Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines?

Autophagy

Volumn 11, Issue 10, 2015, Pages 1949-1952

  Lebovitz, Chandra B ^a,b   Devorkin, Lindsay ^a   Bosc, Damien ^b   Rothe, Katharina ^c,d   Singh, Jagbir ^a,d   Bally, Marcel ^a,d,e   Jiang, Xiaoyan ^c,d   Young, Robert N ^b,e   Lum, Julian J ^a   Gorski, Sharon M ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b SIMON FRASER UNIVERSITY   (Canada)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e Centre for Drug Research and Development   (Canada)

Author keywords

Autophagy; Biomarker; Cancer; Hydroxychloroquine; LC3; Neurodegeneration; Pancreatic cancer; Selective autophagy; SQSTM1; TRIM

Indexed keywords

4 AMINO N [1 (4 CHLOROPHENYL) 3 HYDROXYPROPYL] 1 (7H PYRROLO[2,3 D]PYRIMIDIN 4 YL) 4 PIPERIDINECARBOXAMIDE; ANTINEOPLASTIC AGENT; AUTOPHAGY INHIBITOR; BINDING PROTEIN; BIOLOGICAL MARKER; CARGO RECEPTOR; CHLOROQUINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; HYDROXYCHLOROQUINE; IRON; LAPATINIB; N (3 METHYLPHENYL) 4 (4 PYRIDINYL) 2 THIAZOLAMINE; PACLITAXEL; PEPTIDE; RECEPTOR; SUNITINIB; UBIQUITIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CANCER RESISTANCE; CELL HYPOXIA; DRUG EFFICACY; HUMAN; METABOLIC DISORDER; MOLECULAR RECOGNITION; NEOPLASM; NONHUMAN; PANCREAS CANCER; PHYSICIAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEINOSIS; PROTEOMICS; SELECTIVE AUTOPHAGY; SIGNAL TRANSDUCTION; TRANSLATIONAL RESEARCH; ANIMAL; GENETICS; METABOLISM; NEOPLASMS; PHYSIOLOGY; PROCEDURES;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; BIOMARKERS; CARRIER PROTEINS; HUMANS; NEOPLASMS; PROTEOMICS;

EID: 84953881673     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1078962     Document Type: Article

References (12)

1. Mandell MA, Jain A, Arko-Mensah J, Chauhan S, Kimura T, Dinkins C, Silvestri G, M€unch J, Kirchhoff F, Simonsen A, et al. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev Cell 2014; 30:394-409.
2. Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC. Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations. Cancer Discov 2014; 4:905-913; PMID:24875860; http://dx.doi.org/10.1158/2159-8290.CD-14-0362
3. Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 2014; 509:105-9; PMID:24695223; http://dx.doi.org/10.1038/nature13148
4. Zhang F, Kumano M, Beraldi E, Fazli L, Du C, Moore S, Sorensen P, Zoubeidi A, Gleave ME. Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival. Nat. Commun 2014; 5:5775; PMID:25503391; http://dx.doi.org/10.1038/ncomms6775
5. Shi J, Fung G, Piesik P, Zhang J, Luo H. Dominantnegative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection. Cell Death Differ 2014; 21:1432-41; PMID:24769734; http://dx.doi.org/10.1038/cdd.2014.58
6. Wong BKY, Ehrnhoefer DE, Graham RK, Martin DDO, Ladha S, Uribe V, Stanek LM, Franciosi S, Qiu X, Deng Y, Kovalik V, Zhang W, Pouladi MA, Shihabuddin LS, Hayden MR. Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. Neurobiol Dis 2015; 76:24-36; PMID:25583186; http://dx.doi.org/10.1016/j.nbd.2014.12.030
7. Martin DDO, Heit RJ, Yap MC, Davidson MW, Hayden MR, Berthiaume LG. Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin. Hum Mol Genet 2014; 23:3166-79; PMID:24459296; http://dx.doi.org/10.1093/hmg/ddu027
8. Martin DDO, Ladha S, Ehrnhoefer DE, Hayden MR. Autophagy in Huntington disease and huntingtin in autophagy. Trends Neurosci 2015; 38:26-35; PMID:25282404; http://dx.doi.org/10.1016/j.tins.2014.09.003
9. Liu Y, Palanivel R, Rai E, Park M, Gabor TV, Scheid MP, Xu A, Sweeney G. Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice. Diabetes 2015; 64:36-48; PMID:25071026;http://dx.doi.org/10.2337/db14-0267
10. Vezenkov L, Honson NS, Kumar NS, Bosc D, Kovacic S, Nguyen TG, Pfeifer TA, Young RN. Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B. Bioorg Med Chem 2015; 23:3237-47; PMID:25979376; http://dx.doi.org/10.1016/j.bmc.2015.04.064
11. Nguyen TG, Honson NS, Arns S, Davis TL, Dhe-Paganon S, Kovacic S, Kumar NS, Pfeifer TA, Young RN. Development of Fluorescent Substrates and Assays for the Key Autophagy-Related Cysteine Protease Enzyme, ATG4B. ASSAY Drug Dev Technol 2014; 12:176-89; PMID:24735444; http://dx.doi.org/10.1089/adt.2013.561
12. Amaravadi RK, Winkler JD. Lys05: a new lysosomal autophagy inhibitor. Autophagy 2012; 8:1383-4; PMID:22878685; http://dx.doi.org/10.4161/auto.20958