Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice

Pharmacological Research

Volumn 104, Issue , 2016, Pages 132-139

  Gurusamy, Malarvizhi ^a   Nasseri, Saeed ^a   Lee, Hana ^a   Jung, Birgit ^b   Lee, Dongwon ^a   Khang, Gilson ^a   Abraham, William M ^c   Doods, Henri ^b   Wu, Dongmei ^a,c  

^a Chonbuk National University   (South Korea)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Airway inflammation; Cyclooxygenase 2; Inducible nitric oxide synthase; Kinin B1 receptors; Matrix metalloproteinase; Mucus

Indexed keywords

ANTIINFLAMMATORY AGENT; BI 113823; CYCLOOXYGENASE 2; DEXAMETHASONE; GELATINASE A; IMMUNOGLOBULIN E; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALLERGEN; BRADYKININ B1 RECEPTOR ANTAGONIST; MMP2 PROTEIN, MOUSE; OVALBUMIN; PTGS2 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; EOSINOPHIL; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOCYTE; MACROPHAGE; MALE; MOUSE; MUCUS SECRETION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; ANIMAL; ASTHMA; BAGG ALBINO MOUSE; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CYTOLOGY; IMMUNOLOGY; LUNG; METABOLISM; MUCUS; PATHOLOGY; SECRETION (PROCESS);

ALLERGENS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRADYKININ B1 RECEPTOR ANTAGONISTS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CYCLOOXYGENASE 2; DEXAMETHASONE; IMMUNOGLOBULIN E; INTERLEUKIN-1BETA; LUNG; MALE; MATRIX METALLOPROTEINASE 2; MICE, INBRED BALB C; MUCUS; OVALBUMIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84953270950     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.12.017     Document Type: Article

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