Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice

Biochemical and Biophysical Research Communications

Volumn 469, Issue 3, 2016, Pages 477-482

  Fujita, Yu ^a   Makishima, Makoto ^a   Bhawal, Ujjal K ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Aging; DEC1; FGF21; Hepatic homeostasis; Liver

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; DIFFERENTIATED EMBRYO CHONDROCYTE 1 PROTEIN; FIBROBLAST GROWTH FACTOR 21; LIPID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BHLHE40 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 22, MOUSE; HOMEODOMAIN PROTEIN;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIVER FUNCTION; LIVER STRUCTURE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; LIVER; LIVER CELL; METABOLISM; PHYSIOLOGY;

AGING; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEPATOCYTES; HOMEODOMAIN PROTEINS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 84953431720     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.12.045     Document Type: Article

References (30)

1. M. Boudjelal, R. Taneja, S. Matsubara, and et al. Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells Genes Dev. 11 1997 2052 2065
2. M. Shen, T. Kawamoto, W. Yan, and et al. Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes Biochem. Biophys. Res. Commun. 236 1997 294 298
3. Y. Qian, J. Zhang, B. Yan, and et al. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence J. Biol. Chem. 283 2008 2896 2905
4. B. Marcheva, K.M. Ramsey, E.D. Buhr, and et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes Nature 466 2010 627 631
5. F.W. Turek, C. Joshu, A. Kohsaka, and et al. Obesity and metabolic syndrome in circadian Clock mutant mice Science 308 2005 1043 1045
6. E. Maury, H.K. Hong, and J. Bass Circadian disruption in the pathogenesis of metabolic syndrome Diabetes Metab. 40 2014 338 346
7. Y. He, C.R. Jones, N. Fujiki, and et al. The transcriptional repressor DEC2 regulates sleep length in mammals Science 325 2009 866 870
8. H. Sun, and R. Taneja Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms Proc. Natl. Acad. Sci. U. S. A. 97 2000 4058 4063
9. M. Collado, and M. Serrano The power and the promise of oncogene-induced senescence markers Nat. Rev. Cancer 6 2006 472 476
10. T. Laeger, T.M. Henagan, D.C. Albarado, and et al. FGF21 is an endocrine signal of protein restriction J. Clin. Investig. 124 2014 3913 3922
11. S. Jiang, C. Yan, Q.C. Fang, and et al. Fibroblast growth factor 21 is regulated by the IRE1a-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis J. Biol. Chem. 289 2014 29751 29765
12. K.H. Kim, Y.T. Jeong, H. Oh, and et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine Nat. Med. 19 2013 83 92
13. W. Chen, R.L. Hoo, M. Konishi, and et al. Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes J. Biol. Chem. 286 2011 34559 34566
14. M.D. Chau, J. Gao, Q. Yang, and et al. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1a pathway Proc. Natl. Acad. Sci. U. S. A. 107 2010 12553 12558
15. X.S. Wan, X.H. Lu, Y.C. Xiao, and et al. ATF4- and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress Biomed. Res. Int. 2014 2014 807874
16. A.R. Mendelsohn, and J.W. Larrick Fibroblast growth factor-21 is a promising dietary restriction mimetic Rejuvenation Res. 17 2014 306 311
17. P. Dammann, D.R. Sell, S. Begall, and et al. Advanced glycation end products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli) J. Gerontol. A Biol. Sci. Med. Sci. 67 2012 573 583
18. P. Rolewska, S. Al-Robaiy, A. Navarrete Santos, and et al. Age-related expression, enzymatic solubility and modification with advanced glycation end-products of fibrillar collagens in mouse lung Exp. Gerontol. 48 2012 29 37
19. Y. Liu, C. Wang, Y. Wang, and et al. Cobalt chloride decreases fibroblast growth factor-21 expression dependent on oxidative stress but not hypoxia-inducible factor in Caco-2 cells Toxicol. Appl. Pharmacol. 264 2012 212 221
20. Y. Zhang, Y. Xie, E.D. Berglund, and et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice Elife 1 2012 e00065
21. R. Pazdro, and J.R. Burgess The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells Exp. Diabetes Res. 2012 2012 137607
22. F.M. Fisher, J.L. Estall, A.C. Adams, and et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo Endocrinology 152 2011 2996 3004
23. M. Varela-Rey, N. Beraza, S.C. Lu, and et al. Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration Exp. Biol. Med. 236 2011 402 408
24. F. Sato, Y. Muragaki, and Y. Zhang DEC1 negatively regulates AMPK activity via LKB1 Biochem. Biophys. Res. Commun. 67 2015 711 716
25. U.K. Bhawal, F. Sato, Y. Arakawa, and et al. Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1 J. Pathol. 224 2011 420 429
26. A. Kharitonenkov, J.D. Dunbar, H.A. Bina, and et al. FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho J. Cell. Physiol. 215 2008 1 7
27. B. Kong, J. Huang, Y. Zhu, and et al. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice Am. J. Physiol. Gastrointest. Liver Physiol. 306 2014 G893 G902
28. Y. Suh Age-specific changes in expression, activity, and activation of the c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats Mech. Ageing Dev. 122 2001 1797 1811
29. X. Tong, M. Muchnik, Z. Chen, and et al. Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding J. Biol. Chem. 285 2010 36401 36409
30. M. Suzuki, F. Sato, and U.K. Bhawal The basic helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates Twist1 through an E-box element Biochem. Biophys. Res. Commun. 455 2014 390 395