Perspectives on fetal derived CD5+ B1 B cells

European Journal of Immunology

Volumn 45, Issue 11, 2015, Pages 2978-2984

  Hardy, Richard R ^a   Hayakawa, Kyoko ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

B cell development; B cell leukemia; B1a cells; CD5+ B cells; Stem cells; Transgenic mouse models

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD5 ANTIGEN;

B LYMPHOCYTE; CD5+ B LYMPHOCYTE; CELL FATE; CELL MATURATION; CHRONIC LEUKEMIA; GENE EXPRESSION; HUMAN; LYMPHOCYTE DIFFERENTIATION; LYMPHOPOIESIS; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SHORT SURVEY; SIGNAL TRANSDUCTION; ANIMAL; B CELL LEUKEMIA; FETUS; IMMUNOLOGY; PRE B LYMPHOCYTE;

ANIMALS; ANTIGENS, CD5; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; FETUS; HUMANS; LEUKEMIA, B-CELL; LYMPHOPOIESIS; PRECURSOR CELLS, B-LYMPHOID;

EID: 84951569171     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445146     Document Type: Short Survey

References (78)

1. Hayakawa, K., Hardy, R. R., Parks, D. R. and Herzenberg, L. A., The "Ly-1 B" cell subpopulation in normal, immunodefective, and autoimmune mice. J. Exp. Med. 1983. 157: 202-218.
2. Hayakawa, K., Hardy, R. R., Honda, M., Herzenberg, L. A., Steinberg, A. D. and Herzenberg, L. A., Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc. Natl. Acad. Sci. USA 1984. 81: 2494-2498.
3. Hayakawa, K., Hardy, R. R., Herzenberg, L. A. and Herzenberg, L. A., Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J. Exp. Med. 1985. 161: 1554-1568.
4. Hayakawa, K., Hardy, R. R., Stall, A. M., Herzenberg, L. A. and Herzenberg, L. A., Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage. Eur. J. Immunol. 1986. 16: 1313-1316.
5. Hayakawa, K. and Hardy, R. R., Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage? Annu. Rev. Immunol. 1988. 6: 197-218.
6. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K., Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 1991. 173: 1213-1225.
7. Hardy, R. R. and Hayakawa, K., A developmental switch in B lymphopoiesis. Proc. Natl. Acad. Sci. USA 1991. 88: 11550-11554.
8. Papayannopoulou, T., Nakamoto, B., Agostinelli, F., Manna, M., Lucarelli, G. and Stamatoyannopoulos, G., Fetal to adult hemopoietic cell transplantation in humans: insights into hemoglobin switching. Blood 1986. 67: 99-104.
9. Kantor, A., A new nomenclature for B cells. Immunol. Today 1991. 12: 388.
10. Yuan, J., Nguyen, C. K., Liu, X., Kanellopoulou, C. and Muljo, S. A., Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 2012. 335: 1195-1200.
11. Zhou, Y., Li, Y.-S., Bandi, S., Tang, L., Shinton, S. A., Hayakawa, K. and Hardy, R. R., Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a. J. Exp. Med. 2015. 212: 569-580.
12. Hayakawa, K., Asano, M., Shinton, S. A., Gui, M., Allman, D., Stewart, C. L., Silver, J. and Hardy, R. R., Positive selection of natural autoreactive B cells. Science 1999. 285: 113-116.
13. Wen, L., Brill-Dashoff, J., Shinton, S. A., Asano, M., Hardy, R. R. and Hayakawa, K., Evidence of marginal-zone B cell-positive selection in spleen. Immunity 2005. 23: 297-308.
14. Kantor, A. B., Stall, A. M., Adams, S., Herzenberg, L. A. and Herzenberg, L. A., Differential development of progenitor activity for three B-cell lineages. Proc. Natl. Acad. Sci. USA 1992. 89: 3320-3324.
15. Huang, C. A., Henry, C., Iacomini, J., Imanishi-Kari, T. and Wortis, H. H., Adult bone marrow contains precursors for CD5+ B cells. Eur. J. Immunol. 1996. 26: 2537-2540.
16. Montecino-Rodriguez, E., Leathers, H. and Dorshkind, K., Identification of a B-1 B cell-specified progenitor. Nat. Immunol. 2006. 7: 293-301.
17. Cong, Y. Z., Rabin, E. and Wortis, H. H., Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int. Immunol. 1991. 3: 467-476.
18. Hippen, K. L., Tze, L. E. and Behrens, T. W., CD5 maintains tolerance in anergic B cells. J. Exp. Med. 2000. 191: 883-890.
19. Li, Y. S., Zhou, Y., Tang, L., Shinton, S. A., Hayakawa, K. and Hardy, R. R., A developmental switch between fetal and adult B lymphopoiesis. Ann. N Y Acad. Sci. 2015, in press.
20. Hayakawa, K., Formica, A. M., Colombo, M. J., Ichikawa, D., Shinton, S. A., Brill-Dashoff, J. and Hardy, R. R., B cells generated by B-1 development can progress to chronic lymphocytic leukemia. Ann. N Y Acad. Sci. 2015, in press.
21. Landau, N. R., Schatz, D. G., Rosa, M. and Baltimore, D., Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector. Mol. Cell Biol. 1987. 7: 3237-3243.
22. Xu, J. L. and Davis, M. M., Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 2000. 13: 37-45.
23. Feeney, A. J., Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies. J. Immunol. 1992. 149: 222-229.
24. Gilfillan, S., Dierich, A., Lemeur, M., Benoist, C. and Mathis, D., Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 1993. 261: 1175-1178.
25. Wasserman, R., Li, Y. S., Shinton, S. A., Carmack, C. E., Manser, T., Wiest, D. L., Hayakawa, K. and Hardy, R. R., A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly. J. Exp. Med. 1998. 187: 259-264.
26. Vettermann, C., Herrmann, K. and Jack, H. M., Powered by pairing: the surrogate light chain amplifies immunoglobulin heavy chain signaling and pre-selects the antibody repertoire. Semin. Immunol. 2006. 18: 44-55.
27. Melchers, F., ten Boekel, E., Seidl, T., Kong, X. C., Yamagami, T., Onishi, K., Shimizu, T. et al., Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells. Immunol. Rev. 2000. 175: 33-46.
28. Melchers, F., The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire. Nat. Rev. Immunol. 2005. 5: 578-584.
29. Oettinger, M. A., Schatz, D. G., Gorka, C. and Baltimore, D., RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990. 248: 1517-1523.
30. Hardy, R. R., Carmack, C. E., Shinton, S. A., Riblet, R. J. and Hayakawa, K., A single VH gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells. Definition of the VH11 family. J. Immunol. 1989. 142: 3643-3651.
31. Carmack, C. E., Shinton, S. A., Hayakawa, K. and Hardy, R. R., Rearrangement and selection of VH11 in the Ly-1 B cell lineage. J. Exp. Med. 1990. 172: 371-374.
32. Mercolino, T. J., Arnold, L. W., Hawkins, L. A. and Haughton, G., Normal mouse peritoneum contains a large population of Ly-1+ (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes. J. Exp. Med. 1988. 168: 687-698.
33. ten Boekel, E., Melchers, F. and Rolink, A. G., Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 1997. 7: 357-368.
34. Li, Q. J., Chau, J., Ebert, P. J., Sylvester, G., Min, H., Liu, G., Braich, R. et al., miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 2007. 129: 147-161.
35. Mayr, F., Schutz, A., Doge, N. and Heinemann, U., The Lin28 cold-shock domain remodels pre-let-7 microRNA. Nucleic Acids Res. 2012. 40: 7492-7506.
36. Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y. H. and Weissman, I. L., A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 1990. 62: 863-874.
37. Viswanathan, S. R. and Daley, G. Q., Lin28: a microRNA regulator with a macro role. Cell 2010. 140: 445-449.
38. Zhu, H., Shyh-Chang, N., Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A. et al., The Lin28/let-7 axis regulates glucose metabolism. Cell 2011. 147: 81-94.
39. Shinoda, G., Shyh-Chang, N., Soysa, T. Y., Zhu, H., Seligson, M. T., Shah, S. P., Abo-Sido, N. et al., Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells 2013. 31: 1563-1573.
40. Shyh-Chang, N. and Daley, G. Q., Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell 2013. 12: 395-406.
41. Shyh-Chang, N., Zhu, H., Yvanka de Soysa, T., Shinoda, G., Seligson, M. T., Tsanov, K. M., Nguyen, L. et al., Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 2013. 155: 778-792.
42. Johnson, C. D., Esquela-Kerscher, A., Stefani, G., Byrom, M., Kelnar, K., Ovcharenko, D., Wilson, M. et al., The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007. 67: 7713-7722.
43. Viswanathan, S. R., Powers, J. T., Einhorn, W., Hoshida, Y., Ng, T. L., Toffanin, S., O'Sullivan, M. et al., Lin28 promotes transformation and is associated with advanced human malignancies. Nat. Genet. 2009. 41: 843-848.
44. Madison, B. B., Liu, Q., Zhong, X., Hahn, C. M., Lin, N., Emmett, M. J., Stanger, B. Z. et al., LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Genes Dev. 2013. 27: 2233-2245.
45. Herrscher, R. F., Kaplan, M. H., Lelsz, D. L., Das, C., Scheuermann, R. and Tucker, P. W., The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family. Genes Dev. 1995. 9: 3067-3082.
46. Webb, C. F., Smith, E. A., Medina, K. L., Buchanan, K. L., Smithson, G. and Dou, S., Expression of bright at two distinct stages of B lymphocyte development. J. Immunol. 1998. 160: 4747-4754.
47. Goebel, P., Montalbano, A., Ayers, N., Kompfner, E., Dickinson, L., Webb, C. F. and Feeney, A. J., High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes. J. Immunol. 2002. 169: 2477-2487.
48. Kim, D. and Tucker, P. W., A regulated nucleocytoplasmic shuttle contributes to Bright's function as a transcriptional activator of immunoglobulin genes. Mol. Cell Biol. 2006. 26: 2187-2201.
49. Webb, C. F., Yamashita, Y., Ayers, N., Evetts, S., Paulin, Y., Conley, M. E. and Smith, E. A., The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease. J. Immunol. 2000. 165: 6956-6965.
50. Rajaiya, J., Hatfield, M., Nixon, J. C., Rawlings, D. J. and Webb, C. F., Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol. Cell Biol. 2005. 25: 2073-2084.
51. Schmidt, C., Kim, D., Ippolito, G. C., Naqvi, H. R., Probst, L., Mathur, S., Rosas-Acosta, G. et a., Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright. EMBO J. 2009. 28: 711-724.
52. Hayakawa, K., Asano, M., Shinton, S. A., Gui, M., Wen, L. J., Dashoff, J. and Hardy, R. R., Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J. Exp. Med. 2003. 197: 87-99.
53. Ichikawa, D., Asano, M., Shinton, S. A., Brill-Dashoff, J., Formica, A. M., Velcich, A., Hardy, R. R. et al., Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells. J. Immunol. 2015. 194: 606-614.
54. Hayakawa, K., Carmack, C. E., Hyman, R. and Hardy, R. R., Natural autoantibodies to thymocytes: origin, VH genes, fine specificities, and the role of Thy-1 glycoprotein. J. Exp. Med. 1990. 172: 869-878.
55. Eisenberg, R. A., Theofilopoulos, A. N., Andrews, B. S., Peters, C. J., Thor, L. and Dixon, F. J., Natural thymocytotoxic autoantibodies in autoimmune and normal mice. J. Immunol. 1979. 122: 2272-2278.
56. Gui, M., Wiest, D. L., Li, J., Kappes, D., Hardy, R. R. and Hayakawa, K., Peripheral CD4+ T cell maturation recognized by increased expression of Thy-1/CD90 bearing the 6C10 carbohydrate epitope. J. Immunol. 1999. 163: 4796-4804.
57. Morton, L. M., Wang, S. S., Devesa, S. S., Hartge, P., Weisenburger, D. D. and Linet, M. S., Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood 2006. 107: 265-276.
58. Royston, I., Majda, J. A., Baird, S. M., Meserve, B. L. and Griffiths, J. C., Human T cell antigens defined by monoclonal antibodies: the 65, 000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. J. Immunol. 1980. 125: 725-731.
59. Wang, C. Y., Good, R. A., Ammirati, P., Dymbort, G. and Evans, R. L., Identification of a p69, 71 complex expressed on human T cells sharing determinants with B-type chronic lymphatic leukemic cells. J. Exp. Med. 1980. 151: 1539-1544.
60. Hayakawa, K., Hardy, R. R., Stall, A. M. and Herzenberg, L. A., Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage. Eur. J. Immunol. 1986. 16: 1313-1316.
61. Herve, M., Xu, K., Ng, Y. S., Wardemann, H., Albesiano, E., Messmer, B. T., Chiorazzi, N. et al., Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J. Clin. Invest. 2005. 115: 1636-1643.
62. Bichi, R., Shinton, S. A., Martin, E. S., Koval, A., Calin, G. A., Cesari, R., Russo, G. et al., Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc. Natl. Acad. Sci. USA 2002. 99: 6955-6960.
63. Hardy, R. R., Hayakawa, K., Shimizu, M., Yamasaki, K. and Kishimoto, T., Rheumatoid factor secretion from human Leu-1+ B cells. Science 1987. 236: 81-83.
64. McWilliams, L., Su, K. Y., Liang, X., Liao, D., Floyd, S., Amos, J., Moody, M. A. et al., The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors. J. Leukoc. Biol. 2013. 94: 991-1001.
65. Lee, J., Kuchen, S., Fischer, R., Chang, S. and Lipsky, P. E., Identification and characterization of a human CD5+ pre-naive B cell population. J. Immunol. 2009. 182: 4116-4126.
66. Griffin, D. O., Holodick, N. E. and Rothstein, T. L., Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70. J. Exp. Med. 2011. 208: 67-80.
67. Perez-Andres, M., Grosserichter-Wagener, C., Teodosio, C., van Dongen, J. J., Orfao, A. and van Zelm, M. C., The nature of circulating CD27+CD43+ B cells. J. Exp. Med. 2011. 208: 2565-2566.
68. Descatoire, M., Weill, J. C., Reynaud, C. A. and Weller, S., A human equivalent of mouse B-1 cells? J. Exp. Med. 2011. 208: 2563-2564.
69. -: a reply to "A human equivalent of mouse B-1 cells?" and "The nature of circulating CD27+CD43+ B cells". J. Exp. Med. 2011. 208: 2566-2569.
70. Griffin, D. O. and Rothstein, T. L., A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus. J. Exp. Med. 2011. 208: 2591-2598.
71. Reynaud, C. A. and Weill, J. C., Gene profiling of CD11b(+) and CD11b(-) B1 cell subsets reveals potential cell sorting artifacts. J. Exp. Med. 2012. 209: 433-434.
72. Stall, A. M., Farinas, M. C., Tarlinton, D. M., Lalor, P. A., Herzenberg, L. A., Strober, S. and Herzenberg, L. A., Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Proc. Natl. Acad. Sci. USA 1988. 85: 7312-7316.
73. Forster, I., Gu, H. and Rajewsky, K., Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment. EMBO J. 1988. 7: 3693-3703.
74. Fazi, C., Scarfo, L., Pecciarini, L., Cottini, F., Dagklis, A., Janus, A., Talarico, A. et al., General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood 2011. 118: 6618-6625.
75. Widhopf, G. F., 2nd, Rassenti, L. Z., Toy, T. L., Gribben, J. G., Wierda, W. G. and Kipps, T. J., Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004. 104: 2499-2504.
76. Klein, U. and Dalla-Favera, R., New insights into the pathogenesis of chronic lymphocytic leukemia. Semin. Cancer Biol. 2010. 20: 377-383.
77. Chu, C. C., Catera, R., Zhang, L., Didier, S., Agagnina, B. M., Damle, R. N., Kaufman, M. S. et al., Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood 2010. 115: 3907-3915.
78. Duhren-von Minden, M., Ubelhart, R., Schneider, D., Wossning, T., Bach, M. P., Buchner, M., Hofmann, D. et al., Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012. 489: 309-312.