Traumatic Brain Injury-Induced Neuronal Apoptosis is Reduced Through Modulation of PI3K and Autophagy Pathways in Mouse by FTY720

Cellular and Molecular Neurobiology

Volumn 36, Issue 1, 2016, Pages 131-142

  Zhang, Li ^a   Ding, Ke ^a   Wang, Handong ^a   Wu, Yong ^a   Xu, Jianguo ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; FTY720; PI3K AKT signaling pathway; Traumatic brain injury

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; BECLIN 1; CYTOCHROME C; FINGOLIMOD; LC3 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN CORTEX; BRAIN EDEMA; COGNITION; CONTROLLED STUDY; EXPERIMENTAL MODEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN INJURIES; DRUG EFFECTS; ENZYMOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; NERVE CELL; NEUROPROTECTION; PATHOLOGY; SIGNAL TRANSDUCTION; TUNEL ASSAY;

ANIMALS; APOPTOSIS; AUTOPHAGY; BRAIN INJURIES; FINGOLIMOD HYDROCHLORIDE; IN SITU NICK-END LABELING; MALE; MICE, INBRED ICR; NEURONS; NEUROPROTECTION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84953369165     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-015-0227-1     Document Type: Article

References (41)

1. Ang BT, Yap E, Lim J, Tan WL, Ng PY, Ng I, Yeo TT (2003) Poly(adenosine diphosphate-ribose) polymerase expression in human traumatic brain injury. J Neurosurg 99:125–130
2. Bao HJ, Wang T, Zhang MY, Liu R, Dai DK, Wang YQ, Wang L, Zhang L, Gao YZ, Qin ZH, Chen XP, Tao LY (2012) Poloxamer-188 attenuates TBI-induced blood-brain barrier damage leading to decreased brain edema and reduced cellular death. Neurochem Res 37:2856–2867
3. Campos F, Qin T, Castillo J, Seo JH, Arai K, Lo EH, Waeber C (2013) Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke 44:505–511
4. Chen SF, Tsai HJ, Hung TH, Chen CC, Lee CY, Wu CH, Wang PY, Liao NC (2012) Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury. PLoS One 7:e45763
5. Codogno P, Meijer AJ (2005) Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12(Suppl 2):1509–1518
6. Cox-Limpens KE, Gavilanes AW, Zimmermann LJ, Vles JS (2014) Endogenous brain protection: what the cerebral transcriptome teaches us. Brain Res 1564C:85–100
7. Czech B, Pfeilschifter W, Mazaheri-Omrani N, Strobel MA, Kahles T, Neumann-Haefelin T, Rami A, Huwiler A, Pfeilschifter J (2009) The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia. Biochem Biophys Res Commun 389:251–256
8. Dogan A, Rao AM, Baskaya MK, Rao VL, Rastl J, Donaldson D, Dempsey RJ (1997) Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. J Neurosurg 87:921–926
9. Endo H, Nito C, Kamada H, Yu F, Chan PH (2006) Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats. Stroke 37:2140–2146
10. Flierl MA, Stahel PF, Beauchamp KM, Morgan SJ, Smith WR, Shohami E (2009) Mouse closed head injury model induced by a weight-drop device. Nat Protoc 4:1328–1337
11. Hasegawa Y, Suzuki H, Sozen T, Rolland W, Zhang JH (2010) Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke 41:368–374
12. Hoane MR, Kaplan SA, Ellis AL (2006) The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury. Brain Res 1125:185–193
13. Ishrat T, Sayeed I, Atif F, Hua F, Stein DG (2012) Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway. Neuroscience 210:442–450
14. Kitagishi Y, Matsuda S (2013) Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury. Alzheimers Res Ther 5:42
15. Lin CJ, Chen TH, Yang LY, Shih CM (2014) Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death. Cell Death Dis 5:e1147
16. Lu L, Barfejani AH, Qin T, Dong Q, Ayata C, Waeber C (2014) Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage. Brain Res 1555:89–96
17. Luo CL, Li BX, Li QQ, Chen XP, Sun YX, Bao HJ, Dai DK, Shen YW, Xu HF, Ni H, Wan L, Qin ZH, Tao LY, Zhao ZQ (2011) Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice. Neuroscience 184:54–63
18. Luo CL, Li QQ, Chen XP, Zhang XM, Li LL, Li BX, Zhao ZQ, Tao LY (2013) Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury. Brain Res 1502:1–10
19. Maas AI, Stocchetti N, Bullock R (2008) Moderate and severe traumatic brain injury in adults. Lancet Neurol 7:728–741
20. Marmarou A (2007) A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 22:E1
21. Naziroglu M, Senol N, Ghazizadeh V, Yuruker V (2014) Neuroprotection induced by N-acetylcysteine and selenium against traumatic brain injury-induced apoptosis and calcium entry in hippocampus of rat. Cell Mol Neurobiol 34:895–903
22. Noshita N, Lewen A, Sugawara T, Chan PH (2002) Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol Dis 9:294–304
23. Ovey IS, Naziroglu M (2015) Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channels. Neuroscience 284:225–233
24. Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S (2003) The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett 554:189–193
25. Rink A, Fung KM, Trojanowski JQ, Lee VM, Neugebauer E, McIntosh TK (1995) Evidence of apoptotic cell death after experimental traumatic brain injury in the rat. Am J Pathol 147:1575–1583
26. Senol N, Naziroglu M, Yuruker V (2014) N-acetylcysteine and selenium modulate oxidative stress, antioxidant vitamin and cytokine values in traumatic brain injury-induced rats. Neurochem Res 39:685–692
27. Sun YX, Dai DK, Liu R, Wang T, Luo CL, Bao HJ, Yang R, Feng XY, Qin ZH, Chen XP, Tao LY (2013) Therapeutic effect of SN50, an inhibitor of nuclear factor-kappaB, in treatment of TBI in mice. Neurol Sci 34:345–355
28. Walker CL, Liu NK, Xu XM (2013) PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries. Front Biol (Beijing) 8:421–433
29. Wang YQ, Wang L, Zhang MY, Wang T, Bao HJ, Liu WL, Dai DK, Zhang L, Chang P, Dong WW, Chen XP, Tao LY (2012) Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 37:1849–1858
30. Wang LT, Chen BL, Wu CT, Huang KH, Chiang CK, Hwa Liu S (2013) Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury. PLoS One 8:e79814
31. Wang JW, Wang HD, Cong ZX, Zhou XM, Xu JG, Jia Y, Ding Y (2014) Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. J Surg Res 186:328–337
32. Wei Y, Yemisci M, Kim HH, Yung LM, Shin HK, Hwang SK, Guo S, Qin T, Alsharif N, Brinkmann V, Liao JK, Lo EH, Waeber C (2011) Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol 69:119–129
33. Wirawan E, Vanden Berghe T, Lippens S, Agostinis P, Vandenabeele P (2012) Autophagy: for better or for worse. Cell Res 22:43–61
34. Xu J, Wang H, Ding K, Zhang L, Wang C, Li T, Wei W, Lu X (2014) Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE pathway. Free Radic Biol Med 71:186–195
35. Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS, Workman P (2008) Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol 8:393–412
36. Yeh EA, Weinstock-Guttman B (2011) Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis. Adv Ther 28:270–278
37. Yuruker V, Naziroglu M, Senol N (2015) Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: possible involvement of TRPM2 channels. Metab Brain Dis 30:223–231
38. Zhang X, Chen Y, Jenkins LW, Kochanek PM, Clark RS (2005) Bench-to-bedside review: apoptosis/programmed cell death triggered by traumatic brain injury. Crit Care 9:66–75
39. Zhang YB, Li SX, Chen XP, Yang L, Zhang YG, Liu R, Tao LY (2008) Autophagy is activated and might protect neurons from degeneration after traumatic brain injury. Neurosci Bull 24:143–149
40. Zhang HL, Xu M, Wei C, Qin AP, Liu CF, Hong LZ, Zhao XY, Liu J, Qin ZH (2011) Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-kappaB signaling pathway. Neuroscience 176:381–395
41. Zhang L, Wang HD, Ji XJ, Cong ZX, Zhu JH, Zhou Y (2013) FTY720 for cancer therapy (Review). Oncol Rep 30:2571–2578