Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Kirshberg, Sophie ^a   Izhar, Uzi ^a   Amir, Gail ^a   Demma, Jonathan ^a   Vernea, Fiona ^a   Beider, Katia ^a   Shlomai, Zippora ^a   Wald, Hanna ^a   Zamir, Gideon ^a   Shapira, Oz M ^a   Peled, Amnon ^a   Wald, Ori ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR6; INTERLEUKIN 17; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; CCL20 PROTEIN, HUMAN; CCR6 PROTEIN, HUMAN; IL17A PROTEIN, HUMAN;

AGED; ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER GROWTH; CANCER RECURRENCE; CANCER STAGING; CANCER TISSUE; CLINICAL ARTICLE; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE FREE SURVIVAL; DRUG TARGETING; ENZYME PHOSPHORYLATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MALE; PARACRINE SIGNALING; PROGNOSIS; PROTEIN EXPRESSION; RECURRENCE RISK; SIGNAL TRANSDUCTION; TUMOR GROWTH; CELL PROLIFERATION; DISEASE COURSE; DRUG ANTAGONISM; ENZYMOLOGY; LUNG TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINE CCL20; DISEASE PROGRESSION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INTERLEUKIN-17; LUNG NEOPLASMS; MALE; PHOSPHORYLATION; RECEPTORS, CCR6; SIGNAL TRANSDUCTION;

EID: 80052855773     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024856     Document Type: Article

References (37)

1. Janssen-Heijnen ML, Coebergh JW, (2003) The changing epidemiology of lung cancer in Europe. Lung Cancer 41: 245-258.
2. Spiro SG, Silvestri GA, (2005) One hundred years of lung cancer. Am J Respir Crit Care Med 172: 523-529.
3. Radzikowska E, Glaz P, Roszkowski K, (2002) Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol 13: 1087-1093.
4. Zlotnik A, Yoshie O, (2000) Chemokines: a new classification system and their role in immunity. Immunity 12: 121-127.
5. Mantovani A, Allavena P, Sozzani S, Vecchi A, Locati M, et al. (2004) Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors. Semin Cancer Biol 14: 155-160.
6. Mantovani A, (2004) Chemokines in neoplastic progression. Semin Cancer Biol 14: 147-148.
7. Beider K, Abraham M, Begin M, Wald H, Weiss ID, et al. (2009) Interaction between CXCR4 and CCL20 pathways regulates tumor growth. PLoS One 4: e5125.
8. Homey B, Muller A, Zlotnik A, (2002) Chemokines: agents for the immunotherapy of cancer? Nat Rev Immunol 2: 175-184.
9. Rabin RL, Alston MA, Sircus JC, Knollmann-Ritschel B, Moratz C, et al. (2003) CXCR3 is induced early on the pathway of CD4+ T cell differentiation and bridges central and peripheral functions. J Immunol 171: 2812-2824.
10. Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, et al. (2007) Phenotypic and functional features of human Th17 cells. J Exp Med 204: 1849-1861.
11. Chen Z, O'Shea JJ, (2008) Th17 cells: a new fate for differentiating helper T cells. Immunol Res 41: 87-102.
12. Ouyang W, Filvaroff E, Hu Y, Grogan J, (2009) Novel therapeutic targets along the Th17 pathway. Eur J Immunol 39: 670-675.
13. Miyahara Y, Odunsi K, Chen W, Peng G, Matsuzaki J, et al. (2008) Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc Natl Acad Sci U S A 105: 15505-15510.
14. Zhang JP, Yan J, Xu J, Pang XH, Chen MS, et al. (2009) Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol 50: 980-989.
15. Starner TD, Barker CK, Jia HP, Kang Y, McCray PB Jr, (2003) CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol 29: 627-633.
16. Bracke KR, Demedts IK, Joos GF, Brusselle GG, (2007) CC-chemokine receptors in chronic obstructive pulmonary disease. Inflamm Allergy Drug Targets 6: 75-79.
17. Demedts IK, Bracke KR, Van Pottelberge G, Testelmans D, Verleden GM, et al. (2007) Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 175: 998-1005.
18. Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, et al. (2008) IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14: 275-281.
19. Ghadjar P, Rubie C, Aebersold DM, Keilholz U, (2009) The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer. Int J Cancer 125: 741-745.
20. Wald O, Izhar U, Amir G, Avniel S, Bar-Shavit Y, et al. (2006) CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma. J Immunol 177: 6983-6990.
21. Wald O, Izhar U, Amir G, Kirshberg S, Shlomai Z, et al. (2011) Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: role in non-small cell lung cancer tumor proliferation. J Thorac Cardiovasc Surg 141: 1503-1512.
22. Silva LM, Montes de Oca H, Diniz CR, Fortes-Dias CL, (2001) Fingerprinting of cell lines by directed amplification of minisatellite-region DNA (DAMD). Braz J Med Biol Res 34: 1405-1410.
23. Karra L, Shushan A, Ben-Meir A, Rojansky N, Klein BY, et al. (2010) Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology. Fertil Steril 93: 2646-2651.
24. Ghadjar P, Coupland SE, Na IK, Noutsias M, Letsch A, et al. (2006) Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer. J Clin Oncol 24: 1910-1916.
25. Kimsey TF, Campbell AS, Albo D, Wilson M, Wang TN, (2004) Co-localization of macrophage inflammatory protein-3alpha (Mip-3alpha) and its receptor, CCR6, promotes pancreatic cancer cell invasion. Cancer J 10: 374-380.
26. Ghadjar P, Loddenkemper C, Coupland SE, Stroux A, Noutsias M, et al. (2008) Chemokine receptor CCR6 expression level and aggressiveness of prostate cancer. J Cancer Res Clin Oncol 134: 1181-1189.
27. Reibman J, Hsu Y, Chen LC, Bleck B, Gordon T, (2003) Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. Am J Respir Cell Mol Biol 28: 648-654.
28. Shedden K, Taylor JM, Enkemann SA, Tsao MS, Yeatman TJ, et al. (2008) Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat Med 14: 822-827.
29. Brand S, Olszak T, Beigel F, Diebold J, Otte JM, et al. (2006) Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. J Cell Biochem 97: 709-723.
30. Lee W, Jiang Z, Liu J, Haverty PM, Guan Y, et al. (2010) The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature 465: 473-477.
31. Zumsteg A, Christofori G, (2009) Corrupt policemen: inflammatory cells promote tumor angiogenesis. Curr Opin Oncol 21: 60-70.
32. Schutyser E, Struyf S, Van Damme J, (2003) The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev 14: 409-426.
33. Bracke KR, D'Hulst A I, Maes T, Moerloose KB, Demedts IK, et al. (2006) Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J Immunol 177: 4350-4359.
34. Harrison OJ, Foley J, Bolognese BJ, Long E 3rd, Podolin PL, et al. (2008) Airway infiltration of CD4+ CCR6+ Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol Lett 121: 13-21.
35. Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, et al. (2005) IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol 175: 6177-6189.
36. Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM, (2008) Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol 180: 214-221.
37. Perrot I, Blanchard D, Freymond N, Isaac S, Guibert B, et al. (2007) Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage. J Immunol 178: 2763-2769.