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Volumn 8, Issue 12, 2015, Pages 1625-1633

Human umbilical cord matrix-Derived stem cells exert trophic effects on β-cell survival in diabetic rats and isolated islets

Author keywords

Diabetes; Growth factors; IGF1; Stem cells; cells

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; PANCREAS ENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; SOMATOMEDIN C; STREPTOZOCIN;

EID: 84952776082     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.021857     Document Type: Article
Times cited : (34)

References (37)
  • 1
    • 48249144864 scopus 로고    scopus 로고
    • Immunomodulation by mesenchymal stem cells: A potential therapeutic strategy for type 1 diabetes
    • Abdi, R., Fiorina, P., Adra, C. N., Atkinson, M. and Sayegh, M. H. (2008). Immunomodulation by mesenchymal stem cells: A potential therapeutic strategy for type 1 diabetes. Diabetes 57, 1759-1767.
    • (2008) Diabetes , vol.57 , pp. 1759-1767
    • Abdi, R.1    Fiorina, P.2    Adra, C.N.3    Atkinson, M.4    Sayegh, M.H.5
  • 2
    • 51249114293 scopus 로고    scopus 로고
    • IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice
    • Agudo, J., Ayuso, E., Jimenez, V., Salavert, A., Casellas, A., Tafuro, S., Haurigot, V., Ruberte, J., Segovia, J. C., Bueren, J. et al. (2008). IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice. Diabetologia 51, 1862-1872.
    • (2008) Diabetologia , vol.51 , pp. 1862-1872
    • Agudo, J.1    Ayuso, E.2    Jimenez, V.3    Salavert, A.4    Casellas, A.5    Tafuro, S.6    Haurigot, V.7    Ruberte, J.8    Segovia, J.C.9    Bueren, J.10
  • 3
    • 84892659350 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association
    • American Diabetes Association (2014). Diagnosis and classification of diabetes mellitus. Diabetes Care 37 Suppl. 1, S81-S90.
    • (2014) Diabetes Care , vol.37 , pp. S81-S90
  • 5
    • 77649285139 scopus 로고    scopus 로고
    • Stem cell paracrine actions and tissue regeneration
    • Baraniak, P. R. and McDevitt, T. C. (2010). Stem cell paracrine actions and tissue regeneration. Regen. Med. 5, 121-143.
    • (2010) Regen. Med , vol.5 , pp. 121-143
    • Baraniak, P.R.1    McDevitt, T.C.2
  • 7
    • 84875587586 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from wharton's jelly of the umbilical cord: Biological properties and emerging clinical applications
    • Batsali, A. K., Kastrinaki, M.-C., Papadaki, H. A. and Pontikoglou, C. (2013). Mesenchymal stem cells derived from Wharton's Jelly of the umbilical cord: biological properties and emerging clinical applications. Curr. Stem Cell Res. Ther. 8, 144-155.
    • (2013) Curr. Stem Cell Res. Ther , vol.8 , pp. 144-155
    • Batsali, A.K.1    Kastrinaki, M.-C.2    Papadaki, H.A.3    Pontikoglou, C.4
  • 8
    • 84867507940 scopus 로고    scopus 로고
    • The molecular mechanisms of pancreatic beta-cell glucotoxicity: Recent findings and future research directions
    • Bensellam, M., Laybutt, D. R. and Jonas, J.-C. (2012). The molecular mechanisms of pancreatic beta-cell glucotoxicity: Recent findings and future research directions. Mol. Cell. Endocrinol. 364, 1-27.
    • (2012) Mol. Cell. Endocrinol , vol.364 , pp. 1-27
    • Bensellam, M.1    Laybutt, D.R.2    Jonas, J.-C.3
  • 9
    • 85047287491 scopus 로고    scopus 로고
    • Diabetes mellitus and cellular replacement therapy: Expected clinical potential and perspectives
    • Berezin, A. E. (2014). Diabetes mellitus and cellular replacement therapy: Expected clinical potential and perspectives. World J. Diabetes 5, 777-786.
    • (2014) World J. Diabetes , vol.5 , pp. 777-786
    • Berezin, A.E.1
  • 10
    • 0035210374 scopus 로고    scopus 로고
    • Islet beta cell expression of constitutively active AKT1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
    • Bernal-Mizrachi, E., Wen, W., Stahlhut, S., Welling, C. M. and Permutt, M. A. (2001). Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J. Clin. Invest. 108, 1631-1638.
    • (2001) J. Clin. Invest , vol.108 , pp. 1631-1638
    • Bernal-Mizrachi, E.1    Wen, W.2    Stahlhut, S.3    Welling, C.M.4    Permutt, M.A.5
  • 11
    • 84910651421 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 stimulates regulatory t cells and suppresses autoimmune disease
    • Bilbao, D., Luciani, L., Johannesson, B., Piszczek, A. and Rosenthal, N. (2014). Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease. EMBO Mol. Med. 6, 1423-1435.
    • (2014) EMBO Mol. Med , vol.6 , pp. 1423-1435
    • Bilbao, D.1    Luciani, L.2    Johannesson, B.3    Piszczek, A.4    Rosenthal, N.5
  • 13
    • 80054991835 scopus 로고    scopus 로고
    • PDGF signalling controls age-dependent proliferation in pancreatic beta-cells
    • Chen, H., Gu, X., Liu, Y., Wang, J., Wirt, S. E., Bottino, R., Schorle, H., Sage, J. and Kim, S. K. (2011). PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. Nature 478, 349-355.
    • (2011) Nature , vol.478 , pp. 349-355
    • Chen, H.1    Gu, X.2    Liu, Y.3    Wang, J.4    Wirt, S.E.5    Bottino, R.6    Schorle, H.7    Sage, J.8    Kim, S.K.9
  • 14
    • 84899735086 scopus 로고    scopus 로고
    • SH2B1 in beta-cells promotes insulin expression and glucose metabolism in mice
    • Chen, Z., Morris, D. L., Jiang, L., Liu, Y. and Rui, L. (2014). SH2B1 in beta-cells promotes insulin expression and glucose metabolism in mice. Mol. Endocrinol. 28, 696-705.
    • (2014) Mol. Endocrinol , vol.28 , pp. 696-705
    • Chen, Z.1    Morris, D.L.2    Jiang, L.3    Liu, Y.4    Rui, L.5
  • 15
    • 84861982113 scopus 로고    scopus 로고
    • Metabolic actions of insulin-like growth factor-i in normal physiology and diabetes
    • vii-viii
    • Clemmons, D. R. (2012). Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes. Endocrinol. Metab. Clin. North Am. 41, 425-443, vii-viii.
    • (2012) Endocrinol. Metab. Clin. North Am , vol.41 , pp. 425-443
    • Clemmons, D.R.1
  • 16
    • 0038071783 scopus 로고    scopus 로고
    • Minire view: Integral membrane proteins that function coordinately with the insulin-like growth factor I receptor to regulate intracellular signaling
    • Clemmons, D. R. and Maile, L. A. (2003). Minireview: integral membrane proteins that function coordinately with the insulin-like growth factor I receptor to regulate intracellular signaling. Endocrinology 144, 1664-1670.
    • (2003) Endocrinology , vol.144 , pp. 1664-1670
    • Clemmons, D.R.1    Maile, L.A.2
  • 17
    • 25144464664 scopus 로고    scopus 로고
    • Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance
    • Dai, C., Huh, C.-G., Thorgeirsson, S. S. and Liu, Y. (2005). Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am. J. Pathol. 167, 429-436.
    • (2005) Am. J. Pathol , vol.167 , pp. 429-436
    • Dai, C.1    Huh, C.-G.2    Thorgeirsson, S.S.3    Liu, Y.4
  • 18
    • 77956697181 scopus 로고    scopus 로고
    • Homing pathways of mesenchymal stromal cells (MSCS) and their role in clinical applications
    • Deak, E., Seifried, E. and Henschler, R. (2010). Homing pathways of mesenchymal stromal cells (MSCs) and their role in clinical applications. Int. Rev. Immunol. 29, 514-529.
    • (2010) Int. Rev. Immunol , vol.29 , pp. 514-529
    • Deak, E.1    Seifried, E.2    Henschler, R.3
  • 19
    • 84864370040 scopus 로고    scopus 로고
    • The antidiabetic effect of mesenchymal stem cells is unrelated to their transdifferentiation potential but to their capability to restore Th1/Th2 balance and to modify the pancreatic microenvironment
    • Ezquer, F., Ezquer, M., Contador, D., Ricca, M., Simon, V. and Conget, P. (2012). The antidiabetic effect of mesenchymal stem cells is unrelated to their transdifferentiation potential but to their capability to restore Th1/Th2 balance and to modify the pancreatic microenvironment. Stem Cells 30, 1664-1674.
    • (2012) Stem Cells , vol.30 , pp. 1664-1674
    • Ezquer, F.1    Ezquer, M.2    Contador, D.3    Ricca, M.4    Simon, V.5    Conget, P.6
  • 20
    • 0033954474 scopus 로고    scopus 로고
    • Hepatocyte growth factor over expression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
    • Garcia-Ocana, A., Takane, K. K., Syed, M. A., Philbrick, W. M., Vasavada, R. C. and Stewart, A. F. (2000). Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J. Biol. Chem. 275, 1226-1232.
    • (2000) J. Biol. Chem , vol.275 , pp. 1226-1232
    • Garcia-Ocana, A.1    Takane, K.K.2    Syed, M.A.3    Philbrick, W.M.4    Vasavada, R.C.5    Stewart, A.F.6
  • 22
    • 84882671703 scopus 로고    scopus 로고
    • The current state of pancreas transplantation
    • Gruessner, R. W. G. and Gruessner, A. C. (2013). The current state of pancreas transplantation. Nat. Rev. Endocrinol. 9, 555-562.
    • (2013) Nat. Rev. Endocrinol , vol.9 , pp. 555-562
    • Gruessner, R.W.G.1    Gruessner, A.C.2
  • 23
    • 33748935803 scopus 로고    scopus 로고
    • Intrinsic regulators of pancreatic beta-cell proliferation
    • Heit, J. J., Karnik, S. K. and Kim, S. K. (2006). Intrinsic regulators of pancreatic beta-cell proliferation. Annu. Rev. Cell Dev. Biol. 22, 311-338.
    • (2006) Annu. Rev. Cell Dev. Biol , vol.22 , pp. 311-338
    • Heit, J.J.1    Karnik, S.K.2    Kim, S.K.3
  • 25
    • 84875876271 scopus 로고    scopus 로고
    • Long term effects of the implantation of wharton's jellyderived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus
    • Hu, J., Yu, X., Wang, Z., Wang, F., Wang, L., Gao, H., Chen, Y., Zhao, W., Jia, Z., Yan, S. et al. (2013). Long term effects of the implantation of Wharton's jellyderived mesenchymal stem cells from the umbilical cord for newly-onset type 1 diabetes mellitus. Endocr. J. 60, 347-357.
    • (2013) Endocr. J , vol.60 , pp. 347-357
    • Hu, J.1    Yu, X.2    Wang, Z.3    Wang, F.4    Wang, L.5    Gao, H.6    Chen, Y.7    Zhao, W.8    Jia, Z.9    Yan, S.10
  • 27
    • 84922058213 scopus 로고    scopus 로고
    • Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus
    • Kong, D., Zhuang, X., Wang, D., Qu, H., Jiang, Y., Li, X., Wu, W., Xiao, J., Liu, X., Liu, J. et al. (2014). Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus. Clin. Lab. 60, 1969-1976.
    • (2014) Clin. Lab , vol.60 , pp. 1969-1976
    • Kong, D.1    Zhuang, X.2    Wang, D.3    Qu, H.4    Jiang, Y.5    Li, X.6    Wu, W.7    Xiao, J.8    Liu, X.9    Liu, J.10
  • 28
    • 84901013574 scopus 로고    scopus 로고
    • Human adiposederived stromal/stem cells protect against STZ-induced hyperglycemia: Analysis of hASC-derived paracrine effectors
    • Kono, T. M., Sims, E. K., Moss, D. R., Yamamoto, W., Ahn, G., Diamond, J., Tong, X., Day, K. H., Territo, P. R., Hanenberg, H. et al. (2014). Human adiposederived stromal/stem cells protect against STZ-induced hyperglycemia: Analysis of hASC-derived paracrine effectors. Stem Cells 32, 1831-1842.
    • (2014) Stem Cells , vol.32 , pp. 1831-1842
    • Kono, T.M.1    Sims, E.K.2    Moss, D.R.3    Yamamoto, W.4    Ahn, G.5    Diamond, J.6    Tong, X.7    Day, K.H.8    Territo, P.R.9    Hanenberg, H.10
  • 29
    • 1442326000 scopus 로고    scopus 로고
    • No evidence for significant trans differentiation of bone marrow into pancreatic beta-cells in vivo
    • Lechner, A., Yang, Y.-G., Blacken, R. A., Wang, L., Nolan, A. L. and Habener, J. F. (2004). No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 53, 616-623.
    • (2004) Diabetes , vol.53 , pp. 616-623
    • Lechner, A.1    Yang, Y.-G.2    Blacken, R.A.3    Wang, L.4    Nolan, A.L.5    Habener, J.F.6
  • 30
    • 33751232671 scopus 로고    scopus 로고
    • Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    • Lee, R. H., Seo, M. J., Reger, R. L., Spees, J. L., Pulin, A. A., Olson, S. D. and Prockop, D. J. (2006). Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc. Natl. Acad. Sci. USA 103, 17438-17443.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17438-17443
    • Lee, R.H.1    Seo, M.J.2    Reger, R.L.3    Spees, J.L.4    Pulin, A.A.5    Olson, S.D.6    Prockop, D.J.7
  • 31
    • 0020024396 scopus 로고
    • Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus
    • Leiter, E. H. (1982). Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus. Proc. Natl. Acad. Sci. USA 79, 630-634.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 630-634
    • Leiter, E.H.1
  • 32
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan-and streptozotocin-induced diabetes
    • Lenzen, S. (2008). The mechanisms of alloxan- And streptozotocin-induced diabetes. Diabetologia 51, 216-226.
    • (2008) Diabetologia , vol.51 , pp. 216-226
    • Lenzen, S.1
  • 33
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
    • Livak, K. J. and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 34
    • 84877070464 scopus 로고    scopus 로고
    • Wharton's jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: A preliminary report
    • Lopez, Y., Lutjemeier, B., Seshareddy, K., Trevino, E. M., Hageman, K. S., Musch, T. I., Borgarelli, M. and Weiss, M. L. (2013). Wharton's jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: A preliminary report. Curr. Stem Cell Res. Ther. 8, 46-59.
    • (2013) Curr. Stem Cell Res. Ther , vol.8 , pp. 46-59
    • Lopez, Y.1    Lutjemeier, B.2    Seshareddy, K.3    Trevino, E.M.4    Hageman, K.S.5    Musch, T.I.6    Borgarelli, M.7    Weiss, M.L.8
  • 35
    • 80052461617 scopus 로고    scopus 로고
    • Promising cellular therapeutics for prevention or management of graft-versus-host disease (a review)
    • McGuirk, J. P. and Weiss, M. L. (2011). Promising cellular therapeutics for prevention or management of graft-versus-host disease (a review). Placenta 32 Suppl. 4, S304-S310.
    • (2011) Placenta , vol.32 , pp. S304-S310
    • McGuirk, J.P.1    Weiss, M.L.2
  • 36
    • 78650770246 scopus 로고    scopus 로고
    • Hepatocyte growth factor twenty years on: Much more than a growth factor
    • Nakamura, T., Sakai, K., Nakamura, T. and Matsumoto, K. (2011). Hepatocyte growth factor twenty years on: much more than a growth factor. J. Gastroenterol. Hepatol. 26 Suppl. 1, 188-202.
    • (2011) J. Gastroenterol. Hepatol , vol.26 , pp. 188-202
    • Nakamura, T.1    Sakai, K.2    Nakamura, T.3    Matsumoto, K.4
  • 37
    • 36348977575 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells
    • Nauta, A. J. and Fibbe, W. E. (2007). Immunomodulatory properties of mesenchymal stromal cells. Blood 110, 3499-3506.
    • (2007) Blood , vol.110 , pp. 3499-3506
    • Nauta, A.J.1    Fibbe, W.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.