Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells

Oncology Reports

Volumn 35, Issue 2, 2016, Pages 1065-1074

  Zhao, Guangming ^a   Han, Xiaodong ^a   Zheng, Siwen ^a   Li, Zhen ^a   Sha, Yang ^a   Ni, Jing ^a   Sun, Zhe ^a   Qiao, Song ^a   Song, Zhiqi ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

AKT mTOR pathway; Autophagy; Curcumin; Melanoma; Proliferation invasion

Indexed keywords

CURCUMIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; S6 KINASE; AKT1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TUMOR PROTEIN;

A375 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; C8161 CELL LINE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL INVASION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; MELANOMA CELL; MELANOMA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL CYCLE; CELL DIVISION; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; MELANOMA, EXPERIMENTAL; NUDE MOUSE; PATHOLOGY; RANDOMIZATION; REPORTER GENE; SKIN TUMOR; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CURCUMIN; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84954288105     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4413     Document Type: Article

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