Preventive effect of Vaccinium uliginosum L. extract and its fractions on age-related macular degeneration and its action mechanisms

Archives of Pharmacal Research

Volumn 39, Issue 1, 2016, Pages 21-32

  Yoon, Sun Myung ^a   Lee, Bom Lee ^a   Guo, Yuan Ri ^a   Choung, Se Young ^a  

^a Kyung Hee University   (South Korea)

Author keywords

A2E; Age related macular degeneration (AMD); ARPE 19 cell; Blue light; Vaccinium uliginosum L. (V.U)

Indexed keywords

AGENTS ACTING ON THE EYE; ANTIOXIDANT; CASPASE 3; MYRICETIN; MYRICETIN 3 O GALACTOSIDE; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; QUERCETIN; QUERCETIN 3 O ARABINOFURANOSIDE; QUERCETIN 3 O GALATOSIDE; UNCLASSIFIED DRUG; VACCINIUM ULIGINOSUM EXTRACT;

ADULT; AGE RELATED MACULAR DEGENERATION; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLUE LIGHT; CELL DEATH; CELL FREE SYSTEM; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; EYE PROTECTION; HUMAN; HUMAN CELL; LIGHT STRESS; MOLECULAR WEIGHT; PHOTOOXIDATION; PIGMENT CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VACCINIUM; VACCINIUM ULIGINOSUM; CELL LINE; DRUG EFFECTS; ISOLATION AND PURIFICATION; MACULAR DEGENERATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; RETINAL PIGMENT EPITHELIUM;

CELL DEATH; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MACULAR DEGENERATION; PLANT EXTRACTS; RETINAL PIGMENT EPITHELIUM; VACCINIUM;

EID: 84954287970     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-015-0683-7     Document Type: Article

References (42)

1. Algvere PV, Seregard S (2002) Age-related maculopathy: pathogenetic features and new treatment modalities. Acta Ophthalmol Scand 80:136-143
2. Algvere PV, Marshall J, Seregard S (2006) Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand 84:4-15
3. Avalle LB, Wang Z, Dillon JP, Gaillard ER (2004) Observation of A2E oxidation products in human retinal lipofuscin. Exp Eye Res 78:895-898
4. Ben-Shabat S, Itagaki Y, Jockusch S, Sparrow JR, Turro NJ, Nakanishi K (2002) Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed Engl 41:814-817
5. Bhosale P, Serban B, Bernstein PS (2009) Retinal carotenoids can attenuate formation of A2E in the retinal pigment epithelium. Arch Biochem Biophys 483:175-181
6. Bian Q, Gao S, Zhou J, Qin J, Taylor A, Johnson EJ, Tang G, Sparrow JR, Gierhart D, Shang F (2012) Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic Biol Med 53:1298-1307
7. Chu W, Cheung SCM, Lau RAW, Benzie IFF (2011) Herbal medicine. In: Benzie IFF, Wachtel-Galor S (eds) Biomolecular and clinical aspects, 2nd edn
8. Congdon N, O'Colmain B, Klaver CC, Klein R, Munoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P (2004) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122:477-485
9. Dillon J, Wang Z, Avalle LB, Gaillard ER (2004) The photochemical oxidation of A2E results in the formation of a 5,8,5′,8′-bis-furanoid oxide. Exp Eye Res 79:537-542
10. Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ (1989) Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 30:1691-1699
11. Gaillard ER, Avalle LB, Keller LM, Wang Z, Reszka KJ, Dillon JP (2004) A mechanistic study of the photooxidation of A2E, a component of human retinal lipofuscin. Exp Eye Res 79:313-319
12. Gorgels TG, van Norren D (1995) Ultraviolet and green light cause different types of damage in rat retina. Invest Ophthalmol Vis Sci 36:851-863
13. Grimm C, Wenzel A, Williams T, Rol P, Hafezi F, Reme C (2001) Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching. Invest Ophthalmol Vis Sci 42:497-505
14. Ham WT Jr, Mueller HA, Sliney DH (1976) Retinal sensitivity to damage from short wavelength light. Nature 260:153-155
15. Jang YP, Zhou J, Nakanishi K, Sparrow JR (2005) Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol 81:529-536
16. Jang YJ, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Hong S, Chang M, Kim DK (2015) Paraquat induces apoptosis through a mitochondria-dependent pathway in RAW264. 7 Cells. Biomol Ther 23:407
17. Kim YH, Bang CY, Won EK, Kim JP, Choung YS (2009) Antioxidant activities of Vaccinium uliginosum L. extract and its active components. J Med Food 12:885-892
18. Klein R, Klein BE, Linton KL (1992) Prevalence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 99:933-943
19. Liang FQ, Godley BF (2003) Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res 76:397-403
20. Liu J, Zhang W, Jing H, Popovich DG (2010) Bog bilberry (Vaccinium uliginosum L.) extract reduces cultured Hep-G2, Caco-2, and 3T3-L1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability. J Food Sci 75:H103-H107
21. Mitchell P, Smith W, Attebo K, Wang JJ (1995) Prevalence of age-related maculopathy in Australia: the Blue Mountains Eye Study. Ophthalmology 102:1450-1460
22. Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow J (1998) Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA 95:14609-14613
23. Petrukhin K (2007) New therapeutic targets in atrophic age-related macular degeneration. Expert Opin Ther Targets 11:625-639
24. Rozanowska M, Sarna T (2005) Light-induced damage to the retina: role of rhodopsin chromophore revisited. Photochem Photobiol 81:1305-1330
25. Shi L, Chen J, Yang J, Pan T, Zhang S, Wang Z (2010) MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res 1352:255-264
26. Sparrow JR, Cai B (2001) Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2. Invest Ophthalmol Vis Sci 42:1356-1362
27. Sparrow JR, Nakanishi K, Parish CA (2000) The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 41:1981-1989
28. Sparrow JR, Fishkin N, Zhou J, Cai B, Jang YP, Krane S, Itagaki Y, Nakanishi K (2003a) A2E, a byproduct of the visual cycle. Vis Res 43:2983-2990
29. Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang YP, Jockusch S, Itagaki Y, Nakanishi K (2003b) A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem 278:18207-18213
30. Sparrow JR, Wu Y, Kim CY, Zhou J (2010) Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J Lipid Res 51:247-261
31. Steinmetz RL, Haimovici R, Jubb C, Fitzke FW, Bird AC (1993) Symptomatic abnormalities of dark adaptation in patients with age-related Bruch's membrane change. Br J Ophthalmol 77:549-554
32. Sunness JS, Rubin GS, Applegate CA, Bressler NM, Marsh MJ, Hawkins BS, Haselwood D (1997) Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology 104:1677-1691
33. Suter M, Reme C, Grimm C, Wenzel A, Jaattela M, Esser P, Kociok N, Leist M, Richter C (2000) Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem 275:39625-39630
34. van Norren D, Schellekens P (1990) Blue light hazard in rat. Vis Res 30:1517-1520
35. Vingerling JR, Dielemans I, Hofman A, Grobbee DE, Hijmering M, Kramer CF, de Jong PT (1995a) The prevalence of age-related maculopathy in the Rotterdam study. Ophthalmology 102:205-210
36. Vingerling JR, Klaver CC, Hofman A, de Jong PT (1995b) Epidemiology of age-related maculopathy. Epidemiol Rev 17:347-360
37. Wenzel A, Grimm C, Samardzija M, Reme CE (2005) Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res 24:275-306
38. Westlund BS, Cai B, Zhou J, Sparrow JR (2009) Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light. Apoptosis 14:31-41
39. Winkler BS, Boulton ME, Gottsch JD, Sternberg P (1999) Oxidative damage and age-related macular degeneration. Mol Vis 5:32
40. Kim MJ, Choung SY (2012) Mixture of polyphenols and anthocyanins from Vaccinium uliginosum L. alleviates DNCB-induced atopic dermatitis in NC/Nga mice. Evidence-Based Complement Altern Med 2012:7
41. Zarbin MA (2012) Pathogenesis of age-related macular degeneration. Karger, Basel
42. Zhou J, Gao X, Cai B, Sparrow JR (2006) Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment. Rejuvenation Res 9:256-263