Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method

Pharmaceutical Research

Volumn 33, Issue 1, 2016, Pages 102-109

  Nguyen, Tuong Ngoc Gia ^a   Tran, Phuong Ha Lien ^a,b   Van Vo, Toi ^a   Duan, Wei ^b   Truong Dinh Tran, Thao ^a,b  

^a INTERNATIONAL UNIVERSITY   (Viet Nam)

^b DEAKIN UNIVERSITY   (Australia)

Author keywords

poorly water soluble drug; solid dispersion; sustained release; swellable polymer

Indexed keywords

AEROSIL; HYDROXYPROPYLMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE 4000; ISRADIPINE; MACROGOL 6000; MAGNESIUM STEARATE; MANNITOL; UNCLASSIFIED DRUG; DELAYED RELEASE FORMULATION; MACROGOL DERIVATIVE; TABLET;

ARTICLE; DISPERSION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFRARED SPECTROSCOPY; MATRIX TABLET; MELTING POINT; PRIORITY JOURNAL; SOLID DISPERSION; SUSTAINED DRUG RELEASE; X RAY DIFFRACTION; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG DESIGN; MEDICINAL CHEMISTRY; SOLUBILITY; TABLET;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DESIGN; HYPROMELLOSE DERIVATIVES; POLYETHYLENE GLYCOLS; SOLUBILITY; TABLETS; X-RAY DIFFRACTION;

EID: 84952873877     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1767-2     Document Type: Article

References (29)

1. Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today. 2007;12:1068-75.
2. De Haanand P, Lerk C. Oral controlled release dosage forms. A review. Pharmaceutisch Weekblad. 1984;6:57-67.
3. Tran PHL, Tran TTD, Park JB, Lee B-J. Controlled release systems containing solid dispersions: strategies and mechanisms. Pharm Res. 2011;28:2353-78.
4. Tran TT-D, Tran PH-L, Nguyen MNU, Tran KTM, Pham MN, Tran PC, et al. Amorphous isradipine nanosuspension by the sonoprecipitation method. Int J Pharm. 2014;474:146-50.
5. Riekes MK, Kuminek G, Rauber GS, de Campos CEM, Bortoluzzi AJ, Stulzer HK. HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions. Carbohydr Polym. 2014;99:474-82.
6. Ohara T, Kitamura S, Kitagawa T, Terada K. Dissolution mechanism of poorly water-soluble drug from extended release solid dispersion system with ethylcellulose and hydroxypropylmethylcellulose. Int J Pharm. 2005;302:95-102.
7. Konno H, Handa T, Alonzo DE, Taylor LS. Effect of polymer type on the dissolution profile of amorphous solid dispersions containing felodipine. Eur J Pharm Biopharm. 2008;70:493-9.
8. Won D-H, Kim M-S, Lee S, Park J-S, Hwang S-J. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. Int J Pharm. 2005;301:199-208.
9. Tran TT-D, Tran PH-L, Khanh TN, Van TV, Lee B-J. Solubilization of poorly water-soluble drugs using solid dispersions. Recent Pat Drug Deliv Formulation. 2013;7:122-33.
10. Yang M, Wang P, Huang C-Y, Ku MS, Liu H, Gogos C. Solid dispersion of acetaminophen and poly(ethylene oxide) prepared by hot-melt mixing. Int J Pharm. 2010;395:53-61.
11. Ozeki T, Yuasa H, Kanaya Y. Control of medicine release from solid dispersion composed of the poly(ethylene oxide)-carboxyvinylpolymer interpolymer complex by varying molecular weight of poly(ethylene oxide). J Control Release. 1999;58:87-95.
12. Siepmannand J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2012;64(Supplement):163-74.
13. Devjak Novak S, Šporar E, Baumgartner S, Vrečer F. Characterization of physicochemical properties of hydroxypropyl methylcellulose (HPMC) type 2208 and their influence on prolonged drug release from matrix tablets. J Pharm Biomed Anal. 2012;66:136-43.
14. Nochos A, Douroumis D, Bouropoulos N. In vitro release of bovine serum albumin from alginate/HPMC hydrogel beads. Carbohydr Polym. 2008;74:451-7.
15. Tranand TT-D, Tran PH-L. Investigation of polyethylene oxide - based prolonged release solid dispersion containing isradipine. J Drug Deliv Sci Technol. 2013;23:269-74.
16. Tran PH-L, Tran TT-D, Piao ZZ, Van Vo T, Park JB, Lim J, et al. Physical properties and in vivo bioavailability in human volunteers of isradipine using controlled release matrix tablet containing self-emulsifying solid dispersion. Int J Pharm. 2013;450:79-86.
17. Nguyen TN-G, Tran PH-L, Tran TV, Vo TV, Tran TT-D. Development of a modified - solid dispersion in an uncommon approach of melting method facilitating properties of a swellable polymer to enhance drug dissolution. Int J Pharm. 2015;484:228-34.
18. Ching AL, Liew CV, Chan LW, Heng PWS. Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices. Eur J Pharm Sci. 2008;33:361-70.
19. Leunerand C, Dressman J. Improving drug solubility for oral delivery using SDs. Eur J Pharm Biopharm. 2000;50:47-60.
20. Ghori MU, Ginting G, Smith AM, Conway BR. Simultaneous quantification of drug release and erosion from hypromellose hydrophilic matrices. Int J Pharm. 2014;465:405-12.
21. Li CL, Martini LG, Ford JL, Roberts M. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005;57:533-46.
22. Chaibva FA, Khamanga SM, Walker RB. Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets. Drug Dev Ind Pharm. 2010;36:1497-510.
23. ®. Int J Pharm. 1993;100:155-63.
24. Reza MS, Quadir MA, Haider SS. Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery. J Pharm Pharm Sci. 2003;6:282-91.
25. Bettini R, Catellani P, Santi P, Massimo G, Peppas N, Colombo P. Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. J Control Release. 2001;70:383-91.
26. Coates J. Interpretation of infrared spectra, a practical approach. Encycl Anal Chem. 2000.
27. Ramasahayam B, Eedara BB, Kandadi P, Jukanti R, Bandari S. Development of isradipine loaded self-nano emulsifying powders for improved oral delivery: in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2014 1-11.
28. Ju J, Park M, Suk J.-M, Lah MS, Jeong K.-S. An anion receptor with NH and OH groups for hydrogen bonds. Chem Commun. 2008 3546-3548.
29. Tang X, Pikal M, Taylor L. A spectroscopic investigation of hydrogen bond patterns in crystalline and amorphous phases in dihydropyridine calcium channel blockers. Pharm Res. 2002;19:477-83.