New findings on the in vivo antioxidant activity of Curcuma longa extract by an integrated 1H NMR and HPLC-MS metabolomic approach

Fitoterapia

Volumn 109, Issue , 2016, Pages 125-131

  Dall'Acqua, Stefano ^a   Stocchero, Matteo ^b   Boschiero, Irene ^a   Schiavon, Mariano ^a   Golob, Samuel ^c   Uddin, Jalal ^a   Voinovich, Dario ^c   Mammi, Stefano ^a   Schievano, Elisabetta ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b S IN Soluzioni Informatiche   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Antioxidants; Curcuma longa; HPLC MS; In vivo; Metabolomics; NMR

Indexed keywords

2 OXOGLUTARIC ACID; 3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; ALLANTOIN; CITRIC ACID; CREATININE; CURCUMA LONGA EXTRACT; CURCUMIN; CYSTINE; GLUTATHIONE; HIPPURIC ACID; HYDROXYBUTYRIC ACID; TAURINE; TYROSINE; 3-NITROTYROSINE; 3-TYROSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; ANTIOXIDANT; DEOXYGUANOSINE; METHYLAMINE; PLANT EXTRACT; TRIMETHYLOXAMINE; TURMERIC EXTRACT;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINALYSIS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CURCUMA; DRUG EFFECTS; FEMALE; MALE; METABOLOMICS; SPRAGUE DAWLEY RAT; URINE;

ALLANTOIN; ANIMALS; ANTIOXIDANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMA; DEOXYGUANOSINE; FEMALE; MALE; MASS SPECTROMETRY; METABOLOMICS; METHYLAMINES; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE;

EID: 84952690399     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2015.12.013     Document Type: Article

References (55)

1. C. Manach, J. Hubert, R. Llorach, and A. Scalbert The complex links between dietary phytochemicals and human health deciphered by metabolomics Mol. Nutr. Food Res. 53 2009 1303 1315
2. A.R. Ndhlala, M. Moyo, and J. Van Staden Natural antioxidants: fascinating or mythical biomolecules? Molecules 15 2010 6905 6930
3. M. Teiten, S. Eifes, M. Dicato, and M. Diederich Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment Toxins 2 2010 128 162
4. A. Goel, A.B. Kunnumakkara, and B.B. Aggarwal Curcumin as "Curecumin": from kitchen to clinic Biochem. Pharmacol. 75 2008 787 809
5. H. Hatcher, R. Planalp, J. Cho, F.M. Torti, and S.V. Torti Curcumin: from ancient medicine to current clinical trials Cell. Mol. Life Sci. 65 2008 1631 1652
6. B.B. Aggarwal, C. Sundaram, N. Malani, and H. Ichikawa Curcumin: the Indian solid gold Adv. Exp. Med. Biol. 595 2007 1 75
7. R.K. Maheshwari, A.K. Singh, J. Gaddipati, and R.C. Srimal Multiple biological activities of curcumin: a short review Life Sci. 78 2006 2081 2087
8. R.A. Matchanickal, and M.M. Rafi Curcumin: potential health benefits, molecular mechanism of action, and its anticancer properties in vitro and in vivo ACS Symp. Ser. 925 2006 92 107
9. A. Duvoix, R. Blasius, S. Delhalle, M. Schnekenburger, F. Morceau, E. Henry, M. Dicato, and M. Diederich Chemopreventive and therapeutic effects of curcumin Cancer Lett. 223 2005 181 190
10. R.A. Sharma, A.J. Gescher, and W.P. Steward Curcumin: the story so far Eur. J. Cancer 41 2005 1955 1968
11. I. Chattopadhyay, K. Biswas, U. Bandyopadhyay, and R.K. Banerjee Turmeric and curcumin: biological actions and medicinal applications Curr. Sci. 87 2004 44 53
12. P. Anand, A.B. Kunnumakkara, R.A. Newman, and B.B. Aggarwal Bioavailability of curcumin: problems and promises Mol. Pharm. 4 2007 807 818
13. C. Ireson, S. Orr, D.J.L. Jones, R. Verschoyle, C. Lim, J. Luo, L. Howells, S. Plummer, R. Jukes, M. Williams, W.P. Steward, and A. Gescher Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production Cancer Res. 61 2001 1058 1064
14. B.B. Aggarwal, and K.B. Harikumar Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases Int. J. Biochem. Cell Biol. 41 2009 40 59
15. B.B. Aggarwal, A. Kumar, and A.C. Bharti Anticancer potential of curcumin: preclinical and clinical studies Anticancer Res. 23 2003 363 398
16. P. Anand, C. Sundaram, S. Jhurani, A.B. Kunnumakkara, and B.B. Aggarwal Curcumin and cancer: an "old-age" disease with an "age-old" solution Cancer Lett. 267 2008 133 164
17. A.C. Bharti, N. Donato, S. Singh, and B.B. Aggarwal Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis Blood 101 2003 1053 1062
18. C. Yang, X. Zhang, H. Fan, and Y. Liu Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia Brain Res. 1282 2009 133 141
19. I. Carmona-Ramírez, A. Santamaría, J.C. Tobón-Velasco, M. Orozco-Ibarra, I.G. González-Herrera, J. Pedraza-Chaverrí, and P.D. Maldonado Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity J. Nutr. Biochem. 24 2013 14 24
20. D. Il'yasova, P. Scarbrough, and I. Spasojevic Urinary biomarkers of oxidative status Clin. Chim. Acta 413 2012 1446 1453
21. S. Dall'Acqua, M. Stocchero, M. Clauser, I. Boschiero, E. Ndoum, M. Schiavon, S. Mammi, and E. Schievano Changes in urinary metabolic profile after oral administration of curcuma extract in rats J. Pharm. Biomed. Anal. 100 2014 348 356
22. E. Pfeiffer, S.I. Hoehle, S.G. Walch, A. Riess, A.M. Sólyom, and M. Metzler Curcuminoids form reactive glucuronides in vitro J. Agric. Food Chem. 55 2007 538 544
23. T.H. Marczylo, W.P. Steward, and A.J. Gescher Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method J. Agric. Food Chem. 57 2009 797 803
24. M. Katajamaa, J. Miettinen, and M. Orešic MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data Bioinformatics 22 2006 634 636
25. J. Steghens, F. Flourié, K. Arab, and C. Collombel Fast liquid chromatography-mass spectrometry glutathione measurement in whole blood: Micromolar GSSG is a sample preparation artifact J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 798 2003 343 349
26. J.E. Jackson A Users Guide to Principal Components 1991 John Wiley New York
27. S. Wold, M. Sjöström, and L. Eriksson PLS-regression: a basic tool of chemometrics Chemom. Intell. Lab. Syst. 58 2001 109 130
28. J. Trygg, and S. Wold O2-PLS, a two-block (X-Y) latent variable regression (LVR) method with an integral OSC filter J. Chemom. 17 2003 53 64
29. C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Rémésy Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am. J. Clin. Nutr. 81 2005 230S 242S
30. B. Halliwell Are polyphenols antioxidants or pro-oxidants? what do we learn from cell culture and in vivo studies? Arch. Biochem. Biophys. 476 2008 107 112
31. B. Halliwell, J. Rafter, and A. Jenner Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am. J. Clin. Nutr. 81 2005 268S 276S
32. J. Godzien, M. Ciborowski, S. Angulo, F.J. Ruperez, M.P. Martínez, F.J. Señorans, A. Cifuentes, E. Ibañez, and C. Barbas Metabolomic approach with LC-QTOF to study the effect of a nutraceutical treatment on urine of diabetic rats J. Proteome Res. 10 2011 837 844
33. A. Krastanov Metabolomics - the state of art Biotechnol. Biotechnol. Equip. 24 2010 1537 1543
34. R. Llorach, M. Garcia-Aloy, S. Tulipani, R. Vazquez-Fresno, and C. Andres-Lacueva Nutrimetabolomic strategies to develop new biomarkers of intake and health effects J. Agric. Food Chem. 60 2012 8797 8808
35. T.P. Mulder, A.G. Rietveld, and J.M. Van Amelsvoort Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine Am. J. Clin. Nutr. 81 2005 2565 2605
36. D. An, Q. Zhang, S. Wu, J. Wei, J. Yang, F. Dong, X. Yan, and C. Guo Changes of metabolic profiles in urine after oral administration of quercetin in rats Food Chem. Toxicol. 48 2010 1521 1527
37. J. Pyrzanowska, A. Piechal, K. Blecharz-Klin, M. Lehner, A. Skórzewska, D. Turzynska, A. Sobolewska, A. Plaznik, and E. Widy-Tyszkiewicz The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats Pharmacol. Biochem. Behav. 95 2010 351 358
38. R. Dawson Jr., S. Liu, B. Eppler, and T. Patterson Effects of dietary taurine supplementation or deprivation in aged male Fischer 344 rats Mech. Ageing Dev. 107 1999 73 91
39. W.R. Russell, L. Hoyles, H.J. Flint, and M. Dumas Colonic bacterial metabolites and human health Curr. Opin. Microbiol. 16 2013 246 254
40. S.H. Zeisel, K.A. DaCosta, M. Youssef, and S. Hensey Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship J. Nutr. 119 1989 800 804
41. W.H.W. Tang, and S.L. Hazen The contributory role of gut microbiota in cardiovascular disease J. Clin. Invest. 124 2014 4204 4211
42. C.A. Miller, K.D. Corbin, K. Da Costa, S. Zhang, X. Zhao, J.A. Galanko, T. Blevins, B.J. Bennett, A. O'Connor, and S.H. Zeisel Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study Am. J. Clin. Nutr. 100 2014 778 786
43. A. O'Gorman, H. Gibbons, and L. Brennan Metabolomics in the identification of biomarkers of dietary intake Comput. Struct. Biotechnol. J. 4 2013
44. W.H.W. Tang, Z. Wang, B.S. Levison, R.A. Koeth, E.B. Britt, X. Fu, Y. Wu, and S.L. Hazen Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk N. Engl. J. Med. 368 2013 1575 1584
45. R.T. McFadden, C.B. Larmonier, M.T. Midura-Kiela, R. Ramalingam, C.A. Harrison, D.G. Besselsen, J. Chase, G. Caporaso, F.K. Ghishan, and P.R. Kiela 275 The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention Gastroenterology 146 2014 S-66
46. H. Orhan, N.P.E. Vermeulen, C. Tump, H. Zappey, and J.H.N. Meerman Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography-tandem mass spectrometry as non-invasive biomarkers for oxidative damage J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 799 2004 245 254
47. D. Tsikas, A. Mitschke, M. Suchy, F. Gutzki, and D.O. Stichtenoth Determination of 3-nitrotyrosine in human urine at the basal state by gas chromatography-tandem mass spectrometry and evaluation of the excretion after oral intake J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 827 2005 146 156
48. M. Schwemmer, B. Fink, R. Köckerbauer, and E. Bassenge How urine analysis reflects oxidative stress - nitrotyrosine as a potential marker Clin. Chim. Acta 297 2000 207 216
49. L.L. Wu, C. Chiou, P. Chang, and J.T. Wu Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics Clin. Chim. Acta 339 2004 1 9
50. N. Kamalakkannan, R. Rukkumani, P.S. Varma, P. Viswanathan, K.N. Rajasekharan, and V.P. Menon Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats Basic Clin. Pharmacol. Toxicol. 97 2005 15 21
51. B. Jagatha, R.B. Mythri, S. Vali, and M.M.S. Bharath Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies Free Radic. Biol. Med. 44 2008 907 917
52. S.K. Biswas, D. McClure, L.A. Jimenez, I.L. Megson, and I. Rahman Curcumin induces glutathione biosynthesis and inhibits NF-κB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity Antioxid. Redox Signal. 7 2005 32.41
53. N. Venkatesan, D. Punithavathi, and V. Arumugam Curcumin prevents adriamycin nephrotoxicity in rats Br. J. Pharmacol. 129 2000 231 234
54. K. Yang, L. Lin, T. Tseng, S. Wang, and T. Tsai Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 853 2007 183 189
55. S. Awasthi, U. Pandya, S.S. Singhal, J.T. Lin, V. Thiviyanathan, W.E. Seifert Jr., Y.C. Awasthi, and G.A.S. Ansari Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1 Chem. Biol. Interact. 128 2000 19 38