Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments

Neurobiology of Aging

Volumn 32, Issue 11, 2011, Pages 2016-2029

  Veeranna, ^a,b   Yang, Dun Sheng ^a,b   Lee, Ju Hyun ^a,b   Vinod, K Yaragudri ^a   Stavrides, Philip ^a   Amin, Niranjana D ^c   Pant, Harish C ^c   Nixon, Ralph A ^a,b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Aging; Dephosphorylation; Immunoreactivity; Kinases; Maturation; Neurofilament; Phosphatases; Phosphorylation; RT 97 epitope

Indexed keywords

CALCINEURIN; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR 1; JANUS KINASE 1; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCLONAL ANTIBODY; NEUROFILAMENT PROTEIN; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE; RT 97 MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN MATURATION; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOREACTIVITY; IN VITRO STUDY; MOUSE; NERVE FIBER GROWTH; NEUROFILAMENT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

AGING; ANIMALS; AXONS; BRAIN; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; CYTOSKELETON; MICE; NEURONS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; SPINAL CORD;

EID: 80052640576     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2009.12.001     Document Type: Article

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