Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 1, 2016, Pages 128-133

  Simons, Benjamin D ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cancer; DNA sequencing; Epidermis; Stem cells

Indexed keywords

CELL TRANSFORMATION; EARLY CANCER DIAGNOSIS; EPIDERMIS; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; KERATINOCYTE; METABOLISM; NEOPLASM; PATHOLOGY; POINT MUTATION; STEM CELL;

CELL TRANSFORMATION, NEOPLASTIC; EARLY DETECTION OF CANCER; EPIDERMIS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; KERATINOCYTES; NEOPLASMS; POINT MUTATION; STEM CELLS;

EID: 84953292842     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516123113     Document Type: Article

References (40)

1. Simons BD, Clevers H (2011) Strategies for homeostatic stem cell self-renewal in adult tissues. Cell 145(6):851-862.
2. Van Keymeulen A, Blanpain C (2012) Tracing epithelial stem cells during development, homeostasis, and repair. J Cell Biol 197(5):575-584.
3. Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C (2012) Defining the mode of tumour growth by clonal analysis. Nature 488(7412):527-530.
4. Blanpain C (2013) Tracing the cellular origin of cancer. Nat Cell Biol 15(2):126-134.
5. Vermeulen L, et al. (2013) Defining stem cell dynamics in models of intestinal tumor initiation. Science 342(6161):995-998.
6. Ellenbroek SIJ, van Rheenen J (2014) Imaging hallmarks of cancer in living mice. Nat Rev Cancer 14(6):406-418.
7. Merlo LMF, Pepper JW, Reid BJ, Maley CC (2006) Cancer as an evolutionary and ecological process. Nat Rev Cancer 6(12):924-935.
8. Bozic I, et al. (2010) Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci USA 107(43):18545-18550.
9. Navin N, et al. (2011) Tumour evolution inferred by single-cell sequencing. Nature 472(7341):90-94.
10. Gerlinger M, et al. (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366(10):883-892.
11. Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481(7381):306-313.
12. Vogelstein B, et al. (2013) Cancer genome landscapes. Science 339(6127):1546-1558.
13. Sottoriva A, et al. (2015) A Big Bang model of human colorectal tumor growth. Nat Genet 47(3):209-216.
14. Martincorena I, Campbell PJ (2015) Somatic mutation in cancer and normal cells. Science 349(6255):1483-1489.
15. Stratton MR, Campbell PJ, Futreal PA (2009) The cancer genome. Nature 458(7239): 719-724.
16. Martincorena I, et al. (2015) Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 348(6237):880-886.
17. Teixeira VH, et al. (2013) Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors. eLife 2:e00966.
18. Baker A-M, et al. (2014) Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Reports 8(4):940-947.
19. Martincorena I, Seshasayee ASN, Luscombe NM (2012) Evidence of non-random mutation rates suggests an evolutionary risk management strategy. Nature 485(7396):95-98.
20. Dees ND, et al. (2012) MuSiC: Identifying mutational significance in cancer genomes. Genome Res 22(8):1589-1598.
21. Greenman C, Wooster R, Futreal PA, Stratton MR, Easton DF (2006) Statistical analysis of pathogenicity of somatic mutations in cancer. Genetics 173(4):2187-2198.
22. Krieger T, Simons BD (2015) Dynamic stem cell heterogeneity. Development 142(8): 1396-1406.
23. Hsu Y-C, Li L, Fuchs E (2014) Emerging interactions between skin stem cells and their niches. Nat Med 20(8):847-856.
24. Page ME, Lombard P, Ng F, Göttgens B, Jensen KB (2013) The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell 13(4):471-482.
25. Mackenzie IC (1970) Relationship between mitosis and the ordered structure of the stratum corneum in mouse epidermis. Nature 226(5246):653-655.
26. Potten CS, Kovacs L, Hamilton E (1974) Continuous labelling studies on mouse skin and intestine. Cell Tissue Kinet 7(3):271-283.
27. Clayton E, et al. (2007) A single type of progenitor cell maintains normal epidermis. Nature 446(7132):185-189.
28. Doupé DP, Klein AM, Simons BD, Jones PH (2010) The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell 18(2): 317-323.
29. Mascré G, et al. (2012) Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature 489(7415):257-262.
30. Lim X, et al. (2013) Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342(6163):1226-1230.
31. Rheinwald JG, Green H (1975) Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 6(3):331-343.
32. Barrandon Y, Green H (1987) Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci USA 84(8):2302-2306.
33. Jones PH, Watt FM (1993) Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73(4):713-724.
34. Watt FM (2014) Mammalian skin cell biology: At the interface between laboratory and clinic. Science 346(6212):937-940.
35. Klein AM, Simons BD (2011) Universal patterns of stem cell fate in cycling adult tissues. Development 138(15):3103-3111.
36. Klein AM, Brash DE, Jones PH, Simons BD (2010) Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia. Proc Natl Acad Sci USA 107(1):270-275.
37. Slaughter DP, Southwick HW, Smejkal W (1953) Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6(5):963-968.
38. Jones PH, Harper S, Watt FM (1995) Stem cell patterning and fate in human epidermis. Cell 80(1):83-93.
39. Bailey NTJ (1964) The Elements of Stochastic Processes with Applications to the Natural Sciences (Wiley, New York).
40. Zhang MQ (1998) Statistical features of human exons and their flanking regions. Hum Mol Genet 7(5):919-932.