메뉴 건너뛰기




Volumn 203, Issue , 2016, Pages 543-548

Calcium sensitizers: What have we learned over the last 25 years?

Author keywords

Cardiovascular pharmacology; Heart failure; Inodilators; Inotropes; Myosin; Troponin C

Indexed keywords

CALCIUM SENSITIZER; LEVOSIMENDAN; MYOSIN; OMECAMTIV; PIMOBENDAN; TROPONIN C; UNCLASSIFIED DRUG; CALCIUM; CALCIUM INTAKE; CARDIOTONIC AGENT;

EID: 84952685283     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2015.10.240     Document Type: Review
Times cited : (56)

References (80)
  • 1
    • 0018126169 scopus 로고
    • Hospital treatment of congestive heart failure. Management according to hemodynamic profile
    • J.S. Forrester, and D.D. Waters Hospital treatment of congestive heart failure. Management according to hemodynamic profile Am. J. Med. 65 1 1978 173 180
    • (1978) Am. J. Med. , vol.65 , Issue.1 , pp. 173-180
    • Forrester, J.S.1    Waters, D.D.2
  • 3
    • 84944811856 scopus 로고
    • A further contribution regarding the influence of the different constitutes of the blood on the contraction of the heart
    • S. Ringer A further contribution regarding the influence of the different constitutes of the blood on the contraction of the heart J. Physiol. Lond. 4 1883 29 42
    • (1883) J. Physiol. Lond. , vol.4 , pp. 29-42
    • Ringer, S.1
  • 6
    • 0020035442 scopus 로고
    • Cardiovascular properties of a new cardiotonic agent: MDL 17,043 (1.3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol-2-one)
    • R.C. Dage, L.E. Roebel, C.P. Hsieh, D.L. Weiner, and J.K. Woodward Cardiovascular properties of a new cardiotonic agent: MDL 17,043 (1.3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol-2-one) J. Cardiovasc. Pharmacol. 4 3 1982 500 508
    • (1982) J. Cardiovasc. Pharmacol. , vol.4 , Issue.3 , pp. 500-508
    • Dage, R.C.1    Roebel, L.E.2    Hsieh, C.P.3    Weiner, D.L.4    Woodward, J.K.5
  • 7
    • 0020567448 scopus 로고
    • Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure
    • C.S. Maskin, L. Sinoway, B. Chadwick, E.H. Sonnenblick, and T.H. Le Jemtel Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure Circulation 67 5 1983 1065 1070
    • (1983) Circulation , vol.67 , Issue.5 , pp. 1065-1070
    • Maskin, C.S.1    Sinoway, L.2    Chadwick, B.3    Sonnenblick, E.H.4    Le Jemtel, T.H.5
  • 8
    • 84906070649 scopus 로고    scopus 로고
    • Inotropes and inodilators for acute heart failure: Sarcomere active drugs in focus
    • L. Nagy, P. Pollesello, and Z. Papp Inotropes and inodilators for acute heart failure: sarcomere active drugs in focus J. Cardiovasc. Pharmacol. 64 3 2014 199 208
    • (2014) J. Cardiovasc. Pharmacol. , vol.64 , Issue.3 , pp. 199-208
    • Nagy, L.1    Pollesello, P.2    Papp, Z.3
  • 9
    • 0028789065 scopus 로고
    • Regulation of phospholamban and troponin-I phosphorylation in the intact rat cardiomyocytes by adrenergic and cholinergic stimuli: Roles of cyclic nucleotides, calcium, protein kinases and phosphatases and depolarization
    • P.V. Sulakhe, and X.T. Vo Regulation of phospholamban and troponin-I phosphorylation in the intact rat cardiomyocytes by adrenergic and cholinergic stimuli: roles of cyclic nucleotides, calcium, protein kinases and phosphatases and depolarization Mol. Cell. Biochem. 149-150 1995 103 126
    • (1995) Mol. Cell. Biochem. , vol.149-150 , pp. 103-126
    • Sulakhe, P.V.1    Vo, X.T.2
  • 10
    • 0029146873 scopus 로고
    • The unique amino-terminal peptide of cardiac troponin-i regulates myofibrillar activity only when it is phosphorylated
    • J. Wattanapermpool, X. Guo, and R. Solaro The unique amino-terminal peptide of cardiac troponin-i regulates myofibrillar activity only when it is phosphorylated J. Mol. Cell. Cardiol. 27 7 1995 1383 1391
    • (1995) J. Mol. Cell. Cardiol. , vol.27 , Issue.7 , pp. 1383-1391
    • Wattanapermpool, J.1    Guo, X.2    Solaro, R.3
  • 11
    • 80053264842 scopus 로고    scopus 로고
    • Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression
    • P. Han, W. Cai, Y. Wang, C.K. Lam, D.A. Arvanitis, V.P. Singh, and et al. Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression Am. J. Physiol. Heart Circ. Physiol. 301 4 2011 H1588 H1595
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.301 , Issue.4 , pp. H1588-H1595
    • Han, P.1    Cai, W.2    Wang, Y.3    Lam, C.K.4    Arvanitis, D.A.5    Singh, V.P.6
  • 12
    • 34249844194 scopus 로고    scopus 로고
    • Remodelling of action potential and intracellular calcium cycling dynamics during subacute myocardial infarction promotes ventricular arrhythmias in Langendorff-perfused rabbit hearts
    • C.-C. Chou, S. Zhou, H. Hayashi, M. Nihei, Y.-B. Liu, M.-S. Wen, and et al. Remodelling of action potential and intracellular calcium cycling dynamics during subacute myocardial infarction promotes ventricular arrhythmias in Langendorff-perfused rabbit hearts J. Physiol. 580 Pt 3 2007 895 906
    • (2007) J. Physiol. , vol.580 , pp. 895-906
    • Chou, C.-C.1    Zhou, S.2    Hayashi, H.3    Nihei, M.4    Liu, Y.-B.5    Wen, M.-S.6
  • 13
    • 0027417262 scopus 로고
    • Cardiovascular regulatory mechanisms in advanced age
    • E.G. Lakatta Cardiovascular regulatory mechanisms in advanced age Physiol. Rev. 73 2 Apr 1993 413 467
    • (1993) Physiol. Rev. , vol.73 , Issue.2 , pp. 413-467
    • Lakatta, E.G.1
  • 14
    • 0028317036 scopus 로고
    • Divergent effects of intravenous dobutamine and nitroprusside on left atrial contribution to ventricular filling in dogs with chronic heart failure
    • T. Kono, H.N. Sabbah, H. Rosman, H. Shimoyama, M. Alam, and S. Goldstein Divergent effects of intravenous dobutamine and nitroprusside on left atrial contribution to ventricular filling in dogs with chronic heart failure Am. Heart J. 127 4 Pt 1 1994 874 880
    • (1994) Am. Heart J. , vol.127 , Issue.4 , pp. 874-880
    • Kono, T.1    Sabbah, H.N.2    Rosman, H.3    Shimoyama, H.4    Alam, M.5    Goldstein, S.6
  • 15
    • 84862519619 scopus 로고    scopus 로고
    • Dobutamine for patients with severe heart failure: A systematic review and meta-analysis of randomised controlled trials
    • C.L. Tacon, J. McCaffrey, and A. Delaney Dobutamine for patients with severe heart failure: a systematic review and meta-analysis of randomised controlled trials Intensive Care Med. 38 2012 359 367
    • (2012) Intensive Care Med. , vol.38 , pp. 359-367
    • Tacon, C.L.1    McCaffrey, J.2    Delaney, A.3
  • 16
    • 0028351475 scopus 로고
    • Evaluation of the effect of phosphodiestherase inhibitors on mortality in chronic heart failure patients. A meta-analysis
    • P. Nony, J.P. Boissel, M. Lievre, A. Leizorovicz, M.C. Haugh, S. Fareh, and et al. Evaluation of the effect of phosphodiestherase inhibitors on mortality in chronic heart failure patients. A meta-analysis Eur. J. Clin. Pharmacol. 46 1994 191 196
    • (1994) Eur. J. Clin. Pharmacol. , vol.46 , pp. 191-196
    • Nony, P.1    Boissel, J.P.2    Lievre, M.3    Leizorovicz, A.4    Haugh, M.C.5    Fareh, S.6
  • 17
    • 0019941515 scopus 로고
    • Stimulation of Ca ++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent
    • R.J. Solaro, and J.C. Rüegg Stimulation of Ca ++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent Circ. Res. 51 3 Sep 1982 290 294
    • (1982) Circ. Res. , vol.51 , Issue.3 , pp. 290-294
    • Solaro, R.J.1    Rüegg, J.C.2
  • 18
    • 0039115476 scopus 로고
    • 2 + sensitivity of contractile proteins
    • 2 + sensitivity of contractile proteins Circulation 73 3 Pt 2 Mar 1986 III78 III84
    • (1986) Circulation , vol.73 , Issue.3 , pp. III78-III84
    • Rüegg, J.C.1
  • 19
    • 0019293605 scopus 로고
    • The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase
    • M.J. Holroyde, S.P. Robertson, J.D. Johnson, R.J. Solaro, and J.D. Potter The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase J. Biol. Chem. 255 24 1980 11688 11693
    • (1980) J. Biol. Chem. , vol.255 , Issue.24 , pp. 11688-11693
    • Holroyde, M.J.1    Robertson, S.P.2    Johnson, J.D.3    Solaro, R.J.4    Potter, J.D.5
  • 20
    • 0021687326 scopus 로고
    • Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H)-pyridazinone
    • J.C. Rüegg, G. Pfitzer, D. Eubler, and C. Zeugner Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H)-pyridazinone Arzneimittelforschung 34 12 1984 1736 1738
    • (1984) Arzneimittelforschung , vol.34 , Issue.12 , pp. 1736-1738
    • Rüegg, J.C.1    Pfitzer, G.2    Eubler, D.3    Zeugner, C.4
  • 21
    • 0028172183 scopus 로고
    • 2 + sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study
    • 2 + sensitizer, levosimendan, to recombinant human cardiac troponin C. A molecular modelling, fluorescence probe, and proton nuclear magnetic resonance study J. Biol. Chem. 269 46 1994 28584 28590
    • (1994) J. Biol. Chem. , vol.269 , Issue.46 , pp. 28584-28590
    • Pollesello, P.1    Ovaska, M.2    Kaivola, J.3    Tilgmann, C.4    Lundström, K.5    Kalkkinen, N.6
  • 22
    • 0030895197 scopus 로고    scopus 로고
    • Clinical efficacy and safety of pimobendan in treatment of heart failure-experience in Japan
    • K. Kato Clinical efficacy and safety of pimobendan in treatment of heart failure-experience in Japan Cardiology 88 Suppl. 2 1997 28 36
    • (1997) Cardiology , vol.88 , pp. 28-36
    • Kato, K.1
  • 24
    • 0022648976 scopus 로고
    • Phosphodiesterase-inhibiting properties of newer inotropic agents
    • H. Scholz, and W. Meyer Phosphodiesterase-inhibiting properties of newer inotropic agents Circulation 73 3 Pt 2 Mar 1986 III99 II108
    • (1986) Circulation , vol.73 , Issue.3 , pp. III99-II108
    • Scholz, H.1    Meyer, W.2
  • 25
    • 0023607875 scopus 로고
    • Lack of inotropic selectivity of phosphodiestherase enzyme inhibitors in-vitro
    • G.W. Smith, J.C. Hall, and P.A. West Lack of inotropic selectivity of phosphodiestherase enzyme inhibitors in-vitro J. Pharm. Pharmacol. 39 9 Sep 1987 748 751
    • (1987) J. Pharm. Pharmacol. , vol.39 , Issue.9 , pp. 748-751
    • Smith, G.W.1    Hall, J.C.2    West, P.A.3
  • 26
    • 84864990939 scopus 로고    scopus 로고
    • Levosimendan: Molecular mechanisms and clinical implications: Consensus of experts on the mechanisms of action of levosimendan
    • Z. Papp, I. Édes, S. Fruhwald, S.G. De Hert, M. Salmenperä, H. Leppikangas, and et al. Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan Int. J. Cardiol. 159 2 Aug 23 2012 82 87
    • (2012) Int. J. Cardiol. , vol.159 , Issue.2 , pp. 82-87
    • Papp, Z.1    Édes, I.2    Fruhwald, S.3    De Hert, S.G.4    Salmenperä, M.5    Leppikangas, H.6
  • 27
    • 78650221832 scopus 로고    scopus 로고
    • Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac myosin
    • B.P. Morgan, A. Muci, P.P. Lu, X. Qian, T. Tochimoto, W.W. Smith, and et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac myosin ACS Med. Chem. Lett. 1 9 2010 472 477
    • (2010) ACS Med. Chem. Lett. , vol.1 , Issue.9 , pp. 472-477
    • Morgan, B.P.1    Muci, A.2    Lu, P.P.3    Qian, X.4    Tochimoto, T.5    Smith, W.W.6
  • 28
    • 79952781139 scopus 로고    scopus 로고
    • Cardiac myosin activation: A potential therapeutic approach for systolic heart failure
    • F.I. Malik, J.J. Hartman, K.A. Elias, B.P. Morgan, H. Rodriguez, K. Brejc, and et al. Cardiac myosin activation: a potential therapeutic approach for systolic heart failure Science 331 6023 2011 1439 1443
    • (2011) Science , vol.331 , Issue.6023 , pp. 1439-1443
    • Malik, F.I.1    Hartman, J.J.2    Elias, K.A.3    Morgan, B.P.4    Rodriguez, H.5    Brejc, K.6
  • 29
    • 80051989633 scopus 로고    scopus 로고
    • The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: A double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial
    • J.G. Cleland, J.R. Teerlink, R. Senior, E.M. Nifontov, J.J. Mc Murray, C.C. Lang, and et al. The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial Lancet 378 9792 Aug 20 2011 676 683
    • (2011) Lancet , vol.378 , Issue.9792 , pp. 676-683
    • Cleland, J.G.1    Teerlink, J.R.2    Senior, R.3    Nifontov, E.M.4    Mc Murray, J.J.5    Lang, C.C.6
  • 30
    • 0028436369 scopus 로고
    • Pimobendan. A review of its pharmacology and therapeutic potential in congestive heart failure
    • A. Fitton, and R.N. Brogden Pimobendan. A review of its pharmacology and therapeutic potential in congestive heart failure Drugs Aging 4 5 1994 417 441
    • (1994) Drugs Aging , vol.4 , Issue.5 , pp. 417-441
    • Fitton, A.1    Brogden, R.N.2
  • 31
    • 0023944395 scopus 로고
    • Pimobendane (UD-CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross-over and double-blind study with two different doses
    • M. Walter, I. Liebens, H. Goethals, M. Renard, A. Dresse, and R. Bernard Pimobendane (UD-CG 115 BS) in the treatment of severe congestive heart failure. An acute haemodynamic cross-over and double-blind study with two different doses Br. J. Clin. Pharmacol. 25 3 1988 323 329
    • (1988) Br. J. Clin. Pharmacol. , vol.25 , Issue.3 , pp. 323-329
    • Walter, M.1    Liebens, I.2    Goethals, H.3    Renard, M.4    Dresse, A.5    Bernard, R.6
  • 32
    • 0029742865 scopus 로고    scopus 로고
    • Effect of pimobendan on exercise capacity in patients with heart failure: Main results from the Pimobendan in Congestive Heart Failure (PICO) trial
    • J. Lubsen, H. Just, A.C. Hjalmarsson, D. La Framboise, W.J. Remme, J. Heinrich-Nols, and et al. Effect of pimobendan on exercise capacity in patients with heart failure: main results from the Pimobendan in Congestive Heart Failure (PICO) trial Heart 76 3 1996 223 231
    • (1996) Heart , vol.76 , Issue.3 , pp. 223-231
    • Lubsen, J.1    Just, H.2    Hjalmarsson, A.C.3    La Framboise, D.4    Remme, W.J.5    Heinrich-Nols, J.6
  • 33
    • 0029613261 scopus 로고
    • Mechanisms of action of calcium-sensitizing drugs
    • H. Haikala, and I.B. Linden Mechanisms of action of calcium-sensitizing drugs J. Cardiovasc. Pharmacol. 26 Suppl. 1 1995 S10 S19
    • (1995) J. Cardiovasc. Pharmacol. , vol.26 , pp. S10-S19
    • Haikala, H.1    Linden, I.B.2
  • 36
    • 0033844678 scopus 로고    scopus 로고
    • Further evidence for the cardiac troponin C mediated calcium sensitization by levosimendan: Structure-response and binding analysis with analogs of levosimendan
    • J. Levijoki, P. Pollesello, J. Kaivola, C. Tilgmann, T. Sorsa, A. Annila, and et al. Further evidence for the cardiac troponin C mediated calcium sensitization by levosimendan: structure-response and binding analysis with analogs of levosimendan J. Mol. Cell. Cardiol. 32 2000 479 491
    • (2000) J. Mol. Cell. Cardiol. , vol.32 , pp. 479-491
    • Levijoki, J.1    Pollesello, P.2    Kaivola, J.3    Tilgmann, C.4    Sorsa, T.5    Annila, A.6
  • 37
    • 9444292903 scopus 로고    scopus 로고
    • The contractile apparatus as a target for drugs against heart failure: Interaction of levosimendan, a calcium sensitiser, with cardiac troponin c
    • T. Sorsa, P. Pollesello, and R.J. Solaro The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c Mol. Cell. Biochem. 266 2004 87 107
    • (2004) Mol. Cell. Biochem. , vol.266 , pp. 87-107
    • Sorsa, T.1    Pollesello, P.2    Solaro, R.J.3
  • 38
    • 0013302144 scopus 로고    scopus 로고
    • Calcium sensitivity enhancers
    • H. Haikala, and P. Pollesello Calcium sensitivity enhancers IDrugs 3 2000 1199 1205
    • (2000) IDrugs , vol.3 , pp. 1199-1205
    • Haikala, H.1    Pollesello, P.2
  • 40
    • 0343049171 scopus 로고    scopus 로고
    • Comparison of the vasorelaxing effect of cromakalim and the new inodilator, levosimendan, in human isolated portal vein
    • J. Pataricza, J. Hohn, A. Petri, A. Balogh, and J.G. Papp Comparison of the vasorelaxing effect of cromakalim and the new inodilator, levosimendan, in human isolated portal vein J. Pharm. Pharmacol. 52 2000 213 217
    • (2000) J. Pharm. Pharmacol. , vol.52 , pp. 213-217
    • Pataricza, J.1    Hohn, J.2    Petri, A.3    Balogh, A.4    Papp, J.G.5
  • 41
    • 0035088001 scopus 로고    scopus 로고
    • Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels
    • P. Kaheinen, P. Pollesello, J. Levijoki, and H. Haikala Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels J. Cardiovasc. Pharmacol. 37 2001 367 374
    • (2001) J. Cardiovasc. Pharmacol. , vol.37 , pp. 367-374
    • Kaheinen, P.1    Pollesello, P.2    Levijoki, J.3    Haikala, H.4
  • 42
    • 33745607928 scopus 로고    scopus 로고
    • The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles
    • N. Erdei, Z. Papp, P. Pollesello, I. Edes, and Z. Bagi The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles Br. J. Pharmacol. 148 2006 696 702
    • (2006) Br. J. Pharmacol. , vol.148 , pp. 696-702
    • Erdei, N.1    Papp, Z.2    Pollesello, P.3    Edes, I.4    Bagi, Z.5
  • 43
    • 25144460454 scopus 로고    scopus 로고
    • Cardioprotection: A new paradigm in the management of acute heart failure syndromes
    • M. Maytin, and W.S. Colucci Cardioprotection: a new paradigm in the management of acute heart failure syndromes Am. J. Cardiol. 96 2005 26G 31G
    • (2005) Am. J. Cardiol. , vol.96 , pp. 26G-31G
    • Maytin, M.1    Colucci, W.S.2
  • 44
    • 34047235534 scopus 로고    scopus 로고
    • Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats
    • M. Louhelainen, E. Vahtola, P. Kaheinen, H. Leskinen, S. Merasto, V. Kyto, and et al. Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats Br. J. Pharmacol. 150 2007 851 861
    • (2007) Br. J. Pharmacol. , vol.150 , pp. 851-861
    • Louhelainen, M.1    Vahtola, E.2    Kaheinen, P.3    Leskinen, H.4    Merasto, S.5    Kyto, V.6
  • 45
    • 34548725115 scopus 로고    scopus 로고
    • The cardioprotective effects of levosimendan: Preclinical and clinical evidence
    • P. Pollesello, and Z. Papp The cardioprotective effects of levosimendan: preclinical and clinical evidence J. Cardiovasc. Pharmacol. 50 2007 257 263
    • (2007) J. Cardiovasc. Pharmacol. , vol.50 , pp. 257-263
    • Pollesello, P.1    Papp, Z.2
  • 46
    • 42949135943 scopus 로고    scopus 로고
    • A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart
    • E.F. du Toit, A. Genis, L.H. Opie, P. Pollesello, and A. Lochner A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart Br. J. Pharmacol. 154 2008 41 50
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 41-50
    • Du Toit, E.F.1    Genis, A.2    Opie, L.H.3    Pollesello, P.4    Lochner, A.5
  • 47
    • 1642441317 scopus 로고    scopus 로고
    • The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig
    • S. Szilágyi, P. Pollesello, J. Levijoki, P. Kaheinen, H. Haikala, I. Edes, and et al. The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig Eur. J. Pharmacol. 486 1 Feb 13 2004 67 74
    • (2004) Eur. J. Pharmacol. , vol.486 , Issue.1 , pp. 67-74
    • Szilágyi, S.1    Pollesello, P.2    Levijoki, J.3    Kaheinen, P.4    Haikala, H.5    Edes, I.6
  • 49
    • 33750630750 scopus 로고    scopus 로고
    • Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model
    • I. Leprán, P. Pollesello, S. Vajda, A. Varró, and J.G. Papp Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model J. Cardiovasc. Pharmacol. 48 4 2006 148 152
    • (2006) J. Cardiovasc. Pharmacol. , vol.48 , Issue.4 , pp. 148-152
    • Leprán, I.1    Pollesello, P.2    Vajda, S.3    Varró, A.4    Papp, J.G.5
  • 50
    • 0035843756 scopus 로고    scopus 로고
    • Improved survival with simendan after experimental myocardial infarction in rats
    • J. Levijoki, P. Pollesello, P. Kaheinen, and H. Haikala Improved survival with simendan after experimental myocardial infarction in rats Eur. J. Pharmacol. 419 2-3 2001 243 248
    • (2001) Eur. J. Pharmacol. , vol.419 , Issue.2-3 , pp. 243-248
    • Levijoki, J.1    Pollesello, P.2    Kaheinen, P.3    Haikala, H.4
  • 51
    • 0037142946 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomised double-blind trial
    • F. Follath, J.G. Cleland, H. Just, J.G. Papp, H. Scholz, K. Peuhkurinen, and et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial Lancet 360 2002 196 202
    • (2002) Lancet , vol.360 , pp. 196-202
    • Follath, F.1    Cleland, J.G.2    Just, H.3    Papp, J.G.4    Scholz, H.5    Peuhkurinen, K.6
  • 52
    • 0034739460 scopus 로고    scopus 로고
    • Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators
    • M.T. Slawsky, W.S. Colucci, S.S. Gottlieb, B.H. Greenberg, E. Haeusslein, J. Hare, and et al. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators Circulation 102 2000 2222 2227
    • (2000) Circulation , vol.102 , pp. 2222-2227
    • Slawsky, M.T.1    Colucci, W.S.2    Gottlieb, S.S.3    Greenberg, B.H.4    Haeusslein, E.5    Hare, J.6
  • 53
    • 0034669441 scopus 로고    scopus 로고
    • Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure
    • M.S. Nieminen, J. Akkila, G. Hasenfuss, F.X. Kleber, L.A. Lehtonen, V. Mitrovic, and et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure J. Am. Coll. Cardiol. 36 2000 1903 1912
    • (2000) J. Am. Coll. Cardiol. , vol.36 , pp. 1903-1912
    • Nieminen, M.S.1    Akkila, J.2    Hasenfuss, G.3    Kleber, F.X.4    Lehtonen, L.A.5    Mitrovic, V.6
  • 54
    • 0031976338 scopus 로고    scopus 로고
    • Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting
    • J. Lilleberg, M.S. Nieminen, J. Akkila, L. Heikkila, A. Kuitunen, L. Lehtonen, and et al. Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting Eur. Heart J. 19 1998 660 668
    • (1998) Eur. Heart J. , vol.19 , pp. 660-668
    • Lilleberg, J.1    Nieminen, M.S.2    Akkila, J.3    Heikkila, L.4    Kuitunen, A.5    Lehtonen, L.6
  • 56
    • 84877960102 scopus 로고    scopus 로고
    • Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure
    • M. Packer, W. Colucci, L. Fisher, B.M. Massie, J.R. Teerlink, J. Young, and et al. Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure JCHF 1 2013 103 111
    • (2013) JCHF , vol.1 , pp. 103-111
    • Packer, M.1    Colucci, W.2    Fisher, L.3    Massie, B.M.4    Teerlink, J.R.5    Young, J.6
  • 57
    • 34247857479 scopus 로고    scopus 로고
    • Levosimendan vs dobutamine for patients with acute decompensated heart failure: The SURVIVE randomized trial
    • A. Mebazaa, M.S. Nieminen, M. Packer, A. Cohen-Solal, F.X. Kleber, S.J. Pocock, and et al. Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE randomized trial JAMA 297 2007 1883 1891
    • (2007) JAMA , vol.297 , pp. 1883-1891
    • Mebazaa, A.1    Nieminen, M.S.2    Packer, M.3    Cohen-Solal, A.4    Kleber, F.X.5    Pocock, S.J.6
  • 58
    • 33846082231 scopus 로고    scopus 로고
    • Duration of the haemodynamic action of a 24-h infusion of levosimendan in patients with congestive heart failure
    • J. Lilleberg, M. Laine, T. Palkama, M. Kivikko, P. Pohjanjousi, and M. Kupari Duration of the haemodynamic action of a 24-h infusion of levosimendan in patients with congestive heart failure Eur. J. Heart Fail. 9 2007 75 82
    • (2007) Eur. J. Heart Fail. , vol.9 , pp. 75-82
    • Lilleberg, J.1    Laine, M.2    Palkama, T.3    Kivikko, M.4    Pohjanjousi, P.5    Kupari, M.6
  • 59
    • 23044500417 scopus 로고    scopus 로고
    • Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure
    • J.T. Parissis, F. Panou, D. Farmakis, S. Adamopoulos, G. Filippatos, I. Paraskevaidis, and et al. Effects of levosimendan on markers of left ventricular diastolic function and neurohormonal activation in patients with advanced heart failure Am. J. Cardiol. 96 3 2005 423 426
    • (2005) Am. J. Cardiol. , vol.96 , Issue.3 , pp. 423-426
    • Parissis, J.T.1    Panou, F.2    Farmakis, D.3    Adamopoulos, S.4    Filippatos, G.5    Paraskevaidis, I.6
  • 60
    • 0037422531 scopus 로고    scopus 로고
    • Sustained hemodynamic effects of intravenous levosimendan
    • M. Kivikko, L. Lehtonen, and W.S. Colucci Sustained hemodynamic effects of intravenous levosimendan Circulation 107 2003 81 86
    • (2003) Circulation , vol.107 , pp. 81-86
    • Kivikko, M.1    Lehtonen, L.2    Colucci, W.S.3
  • 62
    • 65549140547 scopus 로고    scopus 로고
    • Intermittent inotropic infusions combined with prophylactic amiodarone for patients with decompensated end-stage heart failure
    • S.G. Drakos, J.V. Kanakakis, S. Nanas, M. Bonios, E. Kaldara, F. Katsaros, and et al. Intermittent inotropic infusions combined with prophylactic amiodarone for patients with decompensated end-stage heart failure J. Cardiovasc. Pharmacol. 53 2009 157 161
    • (2009) J. Cardiovasc. Pharmacol. , vol.53 , pp. 157-161
    • Drakos, S.G.1    Kanakakis, J.V.2    Nanas, S.3    Bonios, M.4    Kaldara, E.5    Katsaros, F.6
  • 64
    • 2942574937 scopus 로고    scopus 로고
    • The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia
    • S. Sonntag, S. Sundberg, L.A. Lehtonen, and F.X. Kleber The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia J. Am. Coll. Cardiol. 43 2004 2177 2182
    • (2004) J. Am. Coll. Cardiol. , vol.43 , pp. 2177-2182
    • Sonntag, S.1    Sundberg, S.2    Lehtonen, L.A.3    Kleber, F.X.4
  • 65
    • 33947713478 scopus 로고    scopus 로고
    • Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: Alteration of force-frequency and relaxation-frequency relationships
    • M.M. Givertz, C. Andreou, C.H. Conrad, and W.S. Colucci Direct myocardial effects of levosimendan in humans with left ventricular dysfunction: alteration of force-frequency and relaxation-frequency relationships Circulation 115 2007 1218 1224
    • (2007) Circulation , vol.115 , pp. 1218-1224
    • Givertz, M.M.1    Andreou, C.2    Conrad, C.H.3    Colucci, W.S.4
  • 66
    • 74449083901 scopus 로고    scopus 로고
    • Levosimendan for the treatment of acute severe heart failure: A meta-analysis of randomised controlled trials
    • A. Delaney, C. Bradford, J. McCaffrey, S.M. Bagshaw, and R. Lee Levosimendan for the treatment of acute severe heart failure: a meta-analysis of randomised controlled trials Int. J. Cardiol. 138 2010 281 289
    • (2010) Int. J. Cardiol. , vol.138 , pp. 281-289
    • Delaney, A.1    Bradford, C.2    McCaffrey, J.3    Bagshaw, S.M.4    Lee, R.5
  • 67
    • 84856185198 scopus 로고    scopus 로고
    • Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies
    • G. Landoni, G. Biondi-Zoccai, M. Greco, T. Greco, E. Bignami, A. Morelli, and et al. Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies Crit. Care Med. 40 2012 634 646
    • (2012) Crit. Care Med. , vol.40 , pp. 634-646
    • Landoni, G.1    Biondi-Zoccai, G.2    Greco, M.3    Greco, T.4    Bignami, E.5    Morelli, A.6
  • 68
    • 79958058396 scopus 로고    scopus 로고
    • Levosimendan and mortality after coronary revascularisation: A meta-analysis of randomised controlled trials
    • R. Maharaj, and V. Metaxa Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials Crit. Care 15 2011 R140
    • (2011) Crit. Care , vol.15 , pp. R140
    • Maharaj, R.1    Metaxa, V.2
  • 70
    • 84946151253 scopus 로고    scopus 로고
    • The effect of inotropes and vasopressors on mortality: A meta-analysis of randomized clinical trials
    • A. Belletti, M.L. Castro, S. Silvetti, T. Greco, G. Biondi-Zoccai, L. Pasin, and et al. The effect of inotropes and vasopressors on mortality: a meta-analysis of randomized clinical trials Br. J. Anaesth. 115 5 2015 656 675
    • (2015) Br. J. Anaesth. , vol.115 , Issue.5 , pp. 656-675
    • Belletti, A.1    Castro, M.L.2    Silvetti, S.3    Greco, T.4    Biondi-Zoccai, G.5    Pasin, L.6
  • 71
    • 84940460494 scopus 로고    scopus 로고
    • The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat
    • EPub Aug 4
    • L. Nagy, Á. Kovács, B. Bódi, E.T. Pásztor, G.Á. Fülöp, A. Tóth, and et al. The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat Br. J. Pharmacol. 2015 10.1111/bph.13235 (EPub Aug 4)
    • (2015) Br. J. Pharmacol.
    • Nagy, L.1    Kovács, Á.2    Bódi, B.3    Pásztor, E.T.4    Fülöp, G.Á.5    Tóth, A.6
  • 72
    • 84942920424 scopus 로고    scopus 로고
    • The myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity
    • ePub May 29
    • J.P. Bakkehaug, A.B. Kildal, E.T. Engstad, N. Boardman, T. Næsheim, L. Rønning, and et al. The myosin activator omecamtiv mecarbil increases myocardial oxygen consumption and impairs cardiac efficiency mediated by resting myosin ATPase activity Circ. Heart Fail. 2015 (ePub May 29)
    • (2015) Circ. Heart Fail.
    • Bakkehaug, J.P.1    Kildal, A.B.2    Engstad, E.T.3    Boardman, N.4    Næsheim, T.5    Rønning, L.6
  • 73
    • 80051967502 scopus 로고    scopus 로고
    • Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: A first-in-man study
    • J.R. Teerlink, C.P. Clarke, K.G. Saikali, J.H. Lee, M.M. Chen, R.D. Escandon, and et al. Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study Lancet 378 9792 2011 667 675
    • (2011) Lancet , vol.378 , Issue.9792 , pp. 667-675
    • Teerlink, J.R.1    Clarke, C.P.2    Saikali, K.G.3    Lee, J.H.4    Chen, M.M.5    Escandon, R.D.6
  • 75
    • 84920265115 scopus 로고    scopus 로고
    • Safety and tolerability of omecamtiv mecarbil during exercise in patients with ischemic cardiomyopathy and angina
    • B.H. Greenberg, W. Chou, K.G. Saikali, R. Escandón, J.H. Lee, M.M. Chen, and et al. Safety and tolerability of omecamtiv mecarbil during exercise in patients with ischemic cardiomyopathy and angina JACC Heart Fail. 3 1 2015 22 29
    • (2015) JACC Heart Fail. , vol.3 , Issue.1 , pp. 22-29
    • Greenberg, B.H.1    Chou, W.2    Saikali, K.G.3    Escandón, R.4    Lee, J.H.5    Chen, M.M.6
  • 76
    • 34548591843 scopus 로고    scopus 로고
    • Effect of levosimendan on ventriculo-arterial coupling in patients with ischemic cardiomyopathy
    • F. Guarracino, C. Cariello, A. Danella, L. Doroni, F. Lapolla, M. Stefani, and et al. Effect of levosimendan on ventriculo-arterial coupling in patients with ischemic cardiomyopathy Acta Anaesthesiol. Scand. 51 9 Oct 2007 1217 1224
    • (2007) Acta Anaesthesiol. Scand. , vol.51 , Issue.9 , pp. 1217-1224
    • Guarracino, F.1    Cariello, C.2    Danella, A.3    Doroni, L.4    Lapolla, F.5    Stefani, M.6
  • 78
    • 84940597500 scopus 로고    scopus 로고
    • Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs
    • Epub ahead of print
    • M.X. Li, and P.M. Hwang Structure and function of cardiac troponin C (TNNC1): implications for heart failure, cardiomyopathies, and troponin modulating drugs Gene Jul 29 2015 10.1016/j.gene.2015.07.074 (pii: S0378-1119(15)00915-4. [Epub ahead of print])
    • (2015) Gene
    • Li, M.X.1    Hwang, P.M.2
  • 79
    • 84929026766 scopus 로고    scopus 로고
    • Targeting the sarcomere to correct muscle function
    • P.M. Hwang, and B.D. Sykes Targeting the sarcomere to correct muscle function Nat. Rev. Drug Discov. 14 2015 313 328
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 313-328
    • Hwang, P.M.1    Sykes, B.D.2
  • 80
    • 84894083362 scopus 로고    scopus 로고
    • Drug discovery and development for acute heart failure drugs: Are expectations too high?
    • P. Pollesello Drug discovery and development for acute heart failure drugs: are expectations too high? Int. J. Cardiol. 172 1 2014 11 13
    • (2014) Int. J. Cardiol. , vol.172 , Issue.1 , pp. 11-13
    • Pollesello, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.