Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in Mice

Diabetes

Volumn 64, Issue 1, 2015, Pages 36-48

  Liu, Ying ^a   Palanivel, Rengasamy ^a   Rai, Esther ^a   Park, Min ^a   Gabor, Tim V ^a   Scheid, Michael P ^a   Xu, Aimin ^b   Sweeney, Gary ^a  

^a YORK UNIVERSITY   (Canada)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; BECLIN 1; FIBROBLAST GROWTH FACTOR 21; GLUTATHIONE; GLUTATHIONE DISULFIDE; PEROXIREDOXIN; PROTEIN KINASE B; PROTEIN P62; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE DISMUTASE; ADIPOQ PROTEIN, MOUSE; ANTIOXIDANT; ATG5 PROTEIN, MOUSE; CATHEPSIN B; CTSB PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PHOTOPROTEIN; RED FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPID PEROXIDATION; MOUSE; MYOTUBE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; ANIMAL; BLOOD; CELL LINE; CYTOLOGY; GENETICS; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PRIMARY CELL CULTURE;

ADIPONECTIN; ANIMALS; ANTIOXIDANTS; AUTOPHAGY; CATHEPSIN B; CELL LINE; DIET, HIGH-FAT; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; GREEN FLUORESCENT PROTEINS; HYPERINSULINISM; INSULIN RESISTANCE; LUMINESCENT PROTEINS; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; MUSCLE, SKELETAL; OXIDATIVE STRESS; PRIMARY CELL CULTURE; SUPEROXIDE DISMUTASE;

EID: 84920000938     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0267     Document Type: Article

References (34)

1. Liu Y, Retnakaran R, Hanley A, Tungtrongchitr R, Shaw C, Sweeney G. Total and high molecular weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects. J Clin Endocrinol Metab 2007;92:4313-4318
2. Turer AT, Scherer PE. Adiponectin: mechanistic insights and clinical implications. Diabetologia 2012;55:2319-2326
3. Newsholme P, Gaudel C, Krause M. Mitochondria and diabetes. An intriguing pathogenetic role. Adv Exp Med Biol 2012;942:235-247
4. Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012;148:852-871
5. Combs TP, Pajvani UB, Berg AH, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004;145:367-383
6. Ge Q, Ryken L, Noel L, Maury E, Brichard SM. Adipokines identified as new downstream targets for adiponectin: lessons from adiponectin-overexpressing or -deficient mice. Am J Physiol Endocrinol Metab 2011;301:E326-E335
7. Gurusamy N, Das DK. Is autophagy a double-edged sword for the heart? Acta Physiol Hung 2009;96:267-276
8. Kubisch J, Türei D, Földvári-Nagy L, et al. Complex regulation of autophagy in cancer-integrated approaches to discover the networks that hold a doubleedged sword. Semin Cancer Biol 2013;23:252-261
9. Kim KH, Jeong YT, Oh H, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 2013;19:83-92
10. He C, Bassik MC, Moresi V, et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 2012;481:511-515
11. Mofarrahi M, Guo Y, Haspel JA, et al. Autophagic flux and oxidative capacity of skeletal muscles during acute starvation. Autophagy 2013;9:1604-1620
12. Lira VA, Okutsu M, Zhang M, et al. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. FASEB J 2013;27:4184-4193
13. Cui M, Yu H, Wang J, Gao J, Li J. Chronic caloric restriction and exercise improve metabolic conditions of dietary-induced obese mice in autophagy correlated manner without involving AMPK. Diabetes Res 2013;2013:852754
14. Jamart C, Naslain D, Gilson H, Francaux M. Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state. Am J Physiol Endocrinol Metab 2013;305:E964-E974
15. Kim YA, Kim YS, Oh SL, Kim HJ, Song W. Autophagic response to exercise training in skeletal muscle with age. J Physiol Biochem 2013;69:697-705
16. Wang Y, Li YB, Yin JJ, et al. Autophagy regulates inflammation following oxidative injury in diabetes. Autophagy 2013;9:272-277
17. Liu Y, Turdi S, Park T, et al. Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes 2013;62:743-752
18. Ceddia RB, Somwar R, Maida A, Fang X, Bikopoulos G, Sweeney G. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia 2005;48: 132-139
19. Liu Y, Sweeney G. Adiponectin action in skeletal muscle. Best Pract Res Clin Endocrinol Metab 2014;28:33-41
20. Matsuda M, Shimomura I. Roles of adiponectin and oxidative stress in obesity-Associated metabolic and cardiovascular diseases. Rev Endocr Metab Disord 2014;15:1-10
21. Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metabolism 2006;55:928-934
22. Förstermann U. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch 2010;459:923-939
23. Carnevale R, Pignatelli P, Di Santo S, et al. Atorvastatin inhibits oxidative stress via adiponectin-mediated NADPH oxidase down-regulation in hypercholesterolemic patients. Atherosclerosis 2010;213:225-234
24. Yuzefovych LV, LeDoux SP, Wilson GL, Rachek LI. Mitochondrial DNA damage via augmented oxidative stress regulates endoplasmic reticulum stress and autophagy: crosstalk, links and signaling. PLoS ONE 2013;8:e83349
25. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012;8:445-544
26. Lin Z, Wu F, Lin S, et al. Adiponectin protects against acetaminopheninduced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. J Hepatol 2014 May 29 [Epub ahead of print]
27. Qi GM, Jia LX, Li YL, Li HH, Du J. Adiponectin suppresses angiotensin IIinduced inflammation and cardiac fibrosis through activation of macrophage autophagy. Endocrinology 2014;155:2254-2265
28. Wu JJ, Quijano C, Chen E, et al. Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany, NY Online) 2009;1:425-437
29. Wen H, Gris D, Lei Y, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 2011;12:408-415
30. Castets P, Rüegg MA. MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy 2013;9:1435-1437
31. Castets P, Lin S, Rion N, et al. Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy. Cell Metab 2013;17:731-744
32. Nepal S, Park PH. Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis. Biochim Biophys Acta 2013;1833:2111-2125
33. Lin Z, Tian H, Lam KS, et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab 2013; 17:779-789
34. Holland WL, Adams AC, Brozinick JT, et al. An FGF21-Adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab 2013;17: 790-797