SiRNA-Loaded Polyion Complex Micelle Decorated with Charge-Conversional Polymer Tuned to Undergo Stepwise Response to Intra-Tumoral and Intra-Endosomal pHs for Exerting Enhanced RNAi Efficacy

Biomacromolecules

Volumn 17, Issue 1, 2016, Pages 246-255

  Tangsangasaksri, Montira ^a   Takemoto, Hiroyasu ^b   Naito, Mitsuru ^c   Maeda, Yoshinori ^c   Sueyoshi, Daiki ^a   Kim, Hyun Jin ^c   Miura, Yutaka ^c   Ahn, Jooyeon ^a   Azuma, Ryota ^a   Nishiyama, Nobuhiro ^b,d   Miyata, Kanjiro ^c,d   Kataoka, Kazunori ^a,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; CELLS; CROSSLINKING; CYTOLOGY; DISEASES; MICELLES; POLYETHYLENE GLYCOLS; POLYMERS; RNA; TUMORS;

ACIDIC ENVIRONMENT; COPPER-FREE CLICKS; ENDOSOMAL COMPARTMENTS; ENDOSOMAL ESCAPES; LUNG CANCER CELLS; POLYION COMPLEX MICELLES; SELECTIVE BINDING; SMALL INTERFERING RNA (SIRNA);

GENE THERAPY;

ASPARTIC ACID DERIVATIVE; ETHYLENE DERIVATIVE; MACROGOL; MALEIC ACID DERIVATIVE; NANOCARRIER; NANOCONJUGATE; POLO LIKE KINASE 1; POLYMER; POLYPEPTIDE; SMALL INTERFERING RNA; MICELLE; PEPTIDE;

A549 CELL LINE; ACIDITY; ALKALINITY; AMINOLYSIS; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CELL CYCLE REGULATION; CELL DISRUPTION; CELL SURFACE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DEGRADATION; DISPERSION; DRUG BINDING; DRUG EFFICACY; DRUG RELEASE; DRUG UPTAKE; ENDOCYTOSIS; ENDOSOME; ENZYMATIC DEGRADATION; GENE DELIVERY SYSTEM; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; INCUBATION TIME; INTERNALIZATION; MICELLE; MICELLIZATION; MOLECULAR STABILITY; MOLECULAR WEIGHT; PARTICLE SIZE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTON TRANSPORT; RNAI THERAPEUTICS; SURFACE PROPERTY; TUMOR MICROENVIRONMENT; ZETA POTENTIAL; CHEMISTRY; CLICK CHEMISTRY; GENE THERAPY; GENETICS; LUNG NEOPLASMS; METABOLISM; PH; PHYSIOLOGY; PROCEDURES; RNA INTERFERENCE; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CLICK CHEMISTRY; ENDOCYTOSIS; GENETIC THERAPY; HUMANS; HYDROGEN-ION CONCENTRATION; LUNG NEOPLASMS; MICELLES; PEPTIDES; POLYMERS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84954116009     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/acs.biomac.5b01334     Document Type: Article

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