Mulberry water extracts inhibit rabbit atherosclerosis through stimulation of vascular smooth muscle cell apoptosis via activating p53 and regulating both intrinsic and extrinsic pathways

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 22, 2014, Pages 5092-5101

  Chan, Kuei Chuan ^a,b   Ho, Hsieh Hsun ^b   Lin, Ming Cheng ^a,b   Wu, Cheng Hsun ^c   Huang, Chien Ning ^a,b   Chang, Wen Chun ^b   Wang, Chau Jong ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

atherosclerosis; extrinsic pathway; intrinsic pathway; mulberry water extracts; p53; vascular smooth muscle cells

Indexed keywords

CELL DEATH; DISEASES; PLANTS (BOTANY); CELLS; MUSCLE; POLYPHENOLIC COMPOUNDS;

ATHEROSCLEROSIS; EXTRINSIC PATHWAY; INTRINSIC PATHWAY; P53; VASCULAR SMOOTH MUSCLE CELLS; WATER EXTRACTS;

EXTRACTION;

PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANIMAL; APOPTOSIS; ATHEROSCLEROSIS; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; FRUIT; GENETICS; HUMAN; METABOLISM; MORUS; PATHOPHYSIOLOGY; RABBIT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; ATHEROSCLEROSIS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; DOWN-REGULATION; FRUIT; HUMANS; MORUS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RABBITS; TUMOR SUPPRESSOR PROTEIN P53;

MORUS (PLANT); ORYCTOLAGUS CUNICULUS;

EID: 84901824361     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf501466t     Document Type: Article

References (42)

1. Stoneman, V. E.; Bennett, M. R. Role of apoptosis in atherosclerosis and its therapeutic implications Clinical Science 2004, 107, 343-354
2. Sata, M.; Perlman, H.; Muruve, D. A.; Silver, M.; Ikebe, M.; Libermann, T. A.; Oettgen, P.; Walsh, K. Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 1213-1217
3. Bennett, M. R. Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture Cardiovascular research 1999, 41, 361-368
4. Walsh, K.; Isner, J. M. Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall Cardiovascular research 2000, 45, 756-765
5. Ward, M. R.; Pasterkamp, G.; Yeung, A. C.; Borst, C. Arterial remodeling mechanisms and clinical implications Circulation 2000, 102, 1186-1191
6. Pollman, M. J.; Hall, J. L.; Mann, M. J.; Zhang, L.; Gibbons, G. H. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease Nature medicine 1998, 4, 222-227
7. Wang, B. Y.; Ho, H. K. V.; Lin, P. S.; Schwarzacher, S. P.; Pollman, M. J.; Gibbons, G. H.; Tsao, P. S.; Cooke, J. P. Regression of atherosclerosis Role of nitric oxide and apoptosis Circulation 1999, 99, 1236-1241
8. Pollman, M. J.; Hall, J. L.; Gibbons, G. H. Determinants of vascular smooth muscle cell apoptosis after balloon angioplasty injury influence of redox state and cell phenotype Circulation research 1999, 84, 113-121
9. Bennett, M.; Macdonald, K.; Chan, S. W.; Luzio, J. P.; Simari, R.; Weissberg, P. Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis Science 1998, 282, 290-293
10. Toshiyuki, M.; Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 1995, 80, 293-299
11. Miyashita, T.; Harigai, M.; Hanada, M.; Reed, J. C. Identification of a p53-dependent negative response element in the bcl-2 gene Cancer research 1994, 54, 3131-3135
12. Bennett, M. R.; Macdonald, K.; Chan, S. W.; Boyle, J. J.; Weissberg, P. L. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques Circulation research 1998, 82, 704-712
13. Yonemitsu, Y.; Kaneda, Y.; Tanaka, S.; Nakashima, Y.; Komori, K.; Sugimachi, K.; Sueishi, K. Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo Circulation research 1998, 82, 147-156
14. El-Deiry, W. S.; Tokino, T.; Velculescu, V. E.; Levy, D. B.; Parsons, R.; Trent, J. M.; Lin, D.; Mercer, W. E.; Kinzler, K. W.; Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression Cell 1993, 75, 817-825
15. Guevara, N. V.; Kim, H. S.; Antonova, E. I.; Chan, L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo Nature medicine 1999, 5, 335-339
16. Ihling, C.; Haendeler, J.; Menzel, G.; Hess, R. D.; Fraedrich, G.; Schaefer, H. E.; Zeiher, A. M. Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions Journal of pathology 1998, 185, 303-312
17. Haupt, Y.; Maya, R.; Kazaz, A.; Oren, M. Mdm2 promotes the rapid degradation of p53 Nature 1997, 387, 296-299
18. Whitmarsh, A.; Davis, R. Role of mitogen-activated protein kinase kinase 4 in cancer Oncogene 2007, 26, 3172-3184
19. Chen, Y. R.; Wang, X.; Templeton, D.; Davis, R. J.; Tan, T. H. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation duration of JNK activation may determine cell death and proliferation J. Biol. Chem. 1996, 271, 31929-31936
20. Wisdom, R.; Johnson, R. S.; Moore, C. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms EMBO journal 1999, 18, 188-197
21. Lenczowski, J. M.; Dominguez, L.; Eder, A. M.; King, L. B.; Zacharchuk, C. M.; Ashwell, J. D. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis Molecular and cellular biology 1997, 17, 170-181
22. Andallu, B.; Suryakantham, V.; Lakshmi Srikanthi, B.; Kesava Reddy, G. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes Clin. Chim. Acta 2001, 314, 47-53
23. Huang, H. P.; Shih, Y. W.; Chang, Y. C.; Hung, C. N.; Wang, C. J. Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway Journal of agricultural and food chemistry 2008, 56, 9286-9293
24. El-Beshbishy, H. A.; Singab, A. N. B.; Sinkkonen, J.; Pihlaja, K. Hypolipidemic and antioxidant effects of Morus alba L.(Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats Life sciences 2006, 78, 2724-2733
25. Kimura, T.; Nakagawa, K.; Kubota, H.; Kojima, Y.; Goto, Y.; Yamagishi, K.; Oita, S.; Oikawa, S.; Miyazawa, T. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans Journal of agricultural and food chemistry 2007, 55, 5869-5874
26. Isabelle, M.; Lee, B. L.; Ong, C. N.; Liu, X.; Huang, D. Peroxyl radical scavenging capacity, polyphenolics, and lipophilic antioxidant profiles of mulberry fruits cultivated in southern China Journal of agricultural and food chemistry 2008, 56, 9410-9416
27. Huang, H.; Ou, T.; Wang, C. Mulberry (Sang Shèn Zǐ) and its Bioactive Compounds, the Chemoprevention Effects and Molecular Mechanisms In vitro and In vivo Journal of Traditional and Complementary Medicine 2013, 3, 7
28. Peng, C. H.; Liu, L. K.; Chuang, C. M.; Chyau, C. C.; Huang, C. N.; Wang, C. J. Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis Journal of agricultural and food chemistry 2011, 59, 2663-2671
29. Chen, C. C.; Liu, L. K.; Hsu, J. D.; Huang, H. P.; Yang, M. Y.; Wang, C. J. Mulberry extract inhibits the development of atherosclerosis in cholesterol-fed rabbits Food chemistry 2005, 91, 601-607
30. Chan, K. C.; Ho, H. H.; Huang, C. N.; Lin, M. C.; Chen, H. M.; Wang, C. J. Mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small GTPase and Akt/NF-κB signals Journal of agricultural and food chemistry 2009, 57, 9147-9153
31. Chan, K. C.; Ho, H. H.; Peng, C. H.; Lan, K. P.; Lin, M. C.; Chen, H. M.; Wang, C. J. Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase Journal of agricultural and food chemistry 2010, 58, 2536-2542
32. Chang, Y. C.; Huang, K. X.; Huang, A. C.; Ho, Y. C.; Wang, C. J. Hibiscus anthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis Food Chem. Toxicol. 2006, 44, 1015-1023
33. Lo, C. W.; Huang, H. P.; Lin, H. M.; Chien, C. T.; Wang, C. J. Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway Molecular nutrition & food research 2007, 51, 1452-1460
34. Lin, H. H.; Chen, J. H.; Kuo, W. H.; Wang, C. J. Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation Chemico-biological interactions 2007, 165, 59-75
35. Mansouri, A.; Ridgway, L. D.; Korapati, A. L.; Zhang, Q.; Tian, L.; Wang, Y.; Siddik, Z. H.; Mills, G. B.; Claret, F. X. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells J. Biol. Chem. 2003, 278, 19245-19256
36. She, H.; Yang, Q.; Shepherd, K.; Smith, Y.; Miller, G.; Testa, C.; Mao, Z. Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients J. Clin. Invest. 2011, 121, 930
37. Burnette, W. N. Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A Analytical biochemistry 1981, 112, 195-203
38. Tarnowski, B. I.; Spinale, F. G.; Nicholson, J. H. DAPI as a useful stain for nuclear quantitation Biotechnic & histochemistry 1991, 66, 296-302
39. Kojima, T.; Fujimoto, Y. Mulberry leaf extract inhibits the oxidative modification of rabbit and human low density lipoprotein Biological & pharmaceutical bulletin 2000, 23, 1066-1071
40. Yang, M. Y.; Huang, C. N.; Chan, K. C.; Yang, Y. S.; Peng, C. H.; Wang, C. J. Mulberry leaf polyphenols possess antiatherogenesis effect via inhibiting LDL oxidation and foam cell formation Journal of agricultural and food chemistry 2011, 59, 1985-1995
41. Park, S. Y.; Bok, S. H.; Jeon, S. M.; Park, Y. B.; Lee, S. J.; Jeong, T. S.; Choi, M. S. Effect of rutin and tannic acid supplements on cholesterol metabolism in rats Nutr. Res. (N.Y.) 2002, 22, 283-295
42. Roos, T. U.; Heiss, E. H.; Schwaiberger, A. V.; Schachner, D.; Sroka, I. M.; Oberan, T.; Vollmar, A. M.; Dirsch, V. M. Caffeic acid phenethyl ester inhibits PDGF-induced proliferation of vascular smooth muscle cells via activation of p38 MAPK, HIF-1α, and heme oxygenase-1 J. Nat. Prod. 2011, 74, 352-356