Triazole-curcuminoids: A new class of derivatives for 'tuning' curcumin bioactivities?

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 2, 2016, Pages 140-152

  Caprioglio, Diego ^a   Torretta, Simone ^a   Ferrari, Maila ^a   Travelli, Cristina ^a   Grolla, Ambra A ^a   Condorelli, Fabrizio ^a   Genazzani, Armando A ^a   Minassi, Alberto ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

1,3 Dipolar cycloaddition; Click chemistry; Curcumin; Curcuminoids; NF B

Indexed keywords

1 (STYRYL) 4 (3,4,5 TRIMETHOXYSTYRYL) 1H 1,2,3 TRIAZOLE; 1,2,3 TRIAZOLE DERIVATIVE; 1,4 DI (STYRYL) 1H 1,2,3 TRIAZOLE; 2 METHOXY 4 VINYLPHENYL PIVALATE; 2 METHOXY 4 [2 [1 (STYRY) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 2 METHOXY 4 [2 [4 (3 METHOXYSTYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 2 METHOXY 4 [2 [4 (3,4,5 TRIMETHOXYSTYRY) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 2 METHOXY 4 [2 [4 (4 METHOXYSTYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 2 METHOXY 4 [2 [4 (STYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL] PHENOL; 4 (2 AZIDO 1 IODOETHYL) 2 METHOXYPHENYL PIVALATE; 4 (2 AZIDOVINYL) 2 METHOXYPHENYL PIVALATE; 4 (3 METHOXYSTYRYL) 1 (STYRYL) 1H 1,2,3 TRIAZOLE; 4 (4 METHOXYSTYRYL) 1 (STYRYL) 1H 1,2,3 TRIAZOLE; 4 [2 [1 (4 HYDROXYSTYRYL) 1H 1,2,3 TRIAZOL 4 YL]VINYL] 2 METHOXYPHENOL; 4 [2 [1 (STYRYL) 1H 1,2,3 TRIAZOL 4 YL]VINYL]BENZENE; 4 [2 [1 (STYRYL) 1H 1,2,3 TRIAZOL 4 YL]VINYL]PHENOL; 4 [2 [4 (3 HYDROXY 4 METHOXYSTYRY) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 4 [2 [4 (3 METHOXYSTYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 4 [2 [4 (3,4,5 TRIMETHOXYSTYRYL) 1H 1,2,3 TRIAZOL 4 YL]VINYL]BENZENE 1,2 DIOL; 4 [2 [4 (4 HYDROXYSTYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL] 2 METHOXYPHENOL; 4 [2 [4 (4 HYDROXYSTYRYL) 1H 1,2,3 TRIAZOL 4 YL]VINYL]BENZENE 1,2 DIOL; 4 [2 [4 (HYDROXYSTYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 4 [2 [4 (METHOXYSTYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; 4 [2 [4 (STYRYL) 1H 1,2,3 TRIAZOL 1 YL]VINYL]PHENOL; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TERT BUTYL[2 METHOXY 4 [4 (TRIMETHYLSILYL)BUT 1 EN3 YN 1 YL]PHENOXY]DIMETHYLSILANE; TRIAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [4 (2 BROMOVINYL) 2 METHOXYPHENOXY](TERT BUTYL)DIMETHYLSILANE; TRIAZOLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CURCUMA LONGA; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; HELA CELL LINE; IC50; PHARMACOPHORE; PLEIOTROPY; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

CELL CYCLE; CELL SURVIVAL; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; NF-KAPPA B; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUMOR CELLS, CULTURED;

EID: 84952639694     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.11.044     Document Type: Article

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