Positive inotropic effect of levosimendan is correlated to its stereoselective Ca2+-sensitizing effect but not to stereoselective phosphodiesterase inhibition

Basic and Clinical Pharmacology and Toxicology

Volumn 98, Issue 1, 2006, Pages 74-78

  Kaheinen, Petri ^a   Pollesello, Piero ^a   Hertelendi, Zita ^b   Borbély, Attila ^b   Szilágyi, Szabolcs ^b   Édes, István ^b   Nissinen, Erkki ^a   Haikala, Heimo ^a   Papp, Zoltán ^b  

^a ORION CORPORATION   (Finland)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; DEXTROSIMENDAN; INOTROPIC AGENT; ISOENZYME; LEVOSIMENDAN; PHOSPHODIESTERASE III; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PURIFICATION; GUINEA PIG; HEART MUSCLE CELL; HEART PAPILLARY MUSCLE; HYPOTHESIS; IC 50; INOTROPISM; ISOMER; MUSCLE FORCE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE TONE; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; THEORY;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; CALCIUM; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART VENTRICLES; HYDRAZONES; ISOMERISM; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PAPILLARY MUSCLES; PHOSPHODIESTERASE INHIBITORS; PYRIDAZINES;

ANIMALIA; CAVIA PORCELLUS;

EID: 33645104482     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2006.pto_231.x     Document Type: Article

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