Production of monodispersed magnetic polymeric microspheres in a microfluidic chip and 3D simulation

Microfluidics and Nanofluidics

Volumn 20, Issue 1, 2016, Pages 1-14

  Bokharaei, Mehrdad ^a   Schneider, Thomas ^a   Dutz, Silvio ^b,c   Stone, Roland C ^d   Mefford, O Thompson ^d   Häfeli, Urs O ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b LEIBNIZ INSTITUTE OF PHOTONIC TECHNOLOGY   (Germany)

^c ILMENAU UNIVERSITY OF TECHNOLOGY   (Germany)

^d AMRL   (United States)

Author keywords

3D simulation; Hyperthermia; Magnetic microspheres; Microfluidics; Monosized polymer microsphere

Indexed keywords

DROP FORMATION; DROPS; FLUIDIC DEVICES; HYPERTHERMIA THERAPY; MAGNETISM; MICROFLUIDICS; MICROSPHERES; NANOMAGNETICS; NANOPARTICLES; POLYMERS; SIZE DISTRIBUTION;

3D SIMULATIONS; ALTERNATING MAGNETIC FIELD; HYDRODYNAMIC INSTABILITIES; HYPERTHERMIA; MAGNETIC MICROSPHERES; MAGNETIC POLYMERIC MICROSPHERES; POLYMER MICROSPHERES; SIZE AND SIZE DISTRIBUTIONS;

MAGNETIC BUBBLES;

EID: 84953259536     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-015-1693-y     Document Type: Article

References (60)

1. Ammar S, Deisenhofer I, Reents T, Hessling G (2014) Remote-controlled magnetic navigation and ablation of atrial flutter in a patient with an extracardiac total cavopulmonary connection. Clin Res Cardiol 103:753–754
2. Anna SL, Mayer HC (2006) Microscale tipstreaming in a microfluidic flow focusing device. Phys Fluids 18:121512
3. Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using “flow focusing” in microchannels. Appl Phys Lett 82:364–366
4. Bai YP et al (2010) A double droplet trap system for studying mass transport across a droplet-droplet interface. Lab Chip 10:1281–1285
5. Brule S, Levy M, Wilhelm C, Letourneur D, Gazeau F, Menager C, Le Visage C (2011) Doxorubicin release triggered by alginate embedded magnetic nanoheaters: a combined therapy. Adv Mater 23:787–790
6. Chen AU, Notz PK, Basaran OA (2002) Computational and experimental analysis of pinch-off and scaling. Phys Rev Lett 88:174501
7. Cui MM, Emrick T, Russell TP (2013) Stabilizing liquid drops in nonequilibrium shapes by the interfacial jamming of nanoparticles. Science 342:460–463
8. Derzsi L, Kasprzyk M, Plog JP, Garstecki P (2013) Flow focusing with viscoelastic liquids. Phys Fluids 25:092001
9. Dutz S, Hergt R (2014) Magnetic particle hyperthermia—a promising tumour therapy? Nanotechnology 25:452001
10. Dutz S, Kettering M, Hilger I, Müller R, Zeisberger M (2011) Magnetic multicore nanoparticles for hyperthermia-influence of particle immobilization in tumour tissue on magnetic properties. Nanotechnology 22:265102
11. Eggers J, Dupont TF (1994) Drop formation in a one-dimensional approximation of the Navier–Stokes equation. J Fluid Mech 262:205–221
12. Finehout E, Tian W-C (2009) Microfluidics for biological applications vol 1. Aufl., vol Book, Whole. Springer, Boston
13. Fu TT, Wu YN, Ma YG, Li HZ (2012) Droplet formation and breakup dynamics in microfluidic flow-focusing devices: from dripping to jetting. Chem Eng Sci 84:207–217
14. Ganan-Calvo AM, Montanero JM, Martin-Banderas L, Flores-Mosquera M (2013) Building functional materials for health care and pharmacy from microfluidic principles and flow focusing. Adv Drug Deliv Rev 65:1447–1469
15. Garstecki P, Stone HA, Whitesides GM (2005) Mechanism for flow-rate controlled breakup in confined geometries: a route to monodisperse emulsions. Phys Rev Lett 94:164501
16. Gillies GT, Ritter RC, Broaddus WC, Grady MS, Howard MA, McNeil RG (1994) Magnetic manipulation instrumentation for medical physics research. Rev Sci Instrum 65:533–562
17. Häfeli UO, Saatchi K, Elischer P, Misri R, Bokharaei M, Labiris NR, Stoeber B (2010) Lung perfusion imaging with monosized biodegradable microspheres. Biomacromolecules 11:561–567
18. Hayden ME, Häfeli UO (2006) ‘Magnetic bandages’ for targeted delivery of therapeutic agents. J Phys Condens Matter 18:S2877–S2891
19. Hilger I (2013) In vivo applications of magnetic nanoparticle hyperthermia. Int J Hyperthermia 29:828–834
20. Hufnagel H, Huebner A, Gulch C, Guse K, Abell C, Hollfelder F (2009) An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets. Lab Chip 9:1576–1582
21. Iacob G, Rotariu O, Strachan NJC, Häfeli UO (2004) Magnetizable needles and wires—modeling an efficient way to target magnetic microspheres in vivo. Biorheology 41:599–612
22. Izumida Y, Sugiura S, Oda T, Satake M, Nakajima M (2005) Production of quasi-monodisperse emulsions with large droplets using a micromachined device. J Am Oil Chem Soc 82:73–78
23. Jain RA (2000) The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21:2475–2490
24. Jiang WL, Schwendeman SP (2001) Stabilization and controlled release of bovine serum albumin encapsulated in poly(d,l-lactide) and poly(ethylene glycol) microsphere blends. Pharm Res 18:878–885
25. Jordan A, Wust P, Fahling H, John W, Hinz A, Felix R (1993) Inductive heating of ferrimagnetic particles and magnetic fluids—physical evaluation of their potential for hyperthermia. Int J Hyperthermia 9:51–68
26. Kato T et al (1984) Magnetic microcapsules for targeted delivery of anticancer drugs. Appl Biochem Biotechnol 10:199–211
27. Kempe H, Kempe M (2010) The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy. Biomaterials 31:9499–9510
28. Kintses B, van Vliet LD, Devenish SRA, Hollfelder F (2010) Microfluidic droplets: new integrated workflows for biological experiments. Curr Opin Chem Biol 14:548–555
29. Lübbe AS, Alexiou C, Bergemann C (2001) Clinical applications of magnetic drug targeting. J Surg Res 95:200–206
30. Martin-Banderas L, Flores-Mosquera M, Riesco-Chueca P, Rodriguez-Gil A, Cebolla A, Chavez S, Ganan-Calvo AM (2005) Flow focusing: a versatile technology to produce size-controlled and specific-morphology microparticles. Small 1:688–692
31. Martin-Banderas L, Gonzalez-Prieto R, Rodriguez-Gil A, Fernandez-Arevalo M, Flores-Mosquera M, Chavez S, Ganan-Calvo AM (2011) Application of flow focusing to the break-up of a magnetite suspension jet for the production of paramagnetic microparticles. J Nanomater 2011:527437
32. Müller R, Dutz S, Neeb A, Cato ACB, Zeisberger M (2013) Magnetic heating effect of nanoparticles with different sizes and size distributions. J Magn Magn Mater 328:80–85
33. Nisisako T, Torii T, Higuchi T (2004) Novel microreactors for functional polymer beads. Chem Eng J 101:23–29
34. Osman MA, Atallah A (2006) Effect of the particle size on the viscoelastic properties of filled polyethylene. Polymer 47:2357–2368
35. Pankhurst QA, Connolly J, Jones SK, Dobson J (2003) Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys 36:R167–R181
36. Qi F, Wu J, Yang TY, Ma GH, Su ZG (2014) Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification. Acta Biomater 10:4247–4256
37. Rayleigh L (1879) On the capillary phenomena of jets. Proc R Soc Lond 29:71–97
38. Saville SL, Stone RC, Qi B, Mefford OT (2012) Investigation of the stability of magnetite nanoparticles functionalized with catechol based ligands in biological media. J Mater Chem 22:24909–24917
39. Schneider T, Häfeli UO (2016) Magnetic drug delivery. In: Ionescu A, Darton N, Liandro J (eds) Magnetic nanoparticles in biosensing and medicine. Cambridge University Press, Cambridge
40. Schneider T, Zhao H, Jackson JK, Chapman GH, Dykes J, Häfeli UO (2008) Use of hydrodynamic flow focusing for the generation of biodegradable camptothecin-loaded polymer microspheres. J Pharm Sci 97:4943–4954
41. Schneider T, Kreutz J, Chiu DT (2013) The potential impact of droplet microfluidics in biology. Anal Chem 85:3476–3482
42. Seiffert S, Romanowsky MB, Weitz DA (2010) Janus microgels produced from functional precursor polymers. Langmuir 26:14842–14847
43. Sen D, Bahadur J, Mazumder S, Bhattacharya S (2012) Formation of hollow spherical and doughnut microcapsules by evaporation induced self-assembly of nanoparticles: effects of particle size and polydispersity. Soft Matter 8:10036–10044
44. Shaw S, Murthy PVSN, Sibanda P (2013) Magnetic drug targeting in a permeable microvessel. Microvasc Res 85:77–85
45. Steinhaus B, Shen AQ, Sureshkumar R (2007) Dynamics of viscoelastic fluid filaments in microfluidic devices. Phys Fluids 19:073103
46. Tirtaatmadja V, McKinley GH, Cooper-White JJ (2006) Drop formation and breakup of low viscosity elastic fluids: effects of molecular weight and concentration. Phys Fluids 18:043101
47. Uchida T, Martin S, Foster TP, Wardley RC, Grimm S (1994) Dose and load studies for subcutaneous and oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin. Pharm Res 11:1009–1015
48. Umbanhowar PB, Prasad V, Weitz DA (2000) Monodisperse emulsion generation via drop break off in a coflowing stream. Langmuir 16:347–351
49. Utada AS, Chu LY, Fernandez-Nieves A, Link DR, Holtze C, Weitz DA (2007) Dripping, jetting, drops, and wetting: the magic of microfluidics. MRS Bull 32:702–708
50. Wagner C, Amarouchene Y, Bonn D, Eggers J (2005) Droplet detachment and satellite bead formation in viscoelastic fluids. Phys Rev Lett 95:164504
51. Widder KJ, Morris RM, Poore G, Howard DP, Senyei AE (1981) Tumor remission in Yoshida sarcoma-bearing rats by selective targeting of magnetic albumin microspheres containing doxorubicin. Proc Natl Acad Sci USA 78:579–581
52. Xu QB et al (2009) Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small 5:1575–1581
53. Yang XQ, Hong H, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Xiao YL, Yang YA, Zhang Y, Nickles R, Cai WB, Steeber DA, Gong SQ (2011) cRGD-functionalized, DOX-conjugated, and Cu-64-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials 32:4151–4160
54. Yue P, Zhou C, Feng JJ, Ollivier-Gooch CF, Hu HH (2006a) Phase-field simulations of interfacial dynamics in viscoelastic fluids using finite elements with adaptive meshing. J Comput Phys 219:47–67
55. Yue PT, Zhou CF, Feng JJ (2006b) A computational study of the coalescence between a drop and an interface in Newtonian and viscoelastic fluids. Phys Fluids 18:102102
56. Yue PT, Zhou CF, Feng JJ (2007) Spontaneous shrinkage of drops and mass conservation in phase-field simulations. J Comput Phys 223:1–9
57. Zhao H, Saatchi K, Häfeli UO (2009) Preparation of biodegradable magnetic microspheres with poly(lactic acid)-coated magnetite. J Magn Magn Mater 321:1356–1363
58. Zhou CF, Yue PT, Feng JJ (2006) Formation of simple and compound drops in microfluidic devices. Phys Fluids 18:092105
59. Zhou CF, Yue PT, Feng JJ, Ollivier-Gooch CF, Hu HH (2010) 3D phase-field simulations of interfacial dynamics in Newtonian and viscoelastic fluids. J Comput Phys 229:498–511
60. Zubarev AY, Fleischer J, Odenbach S (2005) Towards a theory of dynamical properties of polydisperse magnetic fluids: effect of chain-like aggregates. Phys A (Amsterdam, Neth) 358:475–491