Poly-α,β-polyasparthydrazide-based nanogels for potential oral delivery of paclitaxel: In vitro and in vivo properties

Journal of Biomedical Nanotechnology

Volumn 11, Issue 12, 2015, Pages 2231-2242

  Guo, Jingwen ^a   Ma, Mingxin ^b   Chang, Di ^a   Zhang, Qiang ^a   Zhang, Chen ^a   Yue, Yang ^a   Liu, Jia ^a   Wang, Siling ^a   Jiang, Tongying ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Liaoning Foods and Drug Administration   (China)

Author keywords

Adhesion; Oral Administration; Paclitaxel; PAHy Based Nanogel; Permeability; Pharmacokinetic Study; Release Property; Retention

Indexed keywords

ADHESION; CHAINS; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; DYNAMIC LIGHT SCATTERING; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MECHANICAL PERMEABILITY; NANOSTRUCTURED MATERIALS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; X RAY DIFFRACTION;

NANOGELS; ORAL ADMINISTRATION; PACLITAXEL; PHARMACOKINETIC STUDIES; RELEASE PROPERTY; RETENTION;

TARGETED DRUG DELIVERY;

ASPARTIC ACID DERIVATIVE; CYTOCHROME P450 3A4; DISTILLED WATER; FLUORESCEIN ISOTHIOCYANATE; HYDRAZIDE DERIVATIVE; NANOGEL; NANOMATERIAL; PACLITAXEL; UNCLASSIFIED DRUG; VERAPAMIL; ALPHA,BETA-POLYASPARTHYDRAZIDE; DRUG CARRIER; GEL; HYDRAZINE DERIVATIVE; MACROGOL DERIVATIVE; NYLON;

ANIMAL EXPERIMENT; APPARENT PERMEABILITY; AREA UNDER THE CURVE; ARTICLE; BIOCOMPATIBILITY; CIRCULATION TIME; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDRODYNAMICS; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; INTESTINE ABSORPTION; IONIC STRENGTH; LIGHT SCATTERING; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICROEMULSION; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; RAT; SUSTAINED RELEASE FORMULATION; X RAY DIFFRACTION; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; GEL; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PERMEABILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; DRUG CARRIERS; DRUG LIBERATION; GELS; HYDRAZINES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTESTINAL ABSORPTION; MALE; NANOSTRUCTURES; NYLONS; PACLITAXEL; PERMEABILITY; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84953342411     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2015.2118     Document Type: Article

References (37)

1. J. M. Terwogt, B. Nuijen, W. W. Huinink, and J. H. Beijnen, Alternative formulations of paclitaxel. Cancer Treatment Reviews 23, 87 (1997).
2. J. Liebmann, J. A. Cook, J. B. Mitchell, and E. L. Cremophor, Solvent for paclitaxel, and toxicity. Lancet 342, 1428 (1993).
3. M. M. Malingreì, J. H. Schellens, O. Van Tellingen, M. Ouwehand, H. A. Bardelmeijer, H. Rosing, F. J. Koopman, M. E. Schot, W. W. T. B. Huinink, and J. H. Beijnen, The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients. British Journal of Cancer 85, 1472 (2001).
4. A. Sparreboom, O. van Tellingen, W. J. Nooijen, and J. H. Beijnen, Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL. Cancer Research 56, 2112 (1996).
5. A. V. Kabanov and S. V. Vinogradov, Nanogels as pharmaceutical carriers: Finite networks of infinite capabilities. Angew. Chem. Int. Ed. 48, 5418 (2009).
6. M. Hamidia, A. Azadi, and P. Rafiei, Hydrogel nanoparticles in drug delivery. Advanced Drug Delivery Reviews 60, 1638 (2008).
7. M. Zrinyia, T. Gyenes, D. Juriga, and J.-H. Kim, Volume change of double cross-linked poly(aspartic acid) hydrogels induced by cleavage of one of the crosslinks. Acta Biomaterialia 9, 5122 (2013).
8. G. Giammona, B. Carlisi, G. Cavallaro, G. Pitarresi, and S. Spampinato, A new water-soluble synthetic polymer,-polyasparthydrazide as potential plasma expander and drug carrier. J. Controlled Release 29, 63 (1994).
9. H. Huo, Y. Gao, T. Wang, H. Jiang, S. Wang, and T. Jiang, The investigation on polyion complex ratlles composed of diammonium glycyrrhizinate/poly(ethylene glycol)-glycidyltrimethylammonium chloride-grafted polyasparthydrazide. AAPS Pharm. Sci. Tech. 13, 1367 (2012).
10. S. W. Wang, J. Monagle, C. McNulty, D. Putnam, and H. Chen, Determination of P-glycoprotein inhibition by excipients and their combinations using an integrated high-throughput process. J. Pharm. Sci. 93, 2755 (2004).
11. D. Mandracchia, N. Denora, M. Francoa, G. Pitarresi, G. Giammona and G. Trapani, New biodegradable hydrogels based on inulin and -Polyaspartylhydrazide designed for colonic drug delivery: In vitro release of glutathione and oxytocin. Journal of Biomaterials Science, Polymer Edition 22, 313 (2011).
12. G. Pitarresi, F. S. Palumbo, G. Tripodo, G. Cavallaro, and G. Giammona, Preparation and characterization of new hydrogels based on hyaluronic acid and - Polyaspartylhydrazide. Eur. Polym. J. 43, 3953 (2007).
13. T. Zhou, C. Xiao, J. Fan, S. Chen, J. Shen, W. Wu, and S. Zhou, A nanogel of on-site tunable pH-response for efficient anticancer drug delivery. Acta Biomaterialia 9, 4546 (2013).
14. Z. Qiao, R. Zhang, F. Du, D. Liang, and Z. Li, Multi-responsive nanogels containing motifs of ortho ester, oligo (ethylene glycol) and disulfide linkage as carriers of hydrophobic anti-cancer drugs. J. Controlled Release 152, 57 (2011).
15. Z. Zhang, H. Bu, Z. Gao, Y. Huang, F. Gao, and Y. Li, The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats. Int. J. Pharm. 394, 147 (2010).
16. F. Gao, Z. Zhang, H. Bu, Y. Huang, Z. Gao, J. Shen, C. Zhao, and Y. Li, Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism. J. Controlled Release 149, 168 (2011).
17. Y. Zhang, J. Wang, X. Bai, T. Jiang, Q. Zhang, and S. Wang, Mesoporous silica nanoparticles for increasing the oral bioavailability and permeation of poorly water soluble drugs. Molecular Pharmaceutics 9, 505 (2012).
18. Y. Li, Y. Bi, Y. Xi, and L. Li, Enhancement on oral absorption of paclitaxel by multifunctional pluronic micelles. Journal of Drug Targeting 21, 188 (2013).
19. V. Zabaleta, G. Ponchel, H. Salman, M. Agüeros, C. Vauthier, and J. M. Irache, Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: Permeability and pharmacokinetic study. European Journal of Pharmaceutics and Biopharmaceutics 81, 514 (2012).
20. M. Agüeros, L. Ruiz-Gatón, C. Vauthier, K. Bouchemal, S. Espuelas, G. Ponchel, and J. M. Irache, Combined hydroxypropyl-cyclodextrin and poly(anhydride) nanoparticles improve the oral permeability of paclitaxel. European Journal of Pharmaceutical Sciences 38, 405 (2009).
21. R. Mo, X. Jin, N. Li, C. Ju, M. Sun, C. Zhang, and Q. Ping, The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles. Biomaterials 32, 4609 (2011).
22. A. O. Nornoo, H. Zheng, L. B. Lopes, B. Johnson-Restrepo, K. Kannan, and R. Reed, Oral microemulsions of paclitaxel: in situ and pharmacokinetic studies. European Journal of Pharmaceutics and Biopharmaceutics 71, 310 (2009).
23. H. Yao, R. Ju, X. Wang, Y. Zhang, R. Li, Y. Yu, L. Zhang, and W. Lu, The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery. Biomaterials 32, 3285 (2011).
24. S. Kapoor, R. Hegde, and A. J. Bhattacharyya, Influence of surface chemistry of mesoporous alumina with wide pore distribution on controlled drug release. J. Controlled Release 140, 34 (2009).
25. J. Salonena, L. Laitinenb, A. M. Kaukonenb, J. Tuuraa, M. Björkqvista, T. Heikkiläa, K. Vähä-Heikkiläa, J. Hirvonenb, and V. P. Lehtoa, Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drugs. J. Controlled Release 108, 362 (2005).
26. R. Gref, Y. Minamitake, M. T. Peracchia, V. Trubetskoy, V. Torchilin, and R. Langer, Biodegradable long-circulating polymeric nanospheres. Science 263, 1600 (1994).
27. W. Zhu, L. Wan, C. Zhang, Y. Gao, X. Zheng, T. Jiang, and S. Wang, Exploitation of 3D face-centered cubicmesoporous silica as a carrier for a poorly water soluble drug: Influence of pore size on release rate. Mater. Sci. Eng., C 34, 78 (2014).
28. C. Zhang, Q. Zhao, L. Wan, T. Wang, J. Sun, Y. Gao, T. Jiang, and S. Wang, Poly dimethyl diallyl ammonium coated CMK-5 for sustained oral drug release. Int. J. Pharm. 461, 171 (2014).
29. Y. Q. Hu, L. Y. Zheng, C. Q. Qian, and W. H. Yu, Absorption in small intestinal tract of ion drug-phenolsulfonphthalein. Journal of China Pharmaceutical University 27, 355 (1996).
30. J. Ritesh, D. Sridhar, K. Viral, K. M. Nanda, and K. M. Ashim, Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats. Int. J. Pharm. 336, 233 (2007).
31. Z. G. Liao, Q. N. Ping, W. Xiao, and X. L. Liang, The Study in situ on rat intestinal absorption of the active components in Guizhi Fuling capsule. Chinese Journal of Natural Medicines 3, 303 (2005).
32. C. J. Porter, N. L. Trevaskis, and W. N. Charman, Lipids and lipid based formulations: Optimizing the oral delivery of lipophilic drugs. Nat. Rev. Drug Discovery 6, 231 (2007).
33. H. Li, M. Huo, J. Zhou, Y. Dai, Y. Deng, X. Shi, and J. Masoud, Enhanced oral absorption of paclitaxel in N-deoxycholic acid-N, O-hydroxyethyl chitosan micellar system. J. Pharm. Sci. 99, 4543 (2010).
34. F. Kuipers, R. Havinga, H. Bosschieter, G. Toorop, F. Hindriks, and R. Vonk, Enterohepatic circulation in the rat. Gastroenterology 88, 403 (1985).
35. M. T. Huizing, G. Giaccone, L. J. C. van Warmerdam, H. Rosing, and P. J. M. Bakker, Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. Journal of Clinical Oncology 15, 317 (1997).
36. M. G. Carstens, C. J. F. Rijcken, C. F. van Nostrum, and W. E. Hennink, Pharmaceutical micelles: Combining longevity, stability, and stimuli sensitivity, Edited by V. Torchilin, Multifunctional pharmaceutical nanocarriers, 4th edn., Springer, New York (2008), pp. 263-308.
37. L. Y. Qiu and Y. H. Bae, Polymer architecture and drug delivery. Pharm. Res. 23, 1 (2006).