Retinoic acid-related orphan receptor C isoform 2 expression and its prognostic significance for non-small cell lung cancer

Journal of Cancer Research and Clinical Oncology

Volumn 142, Issue 1, 2016, Pages 263-272

  Huang, Qi ^a   Fan, Jinshuo ^a   Qian, Xin ^a,b   Lv, Zhilei ^a   Zhang, Xiuxiu ^a   Han, Jieli ^a   Wu, Feng ^a   Chen, Caiyun ^a,c   Du, Jiao ^a,d   Guo, Mengfei ^a   Hu, Guorong ^a   Jin, Yang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

^c First Hosp of Xi'an Jiaotong Univ   (China)

^d XIAMEN UNIVERSITY   (China)

Author keywords

Cell proliferation; Non small cell lung cancer; Prognosis; RORC2

Indexed keywords

ISOPROTEIN; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORC PROTEIN, HUMAN; TUMOR MARKER;

ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; APOPTOSIS; CANCER STAGING; CELL PROLIFERATION; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; FOLLOW UP; GENETICS; HUMAN; LARGE CELL CARCINOMA; LUNG; LUNG TUMOR; LYMPH NODE METASTASIS; MALE; METABOLISM; MIDDLE AGED; MORTALITY; NON SMALL CELL LUNG CANCER; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECONDARY; SURVIVAL RATE; TUMOR CELL CULTURE; WESTERN BLOTTING;

ADENOCARCINOMA; APOPTOSIS; BIOMARKERS, TUMOR; BLOTTING, WESTERN; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROGNOSIS; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TUMOR CELLS, CULTURED;

EID: 84953635484     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-015-2040-0     Document Type: Article

References (45)

1. β is specifically expressed in pineal gland and retina. Gene 216:277–283
2. Balabko L et al (2014) Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung. Sci Rep 4:7396. doi:10.1038/srep07396
3. Burgler S et al (2009) Differentiation and functional analysis of human T(H)17 cells. J Allergy Clin Immunol 123:588–595. doi:10.1016/j.jaci.2008.12.017
4. Burgler S, Mantel PY, Bassin C, Ouaked N, Akdis CA, Schmidt-Weber CB (2010) RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter. J Immunol 184:6161–6169. doi:10.4049/jimmunol.0903243
5. Cheang MC et al (2009) Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 101:736–750. doi:10.1093/jnci/djp082
6. Chen X et al (2010) Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients. Lung Cancer 69:348–354. doi:10.1016/j.lungcan.2009.11.013
7. Chu S, Zhong X, Zhang J, Lao Q, He Z, Bai J (2011) The expression of Foxp3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients. Int Immunopharmacol 11:1780–1788. doi:10.1016/j.intimp.2011.06.010
8. Cirée A et al (2004) Expression and activity of IL-17 in cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome). Int J Cancer 112:113–120
9. Cording S, Medvedovic J, Cherrier M, Eberl G (2014) Development and regulation of RORgammat innate lymphoid cells. FEBS Lett. doi:10.1016/j.febslet.2014.03.034
10. He YW (2000) The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development. Immunol Res 22:71–82. doi:10.1385/ir:22:2-3:71
11. He YW, Deftos ML, Ojala EW, Bevan MJ (1998) RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9:797–806
12. He G et al (2013) [Th17 cells and IL-17 are increased in patients with brain metastases from the primary lung cancer]. Chin J Lung Cancer 16:476–481. doi:10.3779/j.issn.1009-3419.2013.09.07
13. Hirota K, Martin B, Veldhoen M (2010) Development, regulation and functional capacities of Th17 cells. Semin Immunopathol 32:3–16. doi:10.1007/s00281-009-0187-y
14. Jetten AM, Kang HS, Takeda Y (2013) Retinoic acid-related orphan receptors alpha and gamma: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity. Front Endocrinol 4:1. doi:10.3389/fendo.2013.00001
15. Kato T et al (2001) Expression of IL-17 mRNA in ovarian cancer. Biochem Biophys Res Commun 282:735–738
16. Katsetos CD et al (1998) Cellular distribution of retinoic acid receptor-alpha protein in serous adenocarcinomas of ovarian, tubal, and peritoneal origin: comparison with estrogen receptor status. Am J Pathol 153:469–480
17. Kim WG, Zhu X, Kim DW, Zhang L, Kebebew E, Cheng SY (2013) Reactivation of the silenced thyroid hormone receptor beta gene expression delays thyroid tumor progression. Endocrinology 154:25–35. doi:10.1210/en.2012-1728
18. Kirshberg S et al (2011) Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression. PLoS One 6:e24856. doi:10.1371/journal.pone.0024856
19. Klose CS, Hoyler T, Kiss EA, Tanriver Y, Diefenbach A (2012) Transcriptional control of innate lymphocyte fate decisions. Curr Opin Immunol 24:290–296. doi:10.1016/j.coi.2012.04.004
20. Kobold S et al (2013) Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells. J Thorac Oncol 8:1032–1042. doi:10.1097/JTO.0b013e31829923c8
21. Kumar N et al (2012) Identification of SR2211: a potent synthetic RORgamma-selective modulator. ACS Chem Biol 7:672–677. doi:10.1021/cb200496y
22. Kurebayashi S, Ueda E, Sakaue M, Patel DD, Medvedev A, Zhang F, Jetten AM (2000) Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc Natl Acad Sci USA 97:10132–10137
23. Laudet V (1997) Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor. J Mol Endocrinol 19:207–226
24. Li XB et al (2011) The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells. Cancer Lett 309:137–144. doi:10.1016/j.canlet.2011.05.025
25. Li Q, Han Y, Fei G, Guo Z, Ren T, Liu Z (2012) IL-17 promoted metastasis of non-small-cell lung cancer cells. Immunol Lett 148:144–150. doi:10.1016/j.imlet.2012.10.011
26. Lin A et al (2010) Clinical relevance and functional implications for human leucocyte antigen-g expression in non-small-cell lung cancer. J Cell Mol Med 14:2318–2329. doi:10.1111/j.1582-4934.2009.00858.x
27. Moll J et al (1994) Analysis of molecular functions of the tumor metastasis promoting surface molecule CD44v4-v7 using transgenic mice. Princess Takamatsu Symp 24:142–151
28. Mond M, Alexiadis M, Eriksson N, Davis MJ, Muscat GE, Fuller PJ, Gilfillan C (2014) Nuclear receptor expression in human differentiated thyroid tumors. Thyroid 24:1000–1011. doi:10.1089/thy.2013.0509
29. Numasaki M et al (2005) IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol 175:6177–6189
30. Ohoka N, Kato S, Takahashi Y, Hayashi H, Sato R (2009) The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression. Mol Endocrinol 23:759–771. doi:10.1210/me.2008-0277
31. Ortiz MA, Piedrafita FJ, Pfahl M, Maki R (1995) TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals. Mol Endocrinol 9:1679–1691. doi:10.1210/mend.9.12.8614404
32. Pages F et al (1999) Control of tumor development by intratumoral cytokines. Immunol Lett 68:135–139
33. Purwar R et al (2012) Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med 18:1248–1253. doi:10.1038/nm.2856
34. Raichur S, Lau P, Staels B, Muscat GE (2007) Retinoid-related orphan receptor gamma regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production. J Mol Endocrinol 39:29–44. doi:10.1677/jme.1.00010
35. Reppert S, Boross I, Koslowski M, Tureci O, Koch S, Lehr HA, Finotto S (2011) A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer. Nat Commun 2:600. doi:10.1038/ncomms1609
36. Schaeren-Wierners N, André E, Kapfhammer JP, Becker-André M (1997) The ExDression pattern of the orphan nuclear receptor RORβ in the developing and adult rat nervous system suggests a role in the processing of sensory information and in circadian rhythm. Eur J Neurosci 9:2687–2701
37. Siegel R et al (2012) Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 62:220–241. doi:10.3322/caac.21149
38. Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics. CA Cancer J Clin 64:9–29. doi:10.3322/caac.21208
39. Slominski AT et al (2014) RORalpha and ROR gamma are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. FASEB J 28:2775–2789. doi:10.1096/fj.13-242040
40. Steiner GE, Newman ME, Paikl D, Stix U, Memaran-Dagda N, Lee C, Marberger MJ (2003) Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Prostate 56:171–182
41. Tomida S et al (2009) Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. J Clin Oncol 27:2793–2799. doi:10.1200/jco.2008.19.7053
42. Ueda E, Kurebayashi S, Sakaue M, Backlund M, Koller B, Jetten AM (2002) High incidence of T-cell lymphomas in mice deficient in the retinoid-related orphan receptor RORgamma. Cancer Res 62:901–909
43. Unutmaz D (2009) RORC2: the master of human Th17 cell programming. Eur J Immunol 39(6):1452–1455. doi:10.1002/eji.200939540
44. Vacca M, Degirolamo C, Massafra V, Polimeno L, Mariani-Costantini R, Palasciano G, Moschetta A (2013) Nuclear receptors in regenerating liver and hepatocellular carcinoma. Mol Cell Endocrinol 368:108–119. doi:10.1016/j.mce.2012.06.025
45. Yao J, Liu L, Yang M (2014) Interleukin-23 receptor genetic variants contribute to susceptibility of multiple cancers. Gene 533:21–25. doi:10.1016/j.gene.2013.09.054