The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity

Nature Communications

Volumn 6, Issue , 2015, Pages

  Li, Quan ^a   Yokoshi, Moe ^a   Okada, Hitomi ^a   Kawahara, Yukio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CASPASE 3; CASPASE 4; CASPASE 7; TAR DNA BINDING PROTEIN; TAR DNA BINDING PROTEIN 25 KDA C TERMINAL FRAGMENT; UNCLASSIFIED DRUG; CASP4 PROTEIN, HUMAN; DNA BINDING PROTEIN; INITIATOR CASPASE; MUTANT PROTEIN; PEPTIDE; PROTEIN AGGREGATE; PROTEIN TDP-43;

APOPTOSIS; CELLS AND CELL COMPONENTS; CHEMICAL ALTERATION; CHEMICAL BINDING; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; NERVOUS SYSTEM DISORDER; PROTEIN; TOXICITY;

ARTICLE; CELL DEATH; CELL VIABILITY; CLEARANCE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; AMINO ACID SEQUENCE; CHEMISTRY; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN DEGRADATION; SOLUBILITY; TUMOR CELL LINE;

ANIMALIA;

AMINO ACID SEQUENCE; ASPARTIC ACID; CASPASES, INITIATOR; CELL DEATH; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; HUMANS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PEPTIDES; PHOSPHORYLATION; PROTEIN AGGREGATES; PROTEOLYSIS; SOLUBILITY;

EID: 84954173305     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7183     Document Type: Article

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