Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations

Journal of Molecular and Cellular Cardiology

Volumn 89, Issue , 2015, Pages 297-305

  Noh, Junghyun ^a,b   Wende, Adam R ^a,c   Olsen, Curtis D ^a   Kim, Bumjun ^a   Bevins, Jack ^a   Zhu, Yi ^a,d   Zhang, Quan Jiang ^a,f   Riehle, Christian ^a,e   Abel, E Dale ^a,f  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Inje University   (South Korea)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

Cardiac hypertrophy; Exercise; Mitochondria; PI3 kinase signaling

Indexed keywords

PALMITOYLCARNITINE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; INSULIN; PDPK1 PROTEIN, MOUSE; PHOSPHOTHREONINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; GENOTYPE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SWIMMING; ADAPTATION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CARDIAC MUSCLE CELL; CARDIOMEGALY; COMPLICATION; DIAGNOSTIC IMAGING; DRUG EFFECTS; ECHOGRAPHY; ENZYMOLOGY; GENE DELETION; HEART CATHETERIZATION; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MITOCHONDRION; HOMOZYGOTE; KNOCKOUT MOUSE; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ADAPTATION, PHYSIOLOGICAL; ANIMALS; CARDIAC CATHETERIZATION; CARDIOMEGALY; GENE DELETION; HEART FAILURE; HOMOZYGOTE; INSULIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; ORGAN SIZE; PHOSPHORYLATION; PHOSPHOTHREONINE; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; ULTRASONOGRAPHY; VENTRICULAR FUNCTION, LEFT;

EID: 84952663482     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.10.015     Document Type: Article

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