Inhibition of acid sphingomyelinase depletes cellular phosphatidylserine and mislocalizes K-Ras from the plasma membrane

Molecular and Cellular Biology

Volumn 36, Issue 2, 2016, Pages 363-374

  Cho, Kwang jin ^a   van der Hoeven, Dharini ^b   Zhou, Yong ^a   Maekawa, Masashi ^c,d,e   Ma, Xiaoping ^a   Chen, Wei ^a   Fairn, Gregory D ^c,d   Hancock, John F ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CYCLODEXTRIN; CHOLESTEROL; FENDILINE; GUANOSINE TRIPHOSPHATE; K RAS PROTEIN; K RAS4A PROTEIN; K RAS4B PROTEIN; LIPID; PHOSPHATIDYLSERINE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; RAS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CANCER CELL; CELL MEMBRANE; CELL PROLIFERATION; CHEMICAL COMPOSITION; CLUSTER ANALYSIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; SCREENING TEST; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DOG; DRUG EFFECTS; HAMSTER; HUMAN; METABOLISM;

ANIMALS; CELL LINE; CELL MEMBRANE; CHOLESTEROL; CRICETINAE; DOGS; ENZYME INHIBITORS; FENDILINE; HUMANS; PHOSPHATIDYLSERINES; RAS PROTEINS; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84954096085     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00719-15     Document Type: Article

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