Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 4, 2016, Pages 1165-1177

  Gil Krzewska, Aleksandra ^a   Wood, Stephanie M ^b   Murakami, Yousuke ^a   Nguyen, Victoria ^a   Chiang, Samuel C C ^b   Cullinane, Andrew R ^c   Peruzzi, Giovanna ^a   Gahl, William A ^c   Coligan, John E ^a   Introne, Wendy J ^c   Bryceson, Yenan T ^b   Krzewski, Konrad ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Chediak Higashi syndrome; cytotoxic lymphocyte; cytotoxicity; exocytosis; immune deficiency; lysosomal trafficking regulator; lysosomes; lytic granules; natural killer cell

Indexed keywords

ARMADILLO DOMAIN PROTEIN; CD56 ANTIGEN; ELONGATION FACTOR 3; F ACTIN; GAMMA INTERFERON; GRANZYME A; GRANZYME B; HUNTINGTIN; LYSOSOMAL TRAFFICKING REGULATOR PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PERFORIN; PHOSPHOPROTEIN PHOSPHATASE 2A; SOMATOMEDIN B RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; GENETIC MARKER; LYST PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

ADULT; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CHEDIAK HIGASHI SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEGRANULATION; ENDOSOME; EXOCYTOSIS; FEMALE; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; MALE; MICROTUBULE ORGANIZING CENTER; MISSENSE MUTATION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSPORT VESICLE; GENETIC MARKER; GENETICS; LYSOSOME; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; CHEDIAK-HIGASHI SYNDROME; CYTOKINES; EXOCYTOSIS; FEMALE; GENETIC MARKERS; HUMANS; KILLER CELLS, NATURAL; LYSOSOMES; MALE; MUTATION, MISSENSE; VESICULAR TRANSPORT PROTEINS;

EID: 84951732590     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.08.039     Document Type: Article

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