Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification

Acta Biomaterialia

Volumn 10, Issue 10, 2014, Pages 4247-4256

  Qi, Feng ^a,b   Wu, Jie ^a   Yang, Tingyuan ^a   Ma, Guanghui ^a,c   Su, Zhiguo ^a,c  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Collaborative Innovation Center of Chemical Science and Engineering   (China)

Author keywords

Controlled release; Exenatide; Microsphere; PLGA; SPG membrane emulsification

Indexed keywords

CONTROLLED DRUG DELIVERY; EMULSIFICATION; EVAPORATION; PARTICLE SIZE ANALYSIS; RELIABILITY ANALYSIS; SOLVENT EXTRACTION; SOLVENTS; TARGETED DRUG DELIVERY;

CONTROLLED RELEASE; EXENATIDE; IN-VITRO; MECHANISTIC STUDIES; POLY (DL-LACTIC-CO-GLYCOLIC ACID); POLY(DL-LACTIC-CO-GLYCOLIC ACID); PROPERTY; RELEASE BEHAVIORS; SOLVENT EVAPORATION; SPG MEMBRANE EMULSIFICATION;

MICROSPHERES;

EXENDIN 4; GLASS; GLUCOSE; MICROSPHERE; POLYGLACTIN; SOLVENT; ANTIDIABETIC AGENT; ARTIFICIAL MEMBRANE; DELAYED RELEASE FORMULATION; EMULSION; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DEGRADATION; DOSAGE SCHEDULE COMPARISON; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG STABILITY; EMULSION; EVAPORATION; GLUCOSE BLOOD LEVEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; RELIABILITY; SCANNING ELECTRON MICROSCOPY; SINGLE DRUG DOSE; SOLVENT EXTRACTION; SURFACE PROPERTY; ANIMAL; ARTIFICIAL MEMBRANE; CHEMISTRY; DELAYED RELEASE FORMULATION; MATERIALS TESTING; PHARMACOLOGY; POROSITY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; DELAYED-ACTION PREPARATIONS; EMULSIONS; GLASS; HYPOGLYCEMIC AGENTS; LACTIC ACID; MALE; MATERIALS TESTING; MEMBRANES, ARTIFICIAL; MICROSPHERES; POLYGLYCOLIC ACID; POROSITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84908074367     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.06.018     Document Type: Article

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