Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

Nature Medicine

Volumn 20, Issue 12, 2014, Pages 1397-1400

  Byrareddy, Siddappa N ^a   Kallam, Brianne ^a   Arthos, James ^b   Cicala, Claudia ^b   Nawaz, Fatima ^b   Hiatt, Joseph ^b   Kersh, Ellen N ^c   McNicholl, Janet M ^c   Hanson, Debra ^c   Reimann, Keith A ^d   Brameier, Markus ^e   Walter, Lutz ^e   Rogers, Kenneth ^f   Mayne, Ann E ^a   Dunbar, Paul ^a   Villinger, Tara ^a   Little, Dawn ^a   Parslow, Tristram G ^a   Santangelo, Philip J ^g   Villinger, Francois ^a,f   Fauci, Anthony S ^b   Ansari, Aftab A ^a   more..

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e GERMAN PRIMATE CENTER   (Germany)

^f EMORY UNIVERSITY   (United States)

^g Wallace H Coulter Department of Biomedical Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; INTEGRIN ALPHA4BETA7; MONOCLONAL ANTIBODY; VIRUS DNA;

ANIMAL; ANTAGONISTS AND INHIBITORS; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; COLON; DRUG EFFECTS; FEMALE; GENETICS; ILEUM; IMMUNOLOGY; INTESTINE MUCOSA; JEJUNUM; LYMPHOID TISSUE; MUCOSA; RHESUS MONKEY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; TRANSMISSION; UTERINE CERVIX; VAGINA; VIROLOGY; VIRUS LOAD;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CERVIX UTERI; COLON; DNA, VIRAL; FEMALE; ILEUM; INTEGRINS; INTESTINAL MUCOSA; JEJUNUM; LYMPHOID TISSUE; MACACA MULATTA; MUCOUS MEMBRANE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VAGINA; VIRAL LOAD;

EID: 84939947397     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3715     Document Type: Article

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