Crosstalk between VEGF and MTA1 signaling pathways contribute to aggressiveness of breast carcinoma

Molecular Carcinogenesis

Volumn 54, Issue 5, 2015, Pages 333-350

  Nagaraj, Sachin Raj M ^a   Shilpa, Puttananjaiah ^a   Rachaiah, Kavitha ^a   Salimath, Bharathi P ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

Angiogenesis; Metastasis associated protein; MTA1 gene expression; Phosphorylation; Vascular endothelial growth factor

Indexed keywords

CALVASCULIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TYROSINE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; HISTONE DEACETYLASE; MESSENGER RNA; MTA1 PROTEIN, HUMAN; REPRESSOR PROTEIN; SMALL INTERFERING RNA; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CHORIOALLANTOIS; CONTROLLED STUDY; CORNEA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; METASTASIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BREAST TUMOR; CELL CULTURE; CELL MOTION; DRUG SCREENING; ENZYME IMMUNOASSAY; EXPERIMENTAL MELANOMA; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MOUSE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; WISTAR RAT; WOUND HEALING;

RATTUS;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHORIOALLANTOIC MEMBRANE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; MELANOMA, EXPERIMENTAL; MICE; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84926519815     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22104     Document Type: Article

References (32)

1. Toh Y, Pencil SD, Nicolson GL. A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. J Biol Chem 1994; 269:22958-22963.
2. Nicolson GL, Nawa A, Toh Y, et al. Tumor metastasis-associated human mta1 gene and its mta1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clin Exp Metastasis 2003; 20:19-24.
3. Yoo Y-G, Kong G, Lee M-O. Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J 2006; 25:1231-1241.
4. Manavathi B, Kumar R. Metastasis tumor antigens, an emerging family of multifaceted master coregulators. J Biol Chem 2007; 282:1529-1533.
5. Jang K-S, Paik SS, Chung H, Oh Y-H, Kong G. Mta1 overexpression correlates significantly with tumor grade and angiogenesis in human breast cancers. Cancer Sci 2006; 97:374-379.
6. Moon H-E, Cheon H, Chun K-H, et al. Metastasis-associated protein 1 enhances angiogenesis by stabilization of hif-1alpha. Oncol Rep 2006; 16:929-935.
7. Lamalice L, Houle F, Huot J. Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J Biol Chem 2006; 281:34009-34020.
8. Dardik R, Loscalzo J, Eskaraev R, Inbal A. Molecular mechanisms underlying the proangiogenic effect of factor xiii. Arterioscler Thromb Vasc Biol 2005; 25:526-532.
9. Svensson S, Jirström K, Rydén L, et al. Erk phosphorylation is linked to VEGFR2 expression and ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis. Oncogene 2005; 24:4370-4379.
10. Huang C, Jacobson K, Schaller MD. Map kinases and cell migration. J Cell Sci 2004; 117:4619-4628.
11. Smith DB, Johnson KS. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione s-transferase. Gene 1988; 67:31-40.
12. Ramachandra S, D'Souza SS, Gururaj AE, Shaila MS, Salimath BP. Paracrine action of sFLT-1 secreted by stably-transfected Ehrlich ascites tumor cells and therapy using sFLT-1 inhibits ascites tumor growth in vivo. J Gene Med 2009; 11:422-434.
13. Lucas JT, Salimath BP, Slomiany MG, Rosenzweig SA. Regulation of invasive behavior by vascular endothelial growth factor is hef1-dependent. Oncogene 2010; 29:4449-4459.
14. Shivakumar S, Prabhakar BT, Jayashree K, Rajan MGR, Salimath BP. Evaluation of serum vascular endothelial growth factor (VEGF) and microvessel density (MVD) as prognostic indicators in carcinoma breast. J Cancer Res Clin Oncol 2009; 135:627-636.
15. Lingaraju SM, Keshavaiah K, Salimath BP. Inhibition of in vivo angiogenesis by anacardium occidentale L. involves repression of the cytokine VEGF gene expression. Drug Discov Ther 2008; 2:234-244.
16. Zeng H, Sanyal S, Mukhopadhyay D. Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively. J Biol Chem 2001; 276:32714-32719.
17. Liang C-C, Park AY, Guan J-L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007; 2:329-333.
18. Pang X, Yi T, Yi Z, et al. Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. Cancer Res 2009; 69:518-525.
19. Seo K, Choi J, Park M, Rhee C. Angiogenesis effects of nerve growth factor (NGF) on rat corneas. J Vet Sci 2001; 2:125-130.
20. Olfa K-Z, José L, Salma D, et al. Lebestatin, a disintegrin from macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Lab Invest 2005; 85:1507-1516.
21. Borges J, Tegtmeier FT, Padron NT, et al. Chorioallantoic membrane angiogenesis model for tissue engineering: a new twist on a classic model. Tissue Eng 2003; 9:441-450.
22. Goddard JC, Sutton CD, Berry DP, O'Byrne KJ, Kockelbergh RC. The use of microvessel density in assessing human urological tumours. BJU Int 2001; 87:866-875.
23. Buijs JT, Henriquez NV, van Overveld PGM, et al. Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res 2007; 67:8742-8751.
24. Ikeda T, Wakiya K, Shibuya M. Characterization of the promoter region for flt-1 tyrosine kinase gene, a receptor for vascular endothelial growth factor. Growth Factors 1996; 13:151-162.
25. Qian H, Lu N, Xue L, et al. Reduced MTA1 expression by RNAi inhibits in vitro invasion and migration of esophageal squamous cell carcinoma cell line. Clin Exp Metastasis 2005; 22:653-662.
26. Kawasaki G, Yanamoto S, Yoshitomi I, Yamada S, Mizuno A. Overexpression of metastasis-associated mta1 in oral squamous cell carcinomas: correlation with metastasis and invasion. Int J Oral Maxillofac Surg 2008; 37:1039-1046.
27. Nawa A, Nishimori K, Lin P, et al. Tumor metastasis-associated human mta1 gene: its deduced protein sequence, localization, and association with breast cancer cell proliferation using antisense phosphorothioate oligonucleotides. J Cell Biochem 2000; 79:202-212.
28. Mazumdar A, Wang RA, Mishra SK, et al. Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat Cell Biol 2001; 3:30-37.
29. Gururaj AE, Singh RR, Rayala SK, et al. Mta1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci USA 2006; 103:6670-6675.
30. Toh Y, Ogha T, Endo K, et al. Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. Int J Cancer 2004; 20:362-367.
31. Pakala SB, Reddy SDN, Bui-Nguyen TM, et al., MTA1 coregulator regulates LPS response via. MyD88-dependent signaling. J Biol Chem 2010; 285:32787-32792.
32. Pakala SB, Singh K, Reddy SDN, et al., TGF-β1 signaling targets metastasis-associated protein 1 a new effector in epithelial cells. Oncogene 2011; 30:2230-2241.