Identification of nonessential regions of the nsp2 protein of an attenuated vaccine strain (HuN4-F112) of highly pathogenic porcine reproductive and respiratory syndrome virus for replication in marc-145 cell

Virology Journal

Volumn 9, Issue , 2012, Pages

  Xu, Yan Zhao ^a   Zhou, Yan Jun ^a   Zhang, Shan Rui ^a   Tong, Wu ^a   Li, Ling ^a   Jiang, Yi Feng ^a   Tong, Guang Zhi ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Deletion mutant; HuN4 F112; Nonessential region; Nsp2

Indexed keywords

NONSTRUCTURAL PROTEIN 2; COMPLEMENTARY DNA; LIVE VACCINE; VIRUS DNA; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTERIVIRUS; ARTICLE; DELETION MUTANT; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GROWTH CURVE; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROGENESIS; VIRUS GENOME; VIRUS PLAQUE; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; CELL LINE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NUCLEOTIDE SEQUENCE;

PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS;

ANIMALS; CELL LINE; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; DNA, VIRAL; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; VACCINES, ATTENUATED; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84864439741     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-9-141     Document Type: Article

References (34)

1. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Cavanagh D, Arch Virol 1997 142 629 633 9349308
2. North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. Allende R, Lewis TL, Lu Z, Rock DL, Kutish GF, Ali A, Doster AR, Osorio FA, J Gen Virol 1999 80 Pt 2 307 315 10073689 (Pubitemid 29095189)
3. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Meulenberg JJ, Hulst MM, de Meijer EJ, Moonen PL, den Besten A, de Kluyver EP, Wensvoort G, Moormann RJ, Virology 1993 192 62 72 10.1006/viro.1993.1008 8517032
4. Porcine reproductive and respiratory syndrome virus comparison: divergent evolution on two continents. Nelsen CJ, Murtaugh MP, Faaberg KS, J Virol 1999 73 270 280 9847330 (Pubitemid 28565369)
5. The ever-expanding diversity of porcine reproductive and respiratory syndrome virus. Murtaugh MP, Stadejek T, Abrahante JE, Lam TT, Leung FC, Virus Res 2010 154 18 30 10.1016/j.virusres.2010.08.015 20801173
6. Current knowledge on the structural proteins of porcine reproductive and respiratory syndrome (PRRS) virus: comparison of the North American and European isolates. Dea S, Gagnon CA, Mardassi H, Pirzadeh B, Rogan D, Arch Virol 2000 145 659 688 10.1007/s007050050662 10893147 (Pubitemid 30306142)
7. Porcine reproductive and respiratory syndrome virus: an update on an emerging and re-emerging viral disease of swine. Lunney JK, Benfield DA, Rowland RR, Virus Res 2010 154 1 6 10.1016/j.virusres.2010.10.009 20951175
8. The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner. Van Breedam W, Van Gorp H, Zhang JQ, Crocker PR, Delputte PL, Nauwynck HJ, PLoS Pathog 2010 6 1000730 10.1371/journal.ppat.1000730 20084110
9. Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses. Johnson CR, Griggs TF, Gnanandarajah J, Murtaugh MP, J Gen Virol 2011 92 1107 1116 10.1099/vir.0.030213-0 21307222
10. Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production. Firth AE, Zevenhoven-Dobbe JC, Wills NM, Go YY, Balasuriya UB, Atkins JF, Snijder EJ, Posthuma CC, J Gen Virol 2011 92 1097 1106 10.1099/vir.0.029264-0 21307223
11. Virus-encoded proteinases and proteolytic processing in the Nidovirales. Ziebuhr J, Snijder EJ, Gorbalenya AE, J Gen Virol 2000 81 853 879 10725411 (Pubitemid 30189624)
12. The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins. Fang Y, Snijder EJ, Virus Res 2010 154 61 76 10.1016/j.virusres.2010.07.030 20696193
13. Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus. Han J, Wang Y, Faaberg KS, Virus Res 2006 122 175 182 10.1016/j.virusres.2006.06.003 16860427 (Pubitemid 44637246)
14. The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases. Snijder EJ, Wassenaar AL, Spaan WJ, Gorbalenya AE, J Biol Chem 1995 270 16671 16676 10.1074/jbc.270.28.16671 7622476
15. Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture. Han J, Liu G, Wang Y, Faaberg KS, J Virol 2007 81 9878 9890 10.1128/JVI.00562-07 17522233 (Pubitemid 350067691)
16. Genetic and immunobiological diversities of porcine reproductive and respiratory syndrome genotype I strains. Darwich L, Gimeno M, Sibila M, Diaz I, de la Torre E, Dotti S, Kuzemtseva L, Martin M, Pujols J, Mateu E, Vet Microbiol 2011 150 49 62 10.1016/j.vetmic.2011.01.008 21310555
17. Determination of the complete nucleotide sequence of a vaccine strain of porcine reproductive and respiratory syndrome virus and identification of the Nsp2 gene with a unique insertion. Shen S, Kwang J, Liu W, Liu DX, Arch Virol 2000 145 871 883 10.1007/s007050050680 10881675 (Pubitemid 30332607)
18. Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States. Fang Y, Kim DY, Ropp S, Steen P, Christopher-Hennings J, Nelson EA, Rowland RR, Virus Res 2004 100 229 235 10.1016/j.virusres.2003.12.026 15019241 (Pubitemid 38293047)
19. Genomic characterization of two Chinese isolates of porcine respiratory and reproductive syndrome virus. Gao ZQ, Guo X, Yang HC, Arch Virol 2004 149 1341 1351 15221535 (Pubitemid 38927637)
20. Characterization of emerging European-like porcine reproductive and respiratory syndrome virus isolates in the United States. Ropp SL, Wees CE, Fang Y, Nelson EA, Rossow KD, Bien M, Arndt B, Preszler S, Steen P, Christopher-Hennings J, et al. J Virol 2004 78 3684 3703 10.1128/JVI.78.7.3684- 3703.2004 15016889 (Pubitemid 38568308)
21. Highly pathogenic porcine reproductive and respiratory syndrome, China. Tong GZ, Zhou YJ, Hao XF, Tian ZJ, An TQ, Qiu HJ, Emerg Infect Dis 2007 13 1434 1436 10.3201/eid1309.070399 18252136
22. The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009. Zhou Z, Ni J, Cao Z, Han X, Xia Y, Zi Z, Ning K, Liu Q, Cai L, Qiu P, et al. Vet Microbiol 2011 150 257 269 10.1016/j.vetmic.2011.02.013 21411250
23. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. Tian K, Yu X, Zhao T, Feng Y, Cao Z, Wang C, Hu Y, Chen X, Hu D, Tian X, et al. PLoS One 2007 2 526 10.1371/journal.pone.0000526 17565379
24. Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China. Li Y, Wang X, Bo K, Tang B, Yang B, Jiang W, Jiang P, Vet J 2007 174 577 584 10.1016/j.tvjl.2007.07.032 17869553 (Pubitemid 350082720)
25. An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS. Tian ZJ, An TQ, Zhou YJ, Peng JM, Hu SP, Wei TC, Jiang YF, Xiao Y, Tong GZ, Vet Microbiol 2009 138 34 40 10.1016/j.vetmic.2009.03.003 19339125
26. Highly virulent porcine reproductive and respiratory syndrome virus emerged in China. Zhou YJ, Hao XF, Tian ZJ, Tong GZ, Yoo D, An TQ, Zhou T, Li GX, Qiu HJ, Wei TC, Yuan XF, Transbound Emerg Dis 2008 55 152 164 10.1111/j.1865-1682.2008.01020.x 18405338 (Pubitemid 351530885)
27. Generation of an infectious clone of HuN4-F112, an attenuated live vaccine strain of porcine reproductive and respiratory syndrome virus. Zhang S, Zhou Y, Jiang Y, Li G, Yan L, Yu H, Tong G, Virol J 2011 8 410 10.1186/1743-422X-8-410 21851649
28. Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation. Beura LK, Sarkar SN, Kwon B, Subramaniam S, Jones C, Pattnaik AK, Osorio FA, J Virol 2010 84 1574 1584 10.1128/JVI.01326-09 19923190
29. Expression of a foreign epitope by porcine reproductive and respiratory syndrome virus. Groot Bramel-Verheije MH, Rottier PJ, Meulenberg JJ, Virology 2000 278 380 389 10.1006/viro.2000.0525 11118361 (Pubitemid 32012773)
30. Recombinant PRRSV expressing porcine circovirus sequence reveals novel aspect of transcriptional control of porcine arterivirus. Zheng H, Sun Z, Zhu XQ, Long J, Lu J, Lv J, Yuan S, Virus Res 2010 148 8 16 10.1016/j.virusres.2009. 11.014 19951727
31. Porcine reproductive and respiratory syndrome virus as a vector: immunogenicity of green fluorescent protein and porcine circovirus type 2 capsid expressed from dedicated subgenomic RNAs. Pei Y, Hodgins DC, Wu J, Welch SK, Calvert JG, Li G, Du Y, Song C, Yoo D, Virology 2009 389 91 99 10.1016/j.virol.2009.03.036 19423145
32. Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndrome virus (PRRSV). Kim DY, Calvert JG, Chang KO, Horlen K, Kerrigan M, Rowland RR, Virus Res 2007 128 106 114 10.1016/j.virusres.2007.04.019 17553585 (Pubitemid 47242892)
33. A full-length cDNA infectious clone of North American type 1 porcine reproductive and respiratory syndrome virus: expression of green fluorescent protein in the Nsp2 region. Fang Y, Rowland RR, Roof M, Lunney JK, Christopher-Hennings J, Nelson EA, J Virol 2006 80 11447 11455 10.1128/JVI.01032-06 16971421 (Pubitemid 44788860)
34. Development of genetic markers in the non-structural protein 2 region of a US type 1 porcine reproductive and respiratory syndrome virus: implications for future recombinant marker vaccine development. Fang Y, Christopher-Hennings J, Brown E, Liu H, Chen Z, Lawson SR, Breen R, Clement T, Gao X, Bao J, et al. J Gen Virol 2008 89 3086 3096 10.1099/vir.0.2008/003426-0 19008397