Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract

Mucosal Immunology

Volumn 7, Issue 6, 2014, Pages 1375-1385

  Rodriguez Garcia, M ^a   Barr, F D ^a   Crist, S G ^a   Fahey, J V ^a   Wira, C R ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD123 ANTIGEN; CD14 ANTIGEN; CD19 ANTIGEN; CD36 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR5; INTERLEUKIN 17; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; THY 1 ANTIGEN; CCR5 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ECTOCERVIX; ENDOMETRIUM; FEMALE; FEMALE GENITAL SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INFECTION SENSITIVITY; MENSTRUAL CYCLE; PHENOTYPE; PREMENOPAUSE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T LYMPHOCYTE SUBPOPULATION; TH17 CELL; UTERINE CERVIX; UTERINE ENDOCERVIX; CLINICAL TRIAL; DISEASE PREDISPOSITION; GENE EXPRESSION REGULATION; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; POSTMENOPAUSE;

ADULT; AGED; ANTIGENS, THY-1; CERVIX UTERI; DISEASE SUSCEPTIBILITY; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION; HIV INFECTIONS; HUMANS; MIDDLE AGED; POSTMENOPAUSE; RECEPTORS, CCR5; TH17 CELLS;

EID: 84908202620     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.26     Document Type: Article

References (41)

1. WHO. Progress report 2011: Global HIV/AIDS response (2011).
2. NIAID. HIV infection in Women (2010).
3. UNAIDS. Women, girls, gender equality and HIV (2010).
4. Hankins, C. A. & Dybul, M. R. The promise of pre-exposure prophylaxis with antiretroviral drugs to prevent HIV transmission: a review. Curr. Opin. HIV AIDS 8, 50-58 (2013).
5. Wira, C. R., Fahey, J. V., Ghosh, M., Patel, M. V., Hickey, D. K. & Ochiel, D. O. Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens. Am. J. Reprod. Immunol. 63, 544-565 (2010).
6. Rodriguez-Garcia, M., Patel, M. V. & Wira, C. R. Innate and adaptive anti-HIV immune responses in the female reproductive tract. J. Reprod. Immunol. 97, 74-84 (2013).
7. Hickey, D. K., Patel, M. V., Fahey, J. V. & Wira, C. R. Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections. J. Reprod. Immunol. 88, 185-194 (2011).
8. Rodriguez-Garcia, M. et al. Estradiol reduces susceptibility of CD4() T cells and macrophages to HIV-infection. PLoS One 8, e62069 (2013).
9. McKinnon, L. R. & Kaul, R. Quality and quantity: mucosal CD4 Tcells and HIV susceptibility. Curr. Opin. HIV AIDS 7, 195-202 (2012).
10. Zhang, Z. et al. Sexual transmission and propagation of SIV and HIV in resting and activated CD4 T cells. Science 286, 1353-1357 (1999).
11. Saba, E. et al. HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model. Mucosal Immunol. 3, 280-290 (2010).
12. Li, Q. et al. Glycerol monolaurate prevents mucosal SIV transmission. Nature 458, 1034-1038 (2009).
13. Acosta-Rodriguez, E. V. et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8, 639-646 (2007).
14. Annunziato, F., Cosmi, L., Liotta, F., Maggi, E. & Romagnani, S. Defining the human T helper 17 cell phenotype. Trends Immunol. 33, 505-512 (2012).
15. Sallusto, F., Zielinski, C. E. & Lanzavecchia, A. Human Th17 subsets. Eur. J. Immunol. 42, 2215-2220 (2012).
16. Weaver,C. T., Elson, C. O., Fouser, L. A. & Kolls, J. K. The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu. Rev. Pathol. 8, 477-512 (2013).
17. Chege, D. et al. Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya. PLoS One 7, e43670 (2012).
18. Gosselin, A. et al. Peripheral blood CCR4CCR6 and CXCR3 CCR6CD4 Tcells are highly permissive to HIV-1 infection. J. Immunol. 184, 1604-1616 (2010).
19. McKinnon, L. R. et al. Characterization of a human cervical CD4 T cell subset coexpressing multiple markers of HIV susceptibility. J. Immunol. 187, 6032-6042 (2011).
20. Monteiro, P. et al. Memory CCR6CD4 T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin beta7. J. Immunol. 186, 4618-4630 (2011).
21. Guillot-Delost,M. et al. HumanCD90 identifies Th17/Tc17 Tcell subsets that are depleted in HIV-infected patients. J. Immunol. 188, 981-991 (2012).
22. Annunziato, F. et al. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204, 1849-1861 (2007).
23. Su, C. C., Lin, H. C., Lin, Y. P., Shan, Y. S. & Yang, B. C. Expression of Th17-related genes in PHA/IL-2-activated human T cells by Fas signaling via caspase-1-and Stat3-dependent pathway. Cell. Immunol. 281, 101-110 (2013).
24. Saba, E. et al. Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle. Mucosal Immunol. 6, 1081-1090 (2013).
25. Sheridan, B. S. & Lefrancois, L. Regional and mucosal memory Tcells. Nat. Immunol. 12, 485-491 (2011).
26. Huff, K. R., Akhtar, L. N., Fox, A. L., Cannon, J. A., Smith, P. D. & Smythies, L. E. Extracellular matrix-associated cytokines regulate CD4 effector T-cell responses in the human intestinal mucosa. Mucosal Immunol. 4, 420-427 (2011).
27. Ochiel, D. O., Ochsenbauer, C., Kappes, J. C., Ghosh, M., Fahey, J. V. & Wira, C. R. Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted/founder HIV-1 trans infection by immature dendritic cells. PLoS One 5, e14306 (2010).
28. White, H. D. et al. CD3 CD8 CTL activity within the human female reproductive tract: influence of stage of the menstrual cycle and menopause. J. Immunol. 158, 3017-3027 (1997).
29. Haeryfar, S. M. & Hoskin,D. W. Thy-1: more than amouse pan-Tcell marker. J. Immunol. 173, 3581-3588 (2004).
30. Rudnicka, D. et al. Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses. J. Virol. 83, 6234-6246 (2009).
31. Giglio, T. et al. Immune cell circulating subsets are affected by gonadal function. Life Sci. 54, 1305-1312 (1994).
32. Kumru, S., Godekmerdan, A. & Yilmaz, B. Immune effects of surgical menopause and estrogen replacement therapy in peri-menopausal women. J. Reprod. Immunol. 63, 31-38 (2004).
33. Ghosh, M., Rodriguez-Garcia, M. & Wira, C. R. The immune system in menopause: pros and cons of hormone therapy. J. Steroid Biochem. Mol. Biol. S0960-0760, 00163-00165 (2013).
34. Tyagi, A. M., Srivastava, K., Mansoori, M. N., Trivedi, R., Chattopadhyay, N. & Singh, D. Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis. PLoS One 7, e44552 (2012).
35. Lee, S. K., Kim, J. Y., Lee, M., Gilman-Sachs, A. & Kwak-Kim, J. Th17 and regulatory Tcells in women with recurrent pregnancy loss. Am. J. Reprod. Immunol. 67, 311-318 (2012).
36. Comparison of female to male and male to female transmission of HIV in 563 stable couples. European Study Group on heterosexual transmission of HIV. BMJ 304, 809-813 (1992).
37. Meditz, A. L. et al. CCR5 expression is elevated on endocervical CD4 Tcells in healthy postmenopausal women. J. Acquir. Immune Defic. Syndr. 59, 221-228 (2012).
38. Lahm, H. W. & Stein, S. Characterization of recombinant human interleukin-2 with micromethods. J. Chromatogr. 326, 357-361 (1985).
39. Mane, V. P., Heuer,M. A., Hillyer, P., Navarro,M. B. & Rabin, R. L. Systematic method for determining an ideal housekeeping gene for real-time PCR analysis. J. Biomol. Tech. 19, 342-347 (2008).
40. Biswas, N. et al. Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. PLoS One 8, e78814 (2013).
41. Rodriguez-Garcia, M. et al. Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression. PLoS One 5, e9436 (2010).