메뉴 건너뛰기




Volumn 138, Issue 10, 2015, Pages 3089-3099

Asymmetries of amyloid-β burden and neuronal dysfunction are positively correlated in Alzheimer's disease

Author keywords

Alzheimer's disease; amyloid; biomarkers; hemispheric differences; positron emission tomography

Indexed keywords

AMYLOID BETA PROTEIN; FLUORODEOXYGLUCOSE F 18; PITTSBURGH COMPOUND B;

EID: 84952889115     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv229     Document Type: Article
Times cited : (69)

References (63)
  • 1
    • 79956084514 scopus 로고    scopus 로고
    • The diagnosis of mild cognitive impairment due to Alzheimers disease: Recommendations from the National Institute on Aging-Alzheimers Association workgroups on diagnostic guidelines for Alzheimers disease
    • Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimers disease: recommendations from the National Institute on Aging-Alzheimers Association workgroups on diagnostic guidelines for Alzheimers disease. Alzheimers Dement 2011; 7: 270-9.
    • (2011) Alzheimers Dement , vol.7 , pp. 270-279
    • Albert, M.S.1    DeKosky, S.T.2    Dickson, D.3    Dubois, B.4    Feldman, H.H.5    Fox, N.C.6
  • 2
    • 1542268242 scopus 로고    scopus 로고
    • Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
    • Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol 2004; 61: 378-84.
    • (2004) Arch Neurol , vol.61 , pp. 378-384
    • Bennett, D.A.1    Schneider, J.A.2    Wilson, R.S.3    Bienias, J.L.4    Arnold, S.E.5
  • 3
    • 84884411990 scopus 로고    scopus 로고
    • Understanding cognitive deficits in Alzheimers disease based on neuroimaging findings
    • Braskie MN, Thompson PM. Understanding cognitive deficits in Alzheimers disease based on neuroimaging findings. Trends Cogn Sci 2013; 17: 510-16.
    • (2013) Trends Cogn Sci , vol.17 , pp. 510-516
    • Braskie, M.N.1    Thompson, P.M.2
  • 4
    • 84855351426 scopus 로고    scopus 로고
    • Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain
    • Brinkmann BH, Jones DT, Stead M, Kazemi N, OBrien TJ, So EL, et al. Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain. J Cereb Blood Flow Metab 2012; 32: 190-8.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 190-198
    • Brinkmann, B.H.1    Jones, D.T.2    Stead, M.3    Kazemi, N.4    OBrien, T.J.5    So, E.L.6
  • 5
    • 33751111992 scopus 로고    scopus 로고
    • Biological parametric mapping: A statistical toolbox for multimodality brain image analysis
    • Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, et al. Biological parametric mapping: A statistical toolbox for multimodality brain image analysis. Neuroimage 2007; 34: 137-43.
    • (2007) Neuroimage , vol.34 , pp. 137-143
    • Casanova, R.1    Srikanth, R.2    Baer, A.3    Laurienti, P.J.4    Burdette, J.H.5    Hayasaka, S.6
  • 6
    • 0029800611 scopus 로고    scopus 로고
    • Regional cerebral blood flow pattern in normal young and aged volunteers: A 99mTc-HMPAO SPET study
    • Catafau AM, Lomena FJ, Pavia J, Parellada E, Bernardo M, Setoain J, et al. Regional cerebral blood flow pattern in normal young and aged volunteers: a 99mTc-HMPAO SPET study. Eur J Nucl Med 1996; 23: 1329-37.
    • (1996) Eur J Nucl Med , vol.23 , pp. 1329-1337
    • Catafau, A.M.1    Lomena, F.J.2    Pavia, J.3    Parellada, E.4    Bernardo, M.5    Setoain, J.6
  • 7
    • 72449133293 scopus 로고    scopus 로고
    • Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: An example of brain reserve
    • Cohen AD, Price JC, Weissfeld LA, James J, Rosario BL, Bi W, et al.. Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve. J Neurosci 2009; 29: 14770-8.
    • (2009) J Neurosci , vol.29 , pp. 14770-14778
    • Cohen, A.D.1    Price, J.C.2    Weissfeld, L.A.3    James, J.4    Rosario, B.L.5    Bi, W.6
  • 8
    • 79957800704 scopus 로고    scopus 로고
    • Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
    • Drzezga A, Becker JA, Van Dijk KR, Sreenivasan A, Talukdar T, Sullivan C, et al. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 2011; 134(Pt 6): 1635-46.
    • (2011) Brain , vol.134 , pp. 1635-1646
    • Drzezga, A.1    Becker, J.A.2    Van Dijk, K.R.3    Sreenivasan, A.4    Talukdar, T.5    Sullivan, C.6
  • 10
    • 33847062118 scopus 로고    scopus 로고
    • Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study
    • Edison P, Archer HA, Hinz R, Hammers A, Pavese N, Tai YF, et al. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology 2007; 68: 501-8.
    • (2007) Neurology , vol.68 , pp. 501-508
    • Edison, P.1    Archer, H.A.2    Hinz, R.3    Hammers, A.4    Pavese, N.5    Tai, Y.F.6
  • 11
    • 33749506795 scopus 로고    scopus 로고
    • Two-year follow-up of amyloid deposition in patients with Alzheimers disease
    • Engler H, Forsberg A, Almkvist O, Blomquist G, Larsson E, Savitcheva I, et al.. Two-year follow-up of amyloid deposition in patients with Alzheimers disease. Brain 2006; 129(Pt 11): 2856-66.
    • (2006) Brain , vol.129 , pp. 2856-2866
    • Engler, H.1    Forsberg, A.2    Almkvist, O.3    Blomquist, G.4    Larsson, E.5    Savitcheva, I.6
  • 12
    • 84869097232 scopus 로고    scopus 로고
    • Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimers disease
    • Forster S, Yousefi BH, Wester HJ, Klupp E, Rominger A, Forstl H, et al. Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimers disease. Eur J Nucl Med Mol Imaging 2012; 39: 1927-36.
    • (2012) Eur J Nucl Med Mol Imaging , vol.39 , pp. 1927-1936
    • Forster, S.1    Yousefi, B.H.2    Wester, H.J.3    Klupp, E.4    Rominger, A.5    Forstl, H.6
  • 13
    • 84891698543 scopus 로고    scopus 로고
    • Amyloid-beta load predicts medial temporal lobe dysfunction in Alzheimer dementia
    • Frings L, Spehl TS, Weber WA, Hull M, Meyer PT. Amyloid-beta load predicts medial temporal lobe dysfunction in Alzheimer dementia. J Nucl Med 2013; 54: 1909-14.
    • (2013) J Nucl Med , vol.54 , pp. 1909-1914
    • Frings, L.1    Spehl, T.S.2    Weber, W.A.3    Hull, M.4    Meyer, P.T.5
  • 14
    • 80055028073 scopus 로고    scopus 로고
    • Amyloid-beta and glucose metabolism in Alzheimers disease
    • Furst AJ, Lal RA. Amyloid-beta and glucose metabolism in Alzheimers disease. J Alzheimers Dis 2011; 26 (Suppl 3): 105-16.
    • (2011) J Alzheimers Dis , vol.26 , pp. 105-116
    • Furst, A.J.1    Lal, R.A.2
  • 16
    • 84860633148 scopus 로고    scopus 로고
    • Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia
    • Gefen T, Gasho K, Rademaker A, Lalehzari M, Weintraub S, Rogalski E, et al. Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia. Brain 2012; 135(Pt 5): 1554-65.
    • (2012) Brain , vol.135 , pp. 1554-1565
    • Gefen, T.1    Gasho, K.2    Rademaker, A.3    Lalehzari, M.4    Weintraub, S.5    Rogalski, E.6
  • 18
    • 84879036616 scopus 로고    scopus 로고
    • Diagnosed mild cognitive impairment due to Alzheimers disease with PET biomarkers of beta amyloid and neuronal dysfunction
    • Hatashita S, Yamasaki H. Diagnosed mild cognitive impairment due to Alzheimers disease with PET biomarkers of beta amyloid and neuronal dysfunction. PLoS One 2013; 8: e66877.
    • (2013) PLoS One , vol.8 , pp. e66877
    • Hatashita, S.1    Yamasaki, H.2
  • 19
    • 84962827544 scopus 로고    scopus 로고
    • Multiple brain markers are linked to age-related variation in cognition
    • Advance Access published on October 14, 2014, doi: 10.1093/cercor/bhu238
    • Hedden T, Schultz AP, Rieckmann A, Mormino EC, Johnson KA, Sperling RA, et al. Multiple brain markers are linked to age-related variation in cognition. Cereb Cortex 2014. Advance Access published on October 14, 2014, doi: 10.1093/cercor/bhu238.
    • (2014) Cereb Cortex
    • Hedden, T.1    Schultz, A.P.2    Rieckmann, A.3    Mormino, E.C.4    Johnson, K.A.5    Sperling, R.A.6
  • 21
    • 84872379077 scopus 로고    scopus 로고
    • Tracking pathophysiological processes in Alzheimers disease: An updated hypothetical model of dynamic biomarkers
    • Jack CRJ, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, et al. Tracking pathophysiological processes in Alzheimers disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 2013a; 12: 207-16.
    • (2013) Lancet Neurol , vol.12 , pp. 207-216
    • Crj, J.1    Knopman, D.S.2    Jagust, W.J.3    Petersen, R.C.4    Weiner, M.W.5    Aisen, P.S.6
  • 22
    • 39749108812 scopus 로고    scopus 로고
    • 11C PiB and structural MRI provide complementary information in imaging of Alzheimers disease and amnestic mild cognitive impairment
    • Jack CRJ, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimers disease and amnestic mild cognitive impairment. Brain 2008; 131(Pt 3): 665-80.
    • (2008) Brain , vol.131 , pp. 665-680
    • Crj, J.1    Lowe, V.J.2    Senjem, M.L.3    Weigand, S.D.4    Kemp, B.J.5    Shiung, M.M.6
  • 23
    • 66549106850 scopus 로고    scopus 로고
    • Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: Implications for sequence of pathological events in Alzheimers disease
    • Jack CRJ, Lowe VJ, Weigand SD, Wiste HJ, Senjem ML, Knopman DS, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: implications for sequence of pathological events in Alzheimers disease. Brain 2009; 132(Pt 5): 1355-65.
    • (2009) Brain , vol.132 , pp. 1355-1365
    • Crj, J.1    Lowe, V.J.2    Weigand, S.D.3    Wiste, H.J.4    Senjem, M.L.5    Knopman, D.S.6
  • 24
    • 84888228877 scopus 로고    scopus 로고
    • Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity
    • Jack CRJ, Wiste HJ, Weigand SD, Knopman DS, Lowe V, Vemuri P, et al.. Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity. Neurology 2013b; 81: 1732-40.
    • (2013) Neurology , vol.81 , pp. 1732-1740
    • Crj, J.1    Wiste, H.J.2    Weigand, S.D.3    Knopman, D.S.4    Lowe, V.5    Vemuri, P.6
  • 25
    • 84871001204 scopus 로고    scopus 로고
    • Not fibrillar beta-amyloid, reduces cerebral glucose metabolism in normal aging
    • Jagust WJ, Landau SM. Apolipoprotein E, not fibrillar beta-amyloid, reduces cerebral glucose metabolism in normal aging. J Neurosci 2012; 32: 18227-33.
    • (2012) J Neurosci , vol.32 , pp. 18227-18233
    • Jagust, W.J.1    Landau, S.M.2    Apolipoprotein, E.3
  • 27
    • 82455175189 scopus 로고    scopus 로고
    • Lifespan brain activity, beta-amyloid, and Alzheimers disease
    • Jagust WJ, Mormino EC. Lifespan brain activity, beta-amyloid, and Alzheimers disease. Trends Cogn Sci 2011; 15: 520-6.
    • (2011) Trends Cogn Sci , vol.15 , pp. 520-526
    • Jagust, W.J.1    Mormino, E.C.2
  • 28
    • 84874824543 scopus 로고    scopus 로고
    • Appropriate use criteria for amyloid PET: A report of the amyloid imaging task force, the society of nuclear medicine and molecular imaging, and the Alzheimers association
    • Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, et al. Appropriate use criteria for amyloid PET: a report of the amyloid imaging task force, the society of nuclear medicine and molecular imaging, and the Alzheimers association. J Nucl Med 2013; 54: 476-90.
    • (2013) J Nucl Med , vol.54 , pp. 476-490
    • Johnson, K.A.1    Minoshima, S.2    Bohnen, N.I.3    Donohoe, K.J.4    Foster, N.L.5    Herscovitch, P.6
  • 29
  • 30
    • 81355135439 scopus 로고    scopus 로고
    • Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimers disease
    • Kadir A, Almkvist O, Forsberg A, Wall A, Engler H, Langstrom B, et al. Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimers disease. Neurobiol Aging 2012; 33: 198.e1-14.
    • (2012) Neurobiol Aging , vol.33 , pp. 198e1-19814
    • Kadir, A.1    Almkvist, O.2    Forsberg, A.3    Wall, A.4    Engler, H.5    Langstrom, B.6
  • 32
    • 84925945594 scopus 로고    scopus 로고
    • A 12-step user guide for analyzing voxelwise gray matter asymmetries in statistical parametric mapping (SPM)
    • Kurth F, Gaser C, Luders E. A 12-step user guide for analyzing voxelwise gray matter asymmetries in statistical parametric mapping (SPM). Nat Protoc 2015; 10: 293-304.
    • (2015) Nat Protoc , vol.10 , pp. 293-304
    • Kurth, F.1    Gaser, C.2    Luders, E.3
  • 33
    • 84869056826 scopus 로고    scopus 로고
    • Region-specific hierarchy between atrophy, hypometabolism, and beta-amyloid (Abeta) load in Alzheimers disease dementia
    • La Joie R, Perrotin A, Barre L, Hommet C, Mezenge F, Ibazizene M, et al. Region-specific hierarchy between atrophy, hypometabolism, and beta-amyloid (Abeta) load in Alzheimers disease dementia. J Neurosci 2012; 32: 16265-73.
    • (2012) J Neurosci , vol.32 , pp. 16265-16273
    • La Joie, R.1    Perrotin, A.2    Barre, L.3    Hommet, C.4    Mezenge, F.5    Ibazizene, M.6
  • 35
  • 36
    • 84876522001 scopus 로고    scopus 로고
    • FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimers type
    • Madhavan A, Whitwell JL, Weigand SD, Duffy JR, Strand EA, Machulda MM, et al. FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimers type. PLoS One 2013; 8: e62471.
    • (2013) PLoS One , vol.8 , pp. e62471
    • Madhavan, A.1    Whitwell, J.L.2    Weigand, S.D.3    Duffy, J.R.4    Strand, E.A.5    Machulda, M.M.6
  • 37
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimers disease: Recommendations from the National Institute on Aging- Alzheimers Association workgroups on diagnostic guidelines for Alzheimers disease
    • McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CRJ, Kawas CH, et al. The diagnosis of dementia due to Alzheimers disease: recommendations from the National Institute on Aging- Alzheimers Association workgroups on diagnostic guidelines for Alzheimers disease. Alzheimers Dement 2011; 7: 263-9.
    • (2011) Alzheimers Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3    Hyman, B.T.4    Crj, J.5    Kawas, C.H.6
  • 38
    • 84897827105 scopus 로고    scopus 로고
    • Asymmetry and heterogeneity of Alzheimers and frontotemporal pathology in primary progressive aphasia
    • Mesulam MM, Weintraub S, Rogalski EJ, Wieneke C, Geula C, Bigio EH. Asymmetry and heterogeneity of Alzheimers and frontotemporal pathology in primary progressive aphasia. Brain 2014; 137(Pt 4): 1176-92.
    • (2014) Brain , vol.137 , pp. 1176-1192
    • Mesulam, M.M.1    Weintraub, S.2    Rogalski, E.J.3    Wieneke, C.4    Geula, C.5    Bigio, E.H.6
  • 39
    • 79952803918 scopus 로고    scopus 로고
    • Dual-biomarker imaging of regional cerebral amyloid load and neuronal activity in dementia with PET and 11C-labeled Pittsburgh compound B
    • Meyer PT, Hellwig S, Amtage F, Rottenburger C, Sahm U, Reuland P, et al. Dual-biomarker imaging of regional cerebral amyloid load and neuronal activity in dementia with PET and 11C-labeled Pittsburgh compound B. J Nucl Med 2011; 52: 393-400.
    • (2011) J Nucl Med , vol.52 , pp. 393-400
    • Meyer, P.T.1    Hellwig, S.2    Amtage, F.3    Rottenburger, C.4    Sahm, U.5    Reuland, P.6
  • 41
    • 84918535750 scopus 로고    scopus 로고
    • Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: Studies of a retired NFL player and of a man with FTD and a severe head injury
    • Mitsis EM, Riggio S, Kostakoglu L, Dickstein DL, Machac J, Delman B, et al. Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury. Transl Psychiatry 2014; 4: e441.
    • (2014) Transl Psychiatry , vol.4 , pp. e441
    • Mitsis, E.M.1    Riggio, S.2    Kostakoglu, L.3    Dickstein, D.L.4    Machac, J.5    Delman, B.6
  • 42
    • 0024453856 scopus 로고
    • The Consortium to Establish a Registry for Alzheimers Disease (CERAD) Part I. Clinical and neuropsychological assessment of Alzheimers disease
    • Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, et al. The Consortium to Establish a Registry for Alzheimers Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimers disease. Neurology 1989; 39: 1159-65.
    • (1989) Neurology , vol.39 , pp. 1159-1165
    • Morris, J.C.1    Heyman, A.2    Mohs, R.C.3    Hughes, J.P.4    Van Belle, G.5    Fillenbaum, G.6
  • 43
    • 84868159914 scopus 로고    scopus 로고
    • Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimers parents
    • Mosconi L, Rinne JO, Tsui WH, Murray J, Li Y, Glodzik L, et al. Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimers parents. Neurobiol Aging 2013; 34: 22-34.
    • (2013) Neurobiol Aging , vol.34 , pp. 22-34
    • Mosconi, L.1    Rinne, J.O.2    Tsui, W.H.3    Murray, J.4    Li, Y.5    Glodzik, L.6
  • 45
    • 84863197449 scopus 로고    scopus 로고
    • Amyloid burden and metabolic function in early-onset al.zheimers disease: Parietal lobe involvement
    • Ossenkoppele R, Zwan MD, Tolboom N, van Assema DM, Adriaanse SF, Kloet RW, et al. Amyloid burden and metabolic function in early-onset al.zheimers disease: parietal lobe involvement. Brain 2012; 135(Pt 7): 2115-25.
    • (2012) Brain , vol.135 , pp. 2115-2125
    • Ossenkoppele, R.1    Zwan, M.D.2    Tolboom, N.3    Van Assema, D.M.4    Adriaanse, S.F.5    Kloet, R.W.6
  • 46
    • 0023127343 scopus 로고
    • Regional asymmetries of cerebral blood flow, blood volume, and oxygen utilization and extraction in normal subjects
    • Perlmutter JS, Powers WJ, Herscovitch P, Fox PT, Raichle ME. Regional asymmetries of cerebral blood flow, blood volume, and oxygen utilization and extraction in normal subjects. J Cereb Blood Flow Metab 1987; 7: 64-7.
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 64-67
    • Perlmutter, J.S.1    Powers, W.J.2    Herscovitch, P.3    Fox, P.T.4    Raichle, M.E.5
  • 48
    • 46249096584 scopus 로고    scopus 로고
    • Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimers disease with Pittsburgh Compound B
    • Raji CA, Becker JT, Tsopelas ND, Price JC, Mathis CA, Saxton JA, et al. Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimers disease with Pittsburgh Compound B. J Neurosci Methods 2008; 172: 277-82.
    • (2008) J Neurosci Methods , vol.172 , pp. 277-282
    • Raji, C.A.1    Becker, J.T.2    Tsopelas, N.D.3    Price, J.C.4    Mathis, C.A.5    Saxton, J.A.6
  • 49
    • 0025914324 scopus 로고
    • Abnormal brain glucose metabolism in Alzheimers disease, as measured by position emission tomography
    • Rapoport SI, Horwitz B, Grady CL, Haxby JV, DeCarli C, Schapiro MB. Abnormal brain glucose metabolism in Alzheimers disease, as measured by position emission tomography. Adv Exp Med Biol 1991; 291: 231-48.
    • (1991) Adv Exp Med Biol , vol.291 , pp. 231-248
    • Rapoport, S.I.1    Horwitz, B.2    Grady, C.L.3    Haxby, J.V.4    DeCarli, C.5    Schapiro, M.B.6
  • 52
    • 13444291132 scopus 로고    scopus 로고
    • Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimers Disease with PET
    • Solbach C, Uebele M, Reischl G, Machulla HJ. Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimers Disease with PET. Appl Radiat Isot 2005; 62: 591-95.
    • (2005) Appl Radiat Isot , vol.62 , pp. 591-595
    • Solbach, C.1    Uebele, M.2    Reischl, G.3    Machulla, H.J.4
  • 53
    • 84870503989 scopus 로고    scopus 로고
    • Amyloid Deposition Detected with Florbetapir F 18 ((18)F-AV-45) Is Related to Lower Episodic Memory Performance in Clinically Normal Older Individuals
    • Sperling RA, Johnson KA, Doraiswamy PM, Reiman EM, Fleisher AS, Sabbagh MN, et al. Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiol Aging, 2013; 34: 822-31.
    • (2013) Neurobiol Aging , Issue.34 , pp. 822-831
    • Sperling, R.A.1    Johnson, K.A.2    Doraiswamy, P.M.3    Reiman, E.M.4    Fleisher, A.S.5    Sabbagh, M.N.6
  • 54
    • 84879656825 scopus 로고    scopus 로고
    • Brain [18F]FDDNP binding and glucose metabolism in advanced elderly healthy subjects and Alzheimers disease patients
    • Tauber C, Beaufils E, Hommet C, Ribeiro MJ, Vercouillie J, Vierron E, et al. Brain [18F]FDDNP binding and glucose metabolism in advanced elderly healthy subjects and Alzheimers disease patients. J Alzheimers Dis 2013; 36: 311-20.
    • (2013) J Alzheimers Dis , vol.36 , pp. 311-320
    • Tauber, C.1    Beaufils, E.2    Hommet, C.3    Ribeiro, M.J.4    Vercouillie, J.5    Vierron, E.6
  • 55
    • 0037172826 scopus 로고    scopus 로고
    • Phases of A beta-deposition in the human brain and its relevance for the development of AD
    • Thal DR, Rub U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002; 58: 1791-800.
    • (2002) Neurology , vol.58 , pp. 1791-1800
    • Thal, D.R.1    Rub, U.2    Orantes, M.3    Braak, H.4
  • 56
    • 84875423094 scopus 로고    scopus 로고
    • Alzheimers disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in conitively normal older individuals
    • Wirth M, Madison CM, Rabinovici GD, Oh H, Landau SM, Jagust WJ. Alzheimers disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in conitively normal older individuals. J Neurosci 2013a; 33: 5553-63.
    • (2013) J Neurosci , vol.33 , pp. 5553-5563
    • Wirth, M.1    Madison, C.M.2    Rabinovici, G.D.3    Oh, H.4    Landau, S.M.5    Jagust, W.J.6
  • 57
    • 84887471492 scopus 로고    scopus 로고
    • The effect of amyloid beta on cognitive decline is modulated by neural integrity in cognitively normal elderly
    • Wirth M, Oh H, Mormino EC, Markley C, Landau SM, Jagust WJ. The effect of amyloid beta on cognitive decline is modulated by neural integrity in cognitively normal elderly. Alzheimers Dement 2013b; 9: 687-98.e1.
    • (2013) Alzheimers Dement , vol.9 , pp. 687-687e1
    • Wirth, M.1    Oh, H.2    Mormino, E.C.3    Markley, C.4    Landau, S.M.5    Jagust, W.J.6
  • 58
    • 84890423856 scopus 로고    scopus 로고
    • Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people
    • Wirth M, Villeneuve S, Haase CM, Madison CM, Oh H, Landau SM, et al. Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people. JAMA Neurol 2013c; 70: 1512-19.
    • (2013) JAMA Neurol , vol.70 , pp. 1512-1519
    • Wirth, M.1    Villeneuve, S.2    Haase, C.M.3    Madison, C.M.4    Oh, H.5    Landau, S.M.6
  • 59
    • 0036898647 scopus 로고    scopus 로고
    • Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging
    • Wu Y, Carson RE. Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging. J Cereb Blood Flow Metab 2002; 22: 1440-52.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1440-1452
    • Wu, Y.1    Carson, R.E.2
  • 61
    • 79551531674 scopus 로고    scopus 로고
    • In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimers disease
    • Yokokura M, Mori N, Yagi S, Yoshikawa E, Kikuchi M, Yoshihara Y, et al. In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimers disease. Eur J Nucl Med Mol Imaging 2011; 38: 343-51.
    • (2011) Eur J Nucl Med Mol Imaging , vol.38 , pp. 343-351
    • Yokokura, M.1    Mori, N.2    Yagi, S.3    Yoshikawa, E.4    Kikuchi, M.5    Yoshihara, Y.6
  • 62
    • 84882455578 scopus 로고    scopus 로고
    • Biomarker evidence for uncoupling of amyloid build-up and toxicity in Alzheimers disease
    • Zetterberg H, Blennow K. Biomarker evidence for uncoupling of amyloid build-up and toxicity in Alzheimers disease. Alzheimers Dement 2013; 9: 459-62.
    • (2013) Alzheimers Dement , vol.9 , pp. 459-462
    • Zetterberg, H.1    Blennow, K.2
  • 63
    • 84919402734 scopus 로고    scopus 로고
    • White matter lesion load is associated with resting state functional MRI activity and amyloid PET but not FDG in mild cognitive impairment and early Alzheimers disease patients
    • Zhou Y, Yu F, Duong TQ. White matter lesion load is associated with resting state functional MRI activity and amyloid PET but not FDG in mild cognitive impairment and early Alzheimers disease patients. J Magn Reson Imaging 2015; 41: 102-9.
    • (2015) J Magn Reson Imaging , vol.41 , pp. 102-109
    • Zhou, Y.1    Yu, F.2    Duong, T.Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.