharmacol. , vol.42 , pp. 333-337
    • De Pinieux, G.1    Chariot, P.2    Ammi-Said, M.3    Louarn, F.4    Lejonc, J.L.5    Astier, A.6
  • 136
    • 84872918353 scopus 로고    scopus 로고
    • Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy
    • Stringer H.A., Sohi G.K., Maguire J.A., Cote H.C. Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy. J. Neurol. Sci. 2013, 325:142-147.
    • (2013) J. Neurol. Sci. , vol.325 , pp. 142-147
    • Stringer, H.A.1    Sohi, G.K.2    Maguire, J.A.3    Cote, H.C.4
  • 137
    • 63449088307 scopus 로고    scopus 로고
    • Myotoxic reactions to lipid-lowering therapy are associated with altered oxidation of fatty acids
    • Phillips P.S., Ciaraldi T.P., Kim D.L., Verity M.A., Wolfson T., Henry R.R. Myotoxic reactions to lipid-lowering therapy are associated with altered oxidation of fatty acids. Endocrine 2009, 35:38-46.
    • (2009) Endocrine , vol.35 , pp. 38-46
    • Phillips, P.S.1    Ciaraldi, T.P.2    Kim, D.L.3    Verity, M.A.4    Wolfson, T.5    Henry, R.R.6
  • 140
    • 23944515089 scopus 로고    scopus 로고
    • Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells
    • Sacher J., Weigl L., Werner M., Szegedi C., Hohenegger M. Delineation of myotoxicity induced by 3-hydroxy-3-methylglutaryl CoA reductase inhibitors in human skeletal muscle cells. J. Pharmacol. Exp. Ther. 2005, 314:1032-1041.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 1032-1041
    • Sacher, J.1    Weigl, L.2    Werner, M.3    Szegedi, C.4    Hohenegger, M.5
  • 141
    • 36849045916 scopus 로고    scopus 로고
    • The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
    • Hanai J., Cao P., Tanksale P., Imamura S., Koshimizu E., Zhao J., et al. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J. Clin. Invest. 2007, 117:3940-3951.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3940-3951
    • Hanai, J.1    Cao, P.2    Tanksale, P.3    Imamura, S.4    Koshimizu, E.5    Zhao, J.6
  • 142
    • 81255165866 scopus 로고    scopus 로고
    • Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference
    • Mancini G.B., Baker S., Bergeron J., Fitchett D., Frohlich J., Genest J., et al. Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference. Can. J. Cardiol. 2013, 27:635-662.
    • (2013) Can. J. Cardiol. , vol.27 , pp. 635-662
    • Mancini, G.B.1    Baker, S.2    Bergeron, J.3    Fitchett, D.4    Frohlich, J.5    Genest, J.6
  • 144
    • 0034764889 scopus 로고    scopus 로고
    • A case of atorvastatin combined toxic myopathy and inflammatory myositis
    • Folzenlogen D. A case of atorvastatin combined toxic myopathy and inflammatory myositis. J. Clin. Rheumatol. 2001, 7:340-345.
    • (2001) J. Clin. Rheumatol. , vol.7 , pp. 340-345
    • Folzenlogen, D.1
  • 145
    • 0024594716 scopus 로고
    • The role of cholesterol-lowering agents in drug-induced rhabdomyolysis and polymyositis
    • Goldman J.A., Fishman A.B., Lee J.E., Johnson R.J. The role of cholesterol-lowering agents in drug-induced rhabdomyolysis and polymyositis. Arthritis Rheum. 1989, 32:358-359.
    • (1989) Arthritis Rheum. , vol.32 , pp. 358-359
    • Goldman, J.A.1    Fishman, A.B.2    Lee, J.E.3    Johnson, R.J.4
  • 149
    • 10044231566 scopus 로고    scopus 로고
    • Dermatomyositis-like syndrome and HMG-CoA reductase inhibitor (statin) intake
    • Vasconcelos O.M., Campbell W.W. Dermatomyositis-like syndrome and HMG-CoA reductase inhibitor (statin) intake. Muscle Nerve 2004, 30:803-807.
    • (2004) Muscle Nerve , vol.30 , pp. 803-807
    • Vasconcelos, O.M.1    Campbell, W.W.2
  • 151
    • 54949084597 scopus 로고    scopus 로고
    • A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle
    • Laaksonen R., Katajamaa M., Paiva H., Sysi-Aho M., Saarinen L., Junni P., et al. A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One 2006, 1:e97.
    • (2006) PLoS One , vol.1
    • Laaksonen, R.1    Katajamaa, M.2    Paiva, H.3    Sysi-Aho, M.4    Saarinen, L.5    Junni, P.6
  • 152
    • 79953711138 scopus 로고    scopus 로고
    • Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy
    • Mammen A.L., Chung T., Christopher-Stine L., Rosen P., Rosen A., Doering K.R., Casciola-Rosen L.A. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011, 63:713-721.
    • (2011) Arthritis Rheum. , vol.63 , pp. 713-721
    • Mammen, A.L.1    Chung, T.2    Christopher-Stine, L.3    Rosen, P.4    Rosen, A.5    Doering, K.R.6    Casciola-Rosen, L.A.7
  • 153
    • 84931044932 scopus 로고    scopus 로고
    • The effects of statin medications on aerobic exercise capacity and training adaptations
    • Murlasits Z., Radak Z. The effects of statin medications on aerobic exercise capacity and training adaptations. Sports Med. 2014, 44:1519-1530.
    • (2014) Sports Med. , vol.44 , pp. 1519-1530
    • Murlasits, Z.1    Radak, Z.2
  • 154
    • 79955702903 scopus 로고    scopus 로고
    • Prevention of atherosclerosis in overweight/obese patients-in need of novel multi-targeted approaches
    • Lim S., Despres J.P., Koh K.K. Prevention of atherosclerosis in overweight/obese patients-in need of novel multi-targeted approaches. Circ. J. 2011, 75:1019-1027.
    • (2011) Circ. J. , vol.75 , pp. 1019-1027
    • Lim, S.1    Despres, J.P.2    Koh, K.K.3
  • 155
    • 69449087915 scopus 로고    scopus 로고
    • Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study
    • Monda K.L., Ballantyne C.M., North K.E. Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the Atherosclerosis Risk in Communities Study. J. Lipid Res. 2009, 50:1685-1691.
    • (2009) J. Lipid Res. , vol.50 , pp. 1685-1691
    • Monda, K.L.1    Ballantyne, C.M.2    North, K.E.3
  • 157
    • 64549108539 scopus 로고    scopus 로고
    • Physical activity in statin-treated patients
    • Mascitelli L., Pezzetta F. Physical activity in statin-treated patients. Int. J. Cardiol. 2009, 134:136-137.
    • (2009) Int. J. Cardiol. , vol.134 , pp. 136-137
    • Mascitelli, L.1    Pezzetta, F.2
  • 158
    • 77957865415 scopus 로고    scopus 로고
    • No strain, no gain: psychosocial predictors of physical activity across the adult lifespan
    • Cotter K.A., Lachman M.E. No strain, no gain: psychosocial predictors of physical activity across the adult lifespan. J. Phys. Act. Health 2010, 7:584-594.
    • (2010) J. Phys. Act. Health , vol.7 , pp. 584-594
    • Cotter, K.A.1    Lachman, M.E.2
  • 159
    • 84873180673 scopus 로고    scopus 로고
    • Interactive effects of fitness and statin treatment on mortality risk in veterans with dyslipidaemia: a cohort study
    • Kokkinos P.F., Faselis C., Myers J., Panagiotakos D., Doumas M. Interactive effects of fitness and statin treatment on mortality risk in veterans with dyslipidaemia: a cohort study. Lancet 2013, 381:394-399.
    • (2013) Lancet , vol.381 , pp. 394-399
    • Kokkinos, P.F.1    Faselis, C.2    Myers, J.3    Panagiotakos, D.4    Doumas, M.5
  • 160
    • 77952686086 scopus 로고    scopus 로고
    • Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database
    • Barter P.J., Brandrup-Wognsen G., Palmer M.K., Nicholls S.J. Effect of statins on HDL-C: a complex process unrelated to changes in LDL-C: analysis of the VOYAGER Database. J. Lipid Res. 2010, 51:1546-1553.
    • (2010) J. Lipid Res. , vol.51 , pp. 1546-1553
    • Barter, P.J.1    Brandrup-Wognsen, G.2    Palmer, M.K.3    Nicholls, S.J.4
  • 162
    • 84864616144 scopus 로고
    • Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance
    • Muraki A., Miyashita K., Mitsuishi M., Tamaki M., Tanaka K., Itoh H. Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance. J. Appl. Physiol. 1985, 113:479-486.
    • (1985) J. Appl. Physiol. , vol.113 , pp. 479-486
    • Muraki, A.1    Miyashita, K.2    Mitsuishi, M.3    Tamaki, M.4    Tanaka, K.5    Itoh, H.6
  • 163
    • 1942519775 scopus 로고    scopus 로고
    • Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems
    • Sinzinger H., O'Grady J. Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems. Br. J. Clin. Pharmacol. 2004, 57:525-528.
    • (2004) Br. J. Clin. Pharmacol. , vol.57 , pp. 525-528
    • Sinzinger, H.1    O'Grady, J.2
  • 164
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: a systematic review
    • Law M., Rudnicka A.R. Statin safety: a systematic review. Am. J. Cardiol. 2006, 97:52C-60C.
    • (2006) Am. J. Cardiol. , vol.97 , pp. 52C-60C
    • Law, M.1    Rudnicka, A.R.2
  • 165
    • 84855970707 scopus 로고    scopus 로고
    • Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing
    • Bjornsson E., Jacobsen E.I., Kalaitzakis E. Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. J. Hepatol. 2012, 56:374-380.
    • (2012) J. Hepatol. , vol.56 , pp. 374-380
    • Bjornsson, E.1    Jacobsen, E.I.2    Kalaitzakis, E.3
  • 166
    • 84904698842 scopus 로고    scopus 로고
    • Spectrum of statin hepatotoxicity: experience of the drug-induced liver injury network
    • Russo M.W., Hoofnagle J.H., Gu J., Fontana R.J., Barnhart H., Kleiner D.E., et al. Spectrum of statin hepatotoxicity: experience of the drug-induced liver injury network. Hepatology 2014, 60:679-686.
    • (2014) Hepatology , vol.60 , pp. 679-686
    • Russo, M.W.1    Hoofnagle, J.H.2    Gu, J.3    Fontana, R.J.4    Barnhart, H.5    Kleiner, D.E.6
  • 167
    • 33645888317 scopus 로고    scopus 로고
    • An assessment of statin safety by hepatologists
    • Cohen D.E., Anania F.A., Chalasani N. An assessment of statin safety by hepatologists. Am. J. Cardiol. 2006, 97:77C-81C.
    • (2006) Am. J. Cardiol. , vol.97 , pp. 77C-81C
    • Cohen, D.E.1    Anania, F.A.2    Chalasani, N.3
  • 168
    • 77950625119 scopus 로고    scopus 로고
    • Statins in the treatment of dyslipidemia in the presence of elevated liver aminotransferase levels: a therapeutic dilemma
    • Calderon R.M., Cubeddu L.X., Goldberg R.B., Schiff E.R. Statins in the treatment of dyslipidemia in the presence of elevated liver aminotransferase levels: a therapeutic dilemma. Mayo Clin. Proc. 2010, 85:349-356.
    • (2010) Mayo Clin. Proc. , vol.85 , pp. 349-356
    • Calderon, R.M.1    Cubeddu, L.X.2    Goldberg, R.B.3    Schiff, E.R.4
  • 169
    • 33645853175 scopus 로고    scopus 로고
    • Statin safety: an overview and assessment of the data-2005
    • Bays H. Statin safety: an overview and assessment of the data-2005. Am. J. Cardiol. 2006, 97:6C-26C.
    • (2006) Am. J. Cardiol. , vol.97 , pp. 6C-26C
    • Bays, H.1
  • 170
    • 20544432480 scopus 로고    scopus 로고
    • The safety of rosuvastatin as used in common clinical practice: a postmarketing analysis
    • Alsheikh-Ali A.A., Ambrose M.S., Kuvin J.T., Karas R.H. The safety of rosuvastatin as used in common clinical practice: a postmarketing analysis. Circulation 2005, 111:3051-3057.
    • (2005) Circulation , vol.111 , pp. 3051-3057
    • Alsheikh-Ali, A.A.1    Ambrose, M.S.2    Kuvin, J.T.3    Karas, R.H.4
  • 171
    • 20544443723 scopus 로고    scopus 로고
    • The issue of statin safety: where do we stand?
    • Grundy S.M. The issue of statin safety: where do we stand?. Circulation 2005, 111:3016-3019.
    • (2005) Circulation , vol.111 , pp. 3016-3019
    • Grundy, S.M.1
  • 174
    • 0025345588 scopus 로고
    • Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials
    • Muldoon M.F., Manuck S.B., Matthews K.A. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ 1990, 301:309-314.
    • (1990) BMJ , vol.301 , pp. 309-314
    • Muldoon, M.F.1    Manuck, S.B.2    Matthews, K.A.3
  • 175
    • 0027153371 scopus 로고
    • Cholesterol lowering and mortality: the importance of considering initial level of risk
    • Smith G.D., Song F., Sheldon T.A. Cholesterol lowering and mortality: the importance of considering initial level of risk. BMJ 1993, 306:1367-1373.
    • (1993) BMJ , vol.306 , pp. 1367-1373
    • Smith, G.D.1    Song, F.2    Sheldon, T.A.3
  • 177
    • 0042835785 scopus 로고    scopus 로고
    • Lipid-lowering drugs and the risk of depression and suicidal behavior
    • Yang C.C., Jick S.S., Jick H. Lipid-lowering drugs and the risk of depression and suicidal behavior. Arch. Intern. Med. 2003, 163:1926-1932.
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1926-1932
    • Yang, C.C.1    Jick, S.S.2    Jick, H.3
  • 178
    • 1842844488 scopus 로고    scopus 로고
    • Severe irritability associated with statin cholesterol-lowering drugs
    • Golomb B.A., Kane T., Dimsdale J.E. Severe irritability associated with statin cholesterol-lowering drugs. QJM 2004, 97:229-235.
    • (2004) QJM , vol.97 , pp. 229-235
    • Golomb, B.A.1    Kane, T.2    Dimsdale, J.E.3
  • 179
    • 67650805429 scopus 로고    scopus 로고
    • Statin-associated adverse cognitive effects: survey results from 171 patients
    • Evans M.A., Golomb B.A. Statin-associated adverse cognitive effects: survey results from 171 patients. Pharmacotherapy 2009, 29:800-811.
    • (2009) Pharmacotherapy , vol.29 , pp. 800-811
    • Evans, M.A.1    Golomb, B.A.2
  • 181
    • 0030024585 scopus 로고    scopus 로고
    • Carcinogenicity of lipid-lowering drugs
    • Newman T.B., Hulley S.B. Carcinogenicity of lipid-lowering drugs. JAMA 1996, 275:55-60.
    • (1996) JAMA , vol.275 , pp. 55-60
    • Newman, T.B.1    Hulley, S.B.2
  • 186
    • 1542329169 scopus 로고    scopus 로고
    • Statin use and cancer risk in the General Practice Research Database
    • Kaye J.A., Jick H. Statin use and cancer risk in the General Practice Research Database. Br. J. Cancer 2004, 90:635-637.
    • (2004) Br. J. Cancer , vol.90 , pp. 635-637
    • Kaye, J.A.1    Jick, H.2
  • 190
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
    • Baigent C., Blackwell L., Emberson J., Holland L.E., Reith C., Bhala N., et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010, 376:1670-1681.
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3    Holland, L.E.4    Reith, C.5    Bhala, N.6
  • 192
    • 33846604584 scopus 로고    scopus 로고
    • Statins and risk of cancer: a systematic review and metaanalysis
    • Browning D.R., Martin R.M. Statins and risk of cancer: a systematic review and metaanalysis. Int. J. Cancer 2007, 120:833-843.
    • (2007) Int. J. Cancer , vol.120 , pp. 833-843
    • Browning, D.R.1    Martin, R.M.2
  • 193
    • 84930670749 scopus 로고    scopus 로고
    • Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy
    • Emberson J.R., Kearney P.M., Blackwell L., Newman C., Reith C., Bhala N., et al. Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy. PLoS One 2012, 7:e29849.
    • (2012) PLoS One , vol.7
    • Emberson, J.R.1    Kearney, P.M.2    Blackwell, L.3    Newman, C.4    Reith, C.5    Bhala, N.6
  • 194
    • 4444252160 scopus 로고    scopus 로고
    • Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S)
    • Strandberg T.E., Pyorala K., Cook T.J., Wilhelmsen L., Faergeman O., Thorgeirsson G., et al. Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). Lancet 2004, 364:771-777.
    • (2004) Lancet , vol.364 , pp. 771-777
    • Strandberg, T.E.1    Pyorala, K.2    Cook, T.J.3    Wilhelmsen, L.4    Faergeman, O.5    Thorgeirsson, G.6
  • 196
    • 83255193890 scopus 로고    scopus 로고
    • Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial
    • Bulbulia R., Bowman L., Wallendszus K., Parish S., Armitage J., Peto R., Collins R. Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial. Lancet 2011, 378:2013-2020.
    • (2011) Lancet , vol.378 , pp. 2013-2020
    • Bulbulia, R.1    Bowman, L.2    Wallendszus, K.3    Parish, S.4    Armitage, J.5    Peto, R.6    Collins, R.7
  • 197
    • 56349119861 scopus 로고    scopus 로고
    • Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus
    • Yamakawa T., Takano T., Tanaka S., Kadonosono K., Terauchi Y. Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus. J. Atheroscler. Thromb. 2008, 15:269-275.
    • (2008) J. Atheroscler. Thromb. , vol.15 , pp. 269-275
    • Yamakawa, T.1    Takano, T.2    Tanaka, S.3    Kadonosono, K.4    Terauchi, Y.5
  • 198
    • 4143093784 scopus 로고    scopus 로고
    • Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model
    • Yu Y., Ohmori K., Chen Y., Sato C., Kiyomoto H., Shinomiya K., et al. Effects of pravastatin on progression of glucose intolerance and cardiovascular remodeling in a type II diabetes model. J. Am. Coll. Cardiol. 2004, 44:904-913.
    • (2004) J. Am. Coll. Cardiol. , vol.44 , pp. 904-913
    • Yu, Y.1    Ohmori, K.2    Chen, Y.3    Sato, C.4    Kiyomoto, H.5    Shinomiya, K.6
  • 200
    • 33845985670 scopus 로고    scopus 로고
    • Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and left ventricular diastolic dysfunction in a rat model of type II diabetes
    • Chen Y., Ohmori K., Mizukawa M., Yoshida J., Zeng Y., Zhang L., et al. Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and left ventricular diastolic dysfunction in a rat model of type II diabetes. Circ. J. 2007, 71:144-152.
    • (2007) Circ. J. , vol.71 , pp. 144-152
    • Chen, Y.1    Ohmori, K.2    Mizukawa, M.3    Yoshida, J.4    Zeng, Y.5    Zhang, L.6
  • 201
    • 34547118832 scopus 로고    scopus 로고
    • Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia
    • Mita T., Watada H., Nakayama S., Abe M., Ogihara T., Shimizu T., et al. Preferable effect of pravastatin compared to atorvastatin on beta cell function in Japanese early-state type 2 diabetes with hypercholesterolemia. Endocr. J. 2007, 54:441-447.
    • (2007) Endocr. J. , vol.54 , pp. 441-447
    • Mita, T.1    Watada, H.2    Nakayama, S.3    Abe, M.4    Ogihara, T.5    Shimizu, T.6
  • 202
    • 58149394432 scopus 로고    scopus 로고
    • The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study
    • Sathyapalan T., Kilpatrick E.S., Coady A.M., Atkin S.L. The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study. J. Clin. Endocrinol. Metab. 2009, 94:103-108.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 103-108
    • Sathyapalan, T.1    Kilpatrick, E.S.2    Coady, A.M.3    Atkin, S.L.4
  • 203
    • 84945470638 scopus 로고    scopus 로고
    • Statins and new-onset diabetes mellitus and diabetic complications: a retrospective cohort study of US healthy adults
    • Mansi I., Frei C.R., Wang C.P., Mortensen E.M. Statins and new-onset diabetes mellitus and diabetic complications: a retrospective cohort study of US healthy adults. J. Gen. Intern. Med. 2015, 1-12.
    • (2015) J. Gen. Intern. Med. , pp. 1-12
    • Mansi, I.1    Frei, C.R.2    Wang, C.P.3    Mortensen, E.M.4
  • 204
    • 84866733914 scopus 로고    scopus 로고
    • Statins, risk of diabetes, and implications on outcomes in the general population
    • Wang K.L., Liu C.J., Chao T.F., Huang C.M., Wu C.H., Chen S.J., et al. Statins, risk of diabetes, and implications on outcomes in the general population. J. Am. Coll. Cardiol. 2012, 60:1231-1238.
    • (2012) J. Am. Coll. Cardiol. , vol.60 , pp. 1231-1238
    • Wang, K.L.1    Liu, C.J.2    Chao, T.F.3    Huang, C.M.4    Wu, C.H.5    Chen, S.J.6
  • 205
    • 84864861863 scopus 로고    scopus 로고
    • Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial
    • Ridker P.M., Pradhan A., MacFadyen J.G., Libby P., Glynn R.J. Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial. Lancet 2012, 380:565-571.
    • (2012) Lancet , vol.380 , pp. 565-571
    • Ridker, P.M.1    Pradhan, A.2    MacFadyen, J.G.3    Libby, P.4    Glynn, R.J.5
  • 206
    • 0025194974 scopus 로고
    • On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors
    • Gerson R.J., MacDonald J.S., Alberts A.W., Chen J., Yudkovitz J.B., Greenspan M.D., et al. On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors. Exp. Eye Res. 1990, 50:65-78.
    • (1990) Exp. Eye Res. , vol.50 , pp. 65-78
    • Gerson, R.J.1    MacDonald, J.S.2    Alberts, A.W.3    Chen, J.4    Yudkovitz, J.B.5    Greenspan, M.D.6
  • 208
    • 0037648948 scopus 로고    scopus 로고
    • Cataract and the use of statins: a case-control study
    • Smeeth L., Hubbard R., Fletcher A.E. Cataract and the use of statins: a case-control study. QJM 2003, 96:337-343.
    • (2003) QJM , vol.96 , pp. 337-343
    • Smeeth, L.1    Hubbard, R.2    Fletcher, A.E.3
  • 209
    • 33745255122 scopus 로고    scopus 로고
    • Statin use and incident nuclear cataract
    • Klein B.E., Klein R., Lee K.E., Grady L.M. Statin use and incident nuclear cataract. JAMA 2006, 295:2752-2758.
    • (2006) JAMA , vol.295 , pp. 2752-2758
    • Klein, B.E.1    Klein, R.2    Lee, K.E.3    Grady, L.M.4
  • 210
    • 0028811104 scopus 로고
    • Absence of effect of simvastatin on the progression of lens opacities in a randomised placebo controlled study. Oxford Cholesterol Study Group
    • Harris M.L., Bron A.J., Brown N.A., Keech A.C., Wallendszus K.R., Armitage J.M., et al. Absence of effect of simvastatin on the progression of lens opacities in a randomised placebo controlled study. Oxford Cholesterol Study Group. Br. J. Ophthalmol. 1995, 79:996-1002.
    • (1995) Br. J. Ophthalmol. , vol.79 , pp. 996-1002
    • Harris, M.L.1    Bron, A.J.2    Brown, N.A.3    Keech, A.C.4    Wallendszus, K.R.5    Armitage, J.M.6
  • 211
    • 77953711938 scopus 로고    scopus 로고
    • Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database
    • Hippisley-Cox J., Coupland C. Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database. BMJ 2010, 340:c2197.
    • (2010) BMJ , vol.340
    • Hippisley-Cox, J.1    Coupland, C.2
  • 213
    • 0033812189 scopus 로고    scopus 로고
    • Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia
    • Dobs A.S., Schrott H., Davidson M.H., Bays H., Stein E.A., Kush D., et al. Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia. Metabolism 2000, 49:1234-1238.
    • (2000) Metabolism , vol.49 , pp. 1234-1238
    • Dobs, A.S.1    Schrott, H.2    Davidson, M.H.3    Bays, H.4    Stein, E.A.5    Kush, D.6
  • 215
    • 0029951605 scopus 로고    scopus 로고
    • Testicular function in hypercholesterolemic male patients during prolonged simvastatin treatment
    • Azzarito C., Boiardi L., Vergoni W., Zini M., Portioli I. Testicular function in hypercholesterolemic male patients during prolonged simvastatin treatment. Horm. Metab. Res. 1996, 28:193-198.
    • (1996) Horm. Metab. Res. , vol.28 , pp. 193-198
    • Azzarito, C.1    Boiardi, L.2    Vergoni, W.3    Zini, M.4    Portioli, I.5
  • 216
    • 0642368765 scopus 로고    scopus 로고
    • Atorvastatin treatment does not affect gonadal and adrenal hormones in type 2 diabetes patients with mild to moderate hypercholesterolemia
    • Santini S.A., Carrozza C., Lulli P., Zuppi C., CarloTonolo G., Musumeci S. Atorvastatin treatment does not affect gonadal and adrenal hormones in type 2 diabetes patients with mild to moderate hypercholesterolemia. J. Atheroscler. Thromb. 2003, 10:160-164.
    • (2003) J. Atheroscler. Thromb. , vol.10 , pp. 160-164
    • Santini, S.A.1    Carrozza, C.2    Lulli, P.3    Zuppi, C.4    CarloTonolo, G.5    Musumeci, S.6
  • 217
    • 0042133335 scopus 로고    scopus 로고
    • Use of lipid-lowering agents (statins) during pregnancy
    • Hosokawa A., Bar-Oz B., Ito S. Use of lipid-lowering agents (statins) during pregnancy. Can. Fam. Physician 2003, 49:747-749.
    • (2003) Can. Fam. Physician , vol.49 , pp. 747-749
    • Hosokawa, A.1    Bar-Oz, B.2    Ito, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.