Differential profiles of immune mediators and in vitro HIV infectivity between endocervical and vaginal secretions from women with Chlamydia trachomatis infection: A pilot study

Journal of Reproductive Immunology

Volumn 99, Issue 1-2, 2013, Pages 80-87

  Sperling, Rhoda ^a   Kraus, Thomas A ^a   Ding, Jian ^d   Veretennikova, Alina ^d   Lorde Rollins, Elizabeth ^a   Singh, Tricia ^a   Lo, Yungtai ^c   Quayle, Alison J ^b   Chang, Theresa L ^d,e  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Chlamydia trachomatis; HIV infectivity in vitro.; HIV transmission; Immune mediators; Lower genital tract

Indexed keywords

ANTIBIOTIC AGENT; ANTIBODY; CHEMOKINE; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CHLAMYDIASIS; CLINICAL ARTICLE; CONVALESCENCE; CYTOKINE PRODUCTION; FEMALE; HORMONAL CONTRACEPTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; MIXED INFECTION; PRIORITY JOURNAL; VAGINA MUCOSA; VAGINAL SECRETION;

CHLAMYDIA TRACHOMATIS; HIV INFECTIVITY IN VITRO.; HIV TRANSMISSION; IMMUNE MEDIATORS; LOWER GENITAL TRACT;

ADOLESCENT; ADULT; CERVIX UTERI; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; HIV; HIV INFECTIONS; HUMANS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; MUCOUS MEMBRANE; PILOT PROJECTS; RISK; VAGINA; YOUNG ADULT;

EID: 84883558451     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2013.07.003     Document Type: Article

References (47)

1. Agrawal T., Vats V., Salhan S., Mittal A. Mucosal and peripheral immune responses to chlamydial heat shock proteins in women infected with Chlamydia trachomatis. Clin. Exp. Immunol. 2007, 148:461-468.
2. Arno J.N., Ricker V.A., Batteiger B.E., Katz B.P., Caine V.A., Jones R.B. Interferon-gamma in endocervical secretions of women infected with Chlamydia trachomatis. J. Infect Dis. 1990, 162:1385-1389.
3. Arora M., Malhotra S., Sharma M. Role of Chlamydia trachomatis in pelvic inflammatory disease. Indian J. Med. Res. 1992, 95:41-42.
4. Bard E., Riethmuller D., Biichle S., Meillet D., Pretet J.L., Mougin C., Seilles E. Validation of a high sensitive immunoenzymatic assay to establish the origin of immunoglobulins in female genital secretions. J. Immunoassay Immunochem. 2002, 23:145-162.
5. Brunham R.C., Rey-Ladino J. Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat. Rev. Immunol. 2005, 5:149-161.
6. Buckner, L., Tietzel, I., Greene, S.J., Zea, A., Quayle, A.J., 2011a. Modulation of innate immunity by Chlamydia trachomatis infected endocervical epithelial cells. 111th American Society for Microbiology General Meeting, New Orleans, LA. Abstract# 850.
7. Buckner L.R., Schust D.J., Ding J., Nagamatsu T., Beatty W., Chang T.L., Greene S.J., Lewis M.E., Ruiz B., Holman S.L., Spagnuolo R.A., Pyles R.B., Quayle A.J. Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. J. Reprod. Immunol. 2011, 92:8-20.
8. Caballero-Campo P., Dominguez F., Coloma J., Meseguer M., Remohi J., Pellicer A., Simon C. Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation. Mol. Hum. Reprod. 2002, 8:375-384.
9. Castle P.E., Rodriguez A.C., Bowman F.P., Herrero R., Schiffman M., Bratti M.C., Morera L.A., Schust D., Crowley-Nowick P., Hildesheim A. Comparison of ophthalmic sponges for measurements of immune markers from cervical secretions. Clin. Diagn. Lab. Immunol. 2004, 11:399-405.
10. Centers for Disease Control and Prevention, 2010. . http://www.cdc.gov/std/chlamydia/STDFact-chlamydia-detailed.htm.
11. Chen B.K., Saksela K., Andino R., Baltimore D. Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses. J. Virol. 1994, 68:654-660.
12. Chesson H.W., Pinkerton S.D. Sexually transmitted diseases and the increased risk for HIV transmission: implications for cost-effectiveness analyses of sexually transmitted disease prevention interventions. J. Acquir. Immune Defic. Syndr. 2000, 24:48-56.
13. Cohen M.S., Hoffman I.F., Royce R.A., Kazembe P., Dyer J.R., Daly C.C., Zimba D., Vernazza P.L., Maida M., Fiscus S.A., Eron J.J.J.R. Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group. Lancet 1997, 349:1868-1873.
14. Connor R.I., Sheridan K.E., Ceradini D., Choe S., Landau N.R. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1--infected individuals. J. Exp. Med. 1997, 185:621-628.
15. Dessus-Babus S., Knight S.T., Wyrick P.B. Chlamydial infection of polarized HeLa cells induces PMN chemotaxis but the cytokine profile varies between disseminating and non-disseminating strains. Cell. Microbiol. 2000, 2:317-327.
16. Dezzutti C.S., Hendrix C.W., Marrazzo J.M., Pan Z., Wang L., Louissaint N., Kalyoussef S., Torres N.M., Hladik F., Parikh U., Mellors J., Hillier S.L., Herold B.C. Performance of swabs, lavage, and diluents to quantify biomarkers of female genital tract soluble mucosal mediators. PLoS One 2011, 6:e23136.
17. Dezzutti C.S., Uranker K., Bunge K.E., Richardson-Harman N., Macio I., Hillier S.L. HIV-1 infection of female genital tract tissue for use in prevention studies. J. Acquir. Immune Defic. Syndr. 2013, 63:548-554.
18. Ficarra M., Ibana J.S., Poretta C., Ma L., Myers L., Taylor S.N., Greene S., Smith B., Hagensee M., Martin D.H., Quayle A.J. A distinct cellular profile is seen in the human endocervix during Chlamydia trachomatis infection. Am. J. Reprod. Immunol. 2008, 60:415-425.
19. Fichorova R.N., Anderson D.J. Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells. Biol. Reprod. 1999, 60:508-514.
20. Galvin S.R., Cohen M.S. The role of sexually transmitted diseases in HIV transmission. Nat. Rev. Microbiol. 2004, 2:33-42.
21. Haase A.T. Perils at mucosal front lines for HIV and SIV and their hosts. Nat. Rev. Immunol. 2005, 5:783-792.
22. Haase A.T. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010, 464:217-223.
23. Hel Z., Stringer E., Mestecky J. Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection. Endocrine Rev. 2010, 31:79-97.
24. Ibana J.A., Myers L., Porretta C., Lewis M., Taylor S.N., Martin D.H., Quayle A.J. The major CD8 T cell effector memory subset in the normal and Chlamydia trachomatis-infected human endocervix is low in perforin. BMC Immunol. 2012, 13:66.
25. Kelly K.A., Walker J.C., Jameel S.H., Gray H.L., Rank R.G. Differential regulation of CD4 lymphocyte recruitment between the upper and lower regions of the genital tract during Chlamydia trachomatis infection. Infect. Immun. 2000, 68:1519-1528.
26. Klotman M.E., Rapista A., Teleshova N., Micsenyi A., Jarvis G.A., Lu W., Porter E., Chang T.L. Neisseria gonorrhoeae-Induced Human Defensins 5 and 6 Increase HIV Infectivity: Role in Enhanced Transmission. J. Immunol. 2008, 180:6176-6185.
27. Kraus T.A., Sperling R.S., Engel S.M., Lo Y., Kellerman L., Singh T., Loubeau M., Ge Y., Garrido J.L., Rodriguez-Garcia M., Moran T.M. Peripheral blood cytokine profiling during pregnancy and post-partum periods. Am. J. Reprod. Immunol. 2010, 64:411-426.
28. Lesmeister M.J., Jorgenson R.L., Young S.L., Misfeldt M.L. 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells. Reprod. Biol. Endocrinol.: RB&E 2005, 3:74.
29. Levine W.C., Pope V., Bhoomkar A., Tambe P., Lewis J.S., Zaidi A.A., Farshy C.E., Mitchell S., Talkington D.F. Increase in endocervical CD4 lymphocytes among women with nonulcerative sexually transmitted diseases. J. Infect. Dis. 1998, 177:167-174.
30. Li Q., Estes J.D., Schlievert P.M., Duan L., Brosnahan A.J., Southern P.J., Reilly C.S., Peterson M.L., Schultz-Darken N., Brunner K.G., Nephew K.R., Pambuccian S., Lifson J.D., Carlis J.V., Haase A.T. Glycerol monolaurate prevents mucosal SIV transmission. Nature 2009.
31. Luther S.A., Cyster J.G. Chemokines as regulators of T cell differentiation. Nature immunology 2001, 2:102-107.
32. Mabey D. Interactions between HIV infection and other sexually transmitted diseases. Trop. Med. Int. Health 2000, 5:A32-A36.
33. Maxion H.K., Kelly K.A. Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection. Infect. Immun. 2002, 70:1538-1546.
34. Miller C.J., Alexander N.J., Vogel P., Anderson J., Marx P.A. Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques. J. Med. Primatol. 1992, 21:64-68.
35. Mittal A., Rastogi S., Reddy B.S., Verma S., Salhan S., Gupta E. Enhanced immunocompetent cells in chlamydial cervicitis. J. Reprod. Med. 2004, 49:671-677.
36. Mlisana K., Naicker N., Werner L., Roberts L., Van Loggerenberg F., Baxter C., Passmore J.A., Grobler A.C., Sturm A.W., Williamson C., Ronacher K., Walzl G., Abdool Karim S.S. Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa. J. Infect. Dis. 2012, 206:6-14.
37. Pal S., Hui W., Peterson E.M., De la Maza L.M. Factors influencing the induction of infertility in a mouse model of Chlamydia trachomatis ascending genital tract infection. J. Med. Microbiol. 1998, 47:599-605.
38. Persson E., Eneroth P., Grillner L. Immunoglobulin contents in cervical secretions of women with chlamydial cervicitis. Gyn. Obst. Invest. 1990, 30:109-113.
39. Plummer F.A. Heterosexual transmission of human immunodeficiency virus type 1 (HIV): interactions of conventional sexually transmitted diseases, hormonal contraception and HIV-1. AIDS Res. Hum. Retroviruses 1998, 14(Suppl. 1):S5-S10.
40. Rasmussen S.J., Eckmann L., Quayle A.J., Shen L., Zhang Y.X., Anderson D.J., Fierer J., Stephens R.S., Kagnoff M.F. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J. Clin. Invest. 1997, 99:77-87.
41. Reddy B.S., Rastogi S., Das B., Salhan S., Verma S., Mittal A. Cytokine expression pattern in the genital tract of Chlamydia trachomatis positive infertile women - implication for T-cell responses. Clin. Exp. Immunol. 2004, 137:552-558.
42. Schust D.J., Ibana J.A., Buckner L.R., Ficarra M., Sugimoto J., Amedee A.M., Quayle A.J. Potential mechanisms for increased HIV-1 transmission across the endocervical epithelium during C. trachomatis infection. Curr. HIV Res. 2012, 10:218-227.
43. Schwebke J.R., Desmond R.A. A randomized trial of the duration of therapy with metronidazole plus or minus azithromycin for treatment of symptomatic bacterial vaginosis. Clin. Infect. Dis. 2007, 44:213-219.
44. Wang C., Tang J., Crowley-Nowick P.A., Wilson C.M., Kaslow R.A., Geisler W.M. Interleukin (IL)-2 and IL-12 responses to Chlamydia trachomatis infection in adolescents. Clin. Exp. Immunol. 2005, 142:548-554.
45. Wira C.R., Kaushic C., Richardson J. Role of sex hormones and cytokines in regulating mucosal immune system in the female reproductive tract. Mucosal Immunity 1999, Academic Press, San Diego. P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock, J.R. Mcghee (Eds.).
46. Wira C.R., Grant-Tschudy K.S., Crane-Godreau M.A. Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am. J. Reprod. Immunol. 2005, 53:65-76.
47. Wira C.R., Fahey J.V., Ghosh M., Patel M.V., Hickey D.K., Ochiel D.O. Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens. Am. J. Reprod. Immunol. 2010, 63:544-565.