Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy

Cancer Biology and Therapy

Volumn 11, Issue 2, 2011, Pages 216-228

  Chatterjee, Sudipa June ^a   Pandey, Siyaram ^a  

^a UNIVERSITY OF WINDSOR   (Canada)

Author keywords

Apoptosis; Autophagy; Chemo resistance; Curcumin; Melanoma; Tamoxifen

Indexed keywords

CURCUMIN; ESTROGEN RECEPTOR; OXIDIZING AGENT; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; TAMOXIFEN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; LOW DRUG DOSE; MELANOMA; MITOCHONDRION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; HUMANS; MELANOMA; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SKIN NEOPLASMS; TAMOXIFEN; TIME FACTORS;

EID: 78751564588     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.11.2.13798     Document Type: Article

References (13)

1. Soengas MS, Lowe SW: Apoptosis and melanoma chemoresistance. Oncogene 2003; 22:3138-51.
2. Goel A, Kunnumakkara AB. Aggarwal BB Curcumin as "curecumin": from kitchen to clinic. Biochem Pharmacol 2008; 75:787-809.
3. Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. Turmeric and curcumin: Biological actions and medicinal applications. Current Science 87:44-53.
4. Araujo CAC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz, Rio de Janeiro 2001; 96:723-8.
5. Syng-ai CA, Kumari L, Khar A. Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2. Mol Cancer Ther 2004; 3:1101-8.
6. Jung EM, Lim JH, Lee TJ, Park JW, Choi KS, Kwon TK. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 2005; 26:1905-13.
7. Moussavi M, Assi K, Gómez-Muñoz A, Salh B. Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. Carcinogenesis 2006; 27:1636-44.
8. Atsumi T, Tonosaki K, Fujisawa S. Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin. Arch Oral Biol 2006; 51:913-21.
9. Hail N Jr. Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis. Free Radic Biol Med 2008; 44:1382-93.
10. Cao J, Jia L, Zhou HM, Liu Y, Zhong LF. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol Sci 2006; 91:476-83.
11. Khar A, Ali AM, Pardhasaradhi BV, Varalakshmi CH, Anjum R, Kumari AL. Induction of stress response renders human tumor cell lines resistant to curcuminmediated apoptosis: role of reactive oxygen intermediates. Cell Stress Chaperones 2001; 6:368-76.
12. Bush JA, Cheung KJ Jr, Li G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/ caspase-8 pathway independent of p53. Exp Cell Res 2001; 271:305-14.
13. Siwak DR, Shishodia S, Aggarwal BB, Kurzrock R. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/ extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 2005; 104:879-90.