Purple carrot extract protects against cadmium intoxication in multiple organs of rats: Genotoxicity, oxidative stress and tissue morphology analyses

Journal of Trace Elements in Medicine and Biology

Volumn 33, Issue , 2016, Pages 37-47

  Claudio, Samuel Rangel ^a   Gollucke, Andrea Pittelli Boiago ^a   Yamamura, Hirochi ^a   Morais, Damila Rodrigues ^b   Bataglion, Giovana Anceski ^b   Eberlin, Marcos Nogueira ^b   Peres, Rogerio Correa ^a   Oshima, Celina Tizuko Fujiyama ^a   Ribeiro, Daniel Araki ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cadmium; Genotoxicity; Oxidative stress; Purple carrot; Rat

Indexed keywords

CADMIUM; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; PLANT EXTRACT; PURPLE CARROT EXTRACT; UNCLASSIFIED DRUG; 8-OXO-7-HYDRODEOXYGUANOSINE; DEOXYGUANOSINE; MUTAGENIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CADMIUM INTOXICATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC DAMAGE; GENOTOXICITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTOXICATION; LIVER CELL; MEDICINAL PLANT; MICRONUCLEUS TEST; MULTIPLE ORGAN FAILURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PURPLE CARROT; RAT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE DEGENERATION; TISSUE REGENERATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTIBODY SPECIFICITY; BONE MARROW CELL; CADMIUM POISONING; CARROT; CHEMISTRY; COMET ASSAY; DNA DAMAGE; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; GENE EXPRESSION REGULATION; LIVER; METABOLISM; PATHOLOGY; WEIGHT GAIN; WISTAR RAT;

ANIMALS; BONE MARROW CELLS; CADMIUM POISONING; COMET ASSAY; CYTOCHROMES C; DAUCUS CAROTA; DEOXYGUANOSINE; DNA DAMAGE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LIVER; MICRONUCLEUS TESTS; MUTAGENS; ORGAN SPECIFICITY; OXIDATIVE STRESS; PLANT EXTRACTS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; WEIGHT GAIN;

EID: 84951120289     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2015.08.006     Document Type: Article

References (48)

1. Simon P.W., Freeman R.E., Vieira J.V., Boiteux L.S., Briard M., Nothnagel T., Michalik B., Kwon Y.-S. Carrot. Vegetables II 2008, 327-357. Springer, New York, USA.
2. Gould K.S. Nature's Swiss army knife: the diverse protective roles of anthocyanins in leaves. BioMed Res. Int. 2004, 314-320.
3. Xu Z.S., Huang Y., Wang F., Song X., Wang G.L., Xiong A.S. Transcript profiling of structural genes involved in cyanidin-based anthocyanin biosynthesis between purple and non-purple carrot (Daucus carota L.) cultivars reveals distinct patterns. BMC Plant Biol. 2014, 14:262.
4. Turker N., Aksay S., Ekiz H.I. Effect of storage temperature on the stability of anthocyanins of a fermented black carrot (Daucus carota var. L.) beverage, Shalgam. J. Agric. Food Chem. 2004, 52(12):3807-3813.
5. Montilla E.C., Arzaba M.R., Hillebrand S., Winterhalter P. Anthocyanin composition of black carrot (Daucus carota ssp. sativusvar. atrorubens Alef.) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze. Agric. Food Chem. 2011, 59(7):3385-3390.
6. Järup L., Akesson A. Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol. 2009, 238(3):201-208.
7. Donpunha W., Kukongviriyapan U., Sompamit K., Pakdeechote P., Kukongviriyapan V., Pannangpetch P. Protective effect of ascorbic acid on cadmium-induced hypertension and vascular dysfunction in mice. Biometals 2011, 24(1):105-115.
8. Nemmiche S., Chabane-Sari D., Guiraud P. Role of alpha-tocopherol in cadmium-induced oxidative stress in Wistar rat's blood, liver and brain. Chem. Biol. Interact. 2007, 170(3):221-230.
9. IARC (1993) Monographs on Evaluation of câncer risk to humans.
10. Thévenod F. Catch me if you can! Novel aspects of cadmium transport in mammalian cells. Biometals 2010, 23(5):857-875.
11. Hagar H., Al Malki W. Betaine supplementation protects against renal injury induced by cadmium intoxication in rats, role of oxidative stress and caspase-3. Environ. Toxicol. Pharmacol. 2014, 37(2):803-811.
12. Nemmiche S., Chabane-Sari D., Kadri M., Guiraud P. Cadmium chloride-induced oxidative stress and DNA damage in the human Jurkat T cell line is not linked to intracellular trace elements depletion. Toxicol. In Vitro 2011, 25(1):191-198.
13. Anetor J.I. Rising environmental cadmium levels in developing countries, threat to genome stability and health. Niger. J. Physiol. Sci. 2012, 27(2):103-115.
14. Brzóska M.M., Borowska S., Tomczyk M. Antioxidants as a potential preventive and therapeutic strategy for cadmium. Curr. Drug Targets 2015, in press.
15. de Moura C.F., Ribeiro D.A. Are food compounds able to modulate noxious activities induced by cadmium exposure?. Crit. Rev. Food Sci. Nutr. 2015, in press.
16. Leja M., Kamińska I., Kramer M., Maksylewicz-Kaul A., Kammerer D., Carle R., Baranski R. The content of phenolic compounds and radical scavenging activity varies with carrot origin and root color. Plant Foods Hum. Nutr. 2013, 68(2):163-170.
17. de Moura C.F., Ribeiro F.A., de Jesus G.P., da Silva V.H., Oshima C.T., Gollücke A.P., Aguiar O., Ribeiro D.A. Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmiun. Environ. Sci. Pollut. Res. Int. 2014, 21(22):13118-13126.
18. Silva M.J., Vilegas W., da Silva M.A., de Moura C.F., Ribeiro F.A., da Silva V.H., Ribeiro D.A. Mimosa (Mimosa caesalpiniifolia) prevents oxidative DNA damage induced by cadmium exposure in Wistar rats. Toxicol. Mech. Methods 2014, 24(8):567-574.
19. ADA, American Dietetic Association Position of the American Dietetic Association: functional foods. J. Am. Diet. Assoc. 2004, 104:814-826.
20. Brand-Williams W., Cuvelier M.E., Berset C. Use of free radical method to evaluate antioxidant activity. Lebensm. Wiss. Technol 1995, 28:25-30.
21. Giusti M.M., Wrolstad R.E. Characterization and Measurement of Anthocyanins by UV-visible Spectroscopy. Current Protocols in Food Analytical Chemistry 2001, 1-2. John Wiley & Sons, Inc.
22. Aguiar O., Gollücke A.P., de Moraes B.B., Pasquini G., Catharino R.R., Riccio M.F., Ihara S.S., Ribeiro D.A. Grape juice concentrate prevents oxidative DNA damage in peripheral blood cells of rats subjected to a high-cholesterol diet. Br. J. Nutr. 2011, 105(5):694-702.
23. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay, guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35(3):206-221.
24. Ribeiro D.A., Grilli D.G., Salvadori D.M. Genomic instability in blood cells is able to predict the oral cancer risk, an experimental study in rats. J. Mol. Histol. 2008, 39(5):481-486.
25. Nair P.M., Park S.Y., Chung J.W., Choi J. Transcriptional regulation of glutathione biosynthesis genes, γ-glutamyl-cysteine ligase and glutathione synthetase in response to cadmium and nonylphenol in Chironomus riparius. Environ. Toxicol. Pharmacol. 2013, 36(2):265-273.
26. Tomaszewska E., Winiarska-Mieczan A., Dobrowolski P. Hematological and serum biochemical parameters of blood in adolescent rats and histomorphological changes in the jejunal epithelium and liver after chronic exposure to cadmium and lead in the case of supplementation with green tea vs black, red or white tea. Exp. Toxicol. Pathol. 2015, 67(5-6):331-339.
27. Dkhil M.A., Al-Quraishy S., Diab M.M., Othman M.S., Aref A.M., Abdel M., oneim A.E. The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity. Food Chem. Toxicol. 2014, 74:98-106.
28. Yu Y., Wang X., Yang D., Lei B., Zhang X., Zhang X. Evaluation of human health risks posed by carcinogenic and non-carcinogenic multiple contaminants associated with consumption of fish from Taihu Lake, China. Food Chem. Toxicol. 2014, 69:400-493.
29. Iarmarcovai G., Ceppi M., Botta A., Orsière T., Bonassi S. Micronuclei frequency in peripheral blood lymphocytes of cancer patients, a meta-analysis. Mutat. Res. 2008, 659(3):274-283.
30. Tapisso J.T., Marques C.C., Mathias L., Ramalhinho G. Induction of micronuclei and sister chromatid exchange in bone-marrow cells and abnormalities in sperm of Algerian mice (Mus spretus) exposed to cadmium, lead and zinc. Mutat. Res. 2009, 678(1):59-64.
31. Cheng V.J., Bekhit Ael-D, Sedcole R., Hamid N. The impact of grape skin bioactive functionality information on the acceptability of tea infusions made from wine by-products. J. Food Sci. 2010, 75(4):S167-S712.
32. Thirugnanasampandan R., Jayakumar R. Protection of cadmium chloride induced DNA damage by Lamiaceae plants. Asian Pac. J. Trop. Biomed. 2011, 1(5):391-394.
33. Azevedo L., Alves de Lima P.L., Gomes J.C., Stringheta P.C., Ribeiro D.A., Salvadori D.M. Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous xtract and its main purified anthocyanin (delphinidin) in vivo. Food Chem. Toxicol. 2007, 45(5):852-858.
34. Cichoz-Lach H., Michalak A. Oxidative stress as a crucial factor in liver diseases. World J. Gastroenterol. 2014, 20(25):8082-8091.
35. Erdem O., Yazihan N., Kocak M.K., Sayal A., Akcil E. Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats. Toxicol. Ind. Health 2015, in press.
36. Klaunig J.E., Kamendulis L.M., Hocevar B.A. Oxidative stress and oxidative damage in carcinogenesis. Toxicol. Pathol. 2010, 38(1):96-109.
37. Ognjanović B.I., Marković S.D., Pavlović S.Z., Zikić R.V., Stajn A.S., Saicić Z.S. Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats, protective effect of selenium. Physiol. Res. 2008, 57(3):403-411.
38. Jihen el H., Sonia S., Fatima H., Mohamed Tahar S., Abdelhamid K. Interrelationships between cadmium, zinc and antioxidants in the liver of the rat exposed orally to relatively high doses of cadmium and zinc. Ecotoxicol. Environ. Saf. 2011, 74(7):2099-2104.
39. Flora S.J., Shrivastava R., Mittal M. Chemistry and pharmacological properties of some natural and synthetic antioxidants for heavy metal toxicity. Curr. Med. Chem. 2013, 20(36):4540-4574.
40. Valavanidis A., Vlachogianni T., Fiotakis C. 8-hydroxy-2'-deoxyguanosine (8-OHdG), a critical biomarker of oxidative stress and carcinogenesis. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 2009, 27(2):120-139.
41. Cahill A., Wang X., Hoek J.B. Increased oxidative damage to mitochondrial DNA following chronic ethanol consumption. Biochem. Biophys. Res. Commun. 1997, 235(2):286-290.
42. Kitada T., Seki S., Iwai S., Yamada T., Sakaguchi H., Wakasa K. In situ detectionof oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease. J. Hepatol. 2001, 35(5):613-618.
43. Nomoto K., Tsuneyama K., Takahashi H., Murai Y., Takano Y. Cytoplasmic finegranular expression of 8-hydroxydeoxyguanosine reflects early mitochondrialoxidative DNA damage in nonalcoholic fatty liver disease. Appl. Immunohistochem. Mol. Morphol. 2008, 16(1):71-75.
44. Tong X., Lin S., Fujii M., Hou D.X. Echinocystic acid induces apoptosis in HL-60 cells through mitochondria-mediated death pathway. Cancer Lett. 2004, 212(1):21-32.
45. Fujimura M., Morita-Fujimura Y., Copin J., Yoshimoto T., Chan P.H. Reduction of copper, zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia. Brain Res 2001, 889(1-2):208-213.
46. Cai J., Jones D.P. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem. 1998, 273(19):11401-11404.
47. Ullah I., Park H.Y., Kim M.O. Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons. CNS Neurosci. Ther. 2014, 20(4):327-338.
48. Hui C., Bin Y., Xiaoping Y., Long Y., Chunye C., Mantian M., Wenhua L. Anticancer activities of an anthocyanin-rich extract from black rice against breast cancer cells in vitro and in vivo. Nutr. Cancer 2010, 62(8):1128-1136.