Evodiamine from Evodia rutaecarpa induces apoptosis via activation of JNK and PERK in human ovarian cancer cells

Phytomedicine

Volumn 23, Issue 1, 2016, Pages 68-78

  Chen, Tze Chien ^a,b   Chien, Chih Chiang ^c,d   Wu, Ming Shun ^e   Chen, Yen Chou ^a,f  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

^d CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Evodiamine; Human ovarian cancer; JNK; PERK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKYL GROUP; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE INHIBITOR; CISPLATIN; EVODIAMINE; GSK 2606414; INITIATION FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG; 7-METHYL-5-(1-((3-(TRIFLUOROMETHYL)PHENYL)ACETYL)-2,3-DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO(2,3-D)PYRIMIDIN-4-AMINE; ADENINE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; CASP3 PROTEIN, HUMAN; EIF2AK3 PROTEIN, HUMAN; INDOLE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL ISOLATION; CELL VIABILITY; CLINICAL ASSESSMENT; CONCENTRATION RESPONSE; DNA FRAGMENTATION ASSAY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; FEMALE; GIEMSA STAIN; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; OVARIAN CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TETRADIUM RUTICARPUM; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; EVODIA; METABOLISM; OVARY TUMOR; PATHOLOGY; TUMOR CELL LINE;

ADENINE; ANTHRACENES; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; EIF-2 KINASE; EVODIA; FEMALE; HUMANS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; OVARIAN NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; QUINAZOLINES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84954245328     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.12.003     Document Type: Article

References (30)

1. Alvarez A.A., Krigman H.R., Whitaker R.S., Dodge R.K., Rodriguez G.C. The prognostic significance of angiogenesis in epithelial ovarian carcinoma Clin. Cancer Res. 5 1999 587 591
2. Chien C.C., Wu M.S., Shen S.C., Ko C.H., Chen C.H., Yang L.L., Chen Y.C. Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine PLoS One 9 2014 e99729
3. Fang C., Zhang J., Qi D., Fan X., Luo J., Liu L., Tan Q. Evodiamine induces G2/M arrest and apoptosis via mitochondrial and endoplasmic reticulum pathways in H446 and H1688 human small-cell lung cancer cells PLoS One 9 2014 e115204
4. Fels D.R., Koumenis C. The PERK/elF2 alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth Cancer Biol. Ther. 5 2006 723 728
5. Fulda S., Gorman A.M., Hori O., Samali A. Cellular stress responses: cell survival and cell death Int. J. Cell Biol. 2010 2010 214074
6. Gao L.L., Li F.R., Jiao P., Yao S.T., Sang H., Si Y.H. Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway Asian Pac. J. Cancer Prev. 12 2011 1361 1366
7. Herceg Z., Wang Z.Q. Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis Mol. Cell Biol. 19 1999 5124 5133
8. Johnstone R.W., Ruefli A.A., Lowe S.W. Apoptosis: a link between cancer genetics and chemotherapy Cell 108 2002 153 164
9. Kan S.F., Yu C.H., Pu H.F., Hsu J.M., Chen M.J., Wang P.S. Anti-proliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3 J. Cell Biochem. 101 2007 44 56
10. Kelland L.R. Emerging drugs for ovarian cancer Expert Opin. Emerg. Drugs 10 2005 413 424
11. Kimura H., Okubo N., Chosa N., Kyakumoto S., Kamo M., Miura H., Ishisaki A. EGF positively regulates the proliferation and migration, and negatively regulates the myofibroblast differentiation of periodontal ligament-derived endothelial progenitor cells through MEK/ERK- and JNK-dependent signals Cell Physiol. Biochem. 32 2013 899 914
12. Kobayashi Y. The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice Planta. Med. 69 2003 425 428
13. Lee E.S., Yoon C.H., Kim Y.S., Bae Y.S. The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis FEBS Lett. 581 2007 4325 4332
14. Lee T.J., Kim E.J., Kim S., Jung E.M., Park J.W., Jeong S.H., Park S.E., Yoo Y.H., Kwon T.K. Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells Mol. Cancer Ther. 5 2006 2398 2407
15. Logue S.E., Martin S.J. Caspase activation cascades in apoptosis Biochem. Soc. Trans. 36 2008 1 9
16. Marciniak S.J., Yun C.Y., Oyadomari S., Novoa I., Zhang Y., Jungreis R., Nagata K., Harding H.P., Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum Genes Dev. 18 2004 3066 3077
17. Marsh S. Pharmacogenomics of taxane/platinum therapy in ovarian cancer Int. J. Gynecol. Cancer 19 Suppl 2 2009 S30 S34
18. McKeage M.J. New-generation platinum drugs in the treatment of cisplatin-resistant cancers Expert Opin. Investig. Drugs 14 2005 1033 1046
19. Ogasawara M., Matsunaga T., Takahashi S., Saiki I., Suzuki H. Anti-invasive and metastatic activities of evodiamine Biol. Pharm. Bull. 25 2002 1491 1493
20. Ogasawara M., Suzuki H. Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells Biol. Pharm. Bull. 27 2004 578 582
21. Parmar V.M., Schroder M. Sensing endoplasmic reticulum stress Adv. Exp. Med. Biol. 738 2012 153 168
22. Raja F.A., Chopra N., Ledermann J.A. Optimal first-line treatment in ovarian cancer Ann. Oncol. 23 Suppl 10 2012 x118 x127
23. Rauh-Hain J.A., Krivak T.C., Del Carmen M.G., Olawaiye A.B. Ovarian cancer screening and early detection in the general population Rev. Obstet. Gynecol. 4 2011 15 21
24. Schonthal A.H. Endoplasmic reticulum stress: its role in disease and novel prospects for therapy Scientifica (Cairo) 2012 2012 857516
25. Schonthal A.H. Pharmacological targeting of endoplasmic reticulum stress signaling in cancer Biochem. Pharmacol. 85 2013 653 666
26. Wang S., Kaufman R.J. The impact of the unfolded protein response on human disease J. Cell Biol. 197 2012 857 867
27. Wang S., Wang L., Shi Z., Zhong Z., Chen M., Wang Y. Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein PLoS One 9 2014 e97512
28. Wilson D.J., Fortner K.A., Lynch D.H., Mattingly R.R., Macara I.G., Posada J.A., Budd R.C. JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells Eur. J. Immunol. 26 1996 989 994
29. Xu Y., Wang C., Li Z. A new strategy of promoting cisplatin chemotherapeutic efficiency by targeting endoplasmic reticulum stress Mol. Clin. Oncol. 2 2014 3 7
30. Zhang K., Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response Nature 454 2008 455 462