Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy

Clinical and Translational Science

Volumn 8, Issue 6, 2015, Pages 740-745

  Julian, Colleen G ^a   Pedersen, Brent S ^a   Salmon, Carlos Salinas ^b   Yang, Ivana V ^a   Gonzales, Marcelino ^b   Vargas, Enrique ^b   Moore, Lorna G ^a   Schwartz, David A ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Bolivian Institute of High Altitude Biology   (Bolivia)

Author keywords

Developmental programming; Epigenetics; Gestational hypertension; Preeclampsia

Indexed keywords

GENOMIC DNA;

ADULT; ARID1B GENE; ARTICLE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CONTROLLED STUDY; CTRHC1 GENE; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; GENETIC MARKER; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG ARTERY PRESSURE; MALE; MATERNAL HYPERTENSION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOC2 GENE; ARTERIAL PRESSURE; COMPLICATION; CYTOLOGY; DIAGNOSIS; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HYPERTENSION; LUNG DISEASE; MONONUCLEAR CELL; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; PULMONARY ARTERY; PULMONARY VEIN; RISK FACTOR; VASCULAR DISEASE; YOUNG ADULT;

ADULT; ARTERIAL PRESSURE; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION; HYPERTENSION, PREGNANCY-INDUCED; LEUKOCYTES, MONONUCLEAR; LUNG DISEASES; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PULMONARY ARTERY; PULMONARY VEINS; RISK FACTORS; VASCULAR DISEASES; YOUNG ADULT;

EID: 84952989691     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/cts.12346     Document Type: Article

References (33)

1. Kajantie E, Eriksson JG, Osmond C, Thornburg K, Barker DJ. Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study. Stroke. 2009; 40(4): 1176-1180.
2. Geelhoed JJ, Fraser A, Tilling K, Benfield L, Davey Smith G, Sattar N, Nelson SM, Lawlor DA. Preeclampsia and gestational hypertension are associated with childhood blood pressure independently of family adiposity measures: the Avon Longitudinal Study of Parents and Children. Circulation. 2010; 122(12): 1192-1199.
3. Jayet PY, Rimoldi SF, Stuber T, Salmon CS, Hutter D, Rexhaj E, Thalmann S, Schwab M, Turini P, Sartori-Cucchia C, et al. Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation. 2010; 122(5): 488-494.
4. Rexhaj E, Bloch J, Jayet PY, Rimoldi SF, Dessen P, Mathieu C, Tolsa JF, Nicod P, Scherrer U, Sartori C. Fetal programming of pulmonary vascular dysfunction in mice: role of epigenetic mechanisms. Am J Physiol Heart Circ Physiol. 2011; 301(1): H247-H252.
5. Watson JA, Watson CJ, McCann A, Baugh J. Epigenetics, the epicenter of the hypoxic response. Epigenetics. 2010; 5(4): 293-296.
6. Hollingsworth JW, Maruoka S, Boon K, Garantziotis S, Li Z, Tomfohr J, Bailey N, Potts EN, Whitehead G, Brass DM, et al. In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest. 2008; 118(10): 3462-3469.
7. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002; 3(9): 662-673.
8. Patterson AJ, Xiao D, Xiong F, Dixon B, Zhang L. Hypoxia-derived oxidative stress mediates epigenetic repression of PKCepsilon gene in foetal rat hearts. Cardiovasc Res. 2012; 93(2): 302-310.
9. Blair JD, Yuen RK, Lim BK, McFadden DE, vonDadelszen P, Robinson WP. Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia. Mol Hum Reprod. 2013; 19(10): 697-708.
10. Ching T, Ha J, Song MA, Tiirikainen M, Molnar J, Berry MJ, Towner D, Garmire LX. Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsia. Clin Epigenet. 2015; 7(1): 21.
11. Julian CG, Vargas E, Armaza JF, Wilson MJ, Niermeyer S, Villena M, Moore LG. High-altitude ancestry protects against hypoxia-associated reductions in fetal growth. Arch Dis Child Fetal Neonatal Educ. 2007; 92(5): F372-F377.
12. Keyes LE, Armaza JF, Niermeyer S, Vargas E, Young D, Villena M, Moore LG. Intrauterine growth restriction, preeclampsia and intrauterine mortality at high altitude in Bolivia. Pediatr. Res. 2003; 54(1): 20-25.
13. Julian CG, Gonzales M, Rodriguez A, Bellido D, Salmon CS, Ladenburger A, Reardon L, Vargas E, Moore LG. Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ Physiol. 2015; 309(4): H565-H573.
14. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013; 122(5): 1122-1131.
15. Stegle O, Parts L, Durbin R, Winn J. A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies. PLoS Comput Biol. 2010; 6(5): e1000770.
16. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Applicat Genet Mol Biol. 2004; 3: 1-25.
17. Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biometr J Biometr Zeitsch. 2008; 50(3): 346-363.
18. Pedersen BS, Schwartz DA, Yang IV, Kechris KJ. Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values. Bioinformatics. 2012; 28(22): 2986-2988.
19. Jaffe AE, Murakami P, Lee H, Leek JT, Fallin MD, Feinberg AP, Irizarry RA. Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. Int J Epidemiol. 2012; 41(1): 200-209.
20. Bell JT, Pai AA, Pickrell JK, Gaffney DJ, Pique-Regi R, Degner JF, Gilad Y, Pritchard JK. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol. 2011; 12(1): R10.
21. Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, Li K, Murty VV, Schupf N, Vilain E, et al. Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet. 2008; 40(7): 904-908.
22. Yang IV, Pedersen BS, Liu A, O'Connor GT, Teach SJ, Kattan M, Misiak RT, Gruchalla R, Steinbach SF, Szefler SJ, et al. DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol. 2015; 136(1): 69-80.
23. Sena JA, Wang L, Hu CJ. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol. 2013; 33(19): 3849-3863.
24. Bevilacqua A, Willis MS, Bultman SJ. SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease. Cardiovasc Pathol. 2014; 23(2): 85-91.
25. Fang F, Chen D, Yu L, Dai X, Yang Y, Tian W, Cheng X, Xu H, Weng X, Fang M, et al. Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury. Circ Res. 2013; 113(8): 986-996.
26. Khursheed M, Kolla JN, Kotapalli V, Gupta N, Gowrishankar S, Uppin SG, Sastry RA, Koganti S, Sundaram C, Pollack JR, et al. ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines. Br J Cancer. 2013; 108(10): 2056-2062.
27. Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, Friesel RE, Lindner V. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res. 2005; 96(2): 261-268.
28. Nishimoto S, Hamajima Y, Toda Y, Toyoda H, Kitamura K, Komurasaki T. Identification of a novel smooth muscle associated protein, smap2, upregulated during neointima formation in a rat carotid endarterectomy model. Biochim Biophys Acta. 2002; 1576(1-2): 225-230.
29. Rocnik EF, Liu P, Sato K, Walsh K, Vaziri C. The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. J Biol Chem. 2006; 281(32): 22855-22864.
30. Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012; 2(5): a006627.
31. Chen CH, Ho HH, Wu ML, Layne MD, Yet SF. Modulation of cysteine-rich protein 2 expression in vascular injury and atherosclerosis. Mol Biol Rep. 2014; 41(11): 7033-7041.
32. Nagaraj SR, Shilpa P, Rachaiah K, Salimath BP. Crosstalk between VEGF and MTA1 signaling pathways contribute to aggressiveness of breast carcinoma. Mol Carcinog. 2015; 54(5): 333-350.
33. Carter EB, Stuart JJ, Farland LV, Rich-Edwards J, Zera C, McElrath TF, Seely EW. [118-POS]: Validation of a maternal recall questionnaire for pregnancy complications associated with increased future risk for cardiovascular disease. Pregnancy Hypertens. 2015; 5(1): 63.