Identification of preferential CD4+ T-cell targets for HIV infection in the cervix

Mucosal Immunology

Volumn 9, Issue 1, 2016, Pages 1-12

  Joag, V R ^a   McKinnon, L R ^a,b   Liu, J ^a   Kidane, S T ^a   Yudin, M H ^c   Nyanga, B ^d   Kimwaki, S ^d   Besel, K E ^c   Obila, J O ^e   Huibner, S ^a   Oyugi, J O ^d,f   Arthos, J ^g   Anzala, O ^d,e   Kimani, J ^f   Ostrowski, M A ^a,h   Kaul, R ^a,i  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF NAIROBI   (Kenya)

^e Kenyan AIDS Vaccine Initiative   (Kenya)

^f UNIVERSITY OF MANITOBA   (Canada)

^g NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^h ST MICHAEL'S HOSPITAL   (Canada)

ⁱ UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 140; KI 67 ANTIGEN; MARAVIROC; VERY LATE ACTIVATION ANTIGEN 4; CCR5 PROTEIN, HUMAN; GP140 ENVELOPE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; INTEGRIN; INTEGRIN ALPHA4BETA7; LECTIN; LEUKOCYTE ANTIGEN; T LYMPHOCYTE ANTIGEN; VIRUS ENVELOPE PROTEIN; VIRUS RECEPTOR;

ADULT; ARTICLE; BINDING AFFINITY; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MAJOR CLINICAL STUDY; MUCOSAL IMMUNITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; STOICHIOMETRY; UTERINE CERVIX; VIRUS ENTRY; ANTIBODY SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; MIDDLE AGED; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; VIROLOGY;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CERVIX UTERI; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; FEMALE; GENE EXPRESSION REGULATION; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, MUCOSAL; INTEGRIN ALPHA4BETA1; INTEGRINS; LECTINS, C-TYPE; MIDDLE AGED; ORGAN SPECIFICITY; PRIMARY CELL CULTURE; RECEPTORS, CCR5; RECEPTORS, VIRUS; SIGNAL TRANSDUCTION; VIRUS INTERNALIZATION;

EID: 84953214538     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2015.28     Document Type: Article

References (45)

1. UNAIDS. Global report: UNAIDS report on the globalAIDS epidemic. 1-110 (2012
2. Haase, A.T. Perils at mucosal front lines for HIV and SIV and their hosts. Nat. Rev. Immunol. 5, 783-792 (2005
3. Hladik F., & McElrath, M.J. Setting the stage: host invasion byHIV. Nat. Rev. Immunol. 8, 447-457 (2008
4. McKinnon L.R., & Kaul, R. Quality and quantity: mucosal CD4+ T cells and HIV susceptibility. Curr. Opin. HIV AIDS 7, 195-202 (2012
5. Passmore, J.S.Genital tract inflammationandsusceptibility to HIVinfectionin women fromthe CAPRISA 004 microbicide trial of tenofovir gel (Webcast at: http://aidsvac.capitalreach.com/console/player/19096?mediaType=audio. In: AIDS Vaccine 2012. Boston, MA: 2012
6. Levinson P., et al. Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. AIDS 23, 309-317 (2009
7. Kaul R. et al. Genital levels of soluble immune factors with anti-HIV activity may correlate with increased HIV susceptibility. AIDS 22, 2049-2051 (2008
8. Nazli A. et al. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog. 6, e1000852 (2010
9. Valere K. et al. Alpha-defensins increase HIV transcytosis: role in STImediated enhanced HIV transmission (Abstract #211). In: Conference on Retroviruses and Opportunistic Infections (CROI). Seattle, WA: 2015
10. Margolis, L., & Shattock, R. Selective transmission of CCR5-utilizing HIV-1: the gatekeeper problem resolved? Nat. Rev. Microbiol. 4, 312-317 (2006
11. Gorfu G., Rivera-Nieves, J., & Ley, K. Role of beta7 integrins in intestinal lymphocyte homing and retention. Curr. Mol. Med. 9, 836-850 (2009
12. Elices M.J., et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584 (1990
13. Davila, S.J., Olive, A.J., & Starnbach, M.N. Integrin a4b1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection. J. Immunol. 192, 4284-4293 (2014
14. Mazo I.B., et al. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 22, 259-270 (2005
15. Bauer M., et al. Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc. Natl. Acad. Sci. USA 106, 1920-1925 (2009
16. Arthos, J., et al. HIV-1 envelope protein binds to and signals through integrin a4b7, the gut mucosal homing receptor for peripheral T cells. Nat. Immunol. 9, 301-309 (2008
17. Nawaz, F., et al. The genotype of early-Transmitting HIV gp120s promotes a (4) b(7)-reactivity, revealing a (4) b(7) +/CD4+ T cells as key targets in mucosal transmission. PLoS Pathog. 7, e1001301 (2011
18. Parrish N.F., et al. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin a4b7. PLoS Pathog. 8, e1002686 (2012
19. Tjomsland V., et al. Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions. Eur. J. Immunol. 43, 2361-2372 (2013
20. Hladik F., et al. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity 26, 257-270 (2007
21. Sperling R., et al. Differential profiles of immune mediators and in vitro HIV infectivity between endocervical and vaginal secretions from women with Chlamydia trachomatis infection: a pilot study. J. Reprod. Immunol. 99, 80-87 (2013
22. McKinnon L.R., et al. Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study. PLoS One 9, e85675 (2014
23. Nugent, R.P., Krohn, M.A., & Hillier, S.L. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J. Clin. Microbiol. 29, 297-301 (1991
24. McKinnon L.R., et al. Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility. J. Immunol. 187, 6032-6042 (2011
25. Long, E.M., Rainwater, S.M.J., Lavreys, L., Mandaliya, K., & Overbaugh, J. HIV type 1 variants transmitted to women in Kenya require the CCR5 coreceptor for entry, regardless of the genetic complexity of the infecting virus. AIDS Res. Hum. Retroviruses 18, 567-576 (2002
26. Cicala, C., Arthos, J., & Fauci, A.S. HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV. J. Transl. Med. 9, S2 (2011
27. Talbert-Slagle K., et al. Cellular superspreaders: an epidemiological perspective on HIV infection inside the body. PLoS Pathog. 10, e1004092 (2014
28. Zhang, Z. Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 286, 1353-1357 (1999
29. Haase, A.T. Early events in sexual transmission of HIV and SIV and opportunities for interventions. Annu. Rev. Med. 62, 127-139 (2011
30. Meditz A.L., et al. CCR5 expression is elevated on endocervical CD4+ T cells in healthy postmenopausal women. J. Acquir. Immune Defic. Syndr. 59, 221-228 (2012
31. Zhang, Z.-Q. Roles of substrate availability and infection of resting and activated CD4 T cells in transmission and acute simian immunodeficiency virus infection. Proc. Natl. Acad. Sci. USA 101, 1-6 (2004
32. Freeman E.E., et al. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-Analysis of longitudinal studies. AIDS 20, 73-83 (2006
33. Shannon B., et al. Impact of asymptomatic herpes simplex virus type 2 infection on mucosal homing and immune cell subsets in the blood and female genital tract. J. Immunol. 192, 5074-5082 (2014
34. Saba E., et al. HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model. Mucosal Immunol. 3, 280-290 (2010
35. Rodriguez-Garcia, M., Barr, F.D., Crist, S.G., Fahey, J.V., & Wira, C.R. Phenotype and susceptibility to HIV infection of CD4. Mucosal Immunol. 7, 1375-1385 (2014
36. Byrareddy S.N., et al. Targeting a4b7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-Associated lymphoid tissue from infection. Nat. Med. 20, 1397-1400 (2014
37. Goode D., et al. HSV-2-driven increase in the expression of a4b7 correlates with increased susceptibility to vaginal SHIVSF162P3 infection. PLoS Pathog. 10, e1004567 (2014
38. Kader M., et al. Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection. Mucosal Immunol. 2, 439-449 (2009
39. Mattapallil J.J., et al. Massive infection and loss ofmemory CD4+ Tcells in multiple tissues during acute SIV infection. Nature 434, 1093-1097 (2005
40. Shimizu N., et al. Broad usage spectrum ofGprotein-coupled receptors as coreceptors by primary isolates of HIV. AIDS 27, 761-769 (2009
41. Cavrois, M., de Noronha, C., & Greene, W.C. A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nat. Biotech. 20, 1151-1154 (2002
42. Cavrois, M., Neidleman, J., Bigos, M., & Greene, W.C. Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol. Biol. 263, 333-344 (2004
43. Buonaguro, L., Tornesello, M.L., & Buonaguro, F.M. Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications. J. Virol. 81, 10209-10219 (2007
44. Humes, D., & Overbaugh, J. Adaptation of subtype a human immunodeficiency virus type 1 envelope to pig-Tailed macaque cells. J. Virol. 85, 4409-4420 (2011
45. Cicala, C., & Arthos, J. in Methods in Molecular Biology. Humana Press, 1087, 3-12 (2013