Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance

Cell Reports

Volumn 10, Issue 7, 2015, Pages 1149-1157

  Blanchet, Emilie ^a   VandeVelde, Sam ^a   Matsumura, Shigenobu ^a   Hao, Ergeng ^a   LeLay, John ^a,b   Kaestner, Klaus ^a,b   Montminy, Marc ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; TRANSCRIPTION FACTOR MAFA; CREB1 PROTEIN, MOUSE; CRTC2 PROTEIN, MOUSE; CYCLIC AMP; MAFA PROTEIN, MOUSE; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAF;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INSULIN RESISTANCE; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAT; SECOND MESSENGER; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CYTOLOGY; DEFICIENCY; GENETICS; GLUCOSE TOLERANCE TEST; KNOCKOUT MOUSE; METABOLISM; PANCREAS ISLET; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

MUS;

ANIMALS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLUCOSE TOLERANCE TEST; HYPOXIA-INDUCIBLE FACTOR 1; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MAF TRANSCRIPTION FACTORS, LARGE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84924573868     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.01.046     Document Type: Article

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