Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Chen, Yu Ming ^a   Liu, Yan ^a   Zhou, Rui Fen ^a   Chen, Xiao Ling ^a   Wang, Cheng ^a   Tan, Xu Ying ^a   Wang, Li Jun ^b   Zheng, Rui Dan ^c   Zhang, Hong Wei ^a   Ling, Wen Hua ^a   Zhu, Hui Lian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^c XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; BIOLOGICAL MARKER; CHOLINE; METHYLAMINE; TRIMETHYLOXAMINE;

ADOLESCENT; ADULT; AGED; BIOSYNTHESIS; BLOOD; CASE CONTROL STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; ECHOGRAPHY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE FLORA; MALE; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; PATHOLOGY; SEVERITY OF ILLNESS INDEX; TANDEM MASS SPECTROMETRY;

ADOLESCENT; ADULT; AGED; BETAINE; BIOMARKERS; CASE-CONTROL STUDIES; CHOLINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-SECTIONAL STUDIES; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; METHYLAMINES; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; SEVERITY OF ILLNESS INDEX; TANDEM MASS SPECTROMETRY; ULTRASONOGRAPHY;

EID: 84954144253     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep19076     Document Type: Article

References (42)

1. Farrell G. C., Wong V. W., & Chitturi S. NAFLD in Asia-as common and important as in the West. Nat Rev Gastroenterol Hepatol 10, 307-18 (2013
2. Chen C. H., et al. Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults. J Clin Gastroenterol 40, 745-52 (2006
3. Fan J. G. Epidemiology of alcoholic and nonalcoholic fatty liver disease in China. J Gastroenterol Hepatol 28, Suppl 1 11-7 (2013
4. Fan J. G., & Cao H. X. Role of diet and nutritional management in non-alcoholic fatty liver disease. J Gastroenterol Hepatol 28, Suppl 4 81-7 (2013
5. Wallace J. M., et al. Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. Br J Nutr 108, 1264-71 (2012
6. Wang L. J., et al. Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. J Nutr Biochem 25, 329-36 (2014
7. Raubenheimer P. J., Nyirenda M. J., & Walker B. R. A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. Diabetes 55, 2015-20 (2006
8. Corbin K. D., & Zeisel S. H. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol 28, 159-65 (2012
9. Guerrerio A. L., et al. Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. Am J Clin Nutr 95, 892-900 (2012
10. Imajo K., et al. Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis: A multi-center validation study. Hepatol Res 42, 757-66 (2012
11. Konstantinova S. V., et al. Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr 138, 914-20 (2008
12. Danne O., Lueders C., Storm C., Frei U., & Mockel M. Whole blood choline and plasma choline in acute coronary syndromes: prognostic and pathophysiological implications. Clin Chim Acta 383, 103-9 (2007
13. Wang Z., et al. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-Noxide. Eur Heart J 35, 904-10 (2014
14. Wang Z., et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472, 57-63 (2011
15. Bennett B. J., et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab 17, 49-60 (2013
16. Koeth R. A., et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 19, 576-85 (2013
17. Gao X., et al. Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng 118, 476-81 (2014
18. Tang W. H., et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 368, 1575-84 (2013
19. Chalasani N., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 55, 2005-23 (2012
20. Chen Y. M., et al. Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults. Int J Obes (Lond) 39, 465-71 (2015
21. Kleiner D. E., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313-21 (2005
22. Sanyal A. J., et al. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology 54, 344-53 (2011
23. Graif M., et al. Quantitative estimation of attenuation in ultrasound video images: correlation with histology in diffuse liver disease. Invest Radiol 35, 319-24 (2000
24. Zeng M. D., et al. Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases. J Dig Dis 9, 108-12 (2008
25. Huang B. X., et al. Neck Circumference, along with Other Anthropometric Indices, Has an Independent and Additional Contribution in Predicting Fatty Liver Disease. PLoS One 10, e0118071 (2015
26. Tang W. H., et al. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J Am Coll Cardiol 64, 1908-14 (2014
27. Troseid M., et al. Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. J Intern Med 277, 717-26 (2015
28. Lever M., et al. Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. PLoS One 9, e114969 (2014
29. Tang W. H., et al. Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease. Circ Res 116, 448-55 (2015
30. Dumas M. E., et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 103, 12511-6 (2006
31. Buchman A. L., et al. Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology 22, 1399-403 (1995
32. Ueland P. M. Choline and betaine in health and disease. J Inherit Metab Dis 34, 3-15 (2011
33. Yu D., et al. Higher dietary choline intake is associated with lower risk of nonalcoholic fatty liver in normal-weight Chinese women. J Nutr 144, 2034-40 (2014
34. Dilger R. N., Garrow T. A., & Baker D. H. Betaine can partially spare choline in chicks but only when added to diets containing a minimal level of choline. J Nutr 137, 2224-8 (2007
35. Noga A. A., & Vance D. E. A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. J Biol Chem 278, 21851-9 (2003
36. Kharbanda K. K., et al. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J Hepatol 46, 314-21 (2007
37. Deminice R., et al. Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism. AminoAcids 47, 839-46 (2015
38. Kawakami S., et al. Effects of dietary supplementation with betaine on a nonalcoholic steatohepatitis (NASH) mouse model. J Nutr Sci Vitaminol (Tokyo) 58, 371-5 (2012
39. Miglio F., Rovati L. C., Santoro A., & Setnikar I. Efficacy and safety of oral betaine glucuronate in non-alcoholic steatohepatitis. A double-blind, randomized, parallel-group, placebo-controlled prospective clinical study. Arzneimittelforschung 50, 722-7 (2000
40. Abdelmalek M. F., et al. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepatology 50, 1818-26 (2009
41. Bril F., et al. Clinical value of liver ultrasound for the diagnosis of nonalcoholic fatty liver disease in overweight and obese patients. Liver Int 35, 2139-46 (2015
42. Hernaez R., et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 54, 1082-90 (2011