Activation of JNK contributes to evodiamine-induced apoptosis and G 2/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Chien, Chih Chiang ^a,b   Wu, Ming Shun ^c   Shen, Shing Chuan ^d   Ko, Ching Huai ^e   Chen, Chih Hung ^e   Yang, Ling Ling ^f   Chen, Yen Chou ^d,g  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^f FO GUANG UNIVERSITY   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 9; CYCLIN B1; CYTOCHROME C; EVODIAMINE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE;

ALKYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL VIABILITY; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME SYNTHESIS; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; 3T3 CELL LINE; ANIMAL; CELL PROLIFERATION; COLORECTAL TUMOR; DRUG EFFECTS; HT 29 CELL LINE; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; HT29 CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MAP KINASE SIGNALING SYSTEM; MICE; NIH 3T3 CELLS; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903541364     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099729     Document Type: Article

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