Actin-binding doliculide causes premature senescence in p53 wild type cells

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 2, 2016, Pages 123-129

  Foerster, Florian ^a   Chen, Tao ^b   Altmann, Karl Heinz ^b   Vollmar, Angelika M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

Actin; Doliculide; p53; RT2 Profiler PCR Array; Senescence

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLODEPSIPEPTIDE; DOLICULIDE; MESSENGER RNA; PROTEIN P53; UNCLASSIFIED DRUG; ACTIN; DEPSIPEPTIDE;

ACTIN FILAMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEPOLYMERIZATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; SENESCENCE; SIGNAL TRANSDUCTION; BINDING SITE; CELL AGING; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FEMALE; GENETICS; HEPG2 CELL LINE; MCF 7 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

ACTINS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL AGING; CELL PROLIFERATION; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HEP G2 CELLS; HUMANS; MCF-7 CELLS; POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84952638019     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.11.042     Document Type: Article

References (29)

1. T.D. Pollard, and J.A. Cooper Science 326 2009 1208
2. L.G. Milroy, and et al. J. Am. Chem. Soc. 134 2012 8480
3. C. Dumontet, and M.A. Jordan Nat. Rev. Drug. Disc. 9 2010 790
4. F. Foerster, and et al. Cell Death Dis. 5 2014 e1398
5. I.B. Roninson Cancer Res. 63 2003 2705
6. R.H. te Poele, and et al. Cancer Res. 62 2002 1876
7. A. Vigneron, and et al. Cancer Res. 65 2005 8927
8. J. Campisi Science 309 2005 886
9. P.A. Perez-Mancera, A.R. Young, and M. Narita Nat. Rev. Cancer 14 2014 547
10. T. Chen, and K.H. Altmann Chemistry 2015
11. F. Foerster, and et al. Bioorg. Med. Chem. 22 2014 5117
12. A. Vigneron, and K.H. Vousden Aging (Albany NY) 2 2010 471
13. A. Van Keymeulen, and et al. Nature 525 2015 119
14. G.P. Dimri, and et al. Proc. Natl. Acad. Sci. U.S.A. 92 1995 9363
15. J.S. Allingham, V.A. Klenchin, and I. Rayment Cell. Mol. Life Sci. 63 2006 2119
16. T.N. Hiroyuki Ishiwata, Makoto Ojika, and Kiyoyuki Yamada J. Org. Chem. 1994 4710
17. R. Bai, and et al. J. Biol. Chem. 277 2002 32165
18. P.J. Hornsby J. Clin. Oncol. 25 2007 1852
19. Y.H. Lee, B.S. Kang, and Y.S. Bae Life Sci. 97 2014 116
20. T.R. Kim, and et al. Biochem. Biophys. Res. Commun. 400 2010 100
21. I.B. Roninson, E.V. Broude, and B.D. Chang Drug Resist. Updat. 4 2001 303
22. M. Lee, and J.S. Lee BMB Rep. 47 2014 51
23. J.P. Coppe, and et al. Annu. Rev. Pathol. 5 2010 99
24. T. Pederson, and U. Aebi Mol. Biol. Cell 16 2005 5055
25. M.K. Vartiainen, and et al. Science 316 2007 1749
26. A.L. Okorokov, and et al. Oncogene 21 2002 356
27. M. Trendowski, and et al. In Vivo 28 2014 1021
28. M. Trendowski, and et al. Invest. New Drugs 33 2015 280
29. M. Trendowski, and et al. Invest. New Drugs 33 2015 290