Impact of polyphenolic components from mulberry on apoptosis of vascular smooth muscle cells

Journal of the Science of Food and Agriculture

Volumn 96, Issue 2, 2016, Pages 381-391

  Chan, Kuei Chuan ^a,b   Ho, Hsieh Hsun ^b   Lin, Ming Cheng ^a,b   Huang, Chien Ning ^a,b   Huang, Hui Pei ^b   Wang, Chau Jong ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Fas ligand; Mitochondria; Mulberry polyphenol extracts; P53; Vascular smooth muscle cells

Indexed keywords

CASPASE; FAS LIGAND; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT EXTRACT; POLYPHENOL; PROTEIN P53;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL LINE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MORUS; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE; CELL PROLIFERATION; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; MAP KINASE KINASE 4; MORUS; MUSCLE, SMOOTH, VASCULAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PLANT EXTRACTS; POLYPHENOLS; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84952628560     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.7100     Document Type: Article

References (46)

1. Stoneman VE and Bennett MR, Role of apoptosis in atherosclerosis and its therapeutic implications. Clin Sci 107:343-354 (2004).
2. Sata M, Perlman H, Muruve DA, Silver M, Ikebe M, Libermann TA et al, Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response. Proc Natl Acad Sci USA 95:1213-1217 (1998).
3. Bennett MR, Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture. Cardiovasc Res 41:361-368 (1999).
4. Walsh K and Isner JM, Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall. Cardiovasc Res 45:756-765 (2000).
5. Ward MR, Pasterkamp G, Yeung AC and Borst C, Arterial remodeling mechanisms and clinical implications. Circulation 102:1186-1191 (2000).
6. Pollman MJ, Hall JL, Mann MJ, Zhang L and Gibbons GH, Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Nat Med 4:222-227 (1998).
7. Wang BY, Ho HKV, Lin PS, Schwarzacher SP, Pollman MJ, Gibbons GH et al, Regression of atherosclerosis: role of nitric oxide and apoptosis. Circulation 99:1236-1241 (1999).
8. Pollman MJ, Hall JL and Gibbons GH, Determinants of vascular smooth muscle cell apoptosis after balloon angioplasty injury: influence of redox state and cell phenotype. Circ Res 84:113-121 (1999).
9. Wang CP, Zhang LZ, Li GC, Shi Y, Li JL, Zhang XC et al, Mulberroside a protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. J Neurosci Res 92:944-954 (2014).
10. Lee JS, Kim YR, Park JM, Ha SJ, Kim YE, Baek NI et al, Mulberry fruit extract protects pancreatic β-cells against hydrogen peroxide-induced apoptosis via antioxidative activity. Molecules 19:8904-8915 (2014).
11. Arumugam S, Mito S, Thandavarayan RA, Giridharan VV, Pitchaimani V, Karuppagounder V et al, Mulberry leaf diet protects against progression of experimental autoimmune myocarditis to dilated cardiomyopathy via modulation of oxidative stress and MAPK-mediated apoptosis. Cardiovasc Therapeut 31:352-362 (2013).
12. Bennett M, Macdonald K, Chan SW, Luzio JP, Simari R and Weissberg P, Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis. Science 282:290-293 (1998).
13. Toshiyuki M and Reed JC, Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299 (1995).
14. Miyashita T, Harigai M, Hanada M and Reed JC, Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54:3131-3135 (1994).
15. Bennett MR, Macdonald K, Chan SW, Boyle JJ and Weissberg PL, Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res 82:704-712 (1998).
16. Yonemitsu Y, Kaneda Y, Tanaka S, Nakashima Y, Komori K, Sugimachi K et al, Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo Circ Res 82:147-156 (1998).
17. Ihling C, Haendeler J, Menzel G, Hess RD, Fraedrich G, Schaefer HE et al, Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions. J Pathol 185:303-312 (1998).
18. Haupt Y, Maya R, Kazaz A and Oren M, Mdm2 promotes the rapid degradation of p53. Nature 387:296-299 (1997).
19. Whitmarsh A and Davis R, Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 26:3172-3184 (2007).
20. Chen YR, Wang X, Templeton D, Davis RJ and Tan TH, The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation: duration of JNK activation may determine cell death and proliferation. J Biol Chem 271:31929-31936 (1996).
21. Wisdom R, Johnson RS and Moore C, c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J 18:188-197 (1999).
22. Lenczowski JM, Dominguez L, Eder AM, King LB, Zacharchuk CM and Ashwell JD, Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol Cell Biol 17:170-181 (1997).
23. 2-terminal kinase 1 activation in HeLa cells. J Pharmacol Exp Therapeut 319:1276-1285 (2006).
24. Andallu B, Suryakantham V, Lakshmi Srikanthi B and Kesava Reddy G, Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 314:47-53 (2001).
25. Huang HP, Shih YW, Chang YC, Hung CN and Wang CJ, Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway. J Agric Food Chem 56:9286-9293 (2008).
26. El-Beshbishy HA, Singab ANB, Sinkkonen J and Pihlaja K, Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci 78:2724-2733 (2006).
27. Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K et al, Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 55:5869-5874 (2007).
28. Isabelle M, Lee BL, Ong CN, Liu X and Huang D, Peroxyl radical scavenging capacity, polyphenolics, and lipophilic antioxidant profiles of mulberry fruits cultivated in southern China. J Agric Food Chem 56:9410-9416 (2008).
29. Huang H, Ou T and Wang C, Mulberry and its bioactive compounds, the chemoprevention effects and molecular mechanisms in vitro and in vivo. J Tradit Compl Med 3:7 (2013).
30. Peng CH, Liu LK, Chuang CM, Chyau CC, Huang CN and Wang CJ, Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis. J Agric Food Chem 59:2663-2671 (2011).
31. Chen CC, Liu LK, Hsu JD, Huang HP, Yang MY and Wang CJ, Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. Food Chem 91:601-607 (2005).
32. Chan KC, Ho HH, Huang CN, Lin MC, Chen HM and Wang CJ, Mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small GTPase and Akt/NF-κB signals. J Agric Food Chem 57:9147-9153 (2009).
33. Chan KC, Ho HH, Peng CH, Lan KP, Lin MC, Chen HM et al, Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase. J Agric Food Chem 58:2536-2542 (2010).
34. Hart DJ and Scott KJ, Development and evaluation of an HPLC method for the analysis of carotenoids in foods, and the measurement of the carotenoid content of vegetables and fruits commonly consumed in the UK. Food Chem 54:101-111 (1995).
35. Garcia RL, Coltrera MD and Gown AM, Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis. Am J Pathol 134:733-739 (1989).
36. Pinto AD, Forte V, Guastadisegni MC, Martino C, Schena FP and Tantillo G, A comparison of DNA extraction methods for food analysis. Food Control 18:76-80 (2007).
37. Mora LB, Buettner R, Seigne J, Diaz J, Ahmad N, Garcia R et al, Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res 62:6659-6666 (2002).
38. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W et al, Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464:104-107 (2010).
39. Ida N, Hartmann T, Pantel J, Schröder J, Zerfass R, Förstl H et al, Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem 271:22908-22914 (1996).
40. Winer J, Jung CKS, Shackel I and Williams PM, Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270:41-49 (1999).
41. Otto F, DAPI staining of fixed cells for high-resolution flow cytometry of nuclear DNA. Meth Cell Biol 33:105-110 (1990).
42. Cossarizza A, Baccaranicontri M, Kalashnikova G and Franceschi C, A new method for the cytofluorometric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5, 5′, 6, 6′-tetrachloro-1, 1′, 3, 3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun 197:40-45 (1993).
43. Kojima T and Fujimoto Y, Mulberry leaf extract inhibits the oxidative modification of rabbit and human low density lipoprotein. Biol Pharmaceut Bull 23:1066-1071 (2000).
44. Yang MY, Huang CN, Chan KC, Yang YS, Peng CH and Wang CJ, Mulberry leaf polyphenols possess antiatherogenesis effect via inhibiting LDL oxidation and foam cell formation. J Agric Food Chem 59:1985-1995 (2011).
45. Chan KC, Ho HH, Lin MC, Wu CH, Huang CN, Chang WC et al, Mulberry water extracts inhibit rabbit atherosclerosis through stimulation of vascular smooth muscle cell apoptosis via activating p53 and regulating both intrinsic and extrinsic pathways. J Agric Food Chem 62:5092-5101 (2014).
46. 3/FAK complex and downregulation of nuclear factor κB signaling in vivo and in vitro. J Agric Food Chem 62:9463-9471 (2014).