Magnetic particle hyperthermia - A promising tumour therapy?

Nanotechnology

Volumn 25, Issue 45, 2014, Pages

  Dutz, Silvio ^a,b   Hergt, Rudolf ^b  

^a ILMENAU UNIVERSITY OF TECHNOLOGY   (Germany)

^b LEIBNIZ INSTITUTE OF PHOTONIC TECHNOLOGY   (Germany)

Author keywords

hyperthermia; hysteresis; magnetic nanoparticles; magnetite; tumour therapy

Indexed keywords

MAGNETITE;

HYPERTHERMIA; MAGNETIC NANO-PARTICLES; MAGNETIC PARTICLE; TUMOUR THERAPIES;

HYSTERESIS;

MAGNETITE NANOPARTICLE;

HUMAN; HYPERTHERMIC THERAPY; NEOPLASMS; PARTICLE SIZE; PROCEDURES;

HUMANS; HYPERTHERMIA, INDUCED; MAGNETITE NANOPARTICLES; NEOPLASMS; PARTICLE SIZE;

EID: 84908299661     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/25/45/452001     Document Type: Review

References (231)

1. Adams J D and Soh H T 2009 Perspectives on utilizing unique features of microfl uidics technology for particle and cell sorting J. Lab. Autom. 14 331-40
2. Aharoni A 1996 Introduction to the Theory of Ferromagnetism (Oxford: Clarendon Press)
3. Alexiou C, Arnold W, Klein R J, Parak F G, Hulin P, Bergemann C, Erhardt W, Wagenpfeil S and Lubbe A S 2000 Locoregional cancer treatment with magnetic drug targeting Cancer Res. 60 6641-8 http://cancerres.aacrjournals.org/content/60/23/6641.full
4. Alphandery E, Chebbi I, Guyot F and Durand-Dubief M 2013 Use of bacterial magnetosomes in the magnetic hyperthermia treatment of tumours: a review Int. J. Hyperthermia 29 801-9
5. Alvarez-Berrios M P, Castillo A, Mendez J, Soto O, Rinaldi C and Torres-Lugo M 2013 Hyperthermic potentiation of cisplatin by magnetic nanoparticle heaters is correlated with an increase in cell membrane fluidity Int. J. Nanomed. 8 1003-13
6. Anderson P W 1950 Antiferromagnetismm - theory of superexchange interaction Phys. Rev. 79 350-6
7. Andra W, d'Ambly C G, Hergt R, Hilger I and Kaiser W A 1999 Temperature distribution as function of time around a small spherical heat source of local magnetic hyperthermia J. Magn. Magn. Mater. 194 197-203
8. Andrae W, Haefeli U O, Hergt R and Misri R 2007 Handbook of Magnetism and Advanced Magnetic Materials ed H Kronmueller and S S P Parkin (Chichester: Wiley) pp 2536-68
9. Andres Verges M, Costo R, Roca A G, Marco J F, Goya G F, Serna C J and Morales M P 2008 Uniform and water stable magnetite nanoparticles with diameters around the monodomain-multidomain limit J. Phys. D: Appl. Phys. 41 134003
10. Andreu I and Natividad E 2013 Accuracy of available methods for quantifying the heat power generation of nanoparticles for magnetic hyperthermia Int. J. Hyperthermia 29 739-51
11. Ardenne M V 1994 Principles and concept 1993 of the systemic cancer multistep therapy (SCMT) Strahlenther. Onkol. 170 581-9
12. Arruebo M, Valladares M and Gonzalez-Fernandez A 2009 Antibody-conjugated nanoparticles for biomedical applications J. Nanomater. 439389
13. Atkinson W J, Brezovich I A and Chakraborty D P 1984 Usable frequencies in hyperthermia with thermal seeds IEEE Trans. Biomed. Eng. 31 70-5
14. Attaluri A, Ma R, Qiu Y, Li W and Zhu L 2011 Nanoparticle distribution and temperature elevations in prostatic tumours in mice during magnetic nanoparticle hyperthermia Int. J. Hyperthermia 27 491-502
15. Bagaria H G and Johnson D T 2005 Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment Int. J. Hyperthermia 21 57-75
16. Bakoglidis K D, Simeonidis K, Sakellari D, Stefanou G and Angelakeris M 2012 Size-dependent mechanisms in AC magnetic hyperthermia response of iron-oxide nanoparticles IEEE Trans. Magn. 48 1320-3
17. Barry S E 2008 Challenges in the development of magnetic particles for therapeutic applications Int. J. Hyperthermia 24 451-66
18. Baumgartner J, Carillo M A, Eckes K M, Werner P and Faivre D 2014 Biomimetic magnetite formation: from biocombinatorial approaches to mineralization effects Langmuir 30 2129-36
19. Bazylinski D A and Frankel R B 2004 Magnetosome formation in prokaryotes Nat. Rev. Microbiol. 2 217-30
20. Bazylinski D A, Garrattreed A J and Frankel R B 1994 Electron-microscopic studies of magnetosomes in magnetotactic bacteria Microsc. Res. Tech. 27 389-401
21. Bellizzi G and Bucci O M 2010 On the optimal choice of the exposure conditions and the nanoparticle features in magnetic nanoparticle hyperthermia Int. J. Hyperthermia 26 389-403
22. Berkov D V 1996 Numerical simulations of quasistatic remagnetization processes in fine magnetic particle systems J. Magn. Magn. Mater. 161 337-56
23. Berret J F, Sandre O and Mauger A 2007 Size distribution of superparamagnetic particles determined by magnetic sedimentation Langmuir 23 2993-9
24. Bertotti G 1998 Hysteresis in Magnetism (New York: Academic)
25. Bhagat A A S, Kuntaegowdanahalli S S and Papautsky I 2008 Continuous particle separation in spiral microchannels using dean flows and differential migration Lab Chip 8 1906-14
26. Bordelon D E, Cornejo C, Gruttner C, Westphal F, DeWeese T L and Ivkov R 2011 Magnetic nanoparticle heating ef ficiency reveals magneto-structural differences when characterized with wide ranging and high amplitude alternating magnetic fields J. Appl. Phys. 109 1249041-8
27. Borgert J et al 2013 Perspectives on clinical magnetic particle imaging Biomed. Tech. 58 551-6
28. Borrelli N F, Luderer A A and Panzarino J N 1984 Hysteresis heating for the treatment of tumors Phys. Med. Biol. 29 487-94
29. Brezovich I A 1988 Low frequency hyperthermia Med. Phys. Monogr. 16 82-111
30. Brezovich I A and Young J H 1981 Hyperthermia with implanted electrodes Med. Phys. 8 79-84
31. Brown W F 1963 Thermal fluctuations of a single-domain particle Phys. Rev. 130 1677-86
32. Bulte J W, DeCuyper M, Despres D, Brooks R A, Jordan E K and Frank J A 1997 Short-versus long-circulating magnetoliposomes as bone marrow-seeking MR imaging contrast agents Radiology 205 1298
33. Busch C J 1866 Ein fluss heftiger Erysipeln auf organisierte Neubildungen Verhandlungen Des Naturhistorischen Vereins Der Preussischen Rheinlande und Westphalens ed C J Andrä (Bonn: Max Cohen und Sohn) pp 28-33
34. Carpino F, Zborowski M and Williams P S 2007 Quadrupole magnetic field-flow fractionation: a novel technique for the characterization of magnetic nanoparticles J. Magn. Magn. Mater. 311 383-7
35. Castro L L, da Silva M F, Bakuzis A F and Miotto R 2005 Aggregate formation on polydisperse ferrofluids: a Monte Carlo analysis J. Magn. Magn. Mater. 293 553-8
36. Cetas T C, Hevezi J M, Manning M R and Ozimek E J 1982 Cancer Therapy by Hyperthemia, Drugs, and Radiation (Bethesda, MD: National Cancer Institute) pp 505-7
37. Chanteau B, Fresnais J and Berret J F 2009 Electrosteric enhanced stability of functional sub-10 nm cerium and iron oxide particles in cell culture medium Langmuir 25 9064-70
38. Chantrell R W, Bradbury A, Popplewell J and Charles S W 1980 Particle cluster configuration in magnetic fluids J. Phys. D: Appl. Phys. 13 L119-22
39. Chatterjee J, Haik Y and Chen C J 2003 Size dependent magnetic properties of iron oxide nanoparticles J. Magn. Magn. Mater. 257 113-8
40. Chen G 1996 Nonlocal and nonequilibrium heat conduction in the vicinity of nanoparticles J. Heat Transfer 118 539-45
41. Coffey W T and Kalmykov Y P 2012 Thermal fluctuations of magnetic nanoparticles: fifty years after Brown J. Appl. Phys. 112
42. Coyle S T and Scheinfein M R 1998 Magnetic ordering in Co films on stepped Cu(100) surfaces J. Appl. Phys. 83 7040-2
43. Creixell M, Bohorquez A C, Torres-Lugo M and Rinaldi C 2011 EGFR-targeted magnetic nanoparticle heaters kill cancer cells without a perceptible temperature rise ACS Nano 5 7124-9
44. de la Presa P, Luengo Y, Multigner M, Costo R, Morales M P, Rivero G and Hernando A 2012 Study of heating efficiency as a function of concentration, size, and applied field in gamma-Fe2O3 nanoparticles J. Phys. Chem. C 116 25602-10
45. Debye P 1929 Polar Molecules (New York: Dover)
46. DeNardo S J, DeNardo G L, Miers L A, Natarajan A, Foreman A R, Gruettner C, Adamson G N and Ivkov R 2005 Development of tumor targeting bioprobes (In-111-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy Clin. Cancer Res. 11 7087S
47. DeNardo S J, DeNardo G L, Natarajan A, Miers L A, Foreman A R, Gruettner C, Adamson G N and Ivkov R 2007 Thermal dosimetry predictive of efficacy of In-111-ChL6 nanoparticle AMF-induced thermoablative therapy for human breast cancer in mice J. Nucl. Med. 48 437-44 http://jnm.snmjournals.org/content/48/3/437.full.pdf+html
48. Dennis C L, Jackson A J, Borchers J A, Hoopes P J, Strawbridge R, Foreman A R, van Lierop J, Gruttner C and Ivkov R 2009 Nearly complete regression of tumors via collective behavior of magnetic nanoparticles in hyperthermia Nanotechnology 20 395103
49. Dewey W C 1994 Arrhenius relationships from the molecule and cell to the clinic Int. J. Hyperthermia 10 457-83
50. Dewey W C 2009 Arrhenius relationships from the molecule and cell to the clinic Int. J. Hyperthermia 25 3-20
51. Dewhirst M W, Viglianti B L, Lora-Michiels M, Hanson M and Hoopes P J 2003 Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia Int. J. Hyperthermia 19 267-94
52. Doss J D 1975 Use of rf fields to produce hyperthermia in animal tumors Proc. Int. Symp. Cancer Therapy by Hyperthermia and Radiation pp 226-7
53. Douple E B, Strohbehn J W, Bowers E D and Walsh J E 1979 Cancer-therapy with localized hyperthermia using an invasive microwave system J. Microw. Power Electromagn. Energy 14 181-6
54. Dunin-Borkowski R E, McCartney M R, Posfai M, Frankel R B, Bazylinski D A and Buseck P R 2001 Off-axis electron holography of magnetotactic bacteria: magnetic microstructure of strains MV-1 and MS-1 Eur. J. Mineral. 13 671-84
55. Dunlop D J 1971 Magnetic properties of fi ne-particle hematite Ann. Geophys. 27 269
56. Dutz S, Andrae W, Hergt R, Mueller R, Oestreich C, Schmidt C, Toepfer J, Zeisberger M and Bellemann M E 2007 Influence of dextran coating on the magnetic behaviour of iron oxide nanoparticles J. Magn. Magn. Mater. 311 51-4
57. Dutz S, Clement J H, Eberbeck D, Gelbrich T, Hergt R, Mueller R, Wotschadlo J and Zeisberger M 2009 Ferrofluids of magnetic multicore nanoparticles for biomedical applications J. Magn. Magn. Mater. 321 1501-4
58. Dutz S, Hayden M E, Schaap A, Stoeber B and Haefeli U O 2012 A microfluidic spiral for size-dependent fractionation of magnetic microspheres J. Magn. Magn. Mater. 324 3791-8
59. Dutz S and Hergt R 2012 The role of interactions in systems of single domain ferrimagnetic iron oxide nanoparticles J. Nano-Electron. Phys. 4 20101-7
60. Dutz S and Hergt R 2013 Magnetic nanoparticle heating and heat transfer on a microscale: basic principles, realities and physical limitations of hyperthermia for tumour therapy Int. J. Hyperthermia 29 790-800
61. Dutz S, Hergt R, Muerbe J, Mueller R, Zeisberger M, Andrae W, Toepfer J and Bellemann M E 2007 Hysteresis losses of magnetic nanoparticle powders in the single domain size range J. Magn. Magn. Mater. 308 305-12
62. Dutz S, Hergt R, Murbe J, Topfer J, Muller R, Zeisberger M, Andra W and Bellemann M E 2006 Magnetic nanoparticles for biomedical heating applications Z. Phys. Chem. 220 145-51
63. Dutz S, Kettering M, Hilger I, Muller R and Zeisberger M 2011 Magnetic multicore nanoparticles for hyperthermia-influence of particle immobilization in tumour tissue on magnetic properties Nanotechnology 22 265102
64. Dutz S, Kuntsche J, Eberbeck D, Muller R and Zeisberger M 2012 Asymmetric flow field-flow fractionation of superferrimagnetic iron oxide multicore nanoparticles Nanotechnology 23 355701
65. Eberbeck D, Dennis C L, Huls N F, Krycka K L, Gruttner C and Westphal F 2013 Multicore magnetic nanoparticles for magnetic particle imaging IEEE Trans. Magn. 49 269-74
66. Eberbeck D and Trahms L 2011 Experimental investigation of dipolar interaction in suspensions of magnetic nanoparticles J. Magn. Magn. Mater. 323 1228-32
67. Eggeman A S, Majetich S A, Farrell D and Pankhurst Q A 2007 Size and concentration effects on high frequency hysteresis of iron oxide nanoparticles IEEE Trans. Magn. 43 2451-3
68. Falk M H and Issels R D 2001 Hyperthermia in oncology Int. J. Hyperthermia 17 1-18
69. Ferrari R et al 2014 Integrated multiplatform method for in vitro quantitative assessment of cellular uptake for fluorescent polymer nanoparticles Nanotechnology 25 045102
70. Folkman J 1985 Tumor angiogenesis Adv. Cancer Res. 43 175-203
71. Fortin J-P, Wilhelm C, Servais J, Menager C, Bacri J-C and Gazeau F 2007 Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia J. Am. Chem. Soc. 129 2628-35
72. Garanin D A and Kachkachi H 2003 Surface contribution to the anisotropy of magnetic nanoparticles Phys. Rev. Lett. 90 655041-4
73. Gerber R 1984 Magnetic filtration of ultra-fine particles IEEE Trans. Magn. 20 1159-64
74. Gilchrist R K, Medal R, Shorey W D, Hanselman R C, Parrott J C and Taylor C B 1957 Selective inductive heating of lymph nodes Ann. Surg. 146 596-606
75. Giordano M A, Gutierrez G and Rinaldi C 2010 Fundamental solutions to the bioheat equation and their application to magnetic fluid hyperthermia Int. J. Hyperthermia 26 475-84
76. Gleich B and Weizenecker R 2005 Tomographic imaging using the nonlinear response of magnetic particles Nature 435 1214-7
77. Gloeckl G, Hergt R, Zeisberger M, Dutz S, Nagel S and Weitschies W 2006 The effect of field parameters, nanoparticle properties and immobilization on the specific heating power in magnetic particle hyperthermia J. Phys.: Condens. Matter 18 S2935-49
78. Gneveckow U, Jordan A, Scholz R, Bruss V, Waldofner N, Ricke J, Feussner A, Hildebrandt B, Rau B and Wust P 2004 Description and characterization of the novel hyperthermiaand thermoablation-system MFH (R) 300F for clinical magnetic fluid hyperthermia Med. Phys. 31 1444-51
79. Gneveckow U, Jordan A, Scholz R, Eckelt L, Maier-Hauff K, Johannsen M and Wust P 2005 Magnetic force nanotherapy Biomed. Tech. (Berlin) 50 92-3
80. Golneshan A A and Lahonian M 2011 The effect of magnetic nanoparticle dispersion on temperature distribution in a spherical tissue in magnetic fluid hyperthermia using the lattice boltzmann method Int. J. Hyperthermia 27 266-74
81. Gonzales-Weimuller M, Zeisberger M and Krishnan K M 2009 Size-dependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia J. Magn. Magn. Mater. 321 1947-50
82. Gordon R T, Hines J R and Gordon D 1979 Intracellular hyperthermia - biophysical approach to cancer-treatment via intracellular temperature and biophysical alterations Med. Hypotheses 5 83-102
83. Goya G F, Asin L and Ibarra M R 2013 Cell death induced by ac magnetic fields and magnetic nanoparticles: current state and perspectives Int. J. Hyperthermia 29 810-8
84. Gruettner C, Mueller K, Teller J and Westphal F 2013 Synthesis and functionalisation of magnetic nanoparticles for hyperthermia applications Int. J. Hyperthermia 29 777-89
85. Gruettner C, Mueller K, Teller J, Westphal F, Foreman A and Ivkov R 2007 Synthesis and antibody conjugation of magnetic nanoparticles with improved speci fic power absorption rates for alternating magnetic field cancer therapy J. Magn. Magn. Mater. 311 181-6
86. Hall E J and Giaccia A J Radiobiology for the Radiologist Seventh Ed. (Phildelphia PA: Lippincott Williams and Wilkins)
87. Hamad-Schifferli K, Schwartz J J, Santos A T, Zhang S G and Jacobson J M 2002 Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna Nature 415 152-5
88. Handy E, Ivkov R, Ellis-Busby D, Foreman A, Braunhut S, Gwost D and Ardman B 2003 Thermotherapy via targeted delivery of nanoscale magnetic particles US Patent Appl. Publ. US2003/0032995
89. Hanggi P, Talkner P and Borkovec M 1990 Reaction-rate theory - 50 years after kramers Rev. Mod. Phys. 62 251-341
90. Hao Y L and Teja A S 2003 Continuous hydrothermal crystallization of alpha-Fe2O3 and Co3O4 nanoparticles J. Mater. Res. 18 415-22
91. Harvey P R and Katznelson E 1999 Modular gradient coil: a new concept in high-performance whole-body gradient coil design Magn. Reson. Med. 42 561-70
92. Hasany S F, Abdurahman N H, Sunarti A R and Jose R 2013 Magnetic iron oxide nanoparticles: chemical synthesis and applications review Curr. Nanosci. 9 561-75
93. Hedayati M et al 2013 The effect of cell cluster size on intracellular nanoparticle-mediated hyperthermia: is it possible to treat microscopic tumors? Nanomedicine 8 29-41
94. Heider F, Dunlop D J and Sugiura N 1987 Magnetic-properties of hydrothermally recrystallized magnetite crystals Science 236 1287-90
95. Hendriksen P V, Linderoth S and Lindgard P A 1993 Finite-size modification of the magnetic properties of clusters Phys. Rev. B 48 7259-73
96. Hergt R, Andra W, d'Ambly C G, Hilger I, Kaiser W A, Richter U and Schmidt H G 1998 Physical limits of hyperthermia using magnetite fine particles IEEE Trans. Magn. 34 3745-54
97. Hergt R and Dutz S 2007 Magnetic particle hyperthermia-biophysical limitations of a visionary tumour therapy J. Magn. Magn. Mater. 311 187-92
98. Hergt R, Dutz S and Roeder M 2008 Effects of size distribution on hysteresis losses of magnetic nanoparticles for hyperthermia J. Phys.: Condens. Matter 20 385214
99. Hergt R, Dutz S and Zeisberger M 2010 Validity limits of the Néel relaxation model of magnetic nanoparticles for hyperthermia Nanotechnology 21 015706
100. Hergt R, Hiergeist R, Hilger I, Kaiser W A, Lapatnikov Y, Margel S and Richter U 2004 Maghemite nanoparticles with very high ac-losses for application in RF-magnetic hyperthermia J. Magn. Magn. Mater. 270 345-57
101. Hergt R, Hiergeist R, Zeisberger M, Schuler D, Heyen U, Hilger I and Kaiser W A 2005 Magnetic properties of bacterial magnetosomes as potential diagnostic and therapeutic tools J. Magn. Magn. Mater. 293 80-6
102. Hiergeist R, Andra W, Buske N, Hergt R, Hilger I, Richter U and Kaiser W 1999 Application of magnetite ferrofluids for hyperthermia J. Magn. Magn. Mater. 201 420-2
103. Hildebrandt B, Wust P, Ahlers O, Dieing A, Sreenivasa G, Kerner T, Felix R and Riess H 2002 The cellular and molecular basis of hyperthermia Crit. Rev. Oncol. Hematol. 43 33-56
104. Hilger I, Andra W, Hergt R, Hiergeist R and Kaiser W A 2005 Magnetic thermotherapy of breast tumors: an experimental therapeutic approach Rofo-Fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren 177 507-15
105. Hilger I, Andra W, Hergt R, Hiergeist R, Schubert H and Kaiser W A 2001 Electromagnetic heating of breast tumors in interventional radiology: in vitro and in vivo studies in human cadavers and mice Radiology 218 570-5
106. Hilger I, Hergt R and Kaiser W A 2000 Effects of magnetic thermoablation in muscle tissue using iron oxide particles - an in vitro study Invest. Radiol. 35 170-9
107. Hilger I, Hiergeist R, Hergt R, Winnefeld K, Schubert H and Kaiser W A 2002 Thermal ablation of tumors using magnetic nanoparticles-an in vivo feasibility study Invest. Radiol. 37 580-6
108. Huang H, Delikanli S, Zeng H, Ferkey D M and Pralle A 2010 Remote control of ion channels and neurons through magnetic-field heating of nanoparticles Nat. Nanotechnology 5 602-6
109. Huehn D et al 2013 Polymer-coated nanoparticles interacting with proteins and cells: focusing on the sign of the net charge Acs Nano 7 3253-63
110. Hugounenq P et al 2012 Iron oxide monocrystalline nanoflowers for highly efficient magnetic hyperthermia J. Phys. Chem. 116 15702-12
111. Huh D, Bahng J H, Ling Y B, Wei H H, Kripfgans O D, Fowlkes J B, Grotberg J B and Takayama S 2007 Gravity-driven microfluidic particle sorting device with hydrodynamic separation amplification Anal. Chem. 79 1369-76
112. Hyeon T, Lee S S, Park J, Chung Y and Bin Na H 2001 Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process J. Am. Chem. Soc. 123 12798-801
113. Hynynen K, Deyoung D, Kundrat M and Moros E 1989 The effect of blood perfusion rate on the temperature distributions induced by multiple, scanned and focused ultrasonic beams in dogs kidneys invivo Int. J. Hyperthermia 5 485-97
114. Ito A, Shinkai M, Honda H and Kobayashi T 2005 Medical application of functionalized magnetic nanoparticles J. Biosci. Bioeng. 100 1-11
115. Janko C, Duerr S, Munoz L E, Lyer S, Chaurio R, Tietze R, von Loehneysen S, Schorn C, Herrmann M and Alexiou C 2013 Magnetic drug targeting reduces the chemotherapeutic burden on circulating leukocytes Int. J Mol Sci. 14 7341-55
116. Jeun M, Lee S, Kang J K, Tomitaka A, Kang K W, Kim Y I, Takemura Y, Chung K W, Kwak J and Bae S 2012 Physical limits of pure superparamagnetic Fe3O4 nanoparticles for a local hyperthermia agent in nanomedicine Appl. Phys. Lett. 100 924061-4
117. Johannsen M, Gneueckow U, Thiesen B, Taymoorian K, Cho C H, Waldofner N, Scholz R, Jordan A, Loening S A and Wust P 2007 Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and threedimensional temperature distribution Eur. Urol. 52 1653-62
118. Johannsen M, Gneveckow U, Taymoorian K, Thiesen B, Waldoefner N, Scholz R, Jung K, Jordan A, Wust P and Loening S A 2007 Morbidity and quality of life during thermotherapy using magnetic nanoparticles in locally recurrent prostate cancer: results of a prospective phase I trial Int. J. Hyperthermia 23 315-23
119. Johannsen M, Thiesen B, Wust P and Jordan A 2010 Magnetic nanoparticle hyperthermia for prostate cancer Int. J. Hyperthermia 26 790-5
120. Jordan A, Scholz R, Wust P, Fahling H, Krause J, Wlodarczyk W, Sander B, Vogl T and Felix R 1997 Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo Int. J. Hyperthermia 13 587-605
121. Jordan A, Scholz R, Wust P, Schirra H, Schiestel T, Schmidt H and Felix R 1999 Endocytosis of dextran and silan-coated magnetite nanoparticles and the effect of intracellular hyperthermia on human mammary carcinoma cells in vitro J. Magn. Magn. Mater. 194 185-96
122. Kalambur V S, Longmire E K and Bischof J C 2007 Cellular level loading and heating of superparamagnetic iron oxide nanoparticles Langmuir 23 12329-36
123. Kallumadil M, Tada M, Nakagawa T, Abe M, Southern P and Pankhurst Q A 2009 Suitability of commercial colloids for magnetic hyperthermia J. Magn. Magn. Mater. 321 1509-13
124. Keblinski P, Cahill D G, Bodapati A, Sullivan C R and Taton T A 2006 Limits of localized heating by electromagnetically excited nanoparticles J. Appl. Phys. 100 543051-5
125. Khalafalla S E and Reimers G W 1980 Preparation of dilution-stable aqueous magnetic fluids IEEE Trans. Magn. 16 178-83
126. Khandhar A P, Ferguson R M, Simon J A and Krishnan K M 2012 Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia J. Appl. Phys. 111 7B3061
127. Kim D-H, Rozhkova E A, Ulasov I V, Bader S D, Rajh T, Lesniak M S and Novosad V 2010 Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction Nat. Mater. 9 165-71
128. Kotitz R, Fannin P C and Trahms L 1995 Time-domain study of brownian and neel relaxation in ferrofluids J. Magn. Magn. Mater. 149 42-6
129. Kronmueller H and Faehnle M 2003 Micromagnetism and the Microstructure of Ferromagnetic Solids (Cambridge: Cambridge University Press)
130. Kurland H-D, Grabow J, Staupendahl G, Andrae W, Dutz S and Bellemann M E 2007 Magnetic iron oxide nanopowders produced by CO2 laser evaporation J. Magn. Magn. Mater. 311 73-7
131. 2 laser evaporation - 'in situ' coating and particle embedding in a ceramic matrix J. Magn. Magn. Mater. 321 1381-5
132. LaConte L, Nitin N and Bao G 2005 Magnetic nanoparticle probes Nanotoday 8 32-8
133. Landau L D and Lifshitz E M 1960 Electrodynamics of Continuous Media (London: Pergamon)
134. Langevin D 1992 Micelles and microemulsiond Annu. Rev. Phys. Chem. 43 341-69
135. Lapresta-Fernandez A, Doussineau T, Dutz S, Steiniger F, Moro A J and Mohr G J 2011 Magnetic and fluorescent core-shell nanoparticles for ratiometric pH sensing Nanotechnology 22 415501
136. Lapresta-Fernandez A, Doussineau T, Moro A J, Dutz S, Steiniger F and Mohr G J 2011 Magnetic core-shell fluorescent pH ratiometric nanosensor using a stober coating method Anal. Chim. Acta 707 164-70
137. Lartigue L, Hugounenq P, Alloyeau D, Clarke S P, Levy M, Bacri J-C, Bazzi R, Brougham D F, Wilhelm C and Gazeau F 2012 Cooperative organization in iron oxide multi-core nanoparticles potentiates their efficiency as heating mediators and MRI contrast agents ACS Nano 6 10935-49
138. Laurell T, Petersson F and Nilsson A 2007 Chip integrated strategies for acoustic separation and manipulation of cells and particles Chem. Soc. Rev. 36 492-506
139. Laurent S, Burtea C, Thirifays C, Rezaee F and Mahmoudi M 2013 Significance of cell 'observer' and protein source in nanobiosciences J. Colloid Interface Sci. 392 431-45
140. Laurent S, Forge D, Port M, Roch A, Robic C, Elst L V and Muller R N 2008 Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications Chem. Rev. 108 2064-110
141. Leveen H H, Wapnick S, Piccone V, Falk G and Ahmed N 1976 Tumor eradication by radiofrequency therapy - response in 21 patients J. Am. Med. Assoc. 235 2198-200
142. Levy M et al 2011 Correlating magneto-structural properties to hyperthermia performance of highly monodisperse iron oxide nanoparticles prepared by a seeded-growth route Chem. Mater. 23 4170-80
143. Li Z, Kawashita M, Araki N, Mitsumori M, Hiraoka M and Doi M 2011 Preparation of magnetic iron oxide nanoparticles for hyperthermia of cancer in a FeCl2-NaNO3-NaOH aqueous system J. Biomater. Appl. 25 643-61
144. Lohrke J, Briel A and Maeder K 2008 Characterization of superparamagnetic iron oxide nanoparticles by asymmetrical flow-field-flow-fractionation Nanomedicine 3 437-52
145. Lubbe A S et al 1996 Clinical experiences with magnetic drag targeting: a phase I study with 4′-epidoxorubicin in 14 patients with advanced solid tumors Cancer Res. 56 4686-93 http://cancerres.aacrjournals.org/content/56/20/4686.full.pdf+html
146. Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T and Dawson K A 2008 Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts Proc. Natl. Acad. Sci. USA 105 14265-70
147. Magforce A G press release, 31 March 2014 (available at: www.magforce.de/presse-investoren/news-events/detail/article/einschluss-des-ersten-patienten-in-der-glioblastom-studie-mf-1001-im-universitaetsklinikum-muenster.html)
148. Mahmoudi M et al 2013 Temperature: the 'Ignored' factor at the nanobio interface Acs Nano 7 6555-62
149. Maier-Hauff K, Ulrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H, Budach V and Jordan A 2011 Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme J. Neurooncol. 103 317-24
150. Massart R 1980 Preparation of aqueous ferrofluids without using surfactant - behavior as a function of the pH and the counterions C. R. Hebd. Seances Acad. Sci. C 291 1-3
151. Mee C D and Daniel E D 1996 Magnetic Recording Technology McGraw-Hill) (NewYork:
152. Mi Y, Liu X, Zhao J, Ding J and Feng S-S 2012 Multimodality treatment of cancer with herceptin conjugated, thermomagnetic iron oxides and docetaxel loaded nanoparticles of biodegradable polymers Biomaterials 33 7519-29
153. Milne G, Rhodes D, MacDonald M and Dholakia K 2007 Fractionation of polydisperse colloid with acousto-optically generated potential energy landscapes Opt. Lett. 32 1144-6
154. Moras K, Schaarschuch R, Riehemann W, Zinoveva S, Modrow H and Eberbeck D 2005 Production and characterisation of magnetic nanoparticles produced by laser evaporation for ferrofluids J. Magn. Magn. Mater. 293 119-26
155. Moroz P, Jones S K and Gray B N 2002 Magnetically mediated hyperthermia: current status and future directions Int. J. Hyperthermia 18 267-84
156. Mueller R, Dutz S, Habisreuther T and Zeisberger M 2011 Investigations on magnetic particles prepared by cyclic growth J. Magn. Magn. Mater. 323 1223-7
157. Mueller R, Dutz S, Neeb A, Cato A C B and Zeisberger M 2013 Magnetic heating effect of nanoparticles with different sizes and size distributions J. Magn. Magn. Mater. 328 80-5
158. Muerbe J, Rechtenbach A and Toepfer J 2008 Synthesis and physical characterization of magnetite nanoparticles for biomedical applications Mater. Chem. Phys. 110 426-33
159. Mustin B and Stoeber B 2010 Deposition of particles from polydisperse suspensions in microfluidic systems Microfluid. Nanofluid. 9 905-13
160. Néel L 1949 Influence des fluctuations thermiques a l'aimantation des particules ferromagnetiques C.R. Dir. Rec. Sci. 228 664-8
161. Niira K 1960 Temperature dependence of the magnetization of dysprosium metal Phys. Rev. 117 129-33
162. Nikolajski M, Wotschadlo J, Clement J H and Heinze T 2012 Amino-functionalized cellulose nanoparticles: preparation, characterization, and interactions with living cells Macromol. Biosci. 12 920-5
163. Nyborg W L 1988 Solutions of the bio-heat transfer equation Phys. Med. Biol. 33 785-92
164. Odenbach S 2002 Ferrofluids - Magnetically Controllable Fluids and their Applications; (Lecture notes in Physics) (Berlin: Springer) Bd594
165. Okabe K, Inada N, Gota C, Harada Y, Funatsu T and Uchiyama S 2012 Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopy Nat. Commun. 3 705
166. Okoli C, Sanchez-Dominguez M, Boutonnet M, Jaras S, Civera C, Solans C and Kuttuva G R 2012 Comparison and functionalization study of microemulsion-prepared magnetic iron oxide nanoparticles Langmuir 28 8479-85
167. Orte A, Alvarez-Pez J M and Ruedas-Rama M J 2013 Fluorescence lifetime imaging microscopy for the detection of intracellular pH with quantum dot nanosensors Acs Nano 7 6387-95
168. Ortega D and Pankhurst Q A 2013 Nanoscience ed P O'Brien (Cambridge: Royal Society of Chemistry) pp 60-88
169. Osuna J, deCaro D, Amiens C, Chaudret B, Snoeck E, Respaud M, Broto J M and Fert A 1996 Synthesis, characterization, and magnetic properties of cobalt nanoparticles from an organometallic precursor J. Phys. Chem. 100 14571-4
170. Pamme N 2007 Continuous flow separations in microfluidic devices Lab Chip 7 1644-59
171. Pamme N, Eijkel J C T and Manz A 2006 On-chip free-flow magnetophoresis: Separation and detection of mixtures of magnetic particles in continuous flow J. Magn. Magn. Mater. 307 237-44
172. Pankhurst Q A, Thanh N T K, Jones S K and Dobson J 2009 Progress in applications of magnetic nanoparticles in biomedicine J. Phys. D: Appl. Phys. 42 224001
173. Park J et al 2005 One-nanometer-scale size-controlled synthesis of monodisperse magnetic iron oxide nanoparticles Angew. Chem.-Int. Ed. 44 2872-7
174. Petrosyan A K and Mirzakhanyan A A 1986 Zero-field splitting and G-values of D8 ions in a trigonal crystal-field Phys. Status Solidi b 133 315-9
175. Petryk A A, Giustini A J, Gottesman R E, Kaufman P A and Hoopes P J 2013 Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment Int. J. Hyperthermia 29 845-51
176. Pollert E and Záveta K 2012 Magnetic Nanoparticles: From Fabrication to Clinical Applications ed N T K Thanh (London: CRC Press) pp 449-79
177. Rabin Y 2002 Is intracellular hyperthermia superior to extracellular hyperthermia in the thermal sense? Int. J. Hyperthermia 18 194-202
178. Rand R W, Snow H D, Elliott D G and Haskins G M 1985 Induction heating method for use in causing necrosis of Neoplasm. US Patent 4.545.368
179. Reilly J P 1998 Applied Bioelectricity: From Electrical Stimulation to Electro Pathology (New York: Springer)
180. Richter H, Kettering M, Wiekhorst F, Steinhoff U, Hilger I and Trahms L 2010 Magnetorelaxometry for localization and quantification of magnetic nanoparticles for thermal ablation studies Phys. Med. Biol. 55 623-33
181. Riedinger A, Guardia P, Curcio A, Garcia M A, Cingolani R, Manna L and Pellegrino T 2013 Subnanometer local temperature probing and remotely controlled drug release based on azo-functionalized iron oxide nanoparticles Nano Lett. 13 2399-406
182. Robins H I et al 1997 Phase I clinical trial of melphalan and 41.8 degrees C whole-body hyperthermia in cancer patients J. Clin. Oncol. 15 158-64 http://jco.ascopubs.org/content/15/1/158.full.pdf+html
183. Rodrigues H F, Mello F M, Branquinho L C, Zufelato N, Silveira-Lacerda E P and Bakuzis A F 2013 Real-time infrared thermography detection of magnetic nanoparticle hyperthermia in a murine model under a non-uniform field configuration Int. J. Hyperthermia 29 752-67
184. Rodrigues P A M, Yu P Y, Tamulaitis G and Risbud S H 1996 Laser-induced heating of nanocrystals embedded in glass matrices J. Appl. Phys. 80 5963-6
185. Roggan A, Beuthan J, Schruender S and Mueller G 1999 Diagnostik und therapie mit dem laser Phys. Bl. 55 25-30
186. Rosensweig R E 2002 Heating magnetic fluid with alternating magnetic field J. Magn. Magn. Mater. 252 370-4
187. Salazar-Alvarez G et al 2008 Cubic versus spherical magnetic nanoparticles: the role of surface anisotropy J. Am. Chem. Soc. 130 13234-9
188. Salloum M, Ma R and Zhu L 2009 Enhancement in treatment planning for magnetic nanoparticle hyperthermia: optimization of the heat absorption pattern Int. J. Hyperthermia 25 309-21
189. Schaller V, Wahnstrom G, Sanz-Velasco A, Enoksson P and Johansson C 2009 Monte Carlo simulation of magnetic multi-core nanoparticles J. Magn. Magn. Mater. 321 1400-3
190. Schaller V, Wahnstrom G, Sanz-Velasco A, Gustafsson S, Olsson E, Enoksson P and Johansson C 2009 Effective magnetic moment of magnetic multicore nanoparticles Phys. Rev. B 80 924061-4
191. Scheffel A, Gruska M, Faivre D, Linaroudis A, Plitzko J M and Schuler D 2006 An acidic protein aligns magnetosomes along a filamentous structure in magnetotactic bacteria Nature 440 110-4
192. Schueler D 1999 Formation of magnetosomes in magnetotactic bacteria J. Mol. Microbiol. Biotechnol. 1 79-86
193. Schueler D and Frankel R B 1999 Bacterial magnetosomes: microbiology, biomineralization and biotechnological applications Appl. Microbiol. Biotechnol. 52 464-73
194. Schweiger C, Hartmann R, Zhang F, Parak W J, Kissel T H and Rivera Gil P 2012 Quantification of the internalization patterns of superparamagnetic iron oxide nanoparticles with opposite charge J. Nanobiotechnol. 10 28
195. Serantes D et al 2010 Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles J. Appl. Phys. 108 073918
196. Shliomis M I and Stepanov V I 1994 Theory of dynamic susceptibility of magnetic fluids Adv. Chem. Phys. 87 1-30
197. Smistrup K, Hansen O, Bruus H and Hansen M F 2005 Magnetic separation in microfluidic systems using microfabricated electromagnets-experiments and simulations J. Magn. Magn. Mater. 293 597-604
198. Sollier E, Rostaing H, Pouteau P, Fouillet Y and Achard J L 2009 Passive microfluidic devices for plasma extraction from whole human blood Sensors Actuators B 141 617-24
199. Sonnenschein R and Gross J 1986 Temperature field computation for radiofrequency heating of deep-seated tumors Recent Results Cancer Res. 101 132-7
200. Stiller W 1989 Arrhenius Equation and Non-Equilibrium Kinetics, in Teubner: Texte Zur Physik, Band 21 (Weinheim: VCH)
201. Stoetzel C, Kurland H-D, Grabow J, Dutz S, Mueller E, Sierka M and Mueller F A 2013 Control of the crystal phase composition of FexOy nanopowders prepared by CO2 laser vaporization Cryst. Growth Des. 13 4868-76
202. Stoner E C and Wohlfarth E P 1948 A mechanism of magnetic hysteresis in heterogeneous alloys Phil. Trans. R. Soc. A 240 599-642
203. Strohbehn J W, Bowers E D, Walsh J E and Douple E B 1979 Invasive microwave antenna for locally-induced hyperthermia for cancer-therapy J. Microw. Power Electromagn. Energy 14 339-50
204. Tartaj P, Morales M D, Veintemillas-Verdaguer S, Gonzalez-Carreno T and Serna C J 2003 The preparation of magnetic nanoparticles for applications in biomedicine J. Phys. D: Appl. Phys. 36 R182-97
205. Taupitz M, Schmitz S and Hamm B 2003 Superparamagnetic iron oxide particles: current state and future development Rofo-Fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren 175 752-65
206. Taylor L S 1980 Implantable radiators for cancer-therapy by microwave hyperthermia Proc. IEEE 68 142-9
207. Tenzer S et al 2011 Nanoparticle size is a critical physicochemical determinant of the human blood plasma corona: a comprehensive quantitative proteomic analysis Acs Nano 5 7155-67
208. Thiesen B and Jordan A 2008 Clinical applications of magnetic nanoparticles for hyperthermia Int. J. Hyperthermia 24 467-74
209. Thomas L A, Dekker L, Kallumadil M, Southern P, Wilson M, Nair S P, Pankhurst Q A and Parkin I P 2009 Carboxylic acid-stabilised iron oxide nanoparticles for use in magnetic hyperthermia J. Mater. Chem. 19 6529-35
210. Thrall D E et al 2012 Thermal dose fractionation affects tumour physiological response Int. J. Hyperthermia 28 431-40
211. Thurm S and Odenbach S 2002 Magnetic separation of ferrofluids J. Magn. Magn. Mater. 252 247-9
212. Timko M et al 2013 Hyperthermic effect in suspension of magnetosomes prepared by various methods IEEE Trans. Magn. 49 250-4
213. Toraya-Brown S, Sheen M R, Baird J R, Barry S, Demidenko E, Turk M J, Hoopes P J, Conejo-Garcia J R and Fiering S 2013 Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy Integr. Biol. 5 159-71
214. Urtizberea A, Natividad E, Arizaga A, Castro M and Mediano A 2010 Specific absorption rates and magnetic properties of ferrofluids with interaction effects at low concentrations J. Phys. Chem. C 114 4916-22
215. van der Zee J 2002 Heating the patient: a promising approach? Ann. Oncol. 13 1173-84
216. Veiseh O, Kievit F M, Gunn J W, Ratner B D and Zhang M 2009 A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells Biomaterials 30 649-57
217. Wang H, Li X, Xi X, Hu B, Zhao L, Liao Y and Tang J 2011 Effects of magnetic induction hyperthermia and radiotherapy alone or combined on a murine 4T1 metastatic breast cancer model Int. J. Hyperthermia 27 563-72
218. Weissleder R, Stark D D, Engelstad B L, Bacon B R, Compton C C, White D L, Jacobs P and Lewis J 1989 Superparamagnetic iron-oxide - pharmacokinetics and toxicity Am. J. Roentgenol. 152 167-73
219. Witt A, Fabian K and Bleil U 2005 Three-dimensional micromagnetic calculations for naturally shaped magnetite: octahedra and magnetosomes Earth Planet. Sci. Lett. 233 311-24
220. Wotschadlo J et al 2009 Magnetic nanoparticles coated with carboxymethylated polysaccharide shells - Interaction with human cells J. Magn. Magn. Mater. 321 1469-73
221. Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, Felix R and Schlag P M 2002 Hyperthermia in combined treatment of cancer Lancet Oncol. 3 487-97
222. Xu C and Teja A S 2008 Continuous hydrothermal synthesis of iron oxide and PVA-protected iron oxide nanoparticles J. Supercrit. Fluids 44 85-91
223. Yamada K et al 2010 Minimally required heat doses for various tumour sizes in induction heating cancer therapy determined by computer simulation using experimental data Int. J. Hyperthermia 26 465-74
224. Yamada M and Seki M 2005 Hydrodynamic filtration for onchip particle concentration and classification utilizing microfluidics Lab Chip 5 1233-9
225. Yang J-M, Yang H and Lin L 2011 Quantum dot nano thermometers reveal heterogeneous local thermogenesis in living cells ACS Nano 5 5067-71
226. Yuan Y and Borca-Tasciuc D-A 2013 Anomalously high specific absorption rate in bioaffine ligand-coated iron oxide nanoparticle suspensions IEEE Trans. Magn. 49 263-8
227. Yuan Y, Rende D, Altan C L, Bucak S, Ozisik R and Borca-Tasciuc D-A 2012 Effect of surface modifi cation on magnetization of iron oxide nanoparticle colloids Langmuir 28 13051-9
228. Zborowski M, Sun L P, Moore L R, Williams P S and Chalmers J J 1999 Continuous cell separation using novel magnetic quadrupole flow sorter J. Magn. Magn. Mater. 194 224-30
229. Zeisberger M, Dutz S, Lehnert J and Muller R 2009 Measurement of the distribution parameters of size and magnetic properties of magnetic nanoparticles for medical applications J. Phys.: Conf. Ser. 149 012115
230. Zeng Q, Baker I, Loudis J A, Liao Y, Hoopes P J and Weaver J B 2007 Fe/Fe oxide nanocomposite particles with large speci fic absorption rate for hyperthermia Appl. Phys. Lett. 90 233112
231. Zhang J, Dewilde A H, Chinn P, Foreman A, Barry S, Kanne D and Braunhut S J 2011 Herceptindirected nanoparticles activated by an alternating magnetic field selectively kill HER-2 positive human breast cells in vitro via hyperthermia Int. J. Hyperthermia 27 682-97