Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease

Stem Cells

Volumn 34, Issue 4, 2016, Pages 984-996

  Marteyn, Antoine ^a,b   Sarrazin, Nadège ^a,b   Yan, Jun ^c,d   Bachelin, Corinne ^a,b   Deboux, Cyrille ^a,b   Santin, Mathieu D ^a,b,e   Gressens, Pierre ^c,d   Zujovic, Violetta ^a,b   Baron Van Evercooren, Anne ^a,b  

^a INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^b CNRS   (France)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Cell based therapy; Human neural precursor cells; Modulation of inflammation; Pelizaeus Merzbacher disease; Remyelination

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTOSIS; CELL DIFFERENTIATION; CELL SELECTION; CELL SURVIVAL; CELLS BY BODY ANATOMY; CONTROLLED STUDY; DEMYELINATION; FETUS; HUMAN; HUMAN CELL; IMMUNOMODULATION; INNATE IMMUNITY; LIFE EXPECTANCY; LIFESPAN; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; OLIGODENDROGLIA; PELIZAEUS MERZBACHER DISEASE; POLARIZATION; REMYELINIZATION; WHITE MATTER; ANIMAL; BIOSYNTHESIS; DEMYELINATING DISEASE; GENE EXPRESSION REGULATION; IMMUNOLOGY; INFLAMMATION; METABOLISM; MYELIN SHEATH; PATHOLOGY; PELIZAEUS-MERZBACHER DISEASE; REGENERATION; TRANSPLANTATION;

PLP1 PROTEIN, HUMAN; PROTEOLIPID PROTEIN;

ANIMALS; DEMYELINATING DISEASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNITY, INNATE; IMMUNOMODULATION; INFLAMMATION; MICE; MICROGLIA; MYELIN PROTEOLIPID PROTEIN; MYELIN SHEATH; NEURAL STEM CELLS; OLIGODENDROGLIA; PELIZAEUS-MERZBACHER DISEASE; REGENERATION;

EID: 84952815085     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2263     Document Type: Article

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